No abstract available.
Diagnosis* ; Heart Failure* ; Heart Septal Defects, Ventricular ; Heart*

In the treatment of congenital heart in Korea, a big progress has made so far, and successful results have been achieved. However, there were few reports pertaining to the age and cause of death in congenital heart disease patients. Now, the author made observation on the mortality, the age and the mode of death in 3817 patients of congenital heart disease who had been admitted to Severance Hospital during the period of 15 years, from Jan 1972 to Dec 1986. The overall hospital mortality of the congenital heart disease was 6.1% ; 10.1% in the unoperated cases and 4.5% in the patients who underwent surgery. The hospital mortality of indivisual congenital heart disease was, in the order of increasing frequency, 1.0% for ventricular septal defect, and for the complicated heart disease, such as transposition of great vessels(12.5%), and total anomalous pulmonary venous return(15.8%) the death rate was higher in general. The mortality was highest under 1 year of age, especially during the neonatal period, i.e. under 1 month of age. The mode of death in the unoperated cases were congestive heart failure, infection, and hypoxia, in the order of frequency, comprising 84.5%, and in the patients who underwent surgery were congestive heart faliure or low cardiac output syndrome and htpoxia, 62.3%. Among the patients who died in the neonatal period, 76.9% died without accurate diagnosis, and 38.5% were under 5 days of age. Hypoxia(27%), congestive heart faliure(19.4%), and sepsis(11.6%) were the main mode of death. The analysis of the dead patients with congenital heart disease revealed the following results.The mortality was high in the complicated heart disease ; the major mode of death in surgical patients were congestive heart faliure or low cardiac output syndrome ; and the mortality was high in patients under one year of age, especially in the neonates, and most of then lacked accurate diagnosis.Therefore, more accurate properative diagnosis of complicated heart disease and better surgical techniques, development of diagnostic tools in neonatal period, and the need for early surgery and emergency medical management are uregently demanded.
Anoxia ; Cardiac Output, Low ; Cause of Death ; Child* ; Diagnosis ; Emergencies ; Estrogens, Conjugated (USP) ; Heart ; Heart Defects, Congenital* ; Heart Diseases ; Heart Failure ; Heart Septal Defects, Ventricular ; Hospital Mortality ; Humans ; Infant, Newborn ; Korea ; Mortality

No abstract available.
Heart Septal Defects, Ventricular* ; Pulmonary Subvalvular Stenosis*

A 4 years old Korean male child was presented with delay of regaining consciousness after general anesthesia for the correction of the right hand deformity and limitation of motion. In 1961 Frederich described the failure to regain consciousness after general anesthesia. 1.Hypoxia. 2. Excess of CO2.3. Anesthetic overdose, surgical shock, hypotension. 4. Miscellaneous factors: cerebro-vascular accidents, metabolic acidosis, hypoglycemia, uremia, hemorrhage, cerebral thrombosis, electrolyte imbalance. In this case, we believed that hypoxia was responsible for this complication.
Acidosis ; Anesthesia, General* ; Anoxia ; Cerebral Hemorrhage ; Child ; Child, Preschool ; Consciousness ; Hand Deformities ; Humans ; Hypoglycemia ; Hypotension ; Male ; Shock, Surgical ; Thrombosis ; Uremia

Two cases of upper extremity paralysis following general anesthesia due to malposition paralysis are reported. The one case is brachial plexus paralysis following general anesthesia for hemicoleetomys and the other case is radial nerve paralysis following general anesthesia for radical hysterectomy. In the above two cases, there was not any neurological disease and no trauma history before operation. There was no specific finding in the labaratory test and X-rays. Other authors reported that most of postoperative nerve damage was due to irritating drugs, trauma, hypotension, hypoxia, hypothermia, diabetus mellitus. and malposition. But in the above two cases, we believed that there was no causative factors except malposition.
Anesthesia, General* ; Anoxia ; Brachial Plexus* ; Hypotension ; Hypothermia ; Hysterectomy ; Paralysis* ; Radial Nerve* ; Upper Extremity

The authors have experienced a case of general anesthesia for a patient of congenital esophageal atresia with tracheo-esophageal fistula. Paramount importance of particular attention to the maintenance of patent airway and the removal of secretions whenever necessary for the patient's safety throughout anesthetic and postonesthetic period has been stressed. General anesthetics which irritate the respiratory tract and increase secretions must be avoided. Keeping the patient in an incubator with oxygen and humidity after anesthesia is recommended. In case of respiratory distress due to gastric dilatation, gastrostomy under local anesthesia before operation may be helpful.
Anesthesia ; Anesthesia, General* ; Anesthesia, Local ; Anesthetics, General ; Esophageal Atresia* ; Fistula* ; Gastric Dilatation ; Gastrostomy ; Humans ; Humidity ; Incubators ; Oxygen ; Respiratory System

No abstract available.
Mycobacterium bovis* ; Prostatitis*

Twelve patients with ventricular septal defect with pulmonary hypertension underwent lung biopsy to assess pulmonary obstructive vascular disease at the time of open heart surgery. According to the Heath and Edwards classification in grading of Pulmonary obstructive vasculr disease, there are eleven cases in grade 1 and one case in grade 3. Thickness of media was measured. It was expressed as percentage of medial thickness to outer diameter of artery. The medial thickness was correlated proportionally with elevation of pulmonary arterial pressure and pulmonary vascular resistance to systemic resistance ratio. In tolazoline test performed in 4 cases, one patients who had pulmonary obstructive vascular disease, had no change of pulmonary vascular resistance to systemic vascular resistance after intravenous injection of tolazoline during cardiac catheterization, but Rp/Rs of three cases was decreased significantly.
Arterial Pressure ; Arteries ; Biopsy ; Cardiac Catheterization ; Cardiac Catheters ; Classification ; Heart Septal Defects, Ventricular* ; Humans ; Hypertension, Pulmonary* ; Injections, Intravenous ; Lung ; Pulmonary Artery* ; Thoracic Surgery ; Tolazoline ; Vascular Diseases ; Vascular Resistance

Panax ginseng roots have long been used as a medicinal herb in oriental countries. We have investigated anti-proliferative effects of lipid soluble Panax ginseng components on human renal cancer cell lines. Petroleum ether extract of Panax ginseng roots (GX-PE) or its partially purified preparation (7:3 GX) was added to cultures of three human renal cell carcinoma (RCC) cell lines, A498, Caki-1, and CURC II. Proliferation of RCC cells was estimated by a [3H]thymidine incorporation assay and cell cycle distribution was analyzed by flow cytometry. GX-PE, 7:3 GX, panaxydol and panaxynol inhibited proliferation of all three RCC cell lines in a dose dependent manner in vitro with an order of potency, 7:3 GX > panaxydol > panaxynol = GX-PE. Additive effect of interleukin 4 was also demonstrated, most prominently in Caki-1 which responded poorly to GX-PE alone. Analysis of cell cycle in CURC II and Caki-1 treated with GX-PE demonstrated increase in G1 phase population and corresponding decrease in S phase population. The present study demonstrated that proliferation of human RCC cell lines were inhibited by lipid soluble components of Panax ginseng roots by blocking cell cycle progression at G1 to S phase transition.
Alkanes ; Alkynes/therapeutic use ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents, Phytogenic/therapeutic use* ; Carcinoma, Renal Cell/drug therapy* ; Cell Cycle/drug effects ; Fatty Alcohols/therapeutic use ; Ginseng/therapeutic use* ; Ginseng/chemistry ; Human ; Interleukin-4/therapeutic use ; Kidney Neoplasms/drug therapy* ; Plant Extracts/therapeutic use ; Plant Roots/therapeutic use ; Plant Roots/chemistry

There are several reports to demonstrate that rifampicin, a major anti-tuberculosis agent, is associated with some adverse renal effects, with a few cases of rifampicin-induced minimal change disease (MCD). In the present case, a 68-year-old female presented with nausea, vomiting, foamy urine, general weakness and edema. She had been taking rifampicin for 4 weeks due to pleural tuberculosis. The patient had no proteinuria before the anti-tuberculosis agents were started, but urine tests upon admission showed heavy proteinuria with a 24-h urinary protein of 9.2 g/day, and serum creatinine, albumin, and total cholesterol levels were 1.36 mg/dL, 2.40 g/dL, and 283 mg/dL, respectively. MCD was diagnosed, and the patient achieved complete remission after cessation of rifampicin without undergoing steroid therapy.
Aged ; Antibiotics, Antitubercular/*adverse effects/therapeutic use ; Edema/etiology ; Female ; Humans ; Kidney Function Tests ; Kidney Glomerulus/pathology ; Nausea/etiology ; Nephrosis, Lipoid/*chemically induced/pathology ; Proteinuria ; Remission Induction ; Rifampin/*adverse effects/therapeutic use ; Treatment Outcome ; Tuberculosis, Pleural/*drug therapy