1.A Global Multiregional Proteomic Map of the Human Cerebral Cortex
Guo ZHENGGUANG ; Shao CHEN ; Zhang YANG ; Qiu WENYING ; Li WENTING ; Zhu WEIMIN ; Yang QIAN ; Huang YIN ; Pan LILI ; Dong YUEPAN ; Sun HAIDAN ; Xiao XIAOPING ; Sun WEI ; Ma CHAO ; Zhang LIWEI
Genomics, Proteomics & Bioinformatics 2022;20(4):614-632
The Brodmann area(BA)-based map is one of the most widely used cortical maps for studies of human brain functions and in clinical practice;however,the molecular architecture of BAs remains unknown.The present study provided a global multiregional proteomic map of the human cerebral cortex by analyzing 29 BAs.These 29 BAs were grouped into 6 clusters based on similarities in proteomic patterns:the motor and sensory cluster,vision cluster,auditory and Broca's area cluster,Wernicke's area cluster,cingulate cortex cluster,and heterogeneous function cluster.We identified 474 cluster-specific and 134 BA-specific signature proteins whose functions are closely associated with specialized functions and disease vulnerability of the corresponding clus-ter or BA.The findings of the present study could provide explanations for the functional connec-tions between the anterior cingulate cortex and sensorimotor cortex and for anxiety-related function in the sensorimotor cortex.The brain transcriptome and proteome comparison indicates that they both could reflect the function of cerebral cortex,but show different characteristics.These pro-teomic data are publicly available at the Human Brain Proteome Atlas(www.brain-omics.com).Our results may enhance our understanding of the molecular basis of brain functions and provide an important resource to support human brain research.
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