No abstract available.
Parathyroid Neoplasms*

Cutaneous leishmaniasis is a self-limited infection of the skin caused by Leishmania tropica, a protozoan parasite transmitted by Phlebotomus sandfly. This disease is endemic in tropical and subtropical zone, but recently many cases of cutaneous leishmaniasis were reported in Korean among the peoples who had been worked in the Middle East. We experienced five cases of cutaneous leishmaniasis developed in Korean who had been worked in Saudi Arabia and Jordan. Skin lesions of various sized, central ulcerated and marginal elevated, with serosanguinous discharge and some crust were scattered on exposed area, especially both extremities. Histopathologic findings showed hyperkeratosis, acanthosis, pseudoepitheliomatous hyperplasia, dermal infiltration of histiocytes, lymphocytes, plasma cells and neutrophils, and numerous Leishman-Donovan bodies in and around histiocytes. About 1-4 months treatment with trimethoprim-sulfamethoxazole and metronidazole, two cases were healed with hyperpigmented scar and two cases were improved but one case was not responded.
Cicatrix ; Extremities ; Histiocytes ; Hyperplasia ; Jordan ; Leishmania tropica ; Leishmaniasis, Cutaneous* ; Lymphocytes ; Metronidazole ; Middle East ; Neutrophils ; Parasites ; Phlebotomus ; Plasma Cells ; Psychodidae ; Saudi Arabia ; Skin ; Trimethoprim, Sulfamethoxazole Drug Combination ; Ulcer

Generalized pustular psorissis which is originary described by von Zumbusch in 1910, is the most intense form of the acute exanthematic variant among psoriasis and it is to be occured as a rare disease. We presented a case of generalized pustular psoriasis of a 16 year-old girl, who suddenly developed wide spread pustules during the acute exacerbating course of the psoriasis which had started from the primary plaque on her left anterior chest one month ago. She was free from subjective symptom. As the objective sign, the leukocytosis was only one of the significant laboratory findings. All skin lesions were almost eleared by the oral administration of methotrexate in 3 months.
Administration, Oral ; Adolescent ; Female ; Humans ; Leukocytosis ; Methotrexate ; Psoriasis* ; Rare Diseases ; Skin ; Thorax

Leukemia cutis, skin lesions in leukemia, are clinically divided into specific and nonspecific types. Specific skin lesions demonstrate malignant cell infiltrate when the biopsy is done. We have encountered a typical case of specific skin lesions of leukemia cutis associated with acute lymphocytic leukemia in a 18-year-old male patient. There were multiple, pinhead to rice sized, skin colored to lemon yellow colored, discrete papules on the face, neck and trunk. A review of the literature is presented with a brief discussion of this case.
Adolescent ; Biopsy ; Humans ; Leukemia* ; Male ; Neck ; Precursor Cell Lymphoblastic Leukemia-Lymphoma* ; Skin

We retrospectively studied 53 cases of thymic tumors diagnosed after thymectomy to clearfied the pathologic difference of thymic tumor associated with myasthenia gravis and without myasthenia gravis. Among them, there are 23 cases with myasthenia gravis; 19 among 36 thymomas(52.8%), 3 of 4 thymolipoma (75%) and 1 squamous cell carcinoma. Lymphoma and teratoma are not associated with myasthenia gravis. There is no significant difference in the prevalence of myasthenia gravis between types of the old traditional classification of thymoma. But according to the new Muller-Hermelink classification, about two-thirds of myasthenia gravis have the thymoma with cortical cell origin. The prevalence of myasthenia gavis were relatively low in the patients with thymoma of medullary or mixed type. The frequent association of myasthenia gravis was suggesting that the thymolipoma might be a variant of thymoma, cortical type.
Carcinoma, Squamous Cell ; Classification ; Humans ; Lymphoma ; Myasthenia Gravis* ; Prevalence ; Retrospective Studies ; Teratoma ; Thymectomy ; Thymoma ; Thymus Gland* ; Thymus Neoplasms

Histiocytic medullary reticulosis is a rare, uniformly fatal, acute disease of the reticuloendothelial system. The disease is associated with fever, malaise, weakness, weight loss, lymphadenopathy, hepatosplenomegaly, jaundice, and purpura. Common laboratory findings are severe anemia, leukopenia, and thrombocytopenia. A 49-year-old male patient is described who had multiple purple nodules and tumors in the skin. A biopsy taken from a skin lesion showed a diffuse proliferation of atypical histiocytes in the dermis and subcutaneous tissue.However, erythrophagocytosis of these atypical histiocytes was not seen.
Acute Disease ; Anemia ; Biopsy ; Dermis ; Fever ; Histiocytes ; Humans ; Jaundice ; Leukopenia ; Lymphatic Diseases ; Male ; Middle Aged ; Mononuclear Phagocyte System ; Purpura ; Skin ; Thrombocytopenia ; Weight Loss

No abstract available.
Bursitis*

We have performed the prick test on 70 patients with atopic lermatitis and at the same time measured the levels of serum IgE and peripheral eosinophil counts. The following results were obtained: 1. Patients with atopic dermatitis showed higher rates of positivty in the prick tests, espe cially to inhalant, allergens. 2. The levels of IgE were increased in these patients and those who were positive to at least one allergen in the prick tests showed higher levels of IgE ha those who were negative in the prick tests. 3. The patients with atopic dermatitis with a past history of allergic rhinitis demonstrated higher rates of skin test positivity. 4. There was no correlation between the levels of serum IgE and the peripheral eosinophil counts in these patients with atopic dermatitis,
Allergens ; Dermatitis, Atopic* ; Eosinophils ; Humans ; Immunoglobulin E* ; Rhinitis ; Skin Tests

The Venereal Disease Research Laboratory microflocculation (VDRL) test, especially the quantitative test is well standardized, simple, rapid and, at present, the most widely used non-treponernal test in serodiagnosis and follow up sturly of syphilis. However, the UDRL test result could be influenced by room ternperature, especially in summer and winter in Korea in the abscence of proper air-conditioning and heating. This study was undertaken to evaluate the effect of room temperature on the VDRL test result and to determine the critical temperatures which alter the test result. Eighty six VDRL-reactive serum samples collected at the Soonchunhyang Medical College Hospital and the V.D. Clinic of the Chung-Ku Public Health Center in Seoul during the 7 months periods from September 1982 to March 1983 were used. The results obtained were as follows: The change in the VDRL titer was not obscrved at room temperature of between 18 C and 32 C 2. The VDRL titer became weakly reactive on the same titer or lowered to half titer at room temperature of below 18C. R. The VDRL titer increased two fold at room temperature of above 32C.(countinue..)
Follow-Up Studies ; Heating ; Hot Temperature ; Korea ; Public Health ; Seoul ; Serologic Tests ; Sexually Transmitted Diseases ; Syphilis

Epidermal keratinocytes are important sources of a wide variety of cytokines that include the endothelin-1 (ET-1). Glucocorticoids have been shown to inhibit the production of several cytokines. However, their effect on ET-1 synthesis by keratinocytes is still unknown. It has been reported that ultraviolet B (UVB) irradiation stimulates both the synthesis and release of ET-1 and it was observed that ET-1 secretion by HaCat cells increased with increasing UVB exposure. In this study, the effects of glucocorticoid on ET-1 production were evaluated using cultured HaCat keratinocytes. The results showed that dexamethasone suppressed basal re-lease of ET-1. In addition, it strongly inhibited the UVB-mediated augmentation of ET-1 production. Furthermore, lincomycin slightly enhanced the inhibitory effect of dexamethasone on ET-1 synthesis.
Cytokines ; Dexamethasone* ; Endothelin-1 ; Glucocorticoids ; Keratinocytes* ; Lincomycin