BACKGROUND: Axillary osmidrosis is a distressing problem characterized by unpleasant odor, profuse sweating, and occasional wetting of clothes that may handicap those affected both socially and psychologically. A variety of surgical methods have been developed for the treatment of axillary osmidrosis. OBJECTIVE: To introduce the manual subdermal excision combined with the tumescent liposuction and subcutaneous tissue shaver for axillary osmidrosis. METHODS: Twenty-five patients with axillary osmidrosis were treated by the manual subdermal excision combined with the tumescent liposuction and subcutaneous tissue shaver. RESULTS: Twenty-one(84%) patients had good results, four(16%) fair, and none had a poor result or recurrence. Complications included one case of hematoma, two cases of partial skin necrosis. The wound complication rate was 6.0%(3/50) for the axilla and 12%(3/25) for patients. CONCLUSION: The manual subdermal excision combined with the tumescent liposuction and subcutaneous tissue shaver is effective surgical procedure for the treatment of axillary osmidrosis with a low complication rate and recurrence.
Axilla ; Hematoma ; Humans ; Hyperhidrosis* ; Lipectomy* ; Necrosis ; Odors ; Recurrence ; Skin ; Subcutaneous Tissue* ; Sweat ; Sweating ; Wounds and Injuries

BACKGROUND: Laser resurfacing of cutaneous scars, rhytides, and photodamaged skin has become very popular. Pulsed erbium:YAG laser resurfacing has recently come into favor for the treatment of pitted acne scars. OBJECTIVE: This study was designed to investigate the efficacy and safety of pulsed erbium:YAG laser in cutaneous resurfacing of pitted acne scars. METHODS: 100 patients with pitted acne scars were enrolled in this study. All patients were treated by means of a pulsed erbium:YAG laser with a 2 mm handpiece at the setting of 500 to 1000mJ/pulse and fluences used varied between 5-15J/cm2. Photographs of the face were obtained at baseline and 2 week postoperatively. Two weeks after treatment, postoperative care such as applying hydroquinone 4% and tretinoin 0.05% was recommended for 2 to 4 weeks. RESULTS: Out of 100 patients, 20% of patients showed an excellent response, 50% a good response, 21% a fair response and 9% a poor response. After 6 months, erythema had developed in two patients and and three patients had developed postinflammatory hyperpigmentation, hypopigmentation and delayed contact dermatitis. CONCLUSION: Treatment with pulsed erbium:YAG laser shows high efficacy and low morbidity in pitted acne scar resurfacing.
Acne Vulgaris* ; Cicatrix* ; Dermatitis, Contact ; Erythema ; Humans ; Hyperpigmentation ; Hypopigmentation ; Postoperative Care ; Skin ; Tretinoin

Xanthelasma palpebrum is the most common type of xanthoma that develops mainly on the inner epicanthus of upper eyelids with symmetrical distribution. The lesion tends to be permanent, progressive and cosmetically disfiguring. The recommended treatment has been surgical excision, local treatment with chemicals, and carbon dioxide laser. All of the mentioned treatment have some disadvantages including scarring, pigmentary change and need for local anesthesia. We describe the treatment of xanthelasma palpebrum with the pulsed dye laser which coagulates the hyperpermeable vessels so that the lipid leakage could be blocked and prevent recurrence and further progression.
Anesthesia, Local ; Cicatrix ; Eyelids ; Lasers, Dye* ; Lasers, Gas ; Recurrence ; Xanthomatosis

Trichoblastoma is a rare benign neoplasm that arises in the follicular germinative cells. The terminology and histopathological definition of this tumor is both complex and confusing. Trichoblastoma occurs only on the hair bearing areas such as the scalp, face and pelvic area with varying degrees in size. We describe a case of trichoblastoma occurring as a nodule on the nose. The tumor was composed of numerous lobules of basaloid epithelial cell nests with distinct peripheral palisading of nucleoli that were clearly demarcated from the stroma.
Epithelial Cells ; Hair ; Nose ; Scalp

BACKGROUND/AIMS: Inflammation plays a key role in ischemic acute renal failure (ARF). The present study investigated the infiltration of macrophages in the early phase of ischemic ARF in mice. METHODS: Ischemic ARF was induced by renal clamping for 22 min, while the control mice underwent sham surgery (no clamping). The serum creatinine and blood urea nitrogen (BUN) levels were measured in the control and post-ischemia mice. Immunofluorescence staining was used to measure the number of CD 11b-positive cells in the kidney tissue sections to determine the amount of post-ischemic macrophage infiltration. Lipo-Cl2MBP (clodronate) for macrophages depletion was injected via a tail vein 5 d before ischemia induction and again 2 d before ischemia induction. RESULTS: The study found that the post-ischemia mice had higher levels of serum creatinine and BUN at 16 and 24 h compared to the controls. Immunofluorescence staining showed there were more macrophages in the post-ischemic tissue at 2, 8, 16 and 24 h compared to the control tissue, and that most of these macrophages were located in the outer medulla. The mice treated with clodronate prior to ischemia induction were found to have lower levels of serum creatinine compared to those mice that weren't treated with clodronate. CONCLUSIONS: There was significant infiltration of macrophages from the early phase of ischemic ARF, and this peaked at 16-24 h. Macrophage depletion using clodronate was protective against ischemic ARF.
Animals ; Antigens, CD11b ; Blood Urea Nitrogen ; Clodronic Acid ; Creatinine/blood ; Fluorescent Antibody Technique ; Inflammation/*physiopathology ; Ischemia/*complications/pathology/physiopathology ; Kidney Failure, Acute/blood/etiology/*pathology/physiopathology ; Kidney Medulla/*pathology ; *Macrophages ; Male ; Mice ; Mice, Inbred C57BL ; Perfusion ; Time Factors

No abstract available.
Cicatrix* ; Herpes Zoster* ; Histiocytoma, Benign Fibrous*

PURPOSE: To search for evidence of B cell activation and superantigen involvement in Kawasaki disease. METHODS: Peripheral lymphocytes were first isolated from Kawasaki disease patients in the acute and subacute phases. The T cell and B cell distributions were analyzed, cDNA was generated from the total RNA extracts, and PCR amplification of the cDNA for each immunoglobulin heavy chain family was performed to determine the presence of VH family-specific oligoclonal expansion. CDR3 size analysis was then conducted by two-stage PCR. RESULTS: The percentage of B cells increased significantly(P<0.05) in both the acute and subacute phases. Random utilization of diverse VH family genes was observed in the acute phase, and no family-specific expansion was detected. In 13 out of 15 Kawasaki disease patients, an increase in B cells expressing the VH3 family was seen during the acute phase, making it the most frequently utilized family. Analysis of B cell clonal expansion showed the VH6 family clone of 9 amino acids to be the most common clone, observed in 5 out of 15 Kawasaki disease patients. Analysis of the CDR3 size profile in two patients showed that in the acute phase various prominent bands appeared, some disappearing in the subacute phase, while other newly developed bands appeared. CONCLUSION: VH family-specific B cell expansion was not detected, and clonal expansion of B cells was observed, suggesting that Kawasaki disease may be caused by a conventional antigen, and the antigenic stimulation seen during the acute phase seems to be continuous, resuming after clinical resolution.
Amino Acids ; B-Lymphocytes ; Clone Cells ; DNA, Complementary ; Humans ; Immunoglobulin Heavy Chains ; Lymphocytes ; Mucocutaneous Lymph Node Syndrome* ; Polymerase Chain Reaction ; RNA

No abstract available.
Male ; Penis* ; Xanthogranuloma, Juvenile*

Pediatric epilepsy can be caused by various conditions, including specific syndromes. 1p36 deletion syndrome is reported in 1 in 5,000–10,000 newborns, and its characteristic clinical features include developmental delay, mental retardation, hypotonia, congenital heart defects, seizure, and facial dysmorphism. However, detection of the terminal deletion in chromosome 1p by conventional G-banded karyotyping is difficult. Here we present a case of epilepsy with profound developmental delay and characteristic phenotypes. A 7-year- and 6-month-old boy experienced afebrile generalized seizure at the age of 5 years and 3 months. He had recurrent febrile seizures since 12 months of age and showed severe global developmental delay, remarkable hypotonia, short stature, and dysmorphic features such as microcephaly; small, low-set ears; dark, straight eyebrows; deep-set eyes; flat nasal bridge; midface hypoplasia; and a small, pointed chin. Previous diagnostic work-up, including conventional chromosomal analysis, revealed no definite causes. However, array-comparative genomic hybridization analysis revealed 1p36 deletion syndrome with a 9.15-Mb copy loss of the 1p36.33-1p36.22 region, and fluorescence in situ hybridization analysis (FISH) confirmed this diagnosis. This case highlights the need to consider detailed chromosomal study for patients with delayed development and epilepsy. Furthermore, 1p36 deletion syndrome should be considered for patients presenting seizure and moderate-to-severe developmental delay, particularly if the patient exhibits dysmorphic features, short stature, and hypotonia.
Chin ; Comparative Genomic Hybridization ; Diagnosis ; Ear ; Epilepsy ; Eyebrows ; Fluorescence* ; Heart Defects, Congenital ; Humans ; In Situ Hybridization* ; Infant ; Infant, Newborn ; Intellectual Disability ; Karyotyping ; Male ; Microcephaly ; Muscle Hypotonia ; Nucleic Acid Hybridization* ; Phenotype ; Seizures ; Seizures, Febrile

No abstract available.
Capillaries* ; Granuloma, Pyogenic* ; Hyperplasia* ; Nose* ; Sebaceous Glands*