No abstract available.
Candida

No abstract available.
Onychomycosis

No abstract available.
Candida ; Onychomycosis

No abstract available.
Nevus

No abstract available.
Hair ; Humans ; Piedra ; Scalp ; Trichosporon

BACKGROUND: Few studies have compared the efficacy, cosmetic outcomes, and adverse events between 5-aminolevulinic acid photodynamic therapy (ALA-PDT) and methyl aminolevulinate-PDT (MAL-PDT) for actinic keratoses (AKs) in Asian ethnic populations with dark-skin. OBJECTIVE: We retrospectively compared the long-term efficacy, recurrence rates, cosmetic outcomes, and safety of ALA-PDT versus MAL-PDT for facial AKs in Koreans. METHODS: A total of 222 facial AKs in 58 patients were included in this study. A total of 153 lesions (29 patients) were treated with 5-ALA, and 69 lesions (29 patients) with MAL. ALA and MAL creams were applied for 6 hours and 3 hours, respectively; the lesions were then illuminated with a halogen lamp at 150 J/cm2 for ALA-PDT and a diode lamp at 37 J/cm2 for MAL-PDT. RESULTS: The complete response rates of ALA-PDT and MAL-PDT were 56.9% and 50.7%, respectively, with no significant difference at 12 months after treatment. No significant difference in recurrence rates was observed between the 2 PDT modalities at either 6 or 12 months after treatment. There was no significant difference in the cosmetic outcomes between the 2 treatment modalities at 12 months after PDT. However, ALA-PDT caused significantly more painful than MAL-PDT (p=0.005). The adverse events were mild to moderate, transient, and self-limiting for both modalities. CONCLUSION: MAL-PDT was similar to ALA-PDT in terms of long-term efficacy, recurrence rates, cosmetic outcomes, and adverse events; however, it was a significantly less painful procedure than ALA-PDT in our study.
Asian Continental Ancestry Group ; Follow-Up Studies* ; Humans ; Keratosis, Actinic* ; Photochemotherapy* ; Recurrence ; Retrospective Studies

Erythema annulare centrifugum (EAC), first described by Darier in 1916, is characterized by annular, circinate, gyrate or serpiginous lesions. Although the pathogenesis of EAC is not fully understood, it is considered to be a hypersensitivity reaction to a wide variety of etiological factors, including autoimmune diseases, internal malignancies, drugs, infections, and pregnancy. To the best our knowledge, no case of EAC associated with Candida guilliermondii infection has ever been published in the Korean medical literature, and there have been a few reported cases associated with Candida albicans in other countries. Herein, we report on a rare and interesting case of EAC in a 62-year-old female patient with Candida guilliermondii infection.
Aminocaproic Acids ; Autoimmune Diseases ; Candida ; Candida albicans ; Erythema ; Female ; Humans ; Hypersensitivity ; Middle Aged ; Pregnancy

Palisaded neutrophilic and granulomatous dermatitis (PNGD) is characterized histopathologically by the presence of granulomatous inflammation with or without leukocytoclastic vasculitis. It has been associated with multiple systemic diseases, particularly autoimmune conditions like rheumatoid arthritis and Behcet's disease. We report a 52-year-old woman with rheumatoid arthritis who presented with a single, non-tender, rapidly growing nodule on her right elbow. Histologic examination of the nodule revealed degenerated collagen, neutrophils, neutrophilic dust, fibrin, and mucin present in the centers of the palisades of histiocytes throughout the dermis. Herein, we report the abrupt onset of PNGD in a patient with rheumatoid arthritis.
Arthritis, Rheumatoid* ; Collagen ; Dermatitis* ; Dermis ; Dust ; Elbow ; Female ; Fibrin ; Histiocytes ; Humans ; Inflammation ; Middle Aged ; Mucins ; Neutrophils* ; Vasculitis

Chilblain lupus erythematosus (LE) is a rare, chronic form of cutaneous LE (CLE), which presents mostly in women as erythematous to violaceous plaques on the acral areas and face, precipitated by cold and damp climates. It may be accompanied by discoid LE (DLE) lesions or other forms of CLE. Up to 20% of patients develop systemic LE (SLE). Although two missense mutations in TREX1, encoding the 3'-5' repair exonuclease 1, were described in familial chilblain LE, the pathogenesis of sporadic chilblain LE remains unknown. To our knowledge, there are a few reports of chilblain LE in the Korean dermatologic literature. Herein, we present a rare and interesting case of sporadic chilblain LE in 71-year-old man and review the Korean literatures.
Aged ; Chilblains ; Climate ; Cold Temperature ; Exodeoxyribonucleases ; Female ; Humans ; Lupus Erythematosus, Cutaneous ; Mutation, Missense

BACKGROUND: T cells and dendritic cells (DCs) are more observed in the psoriatic lesion. Inflammatory DCs stimulate T cell differentiation (Th1 or Th17 cells) by producing IL-12 and IL-23 in psoriasis. Th1 expresses CCR5, while CCR6 is expressed by Th17. CCL20, the ligand of CCR6, is expressed mostly in keratinocytes to play an important role in the migration of Th17 cells. Transforming growth factor (TGF)beta inhibits the inflammatory cytokines and induces fibrosis. But, there are still controversies about the role of TGFbeta1 in psoriasis. OBJECTIVE: The purpose of this study is to clarify the pathogenesis of psoriasis by comparing the expression patterns of CD11c/IL-23, CCR5/CCR6, CCR6/CCL20, CD11c, IFN-gamma, and TGFbeta1 among overall lesional assessment (OLA) 1, 3, 5, and the control group. METHODS: We performed CD11c/IL-23, CCR5/CCR6, CCR6/CCL20 double-immunofluorecence and immunohistochemistry of CD11c, IFN-gamma, and TGFbeta1 after classifying the severity of the lesion in 1, 3, 5 with OLA score. RESULTS: As OLA score increased, the infiltration of CD11c+IL-23+ cells, CCR5+ cells, and CCR6+ cells and the expression of CCL20 also showed a significant increase. While IFN-gamma+ cells also increased with the OLA score, TGFbeta1 showed positivity usually in the increased vascular endothelial cells and the number of TGFbeta1+ vascular endothelial cells increased with OLA score. CONCLUSION: From the results, the interaction among the dendritic cell-effector T cell, and cytokine derived from the cells, and chemokine/chemokine receptor was confirmed to be important in pathogenesis of psoriasis. It was also confirmed that TGFbeta1 is not only important at neoangiogenesis, but at inflammatory angiogenesis in psoriasis.
Cell Differentiation ; Cytokines ; Dendritic Cells ; Endothelial Cells ; Fibrosis ; Immunohistochemistry ; Interleukin-12 ; Interleukin-23 ; Keratinocytes ; Psoriasis ; T-Lymphocytes ; Th17 Cells ; Transforming Growth Factors