No abstract available.
Germ Cells* ; Neoplasms, Germ Cell and Embryonal*

We experienced the 17 hands of 11 patients with Dupuytren disease, which was known as relatively rare in orientals. Retrospectively, we analyse it and the results were followings; l. Among 11 patients, 10 patients were male and average age was 62.5 years (49 to 77 years) 2. Most (15 hands, 88%) of patients had symptoms of flexion contracture, nodule and contracted cord, simultaneously. 3. Occupation of patients was agricultural laborer in 9 patients (82%). 4. In 9 patients(82%); individual habit of alcoholic drinking, more than 3 times per week, and smoking, 1 package per day, over 20 years more, was observed. 5. In 15 hands (88%), ulnar side of fingers (4th+5th, 5th only or 3rd+4th+5th)was involved. 6. Surgical treatment was performed in 9 hands of 7 patients, with results of excellent in 6 hands (67%) and no recurrence, in average follow up 2.6 years (1.5 year to 3.7 year)
Alcoholics ; Clinical Study ; Contracture ; Drinking ; Dupuytren Contracture ; Fingers ; Follow-Up Studies ; Hand ; Humans ; Male ; Occupations ; Recurrence ; Retrospective Studies ; Smoke ; Smoking

With the improvement of economic conditions and medical care, the average life span has increased, thus making geriatrics an important consideration in the medical field. Degenerative changes of the cervical spine in aged are not uncommon. Also it is well known tha subjects with radiologic features of cervical spondylosis may be symptom free. On the other hand, cervical myelopathy may occur in the presence of minimal spondylosis as shown radiologically. This discrepancy between symptoms and radiologic features seems to be attributed to the differences in the initial structure of the cervical spine. The authors surveyed at random the various radiographic measurements of 300 Koreans having normal cervical spines and 120 Koreans with cervical spondylosis. The results of the survey are as follows: 1. Osteophyte was noticed more frequently at the 3 rd, 4 th and 5 th cervical vertebrae. 2. Lordosis angle was greater in spondylosis group than in normal group, which might be attributed to paravertebral muscle spasm. 3. Normal sagittal diameter of the canal decreased between C3-C6 and the narrowest was at C4 level. The sagittal diameter, on the average, was 1.5 mm shorter than in European population and 1 mm longer than Japanese. This might be attributed to the difference in the body height. 4. In the normal spine group the average interpedicular distance was greatest at the 5 th, and 6 th cervical vertebra. In the cervical spondylosis group the average interpedicular distance was greater than in normal population it was greatest at the 5 th and 6 th cervical vertebra.
Animals ; Asian Continental Ancestry Group ; Body Height ; Cervical Vertebrae ; Female ; Geriatrics ; Hand ; Humans ; Lordosis ; Osteophyte ; Spasm ; Spinal Cord Diseases ; Spine ; Spondylosis

No abstract available.
Hypopigmentation* ; Mosaicism ; Turner Syndrome*

Cognitive deficit is frequently observed in patients with schizophrenia. It is significantly associated with functional outcome. In the past 20 years, due to significant advances on the concept of schizophrenia, cognitive deficit has been accepted as a core feature. In the DSM-5, cognitive deficit does not introduce diagnostic criteria of schizophrenia, but did one dimension of diagnosis of psychosis. Existing schizophrenia drugs are effective in treatment of positive symptoms of schizophrenia, but lack of effectiveness on improving cognitive function. Led by NIMH (National Institute of Mental Health), the MATRICS (Measurement and Treatment Research to Improve Cognition in Schizophrenia) meeting was conducted in order to achieve consensus on measuring tools and neuropharmacological targets for clinical trials for development of new drugs for improvement of cognitive function in schizophrenia. At the MATRICS consensus meeting, glutamatergic modulators and nicotinic and muscarinic agonists are expected to be promising, but should be proven by a double-blind placebo-controlled multicenter study for patients.
Cognition ; Consensus ; Diagnosis ; Drug Therapy ; Humans ; Muscarinic Agonists ; National Institute of Mental Health (U.S.) ; Psychotic Disorders ; Schizophrenia*

No abstract available.
Bronchi*

No abstract available.
Colon* ; Dilatation* ; Humans ; Infant, Newborn*

Recent investigations have revealed that autocrine growth factors and their receptors are closely related and play an important role in controlling cancer cell growth. We performed an immunohistochemical study on the expression of epidermal growth factor (EGF), transforming growth factor-alpha (TGF-alpha), epidermal growth factor receptor (EGF-R), c-erbB-2, and PCNA labelling index in 60 cases of human gastric carcinomas. TGF-alpha was detected in 38 cases (63.3%), EGF in 26 cases (43.3%), EGF-R in 44 cases (73.3%), and c-erbB-2 in 18 cases (30%). These growth factors, EGF-R and c-erbB-2, were found more often in advanced gastric cancers. The PCNA labeling index was significantly higher in tumors with the expression of EGF-R or c-erbB-2. Tumors with simultaneous expression of EGF, TGF-alpha, EGF-R and c-erbB-2 was associated with a high PCNA labeling index. A correlation was observed between the synchronous expression of growth factors and its receptors and histological differentiation. The results suggest that the expression of EGF, TGF-alpha, EGF-R and c-erbB-2 are closely related and plays an important role in the growth and progression of human gastric carcinoma.
Epidermal Growth Factor* ; Humans ; Intercellular Signaling Peptides and Proteins ; Peptides* ; Proliferating Cell Nuclear Antigen ; Receptor, Epidermal Growth Factor ; Stomach Neoplasms ; Transforming Growth Factor alpha

No abstract available.
Cisplatin* ; Drug Therapy* ; Ovarian Neoplasms*

No abstract available.
Cisplatin* ; Drug Therapy* ; Ovarian Neoplasms*