Liver fibrosis is a primary cause of liver cirrhosis, and even hepatocarcinoma. Recently, the usage of mesenchymal stem cells (MSCs) has been investigated to improve liver fibrosis. It has been reported that the differentiation, proliferation and migration of MSCs can be regulated by traditional Chinese medicine treatment; however, the mechanisms are still unclear. In this article, the authors review the characteristics of MSCs such as multidirectional differentiation and homing, and its application in animal experiments and clinical trials. The authors also list areas that need further investigation, andlook at the future prospects of clinical application of MSCs.

Objective To realize the automatic conversion of material management information to branch-level material cost accounting. Methods According to the structure of material management system and cost accounting system, memory procedure of HIS was set to undertake the mission of information conversion. Results Automatic conversion of material management information to branch-level material cost accounting saved a lot of manpower and raised the efficiency and accuracy of cost accounting. Conclusion This solution is worth popularizing not only in other cost accounting but in information system integration and data sharing.

Objective To construct a computerized medical case archive system, which can realize the electronic storage of medical case. Methods Virtual print was used in archive computerized medical cases and electronic signature was used to ensure the legality of the archives. Results The system realized the patient-centered medical information integration and raised the level of medical information storage and management significantly. Conclusion The favorable foundation was established fully in the medical cases archiving system, but the system can be improved in future.

Frailty is an age-related non-specificity status caused by a decline of physiological reservation,which leads to an increase of vulnerability in body and decrease of ability in stress resistance.The pathophysiology of frailty involves multiple systems including neuromuscular system,metabolism and immune system.Studies have showed that frailty is closely related with negative events of elder people.People with frailty are subject to higher risks for fall,hospitalization,and mortality.However,the development of frailty can be delayed if early prevention or interventions are performed.Prospective cohort studies have showed that the risk factors for frailty include age,gender,family history of obesity,BMI,waist circumference,blood pressure,hyperglycemia,smoking and lack of exercise.Among them,nutrition,exercise and therapeutic drugs are hot spots in prevention study.Here,we reviewed the intervention studies by focusing on nutrition,exercise and therapeutic drugs in frail population.

Alzheimer's disease (AD) is the most common cause of dementia in the elderly population. The occurrence of dementia correlates with inflammation. Inflammation processes may play a critical role in the pathogenesi s of the degenerative changes and cognitive impairments associated with Alzheime r's disease. Cyclooxygense-2 (COX-2) inhibitors are reported to be e ffective in reducing the risk of developing AD or cognitive impairments. Studies on this field are of important significance in the understanding the pathogenes is and therapeutic measures for AD. This review will discuss the progress in the treatment of Alzheimer's disease by COX-2 inhibitors.

Objective To detect the expression of vascular endothelial growth factor(VEGF)-C and VEGF-D in normal gastric tissue and gastric carcinoma tissue,and further investigate the relationship between VEGF-C,VEGF-D and lymph vessel density (LVD),lymph node metastasis.Methods The expression of VEGF-C and VEGF-D in gastric carcinoma tissues were examined by using SP immunohistochemical method in 30 normal gastric tissue and 75 gastric carcinoma tissue respectively.The lymph vessel were marked by LYVE-1 and calculated LVD.Results The rate of positive expression of VEGF-C and VEGF-D in gastric carcinoma tissue was significantly higher than that in normal gastric tissue,there was significant difference [73.3 ％ (55/75) vs.33.3 ％ (10/30),66.7 ％ (50/75) vs.30.0 ％ (9/30),P ＜0.01].The level of LVD in gastric carcinoma tissue with lymph node metastasis (40 cases) was significantly higher than that in without lymph node metastasis (35 cases)[(8.85 ± 1.24)/HP vs.(4.75 ± 1.04)/HP](P =0.000).The level of LVD increased when the expression level of VEGF-C and VEGF-D gradually went up.Conclusions The level of LVD increases in gastric carcinoma tissue.VEGF-C and VEGF-D are two significant factors for LVD and lymph node metastasis.

Objective To compare the biomechanical properties of single-segment and two-segment fusion for Denis type B spinal fracture.Methods Two female patients with Denis type B L1 vertebral fracture were enrolled in this study.The 45-year-old patient (Frankel B) underwent posterior reduction and fixation with pedicle screw system plus anterior two-segment fusion and the 41-year-old patient (Frankel C) underwent posterior reduction and fixation with pedicle screw system plus anterior one-segment fusion.The intervertebral fusion was achieved in both patients 1 year after operation.CT data of the two patients at 1 year after surgery was collected,including data of 41-year-old patient before and after removal of pedicle screws and data of 45-year-old patient without removal of pedicle screws.These three sets of data were imported into the Mimics software to establish T11-L2 three dimensional models.After construction of the models,they were imported into ANSYS software.An axial load (260 N) and 10 Nm torque were loaded to simulate the flexion,extension,lateral bending and rotation of the spine,respectively.Meantime,under above 6 kinds of motion form,the average displacement of the spine and the average Von Mises stress of T11-12 intervertebral disc were recorded and compared.Results There was no significant difference in the average displacement of the spine between two-segment fusion patient and single-segment fusion patient without removal of pedicle screws.However,under all motion forms,the average displacement of the spine of single-segment fusion patient after removal of pedicle screws was significantly higher than that before removal of pedicle screws and that of two-segment fusion patient.The average Von Mises stress of T11-12 intervertebral discs of two-segment fusion patient was significantly higher than that of one-segment fusion patient.Moreover,the average Von Mises stress of T11-12 intervertebral discs of single-segment fusion patient before removal of pedicle screw was higher than that after removal of pedicle screw.Conclusion Under the premise of satisfactory interbody fusion,removal of pedicle screws after one-segment fusion can increase spinal motion,reduce the stress of the adjacent intervertebral discs and delay disc degeneration.

Objective To make a plan for the backup of electronic medical records. Methods The background of electronic medical records backup was analyzed, and NTBACKUP tool and batch technology were used to realize the backup plan. Results An automatic-execution backup plan raised the security of electronic medical records greatly. Conclusion The automatic-execution backup plan satisfies the basic demands for medical information security, though there is room for further improvement in data synchronization.

Objective To determine the changes of coagulation indexes of rabbits struck at different levels and sieve the traditional coagulation indexes, such as activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and fibrinogen (FIB). Methods We used correlation analysis to precondition the data to reject indexes, and used stepwise discriminatory analysis to choose indexes and made the diagnosis by multiple linear discrimination analysis. Then, by random sampling we compared the correct diagnostic rate by 4 indexes with that by 3 indexes. Results The correct discrimination rate of blood coagulation function diagnosis in rabbits was up to 87.60% by the four indexes and 96.12% with the three indexes (APTT, PT and TT). The average correct discrimination rate of blood coagulation function diagnosis in 1 000-time random sampling was up to 83.07% by the four indexes and 85.16% by the three indexes. Conclusion Stepwise discriminatory analysis can be used to discriminate hemorrhage from thromboxane. The correct diagnostic rate gets higher when FIB was rejected.

Objective To investigate and compare the food consumption concepts and behaviors of Beijing's urban and suburban residents. Methods Intercept questionnaire surveys were conducted on 287 urban customers shopping at a Jingkelong supermarket located in Chaoyang district and 307 suburban customers shopping at a Meilianmei supermarket located in town of Changping, Changping district at 2 randomly chosen times (all between 1:00PM and 5:00PM) from October to December 2007 in each supermarket. Results 93.1% of Beijing residents went to supermarket as their primary place for food shopping. 47.8% and 38.2% of residents thought the most important factors considered for their food shopping were "food hygiene and safety" and "its effects on health" respectively. Suburban residents were concerned more about "food hygiene and safety", while urban residents more about "effects on health" (P