Cutaneous leishmaniasis is a self-limited infection of the skin caused by Leishmania tropica, a protozoan parasite transmitted by Phlebotomus sandfly. This disease is endemic in tropical and subtropical zone, but recently many cases of cutaneous leishmaniasis were reported in Korean among the peoples who had been worked in the Middle East. We experienced five cases of cutaneous leishmaniasis developed in Korean who had been worked in Saudi Arabia and Jordan. Skin lesions of various sized, central ulcerated and marginal elevated, with serosanguinous discharge and some crust were scattered on exposed area, especially both extremities. Histopathologic findings showed hyperkeratosis, acanthosis, pseudoepitheliomatous hyperplasia, dermal infiltration of histiocytes, lymphocytes, plasma cells and neutrophils, and numerous Leishman-Donovan bodies in and around histiocytes. About 1-4 months treatment with trimethoprim-sulfamethoxazole and metronidazole, two cases were healed with hyperpigmented scar and two cases were improved but one case was not responded.
Cicatrix ; Extremities ; Histiocytes ; Hyperplasia ; Jordan ; Leishmania tropica ; Leishmaniasis, Cutaneous* ; Lymphocytes ; Metronidazole ; Middle East ; Neutrophils ; Parasites ; Phlebotomus ; Plasma Cells ; Psychodidae ; Saudi Arabia ; Skin ; Trimethoprim, Sulfamethoxazole Drug Combination ; Ulcer

We retrospectively studied 53 cases of thymic tumors diagnosed after thymectomy to clearfied the pathologic difference of thymic tumor associated with myasthenia gravis and without myasthenia gravis. Among them, there are 23 cases with myasthenia gravis; 19 among 36 thymomas(52.8%), 3 of 4 thymolipoma (75%) and 1 squamous cell carcinoma. Lymphoma and teratoma are not associated with myasthenia gravis. There is no significant difference in the prevalence of myasthenia gravis between types of the old traditional classification of thymoma. But according to the new Muller-Hermelink classification, about two-thirds of myasthenia gravis have the thymoma with cortical cell origin. The prevalence of myasthenia gavis were relatively low in the patients with thymoma of medullary or mixed type. The frequent association of myasthenia gravis was suggesting that the thymolipoma might be a variant of thymoma, cortical type.
Carcinoma, Squamous Cell ; Classification ; Humans ; Lymphoma ; Myasthenia Gravis* ; Prevalence ; Retrospective Studies ; Teratoma ; Thymectomy ; Thymoma ; Thymus Gland* ; Thymus Neoplasms

Herpes Gestationis is a rare polymorphous, vesiculobullous disease of pregnancy and puerperium. It is characterized by rapidly progressive skin eruption heraled initially by severe generalized pruritus. Erythematous papules and urticaria like plaques rapidly appear followed by grouped, tense, vesiculobullous eruptions. A 23 year-old pregnant woman was admitted to our departrnent of dermatology hecause of erythematous patches with pruritic vesiculobullous and pustular eruption on the whole body since third week of conception, Biopsy specimen of bullous skin lesion showed spongiosis of epidermal cells, mild necrosis of basal cells, subepidermal bulla, edema, of papillary derrnis and perivascular infiltration of inflammatory cells. Ultrastructural findings showed mild necrosis of basal cells, bulla above or below basement membrane zone and partial separation of basal larnina. Direct immunofluorescences of bullous lesion and normal appearing skin demonstrated deposition of IgG in linear pattern along basement rnembra,ne zone. After treatment with systemic corticosteroid and antihistamin, the lesions were cleared, leaving residual hyperpigmentation, and she delivered normal female baby.
Basement Membrane ; Biopsy ; Blister ; Dermatology ; Edema ; Female ; Fertilization ; Fluorescent Antibody Technique, Direct ; Humans ; Hyperpigmentation ; Immunoglobulin G ; Necrosis ; Pemphigoid Gestationis* ; Postpartum Period ; Pregnancy ; Pregnant Women ; Pruritus ; Skin ; Transcutaneous Electric Nerve Stimulation ; Urticaria ; Young Adult

The Venereal Disease Research Laboratory microflocculation (VDRL) test, especially the quantitative test is well standardized, simple, rapid and, at present, the most widely used non-treponernal test in serodiagnosis and follow up sturly of syphilis. However, the UDRL test result could be influenced by room ternperature, especially in summer and winter in Korea in the abscence of proper air-conditioning and heating. This study was undertaken to evaluate the effect of room temperature on the VDRL test result and to determine the critical temperatures which alter the test result. Eighty six VDRL-reactive serum samples collected at the Soonchunhyang Medical College Hospital and the V.D. Clinic of the Chung-Ku Public Health Center in Seoul during the 7 months periods from September 1982 to March 1983 were used. The results obtained were as follows: The change in the VDRL titer was not obscrved at room temperature of between 18 C and 32 C 2. The VDRL titer became weakly reactive on the same titer or lowered to half titer at room temperature of below 18C. R. The VDRL titer increased two fold at room temperature of above 32C.(countinue..)
Follow-Up Studies ; Heating ; Hot Temperature ; Korea ; Public Health ; Seoul ; Serologic Tests ; Sexually Transmitted Diseases ; Syphilis

Primary hemangiopericytoma of chest wall is very rate and only a few cases have ever been reported. The tumor aries from the capillary pericyte of Zimmerman. It is a highly vascular slow growing tumor which can be calssified as both malignant and benign varieties. We report a case of a 66 year-old man in whom recurrent hemangiopericytoma was treated by complete surgical excision. In October 1993 he had received surgical excision of hemangiopericytoma on posterior chest wall. For more than 6 years after the operation he was in good condition until a recurrent mass was found on the chest X-ray. The patient was discharged 9 days after the operation and is receiving radiotherapy.
Aged ; Capillaries ; Hemangiopericytoma* ; Humans ; Pericytes ; Radiotherapy ; Thoracic Wall* ; Thorax*

Wilms' tumor is one of the most common primary malignant tumors of the kidney during infancy and childhood and is known to be originated from the primitive cells of metanephric blastema. It presents difficulties when encountered in deciding the presence of anaplasia or in differentiating it from other renal tumors of childhood with different biologic behavior because of its diverse histologic patterns and varying degrees of differentiation. Evaluation of clinical and histopathologic features in terms of prognostication was done of 32 cases of Wilms' tumor which were surgically resected and diagnosed in the period from January 1979 through June 1992. Immunohistochemical reaction for cytokeratin, vimentin, actin and desmin was also analysed on all cases of Wilms' tumor in conjunction with clear cell sarcoma of the kidney(CCSK), malignant rhabdoid tumor of the kidney(MRTK) and congenital mesoblastic nephroma(CMN) to assess the validity of immunohistochemistry in differentiating Wilms' tumor from these renal tumors. Twenty four(75%) cases were diagnosed before the age of 5 and 40.7% were under 2 years old. Mixed type was most common(62.5%), followed by epithelial, blastemal and stromal predominant type in descending order of frequency. Anaplasia was observed in 3 cases(9.4%), two of which were epithelial predominant type and one blastemal predominant type. Treatment modality and presence of anaplasia were significantly correlated with 5 year survival rate of patients. Immunohistochemical stain revealed that all epithelial component of Wilms' tumor were positive for cytokeratin and 56.3% of Wilms' tumor had blastemal component which were positive for both cytokeratin and vimentin. Twenty cases(62.5%) of Wilms' tumor had blastemal component which were positive for cytokeratin with a proportion of more than 5% of reactive cells. Stromal component of Wilms' tumor generally did not show differentiation into the specialized type of tissue and all revealed positive reactions for vimentin among which some revealed positive reactions for actin. Only 3 out of 6 cases with rhabdomyoblastic differentiation were positive for desmin. CCSK, MRTK and CMN which have different biologic behavior and treatment modality compared to Wilm's tumor showed positivity only for vimentin and/or actin. In summary, treatment modality and presence of anaplasia are significantly correlated with patients' survival and the immunohistochemical stain for cytokeratin is very helpful in confirming the presence of blastemal component and useful in the differential diagnosis of Wilms' tumor from other kinds of pediatric renal tumors.
Child ; Male ; Female ; Humans ; Diagnosis, Differential

An unusual placentoid bullous lesion of the lung was reported. The patient was a 27-year-old woman with a 1-week history of chest pain and mild dyspnea. Chest radiographic studies showed multiple huge bullae in right upper lobe and variable-sized bullae in middle and lower lobes with collapse. She underwent right pneumonectomy with preoperative impression of bullous lung disease and emphysema. Histopathologically, the most distinctive features were villous structures within bullous airspace, which resembled placetal villi with degeneration.
Adult ; Blister* ; Chest Pain ; Dyspnea ; Emphysema ; Female ; Humans ; Lung Diseases ; Lung* ; Pneumonectomy ; Radiography, Thoracic

No abstract available.
Hodgkin Disease*

No abstract available.
Hodgkin Disease*

This study was undertaken to evaluate the efficacy and safety of orally administered ketoconazole in the treatment of onychomycosis. Thirteen patients with onychomycoiis were selected for this study. For evaluation of ketoconazole efficacy twelve patients received a 200 mg tablet of ketoconazole daily and one patient received a. 10() mg tablet of ketoconazole daily. All patients were studied monthly clinically and mycologically by KOH mount and culture on Sabourauds medium. The results were as follows: 1. Seven(53.8%) of thirteen cases achieved remission, marked improvement occurred in three cases(23.1%) and moderate improvement occurred in three cases (23. 1 %). 2. The mean duration of remission or clinical improvement was 5 months for all lesions and toenail lesions(5. 4 months) took longer to heal than finger nail lesions (4 months). 3. One hundred percent of patient who previously failed to respond to griseofulvin were cured or clinically improved by ketoconazole. 4. Two patients cornplained of indigestion and one of headache. In our study, ketoconazole was highly effective in the treatment of onychomycosis.
Dyspepsia ; Fingers ; Griseofulvin ; Headache ; Humans ; Ketoconazole* ; Nails ; Onychomycosis*