No abstract available.
Personality Disorders*

Total 74 cases of colon cancer were examined in the Inje Medical College, Pusan Paik-hospital, which were collected from 1979 to the April 1986. The stromal histopathological findings are as followings; 1) The highest frequency of the good reactions of the four parameters of the stromal response (i.e., good general stromal reaction, peripheral tumor disintergration, and each inflammatory cell infiltration and fibrous proliferation alone) was found in Dukes class B1 and the least frequency in Dukes C1. The good general stromal response and the peripheral tumor disintegration are more closely related with the stage than the other two parameters. They are about 60% in class B1, 30% in class B2 and C2, and 20% in class C1. 2) The insistent poorest stromal response of the Dukes C1 in all parameters may be explained from the fact that the cancer cells of this particular stage are very aggressive biologically because the cancer cells are capable to invade the regional lymph nodes before the main tumor can infiltrate all through the layers of the wall. 3) Among the four types of the colon cancer, the better stromal reactions are observed in more than half of the cases of the well and moderately differentiated adenocarcinoma while this trend is completely opposite in the mucinous and poorly differentiated types. 4) The above findings indicate that how closely the stroma influences upon the progress of the colon cancer, or how closely it represents the status of the individual immunological force.
Adenocarcinoma

No abstract available.
Lymphocytes* ; T-Lymphocyte Subsets* ; Thyroid Gland*

No abstract available.

No abstract available.
Humans ; T-Lymphocyte Subsets* ; Thyroid Gland*

No abstract available.
Humans ; T-Lymphocyte Subsets* ; Thyroid Gland*

Gated myocardial SPECT and attenuation correction gave birth to new insights into the pathophysiology of ischemic myocardial perfusion and function in clinical routine practice. Gated myocardial Tc-99m-compound SPECT improved diagnostic accuracy of coronary artery disease and enabled us to observe motion and thickening of myocardial walls as well as myocardial perfusion at the same time. Quantitative and qualitative assessement of myocardial performance and perfusion let us to understand the myocardial physiology in ischemia and infarction. In every patient who underwent gated perfusion SPECT, we will find ejection fraction, left ventricular volumes and regional wall motion. There are hopes to use gated T1-201 SPECT for the same purpose and to use gated SPECT for evaluation of wall motion and thickening at stress or immediate post-stress. Attenuation correction could improve diagnostic accuracy mainly by increasing normalcy ratio or performance of non-expert physicians. Both gated methods and attenuation correction improved specificity of non-expert physicians in diagnosing patients with moderate pretest likelihood. New imaging techniques will fill the desire of cardiologists examine function and perfusion, and possibly metabolism in their clinical routine practice.
Coronary Artery Disease ; Hope ; Humans ; Infarction ; Ischemia ; Linear Energy Transfer ; Metabolism ; Parturition ; Perfusion* ; Physiology ; Sensitivity and Specificity ; Tomography, Emission-Computed, Single-Photon*

Two autopsy cases of polycystic disease of kidney were reported, both female,31 and 61 years of age: gravida 2,and 7 respectively. The incidence among autopsies was 0.3%.Both cases were accompanied with congenital polycysts in liver. The blood pressure of the cases was slightly or moderately elevated and hearts were moderately hpertropic. Renal function were not considerably impaired. Clinically the correct diagnosis were subarachnoidal hemorrhage(by rupture of aneurism) in 1st case and uremia after right nephrectomy in 2nd case. Etiology of the condition was discussed.
Autopsy* ; Blood Pressure ; Diagnosis ; Heart ; Incidence ; Kidney ; Liver ; Nephrectomy ; Rupture ; Uremia

Normal, hepatectomied(partial) or CCI4 injected rats are infected intraperitoneally with human HBV-infected serum, and histopathological examination of major organs, and serologically HBV markers are checked. In the latter groups, the relationship between the regenerating hepatocytes and their infectivity toward HBV are investigated. 1) There are no specific histological changes in the liver which might suggest HBV infection of hepatocytes. 2) There is a tendency to increase basophilic mononuclear cells in the lymphoid organs. At the same time, HBcAb are positive in the rat's serum suggesting that these cells are immunologically oriented effector cells in the defense system. In the groups which received hepatic injury, the number of these cells are decreased. 3) HBcAb are positive in the groups of 5th day, 1 week, and 2 weeks' post-HBV injection. All groups with hepatic injury show trace in the 2 weeks post-HBV injection which corresponds to the concomitant decreased number of basophilic mononuclear cells in the lymphoid organs. 4) Above findings suggest that HBV will promote a proliferative reaction of the mononuclear cells in the lymphoid organs in the early stage of HBV infection. It appears that the infection stops there, and there would be no activation of the mechanism of antibody-dependent cellular cytotoxicity followed by injury of hepatocytes due to the attack of T-lymphocytes manifesting the clinical hepatitis.
Humans ; Rats ; Animals

OBJECTIVE: No medication currently available for the treatment of rheumatoid arthritis is universally effective, and all can produce adverse effects. It is well known that the Acanthopanax koreanum extract has an anti-inflammatory action without any adverse effects reported. We conducted this study whether the Acanthopanax koreanum extract has a preventive and/or regressive effect of collagen induced arthritis in DBA/1J mice. METHODS: Three groups of BDA/1J mice were immunized by intradermal injection of 5ma/ka bovine type lI collagen with complete Freund s adjuvant. Group received 20ma/ka of Acanthopanax koreanum extract orally twice weekly and group K received 1ma/ka dexamethasone intraperitoneally twice weekly. Group ll and lll were divided into two subgroups respectively(Group Il-A, E-B, lll-A and Ill-B). Subgroup A is prevention group(Drugs were started to be given 3 weeks after immunization) and subgroup B is suppression group(Drugs were started to be given 6 weeks after immunization when CIA had been developed already). Group I received no treatment. The prevalence of arthritis were assessed twice weekly. Serum anti-collagen antibody and splenic mononuclear cell stimulation indices (SI) to collagen were measured. Serum tumor necrosis factor-a and interleukin-10 levels were also measured by ELISA. RESULT: Collagen induced arthritis(CIA) started to develop 4 weeks after collagen injections. In Acanthopanax koreanum extract treated group, CIA induction seemed not to be inhibited, but questionably partial supressive effect of arthritis were observed at 10 weeks after collagen injection. In dexamethasone treated group, both of prevention and suppression of CIA could be observed. Levels of anti-collagen antibodies were reduced in dexamethasone treated group, but not in the Acanthopanax koreanum extract treated group. No significant differences of splenic mononuclear cell SI among the groups was observed. There were no significant differences in the levels of serum tumor necrosis factor-a and interleukin-10 among the groups. CONCLUSIONS: These findings showed that the Acanthopanax koreanum extract does not have a definite effect on induction or supression of CIA.
Eleutherococcus* ; Animals ; Antibodies ; Arthritis* ; Arthritis, Rheumatoid ; Collagen* ; Dexamethasone ; Enzyme-Linked Immunosorbent Assay ; Immunization ; Injections, Intradermal ; Interleukin-10 ; Mice* ; Necrosis ; Prevalence