Angiography technique is one of the most important technique in the diagnosis of vascular diseases,espcially in the diagnosis and treatment of intracranial aneurysms,coronary arterial and extremity arterial diseases.Preliminary application of angiography has been carried out on the diagnosis and pre-operative evaluation of some kinds of tumors such as musculoskeletal tumors.In this review,current clinical application and progress,advantages and disadvantages of digital subtraction angiography,computed tomography angiography and magnetic resonance angiography on the diagnosis of musculoskeletal soft tissue tumors are described and analysed.

Objective:To investigate the relationship between meaning in life and procrastination of college students, and whether time value plays an mediating role between them.Methods:A total of 605 college students in Guizhou completed general procrastination scale, time value scale and life meaning scale.SPSS 22.0 software and PROCESS maro program were used for descriptive statistics, correlation analysis and mediating effect exploration.Results:(1) The procrastination score of college students was (34.40±7.74), the score of time value was (33.17±4.41), and the score of meaning in life was(46.03±8.81). (2) Procrastination was negatively correlated with meaning in life and time value ( r=-0.38, -0.16 respectively, P<0.01). While meaning in life was positively correlated with time value( r=0.31, P<0.01). (3) The mediating effect of time value perception between meaning seeking and procrastination was 22.6%.The direct effect of meaning in life on procrastination was 77.4%. Conclusion:College students with high meaning seeking is less procrastination, and time value mediates the effect between procrastination and meaning in life.Improving college students' meaning in life is conducive to indirectly reducing procrastination through time value.

Objective To evaluate arthroscopic reconstruction of a torn anterior cruciate ligament with either a central-third bone-patellar tendon-bone autograft or a two-strand semitendinosus-gracilis autograft and compare the results of clinical testing, satisfaction and functional status. Methods A retrospective study was done on 49 cases undergoing reconstruction with an ipsilateral central-third bone-patellar tendon-bone autograft and 54 treated with an ipsilateral two-strand semitendinosus-gracilis autograft. Patients were followed up for an average of 31.6 months (24-48 months). At the time of final follow-up, patients in each group were evaluated by Lysholm knee score, International Knee Documentation Committee (IKDC) rating scale and KT-1000 arthrometer for ACL ligament stability. Results No statistical difference was found between the groups in regard of the Lysholm knee score, overall IKDC score or KT-1000 arthrometrical measurements that stand for patient satisfaction, knee function and objective stability, respectively. The patellar tendon procedure group had a significantly higher knee pain rate than the hamstring group (37% versus 11%). Conclusions The bone-patellar tendon-bone autograft and the two-strand semitendinosus-gracilis autograft can attain comparable results for anterior cruciate ligament reconstruction in regard to patient satisfaction, knee stability and knee function in the medium-term follow-up. However, reconstruction of anatomic attachment sites, firm initial fixation and a structured postoperative rehabilitation program may have more influence on clinical outcomes and knee stability.

ObjectiveTo explore pathogenesis of headache after subarachnoid hemorrhage (SAH) whether related with immune inflammatory reaction in subarachnoid and observe the effect of immunosuppressive action of dexamethasone on headache.Methods80 patients who was consciousness and complained headache after SAH were randomly divided into four groups, treated only with mannitol, mannitol plus cerebrospinal fluid (CSF) replacement, intrathecal and vein injection with dexamethasone. Effects of four groups were observed.ResultsEfficiencies of four groups were respectively the mannitol group 27.27%, the permutation group 66.67%, the intrathecal group 92.36% and the vein group 30.00%. There was a significantly difference between the intrathecal group and other three groups, and the time of headache remission for intrathecal group was also longer than that of other three groups (P<0.01).ConclusionThe wide immune inflammatory responses in subarachnoid induced by degenerative and hemic CSF is likely main cause of headache after SAH and intrathecal injection with dexamethasone has an obviously effect.

For engineering an efficient butanol-producing Escherichia coli strain, many efforts have been paid on the known genes or pathways based on current knowledge. However, many genes in the genome could also contribute to butanol production in an unexpected way. In this work, we used Tn5 transposon to construct a mutant library including 1 196 strains in a previously engineered butanol-producing E. coli strain. To screen the strains with improved titer of butanol production, we developed a high-throughput method for pyruvate detection based on dinitrophenylhydrazine reaction using 96-well microplate reader, because pyruvate is the precursor of butanol and its concentration is inversely correlated with butanol in the fermentation broth. Using this method, we successfully screened three mutants with increased butanol titer. The insertion sites of Tn5 transposon was in the ORFs of pykA, tdk, and cadC by inverse PCR and sequencing. These found genes would be efficient targets for further strain improvement. And the genome scanning strategy described here will be helpful for other microbial cell factory construction.
Butanols ; chemistry ; DNA Transposable Elements ; Escherichia coli ; metabolism ; Fermentation ; Gene Library ; Hydrazines ; Industrial Microbiology ; Mutagenesis ; Open Reading Frames ; Organisms, Genetically Modified ; Polymerase Chain Reaction ; Pyruvic Acid ; chemistry

0.05)respectively.Conclusions:Treatment of condylar process fracture should be based on the type of the fracture.

Total laparoscopic splenectomy combined with pericardial devascularization has become an important surgical treatment for portal hypertension patients. Compared with the traditional open surgery, laparoscopic surgery has multiple advantages including precise operation, small trauma and quick recovery. Accurate preoperative evaluation, precise surgical operation and delicate perioperative management are still important parts in perioperative management of laparoscopic surgery. Preoperative reasonable and accurate individualized assessment, strict control surgical indications and contraindications are the important basis to ensure the perioperative surgery to be safe and rational; standardized and individualized surgical operation is the key for accurate vascular disconnection, reducing intraoperative bleeding and perioperative complications; the concept of fast-track surgery is conducive to the rapid recovery of patients with portal hypertension and reduce the operation related complications. Anticoagulant therapy is a safe and effective treatment to reduce portal vein thrombosis. It is an important task to strengthen the cooperation among different disciplines for the treatment of portal hypertension in the future.

OBJECTIVE: To investigate the efficacy, safety and patient compliance of transdermal estrogen patches(17-β estradiol, 1.5 mg per patch) in the hormone therapy in menopausal women. METHODS: Thirty-five naturally menopausal women with serum levels of FSH >40 u · L-1 and E2 < 30 pg · mL-1 were chosen. Transdermal estrogen patches were continuously used once a week for 24 weeks. On the same day of using the forth patches every month, the patients began taking 10 mg dydrogesterone per day for 10 d. Menopausal complaints were evaluated, and the serum FSH and E2 levels were determined before and after the hormone therapy. The safety index and the compliance of patients were observed. RESULTS: Kupperman index were decreased significantly and menopausal complaints were relieved notablely; serum E2 levels increased after therapy. Before and after treatment, liver and kidney functions, blood glucose and blood coagulation were within the normal range. CONCLUSION: Transdermal estrogen patches (17-β estradiol, 1.5 mg per patch) is effective and safe for relieving menopausal symptoms at least in a short term.

Histone deacetylases inhibitors (HDACIs) are a group of compound regulating gene expression at transcriptional level. HDACIs can induce protein hyperacetylation and subsequently lead to chromatin remodeling, cell-cycle arrest, cell differentiation and apoptosis, and transcriptional activation and repression. HDACIs demonstrate promising antitumor activity and are presently tested in clinical studies for solid and hematologic malignancies. Cumulating evidence in animal models of immune disorders also suggests immunosuppressive properties of HDACIs, which provides us with new ideas for treating immune disorders and rejection after transplantation. This paper reviews the recent progress of immunosuppressive function induced by HDACIs from the following aspects: immune diseases, T lymphocytes, inflammatory cytokines and dendritic cells.

Objective To study the etiology, differential diagnosis and effective treatment of hyponatremia after the tumor resection in sellar area. Methods 25 patients with tumor in sellar area which have suffered hyponatremia after surgery were retrospectively analyzed. Among them 14 cases were underwent a whole resection, 6 cases great part resection, and 5 cases partial resection. Water and blood sodium and central vein pressure in these patients were daily examined after surgery. Methods of treatment were adopted according to the results of examination. Results All the patients have suffered hyponatremia after surgery, accounting for 21.4% of all patients with tumors in sellar area in the same period. There are 10 of syndrome of inappropriate antidiuretic hormone (SIADH) and 15 of cerebral salt wasting syndrome (CSWS). Twenty-four patients were cured, one died of pneumonia(ARDS). Conclusions After surgery, the hyponatremia is prone to emergence in the patients with tumors in sellar area and simultaneously invading the hypothalamus. SIADH and CSWS are easily confused in clinical diagnosis, so a careful differentiation should always be done and followed a right therapy.