No abstract available.
Sternotomy*

Chronic kidney disease (CKD) is a common condition leading to renal dysfunction and is closely related to increased cardiovascular and mortality risk. CKD is an important public health issue, and recent genetic studies have verified common CKD susceptibility variants. This research examines the interrelationship between candidate genes polymorphisms of interferon lambda (IFNL) induction, its signaling pathway, and CKD. Methods: Seventy-five patients with advanced CKD and 312 healthy subjects (as controls) participated in this research. A replication set composed of 172 patients with advanced CKD and 365 controls was used for additional analysis. The genotype of single nucleotide polymorphisms (SNPs) was determined by the Axiom Genome-Wide Human Assay and SNaPshot assay. Results: The SNP of IFNL3 was significantly associated with CKD in the codominant (p = 0.02) and dominant models (p = 0.02). In addition, the SNPs of IFNL2 were significantly associated with CKD in the dominant model (p = 0.03), and the SNP of interferon alpha receptor 2 (IFNAR2) was significantly associated with CKD in the log-additive model (p = 0.03). Concerning rs148543092, in the IFNL3 gene, a significant association was observed after pooling the original and replication sets. Conclusion: These results indicate that SNPs in the IFNL induction and signal pathway may be associated with CKD risk in the Korean population. Finally, our results also show that the IFNL3 gene variant may be associated with CKD risk.

Caudal anesthesia for total hip replacement in geriatric patients has been evaluated clinically. The caudal epidural puncture was performed by a 22 G short needle through sacral hiatus with a lateral decubitus position. 1.5% lidocaine 20 mL and 0.5% bupivacaine 15 mL mixed with 1:200,000 epinephrine and 2 mg morphine was used as an anesthetics. The results were follows ; 1) The onset of caudal anesthesia was 7.9+/-4.5 min (2-20 min) and the duration was 4.8+/-3.0 hrs (1-12 hrs). 2) Anesthetic sensory level was not related with the patient's weight or height. 3) The failure rate including systemic toxicity was 13%. 4) The most common complication was hypotension and its incidence was 26.6%. 5) Time to first analgesics was 8.3+/-3.6 hrs. These results indicate that caudal anesthesia in lateral decubitus position is a recommendable anesthetic technique for total hip replacement in geriatric patients. However, the further studies for the determinations of the optimum dose of local anesthetics are needed.
Analgesics ; Anesthesia, Caudal* ; Anesthetics ; Anesthetics, Local ; Arthroplasty, Replacement, Hip* ; Bupivacaine ; Epinephrine ; Geriatrics ; Humans ; Hypotension ; Incidence ; Lidocaine ; Morphine ; Needles ; Punctures

No abstract available.
Humans ; Referral and Consultation*

The common cause of tracheoesophageal fistula(T-E fistula) after tracheal intubation is ulceration and necrosis of the posterior wall of trachea by compression pressure generated by cuff. We experienced a young woman sustaining a T-E fistula which was found on the 12th day of intubation for cardiopulmonary resuscitation. Because spontaneous closure of the fistula is far uncommon, operative closure should be aimed for and should be done as soon as diagnosis is conformed. We delayed operative closure because of poor general condition of the patient. In spite of delayed reconstruction, the tracheal reconstruction itself was successful, but the patient died of peritonitis induced sepsis on the postoperative 41th day.
Cardiopulmonary Resuscitation ; Diagnosis ; Female ; Fistula ; Humans ; Intubation ; Intubation, Intratracheal* ; Necrosis ; Peritonitis ; Sepsis ; Trachea ; Tracheoesophageal Fistula* ; Ulcer

OBJECTS: The purpose of this study was to examine the reliability and validity of Geriatric Depression Scale(GDS). METHODS: GDS, BDI, SDS, MMPI-D, K-CES-D were administered to 81 depressed elderlies and 75 nondepressed elderlies. Those who obtained the 'definite impairment' score in MMSE-K were excluded in the final analyses. RESULTS: The values of Cronbach's alpha and test-retest correlation coefficient were 0.88 and 0.66(p< .001) respectively, The GDS was highly correlated with BDI(r= .72), SDS(r= .78), K-CES-D(r= .75), and MMPI-D(r= .65). The result of the factor analysis showed that GDS had seven factors. They could be labeled as core depressive feature(factor 1), loss of interest/pleasure(factor 2), feeling of unhappiness(factor 3), agitation(factor 4), cognitive inefficiency (factor 5), social withdrawal tendency(factor 6), and lack of motivation(factor 7), which represent important characteristics (emotional, cognitive, and behavioral aspects) of depression in the elderly. The total percent of variance of 7 factors was 53.4%. finally, the result of discrimination analysis showed that the hit ratio of GDS was 64%. CONCLUSION: Although GDS had the reasonable reliability and validity, it seemed to have some limitations in relation to absolute discrimination power. It is necessary to investigate the cultural differences in geriatric depressive symptoms and to develope a new depression scale for elderly people with consideration of the cultural differences.
Aged ; Depression* ; Discrimination (Psychology) ; Humans ; Reproducibility of Results*

No abstract available.
Lasers, Solid-State* ; Papilloma*

No abstract available.
Air Pollutants/*toxicity ; Animals ; Biological Markers/metabolism ; Cell Proliferation/*drug effects ; Female ; Immunohistochemistry ; Inhalation Exposure ; Mice ; Mice, Inbred BALB C ; Nasal Mucosa/drug effects/pathology ; Ozone/*toxicity ; Proliferating Cell Nuclear Antigen/metabolism ; Respiratory Mucosa/*drug effects/metabolism/pathology ; Skin/*drug effects/metabolism/pathology

No abstract available.
Eosinophilic Granuloma* ; Eosinophils* ; Lymph Nodes*

BACKGROUND AND OBJECTIVES: Most reports about coronary angiographic findings in acute myocardial infarction were done after thrombolytic therapy or several days after onset of symptom. The aim of this study is to evaluate coronary angiographic findings in patients with AMI within 24 hours after onset of symptoms and without thrombolytic therapy. Also we evaluated the correlation between the risk factors and severity of coronary artery disease. MATERIALS AND METHODS: We studied 70 patients with acute myocardial infarction admitted to Kyungpook National University Hospital (KNUH) from November 1997 to January 1999, and evaluated the clincial and coronary angiographic findings. We analyzed risk factors of coronary artery disease: age, total cholesterol, tiglyceride, high density lipoprotein (HDL)-cholesterol, low density lipoprotein (LDL)-cholesterol, hypertension, smoking, diabetes and family history of CAD. Coronary angiography was done immediately after the arrival at emergency room (door-to- angiography time). Exclusion criteria were delayed arrival (more than 24 hours after symptom onset), previous history of anticoagulation or medication of antiplatelet agents. RESULTS: 1) Among 70 patients (M/F: 53/17), 59 patients had Q wave myocardial infarction (QMI) (84%), 11 patients had non-Q wave-MI (NQMI) (16%). 2) The mean age was 61+/-12.2 years (range: 26 to 82 years). 3) The mean time from the onset of chest pain to angiography was 6.2+/-4.7 hours. 4) Twenty eight patients (40%) had one-vessel disease, 25 (36%) had two-vessel disease and 17 (24%) had three-vessel disease. 5) The location of infarct related arteries were as follows: LAD in 33 (47%), LCX in 13 (19%) and RCA in 24 (34%). 6) The mean diameter stenosis of infarct related artery (IRA) was 95+/-10.9%. According to the American College of Cardiology/American Heart Association (ACC/AHA) classification of IRA, type B lesion occurred most commonly in 56 patients (80%). 7) Thrombus was observed in 44 patients (63%) with QMI versus 3 patients (27%) with NQMI (p=0.006). 8) Calcifications of the wall of coronary arteries were observed in 28 patients (40%) and correlated with ages of patients. 9) History of cigarette smoking was present in 73%, hypertension in 31% and hypercholesterolemia in 15% of patients. The mean number of risk factor for each patient was 1.3. 10) Multivessel disease was significantly more frequent in patients who had two more risk factors. 11) The frequency of cigarette smoking was greater and the level of plasma triglyceride were higher in patients under 50 years of age. 12) One patient died during coronary angiography and another 2 patients died at 5 and 8 days after coronary angiography due to cardigenic shock. CONCLUSION: In immediate coronary angiographic findings in patients with AMI, multivessel disease and thrombus, and severe stenosis of IRA were observed more frequently than other studies after thrombolytic therapy or after several days of delay. Multivessel disease was significantly more frequent in the patients who had two or more risk factors of atherosclerosis.
Angiography ; Arteries ; Atherosclerosis ; Chest Pain ; Cholesterol ; Classification ; Constriction, Pathologic ; Coronary Angiography ; Coronary Artery Disease ; Coronary Vessels ; Emergency Service, Hospital ; Gyeongsangbuk-do ; Heart ; Humans ; Hypercholesterolemia ; Hypertension ; Lipoproteins ; Myocardial Infarction* ; Plasma ; Platelet Aggregation Inhibitors ; Risk Factors ; Shock ; Smoke ; Smoking ; Thrombolytic Therapy ; Thrombosis ; Triglycerides