Cardiovascular Diseases ; psychology ; Humans ; Life Style

Cerebral ischemic postconditioning refers to conduct a series of intermittent occlusion in order to reduce ischemia-reperfusion injury during the early reperfusion after cerebral ischemia.Because of its good prospects for clinical application,it has attracted widespread attention in recent years.This article reviews the neuroprotective mechanisms of ischemic postconditioning.

Objective: To explore the relationship between endogenous estrogen level and myocardial no-reflow after reperfusion in postmenopausal acute ST-elevation myocardial infarction (STEMI) patients. Methods: A total of 100 postmenopausal STEMI patients with percutaneous coronary intervention (PCI) were enrolled and divided into 2 groups: Reflow group,n=77 and No-reflow group,n=23. Myocardial no-reflow was defined by TIMI≤2 grade or TIMI 3 grade and MBG≤2 grade after PCI. Blood levels of endogenous estrogen were examined before PCI; the relationship between endogenous estrogen level and myocardial no-reflow was assessed by Logistic regression analysis. Results: Compared with Reflow group, No-reflow group showed increased blood levels of estrone, estradiol, high sensitivity C-reaction protein (hs-CRP),P<0.05 and decreased sex hormone binding globulin (SHBG),P<0.05. Univariate analysis indicated that the length of lesion, thrombus score≥4, blood levels of estrone, estradiol and hs-CRP were positively related to no-reflow occurrence,P<0.05. Multi Logistic regression analysis presented that thrombus score≥4 (OR=4.994, 95%CI 1.987-10.518,P=0.035) and estradiol level (OR=4.091, 95% CI 1.105-8.582;P=0.046) were the independent risk factors for no-reflow occurrence. Conclusion: High blood level of endogenous estrogen was positively related to myocardial no-reflow after PCI in postmenopausal STEMI patients, which implied that endogenous estrogen might be the independent risk factor for no-reflow occurrence.

Objective: This work studied platelet-neutrophil aggregates (PNA) expression in patients with acute ST-segment elevation myocardial infarction (STEMI). Methods: Our research included in 2 groups: STEMI group, n=40 patients admitted in our hospital and Control group, n=30 normal subjects. Blood levels of PNA, platelet-monocyte aggregates (PMA) and platelet-lymphocyte aggregates (PlyA) were measured by lfow cytometry at admission and the results were compared between 2 groups. Results: Compared with Control group, STEMI group had similar blood levels of PlyA and PMA,P=0.245 andP=0.312; while increased blood level of PNA,P<0.05. Correlation analysis showed that platelet-leukocyte aggregates (PLA) level was positively related to CK-MB (r=0.4992,P<0.01) and cTnI (r=0.4365,P<0.01). Conclusion: Blood level of PLA, especially PNA was significantly higher in STEMI patients which suggested that increased PNA might be sued as a new index for AMI diagnosis in clinical practice.

Objective To investigate the mental health status of patients with coronary artery stent implantation. Methods Symptom Checklist (SCL-90) was used to evaluate the mental health conditions of 218 patients after coronary artery stent implantation with man-machine conversation and computer evaluation. Results It was found that 48 cases in excellent mental health, accounting for 22.02%; 56 cases in good mental health condition, accounting for 25.69%; 82 cases in normal mental health condition, accounting for 37.61%; and 32 cases in poor mental health, accounting for 14.68%. In addition to the interpersonal factor, hostility and psychosis factors, the other six factors’overall average score was more than 2. More than 50% of the staff scored greater than 3, and their average positive factors were greater than 43 items in somatization, depression, anxiety and fear. Conclusion The patients after coronary artery stent implantation suffered from many psychological problems.

Objective:To investigate the mechanism of the effect of tonifying kidney recipes(TKR) on osseointegration of the Titanium Implants by established animal model of osteoporosis rats.Methods:Fifty-four female SD rats were randomly divided into three groups:A:Sham group, B:ovariectomy(OVX) group C:OVX+TKR group. After operation, tonifying kidney recipes was given orally in C group. The results were observed by bone histomorphometry. Results:Trabeculae area (Tb?Ar,%), trabeculae width (Tb?Wi), combined bone lamella width (CBLW), osteoblast number (OB?N) in C group were significantly increased compared with B group (P

Objective To evaluate the clinical efficacy of external biplanar mini-fixator and limited internal fixation in treatment of severe midfoot fracture-dislocation.Methods Eight patients with severe midfoot fracture-dislocation were admitted from May 2009 to August 2012.They were 6 men and 2 women,28 to 57 years of age (average,35.4 years).According to the Gustilo classification,there were one type Ⅱand 7 cases of type Ⅲ.Two cases of midfoot fracture were complicated with dislocation of the transverse tarsal joint,4 with dislocation of the tarsometatarsal joint,and 2 with dislocation of both the transverse tarsal joint and the tarsometatarsal joint.The external biplanar mini-fixator was applied to stabilize and maintain lengths of the medial and lateral columns and normal geometry of the foot arch after reduction of the fracture-dislocation.K-wires were used if limited internal fixation was necessary.The external fixator was removed at 12 to 16 weeks postoperatively.The clinical treatment efficacy was assessed by the American Orthopaedic Foot and Ankle Society (AOFAS) midfoot scale and the visual analogue scale (VAS).Results The patients were followed up for an average of 13.4 months (from 10 to 24 months).Postoperative radiological films showed fine reduction of the fractures and dislocations.No reduction was lost after removal of external and internal fixations.They were able to walk independently and had good functional recovery of the injured feet without traumatic arthritis during the follow-up period.Their average AOFAS scores were 65.8 at 3 months after operation,71.3 at 6 months and 80.6 at 12 months; the average VAS scores were 7.5 at 3 months,4.3 at 6 months,and 1.2 at 12 months,respectively.Conclusion In treatment of severe midfoot fracture-dislocation,external biplanar mini-fixator combined with limited internal fixation can perfectly reconstruct and maintain the medial and lateral columns and normal geometry of the foot arch,preventing functional disability caused by foot malformation.

Objective To introduce the clinical significance and pathophysiologic aspects of the circulatory and cardiac complications in terminal stage cirrhosis.Methods Recently relevant literatures were reviewed and summarized.Results Haemodynamic changes in cirrhosis arose on the basis of combined humoral and nervous dysregulation,with abnormalities in cardiovascular regulation,volume distribution and cardiac performance.Conclusion Comprehending the mechanisms of cardiovascular complications will contribute a lot for the treatment of terminal stage cirrhosis.

Objective:To investigate the effect of methylphenidate on the ERP waveform of children with attention deficit hyperactivity disorder(ADHD) between responders and non-responders and it's psychological significance.Methods:ERP elicited by the continuous performance test were recorded before and under methylphenidate treatment in 28 ADHD children and their behavioral performance were collected simultaneously.Based on the behavioral results,the patients were divided into two groups:responders and non-responders.Results:After medcation,the responders' behavioral performance were significantly better,amplitude of NOGO-P3(30.24?10.78?v) were also larger than that of before treatment(20.34?11.42?v,P=0.04);No significant differences were found in the behavioral performance and NOGO-P3 amplitude before and after treatment(23.51?11.97?v/25.88?13.96?v,P=0.61) in the non-responders group.The amplitude of NOGO-N2 of the two groups did not have significant difference before and under methylphenidate treatment.Off medication,there were no differences between responders and non-responders.Conclusion:Methylphenidate can improve the ability of response inhibition in responders as well as increase the amplitude of NOGO-P3 of them.

Objective To make a plan for the backup of electronic medical records. Methods The background of electronic medical records backup was analyzed, and NTBACKUP tool and batch technology were used to realize the backup plan. Results An automatic-execution backup plan raised the security of electronic medical records greatly. Conclusion The automatic-execution backup plan satisfies the basic demands for medical information security, though there is room for further improvement in data synchronization.