2.To understand common pathogenic viruses in pediatrics from the perspectives of viral taxonomy.
Chinese Journal of Pediatrics 2004;42(1):7-9
Child
;
Herpesviridae
;
classification
;
Herpesviridae Infections
;
diagnosis
;
Humans
;
Paramyxoviridae
;
classification
;
Paramyxoviridae Infections
;
diagnosis
;
Parechovirus
;
classification
;
Pediatrics
;
Picornaviridae
;
classification
;
Picornaviridae Infections
;
diagnosis
;
SARS Virus
;
classification
;
Severe Acute Respiratory Syndrome
;
diagnosis
;
Virus Diseases
;
diagnosis
;
Viruses
;
classification
3.Autoimmune hepatitis in children.
Chinese Journal of Pediatrics 2004;42(6):477-479
Adrenal Cortex Hormones
;
therapeutic use
;
Autoantigens
;
immunology
;
Child
;
Cytokines
;
metabolism
;
HLA Antigens
;
genetics
;
Hepatitis, Autoimmune
;
diagnosis
;
immunology
;
therapy
;
Humans
;
Immunosuppressive Agents
;
therapeutic use
;
Liver
;
drug effects
;
metabolism
;
pathology
;
Liver Transplantation
4.Real-time and retrospective analyze of cardiac remote monitoring based on differential threshold method
Chuntao DONG ; Wei SUI ; Hongliu YU
China Medical Equipment 2014;(11):52-54
Objective:To observe the effects of real-time and retrospective analyze of cardiac remote monitoring based on differential threshold method.Methods: Xin An Bao XAB - M3AG ECG remote monitoring system which based on the differential threshold method of improvement being used to determine the parameters of electro cardio signal was installed in 8957 patients.Results: We had collected all 46967 ECG real-time data, including 9564 manual transmission, 25830 timing transmitting and 11573 automatically transmission. 5728 of automatically transmission was with arrhythmia (49.5%) and the others of automatically transmission was attribute to inference.Conclusion: The results showed that algorithm complexity based on the improved differential threshold method is low, the precision is high and it has a good real-time performance. It realized the real-time monitoring of ECG.
5.Effects of Captopril on structure and function of sciatic nerve in diabetic rats
Guoliang SUI ; Guoqing LIU ; Yanhu DONG
Chinese Journal of Endocrinology and Metabolism 1986;0(04):-
Objective To investigate the effects of captopril on structure and function of sciatic nerve in diabetic rats. Methods Streptozotocin induced diabetic male Sprague Dawley rats were treated with 0.1% captopril in drinking water for 12 weeks, then advanced glycation end products (AGEs), cAMP content, and the nerve conduction velocity of sciatic nerve in diabetic rats were measured, morphometric quantitative analysis and ultrastructure of sural nerve were also performed. Results Captopril reduced accumulation of AGEs, restored synthesis of cAMP in sciatic nerve, improved nerve conduction velocity partialy, and ameliorated morphology abnormalities in myelin nerve fibre. Conclusion These findings suggest that captopril may exert a therapeutic effects on diabetic peripheral neuropathy.
6.Immunoadsorption preventing hyperacute rejection of highly sensitized recipients of renal allografts
Weiguo SUI ; Qiang YAN ; Li DONG
Chinese Journal of Organ Transplantation 1996;0(04):-
Objective To investigate immunoadsorption in the prevention of hyperacute rejection in highly sensitized recipients of renal allografts.Methods Immunoadsorption treatment was performed on 10 patients whose panel reactive antigen (PRA) was more than 40 %. The adverse effect and hyperacute rejection were observed.Results Two cases of acute rejection of renal allografts were found in highly sensitized recipients and reversed by the therapy of immunoadsorption and adjusting immuno-suppressive drugs.Conclusion Immunoadsorption treatment could effectively and safely prevent highly sensitized recipients from hyperacute rejection post-transplantation.
7.Diagnose and Treatment of Liver Functional Lesion After Kidney Transplantation
Qiang YAN ; Weiguo SUI ; Li DONG
Journal of Chinese Physician 2001;0(07):-
Objective To investigate the etiological diagnosis and therapy of liver function lesion after kidney transplantation.Methods By analyzing the etiological factor of 82 cases of liver function lesion,we provided a reasonable and operative therapy scheme in kidney post-transplantation.Results Of 82 cases,the number of drug toxicity and viral hepatitis B which result in liver functional lesion were 70 cases(85 5%) and 12 cases(14 5%) respectively.The former were all cured,8 cases in the latter were cured and the other 4 cases were died from acute hepatic failure.Conclusions The liver function lesion of post-transplantation should be diagnosed carefully and treated particularly.Morever,the adjustment of immuno-suppressive drugs and monitoring circlosporin A concentration should be done for the patients with liver function damaged.
8.Research status of health coaching in patients with chronic obstructive pulmonary disease
Dong CHEN ; Dong PANG ; Chunling TAI ; Yuhuan ZHANG ; Shujie SUI
Chinese Journal of Practical Nursing 2021;37(14):1116-1120
Health coaching is a patient-centered intervention process, which had conducted many years in patients with chronic obstructive pulmonary disease (COPD) and made many positive outcomes. This article reviews the concept of health coaching, specific implementation measures, application effects, existing deficiencies and inspiration in patients with COPD, with a view to providing reference for the further development of health coach technology in patients with COPD.
9.Effect of IL-29 on trypsin-induced protease-activated receptor expression on P815 mast cells
Li SUI ; Dong CHEN ; Huiyun ZHANG ; Shaoheng HE
Chinese Journal of Immunology 2014;(5):609-612,622
Objective:To investigate the modulatory effect of IL-29 on trypsin-induced protease activated receptors (PARs) ex-pression on P815 mast cell.Methods:After P815 mast cells were challenged with different concentrations of IL-29 alone or combined with trypsin for 2 h, 6 h and 16 h, the challenged cells were collected and analysed by flow cytometry to detect the protein expression of PARs on P815 cells, and analysed by real time RT-PCR to detect the mRNA expression of PARs on P 815 cells.Results:Compared with the corresponding control , IL-29 induced significantly decreased expression of PAR-1 at protein and mRNA level on P815 cells, and upregulated PAR-3, PAR-4 mRNA level on P815 cells, whereas IL-29 did little effect on the expressions of PAR-2,3,4 at protein level on P815 cells accordingly.Preincubation of mast cell with IL-29 did not alter trypsin-induced PAR-1 expression on P815 cells, whereas up-regulated expression of PAR-2, 3, 4 were detected when P815 cell were pre-treated with IL-29 before being challenged with trypsin compared with the corresponding control .Conclusion: IL-29 can upregulate trypsin-induced PARs expression on mast cells through which participated in mast cell related inflammation .
10.Effects of chronic benzene poisoning on DNA and antioxidase of mice
Dong CHANG ; Hong SUI ; Hongzhi PAN ; Lixin NA
Chinese Journal of Tissue Engineering Research 2005;9(3):240-242
BACKGROUND:As an important industrial solvent,benzene can cause DNA damage,chromosome aberrence,formation of DNA adducts and gene mutation. OBJECTIVE:To explore the effects of benzene on DNA and the mechanism,as well as the changes of antioxidase system it caused. DESIGN:Randomized case control study. SETTING:The Department of Clinical Laboratory of First Affiliated Hospital and Public Health College of Harbin Medical University. PARTICIPANTS:The experiment was completed in the Animal Centre in Public Health College,Harbin Medical University.Twenty-four healthy male mice of Kunming species weighed between 18 g to 22 g were chosen.The mice were provided by Experimental Animal Centre of Second Affiliated Hospital,Harbin Medical University. INTERVENTIONS:The mice were divided into control group,low dose benzene group and high dose benzene group.Inhaling benzene smoke method was used 4 hours per day to cause benzene poisoning to mice except those of the control group.The mice were executed two months later to separate marrow cells and peripheral lymphocytes and remove liver,spleen and brain to make homogenate. MAIN OUTCOME MEASURES:Single cell gel electrophoresis (SCGE) was used to assay the DNA damages of marrow cells and peripheral lymphocytes.Meanwhile,the contents of superoxide dismulase(SOD),glutathione peroxidase(GSH-Px) and malondialdehyde(MDA) in liver,spleen and brain tissues were also detected. RESULTS:The comet percentage of marrow cells and peripheral lymphocytes in two benzene poisoning groups were(83.56± 10.28),(92.54± 15.93)% ,and(41.27± 6.03)% ,(65.79± 11.62)% respectively which were much higher than those in control group[(4.13± 0.52)% ,(2.21± 0.31)% ](P< 0.01) and represented dose-response relationship.The SOD activity of liver homogenate and GSH-Px activity of high dose and low dose groups were (11 573.31± 1 938.72),(12 574.68± 1 938.72) nkat/g and (309.40± 82.85),(375.41± 55.18) nkat/g respectively which were much lower than those in control group [(16 668.67± 3 137.96),(588.62± 110.52) nkat/g] (P< 0.05).However, there was no significant difference between different dose groups. The GSH-Px activity in spleen homogenate in two experimental groups was(421.75± 124.02) and(523.10± 45.18) nkat/g respectively which was much lower than that of control group [(618.42± 57.01) nkat/g](P< 0.05) and there was significant difference between two groups (P< 0.05).In the brain homogenate of both benzene groups,the GSH-Px activity was(87.35± 19.84) and(95.02± 14.00) nkat/g respectively which was much lower than that of control group[(118.36± 7.67) nkat/g] (P< 0.05) and without difference between two groups.The MDA content in brain homogenate of high dose group was(3.99± 1.15) μ mol/mg which was much higher than that of control group [(2.58± 0.53) μ mol/g] (P< 0.05). CONCLUSION:Chronic benzene poisoning can cause DNA impairment of marrow cells and peripheral lymphocytes and reduce the activity of antioxidase.