1.Bilateral Congenital Coronary Arteriovenous Fistulas.
Byoung Wook NA ; Sang Wook LIM ; Jae Wan PARK ; Pil Won PARK ; Yoon Kyoung CHO ; Tae Yong KIM ; Dong Hoon CHA
Korean Circulation Journal 1998;28(9):1630-1632
Coronary arteriovenous fistulas (CAVF) are rare malformations of the coronary circulation. They are seen in approximately 0.1% to 0.2% of all patients undergoing selective coronary angiography. We experienced a 58-years old male patient with bilateral coronary AV fistulas whoes diagnosis was confirmed by selective coronary angiography.
Arteriovenous Fistula*
;
Coronary Angiography
;
Coronary Circulation
;
Diagnosis
;
Fistula
;
Humans
;
Male
;
Middle Aged
2.Analysis of fMRI Signal Using Independent Component Analysis.
Chan Hong MOON ; Dong Gyu NA ; Hyun Wook PARK ; Jae Wook RYOO ; Eun Jung RHEE ; Hong Sik BYUN
Journal of the Korean Society of Magnetic Resonance in Medicine 1999;3(2):188-196
The fMRI signals are composed of many various signals. It is very difficult to find the accurate parameter for the model of fMRI signal containing only neural activity, though we may estimating the signal patterns by the modeling of several signal components. Besides the nose by the physiologic motion, the motion of object and noise of MR instruments make it more difficult to analyze signals of fMRI. Therefore, it is not easy to select an accurate reference data that can accurately reflect neural activity, and the method of an analysis of various signal patterns containing the information of neural activity is an issue of the post-processing methods for fMRI. In the present study, fMRI data was analyzed with the Independent Component Analysis(ICA) method that doesn't need a priori-knowledge or reference data. ICA can be more effective over the analytic method using cross-correlation analysis and can separate the signal patterns of the signals with delayed response or motion related components. The Principal Component Analysis (PCA) threshold, wavelet spatial filtering and analysis of a part of whole images can be used for the reduction of the freedom of data before ICA analysis, and these preceding analyses may be useful for a more effective analysis. As a result, ICA method will be effective for the analysis of signal patterns in fMRI and the pre-filtering may be necessary for the reduction of the degree of freedom of the data.
Freedom
;
Magnetic Resonance Imaging*
;
Noise
;
Nose
;
Principal Component Analysis
3.A Case of Congenital Pericardial Defect Diagnosed by Computed Tomography.
Hong Youp CHOI ; Sang Wook LIM ; Joon Young KIM ; Byung Wook NA ; Kyung Wha WHANG ; Eun Mi JEONG ; Tae Yong KIM ; Dong Hoon CHA ; Jeung Sook KIM
Korean Circulation Journal 2000;30(10):1281-1284
Pericardial defect is a rare congenital cardiac disorder. Most patients were asymptomatic but some patients with partial pericardial defect occasionally complain acute symptoms such as angina, syncope, rarely sudden cardiac death. So, differential diagnosis with other ischemic or structural heart disease is crucial in the management of such patients. But there is no consistently successful diagnostic method. In the past, artificial diagnostic pneumothorax was used to document the absence of pericardium. However, it is not easily accepted due to excess morbidity and failure rate. Recently, echocardiography and more often, computed tomography, magnetic resonance imaging are used to confirm the diagnosis. We experienced a 52 years old male patient with atypical chest pain, who was diagnosed as complete left pericardial defect with computed tomography.
Chest Pain
;
Death, Sudden, Cardiac
;
Diagnosis
;
Diagnosis, Differential
;
Echocardiography
;
Heart Diseases
;
Humans
;
Magnetic Resonance Imaging
;
Male
;
Middle Aged
;
Pericardium
;
Pneumothorax
;
Syncope
4.Behavioral Manifestation of Neuropathic Pain Following Sciatic Nerve Section in Rats.
Dong Jin YOO ; Heung Sik NA ; Young Wook YOON
Experimental Neurobiology 2008;17(2):79-86
The present study was performed to observe the time course of behavioral signs of painful sensations in sciatic neurectomy animal model and to test the effects of sympathectomy and saphenous nerve section on these behavioral signs. Sciatic nerve was ligated and cut at the mid-thigh level under gaseous anesthesia. The application of von Frey filaments to the medial plantar surface of foot revealed weak and long-lasting mechanical allodynia (until end of test period, 20 weeks PO). Acetone application to the plantar surface of foot was used ti measure the sensitivity to cold stimulation. Cold allodynia which is interpreted as increased response to acetone application developed fairly well and lasted the end of test period (20 weeks PO). The cumulative duration of foot lifts off neutral or cold plate was used to test spontaneous, ongoing pain and was increased until 16 weeks PO and 20 weeks PO respectively. These results suggest that sciatic neurectomy which has been widely used as chronic pain model shows behavioral signs suggsting painful sensations except autotomy, which has been used as index of pain in experimental animal. Surgical sympathectomy performed 1 week after sciatic neurectomy partially reduced the behavioral signs of mechanical allodynia and cold allodynia, suggesting behavioral changes developed following section of sciatic nerve was partially sympathetic dependent. Saphenous nerve section 1 week after sciatic neurectomy almost completely reduced mechanical allodynia and cold allodynia, but did not change spontaneous, ongoing pain. These results suggest that evoked responses such as mechanical and cold allodynia are mediated by saphenous nerve activity and activating and/or maintaining mechanisms of spontanous, ongoing pain and evoked pain may be different.
Acetone
;
Anesthesia
;
Animals
;
Chronic Pain
;
Cold Temperature
;
Foot
;
Hyperalgesia
;
Models, Animal
;
Neuralgia
;
Rats
;
Sciatic Nerve
;
Sensation
;
Sympathectomy
5.Association of Depression with Atypical Features and Metabolic Syndrome in Korean Adults
Chung Yeol LEE ; Do Un JUNG ; Sung Jin KIM ; Je Wook KANG ; Jung Joon MOON ; Dong Wook JEON ; You Na KIM ; Dong Jin SHIN ; Sang Hun NAM
Korean Journal of Psychosomatic Medicine 2019;27(2):90-100
OBJECTIVES:
This study aimed to investigate the association between depression with atypical features and metabolic syndromes in Korean adults using the 2016 Korean National Health and Nutrition Examination Survey (KNHANES) data.
METHODS:
We used the 2016 KNHANES data to enroll 277 participants with a score of 10 or higher on Patient Health Questionnaire-9. Depression with atypical features was diagnosed when at least two of the following criteria were met : 1) sleeping more than 10 hours a day ; 2) weight gain of more than 3 kg in a year ; and 3) fatigue/anergia. Depression was divided into two groups based on the presence/absence of atypical features. Physical and mental health, and risk of metabolic syndrome were compared between the groups.
RESULTS:
Among the 277 participants, 91 had depression with atypical features. We identified significant differences in age, sex, income, and education between the two groups. After adjusting for these variables, depression with atypical features had lower EuroQol-5D index scores (p<0.001) and higher prevalence of metabolic syndromes (p=0.035) compared to the depression without atypical features. Depression with atypical features had higher odds ratio (OR) in association with metabolic syndromes after adjusting for confounding variables (OR=1.923 ; 95% confidence interval : 1.069–3.460).
CONCLUSIONS
Depression with atypical features increases the risk of metabolic syndromes and lowers the quality of life.
6.Korean Thyroid Association Guidelines on the Management of Differentiated Thyroid Cancers; Part I. Initial Management of Differentiated Thyroid Cancers - Chapter 4. Pathological Diagnosis and Staging after Thyroidectomy 2024
Su-Jin SHIN ; Hee Young NA ; Ho-Cheol KANG ; Sun Wook KIM ; Dong Gyu NA ; Young Joo PARK ; Young Shin SONG ; Eun Kyung LEE ; Dong-Jun LIM ; Yun Jae CHUNG ; Chan Kwon JUNG ;
International Journal of Thyroidology 2024;17(1):61-67
Postoperative pathological diagnosis of differentiated thyroid cancer (DTC) is important to confirm the diagnosis and predict the risk of recurrence and death. Further treatment plans, such as completion thyroidectomy, radioiodine remnant ablation, or external beam radiation therapy, are then opted for to reduce the predicted risk of recurrence or death. The World Health Organization has classified thyroid cancers into seven distinct categories based on the molecular profile and tumor cell origin. Our recommendation is applicable to differentiated follicular cell-derived carcinoma, the most common form of thyroid cancer, and cribriform morular thyroid carcinoma. Postoperative clinical and pathological staging is recommended for all patients with DTC to determine their prognosis and subsequent treatment decisions. In particular, the American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) staging system is recommended for staging DTCs for disease mortality prediction and national cancer registries. The information in the pathology report, including histologic features of the tumor that are necessary for AJCC/UICC staging and recurrence prediction, can help assess the patient’s risk.
7.Analysis of Enhancement Pattern of Sellar and Parasellar Tumors Using Two-Phase Helical CT.
Ji Young WOO ; Jae Wook RYOO ; Dong Gyu NA ; Hong Gee ROH ; Hong Sik BYUN
Journal of the Korean Radiological Society 2002;46(1):9-15
PURPOSE: To assess the enhancement patterns of sellar and parasellar tumors at two-phase helical CT. MATERIALS AND METHODS: Thirty-two patients with pathologically proven sellar and parasellar tumors [meningioma (n=17), pituitary mocroadenoma (n=6), neurogenic tumor (n=5), cavernous angioma (n=1), chondrosarcoma (n=1), osteosarcoma (n=1), sphenoid carcinoma (n=1)] were included in this study. Two-phase helical CT was performed after the injection of 90 mL of contrast material at a rate of 3 mL/sec. Transverse helical CT scans were obtained during the early and late phases, with scanning delays of 30 and 120 seconds, respectively. Delayed coronal images were obtained after delayed axial images. Attenuation change and the enhancement patterns of the tumors were visually assessed; the former was also assessed quantitatively as the ratio of the CT number at late-phase axial and coronal scanning to that at early-phase scanning. RESULTS: Visual assessment of two-phase helical CT images revealed decreased attenuation in all 17 meningiomas, no change in all six pituitary macroadenomas and increased attenuation in 5 all five neurogenic tumors on late-phase axial scans as compared with early phase scans. Coronal images showed decreased attenuation in all 17 meningiomas, increased attenuation in all five neurogenic tumors and no change in four pituitary macroadenomas (66.7%). The ratio of CT numbers was significantly different between meningiomas, neurogenic tumors and pituitary macroadenomas(p<0.05). CONCLUSION: According to their histopathology, sellar and parasellar tumors showed characteristic enhancement patterns at two-phase helical CT. An analysis of the observed enhancement patterns can be useful in the differential diagnosis of juxtasellar tumors.
Chondrosarcoma
;
Diagnosis, Differential
;
Hemangioma, Cavernous
;
Humans
;
Meningioma
;
Osteosarcoma
;
Tomography, Spiral Computed*
8.A Case of Lichen Spinulosus.
Gi Na KIM ; Dong Soo YU ; Sang Wook SON ; Ae Ree KIM ; Il Whan KIM
Korean Journal of Dermatology 2001;39(9):1046-1048
Lichen spinulosus is a benign follicular eruption seen primarily in younger persons and is frequently classified a disorder of keratinization. The lesion is characterized by the development of patches of small perifollicular papules that have a central horny spine. We report a case of lichen spinulosus developed in an 8-year-old male patient who had atopic dermatitis.
Child
;
Dermatitis, Atopic
;
Humans
;
Lichens*
;
Male
;
Spine
9.Early Detection of Hyperacute Cerebral Infarction in Dogs: Comparison of Unenhanced CT, Diffusion-weighted,Spin-echo T2 - weighted, and Fast FLAIR MR Imaging.
Jung Hwan YOON ; Dong Gyu NA ; Hong Sik BYUN ; Seung Kwon KIM ; Sung Ki CHO ; Jae Wook RYU ; Jae Min CHO ; Byung Tae AHN ; Hae Kyung LEE
Journal of the Korean Radiological Society 1999;41(1):17-25
PURPOSE: This study was performed in order to compare unenhanced CT with diffusion-weighted, T2-weight-ed,and fast FLAIR MR imaging in the detection of hyperacute cerebral ischema induced in a dog and to deter-mine whichmodality first detected cerebral ischemia. MATERIALS AND METHODS: Experimental cerebral infarction was induced bythe occlusion of intracerebral arter-ies using embolic materials (polyvinyl-alcohol, 300 -6 00 micro) introducedthrough a microcatheter into the internal carotid artery of five dogs weighing 12 -20 kg. Serial CT and MR imageswere obtained at one hour intervals from one to five hours after occlusion, and were analyzed independently by tworadiologists. We assessed changes in attenuation, as seen on unenhanced CT and the signal intensity of the lesionon each MR image, and measured the contrast-to-noise ratio (CNR) of the lesions. RESULTS: Ischemic lesions weredetected on unenhanced CT 1 -3 hours after occlusion of cerebral arteries. In all dogs, the lesions were detectedearliest on diffusion-weighted images obtained at 1 hour. They were detect-ed on T2-weighted images at 3 -5 hoursand on fast FLAIR images of 2 -5 hours. The CNR of ischemic lesions increased gradually during the 5-hour period.It was highest on diffusion-weighted images, while on unen-hanced CT, T2-weighted, and fast FLAIR images it wassimilar. CONCLUSION: Hyperacute ischemic lesions were detected earliest on diffusion-weighted images, and earlieron unenhanced CT than on fast FLAIR or T2-weighted MR image.
Animals
;
Brain Ischemia
;
Carotid Artery, Internal
;
Cerebral Arteries
;
Cerebral Infarction*
;
Dogs*
;
Magnetic Resonance Imaging*
10.Inflammatory Pseudotumor of the Extraorbital Head and Neck: CT and MR Imaging Findings.
Eun Jin RHO ; Jae Wook RYOOG ; Dong Gyu NA ; Sam Soo KIM ; Heon HAN ; Choon Hwan HAN ; Ski Kyung LEE
Journal of the Korean Radiological Society 2002;46(5):441-448
PURPOSE: To determine the MR and CT imaging findings of inflammatory pseudotumor of the extraorbital head and neck. MATERIALS AND METHODS: We reviewed the MR (n=10) and CT (n=9) imaging studies of 11 patients with this condition (M:F=5:6, age range: 35-75 years), analysing each case in terms of location, occupying space, signal intensity, intracranial involvement, degree of contrast enhancement and adjacent bone change. Follow-up images were obtained in nine cases, and the response of each patient to steroid treatment was reviewed. RESULTS: Lesions involved the masticator space (n=8), the buccal space (n=6), the nasopharynx (n=5), the paranasal sinus (n=4), the parapharyngeal space (n=3), the prevertebral space (n=2), the orbit (n=2), the carotid space (n=2), the paravertebral space (n=1), parotid space (n=1), and the oral cavity (n=1). In ten of eleven cases, there was adjacent bone change. In three cases, the cavernous sinus was involved, and in two, the dura. One case involved both of them. At T2-weighted imaging, the lesions showed hypointensity in nine of ten cases; in four of nine, signal intensity was markedly low, and in no case was it diffusely high. In five of nine cases, the mass decreased in size after steroid therapy. CONCLUSION: Inflammatory pseudotumor showed iso-to hypointensity at T2-weighted imaging. Lymphadenopathy was not apparent.
Cavernous Sinus
;
Follow-Up Studies
;
Granuloma, Plasma Cell*
;
Head*
;
Humans
;
Lymphatic Diseases
;
Magnetic Resonance Imaging*
;
Mouth
;
Nasopharynx
;
Neck*
;
Orbit