1.The Treatment of Intertrochanteric Fracture using a Compression Hip Screw and a Nail Plate
Myung Chul YOO ; Chung O KIM ; Bong Kun KIM ; Jin Whan AHN ; Dong Wook PARK
The Journal of the Korean Orthopaedic Association 1979;14(2):199-209
The principle in the treatment of an elderly patient with an intertrochanteric fracture has swung from traction to internal fixation due to complication such as pneumonia, skin ulcer, and throm-boembolic disease, etc. Since the introduction of the Smith-Peterson nail, numerous internal fixation devices such as I-beam nail, Thornton plate, Jewett nail and Holt nail have been developed by gadgeteers and instrument companies. Recently Compression Hip Screw is popular because of rigid internal fixation. The operative management of intertrochanteric fractures of the hip using Compression Hip Screwplate was performed in thirty-three patients who were followed more than 5 months after operation at Department of Orthopedic Surgery, Kyung Hee University Hospital, from Feb. 1974 to 1978. The results were as follows. 1. Of 33 cases of intertrochanteric fractures, 3 cases were stable fracture and 30 cases were unstable fracture. The commonest type was Tronzo type III with 42 percentage. 2. Dimon-Hughston reduction in 13 cases with unstable fracture and anatomical reduction in 20 cases with stable and unstable fracture were achieved. 3. The average time to fracture union was 12 weeks, minimum in 8 weeks (maximum 20 weeks). The average union time in age group over 50 years was 14 weeks and 11 weeks in age group under 50 years. 4. The average union time was 13 weeks in medial displased group and 10 weeks in anatomical reduction group. 5. Complication after internal fixation were 4 cases e.g., two cases of varus deformity, one case of genitourinary tract infection and one transient peroneal nerve palsy. 6. Compression Hip Screw is a good internal fixation device to treat intertrochanteric fracture.
Aged
;
Congenital Abnormalities
;
Hip Fractures
;
Hip
;
Humans
;
Internal Fixators
;
Orthopedics
;
Paralysis
;
Peroneal Nerve
;
Pneumonia
;
Skin Ulcer
;
Traction
2.A Case of Maple Syrup Urine Disease detected by Tandem Mass Spectrometry in Newborn Screening Test.
Chong Gwon O ; Young Soo JUNG ; Byoung Hoon YOO ; Dong Keun LEE ; In Seok LIM
Journal of the Korean Society of Neonatology 2003;10(1):88-93
Maple syrup urine disease (MSUD) is an autosomal recessive disorder. Impaired activity of the branched-chain 2-oxo acid dehydrogenase complex causes accumulation of branched-chain L-amino and 2-oxo acid that can exert neurotoxic effects. MSUD presents heterogeneous clinical and molecular phenotypes. Severity of the disease, ranging from classical to mild variant types, is commonly classified on the basis of indirect parameters, e.g. onset, leucine tolerance and/or residual enzyme activity in cell. Since early 1990's, tandem mass spectrometry has been applied to newborn screening, because it is amenable to population-wide testing for a large number of disorders of fatty acid, organic acid, and amino acid metabolism. And so, we report a case of MSUD in 15 days old boy detected by newborn screening using tandem mass spectrometry.
3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)
;
Acer*
;
Humans
;
Infant, Newborn*
;
Leucine
;
Male
;
Maple Syrup Urine Disease*
;
Mass Screening*
;
Metabolism
;
Phenotype
;
Tandem Mass Spectrometry*
3.Low-dose UVA1 Phototherapy for Localized Scleroderma.
Nyoung Hoon YOUN ; Dong O YOO ; Seung Hoon CHA ; Seok Don PARK
Korean Journal of Dermatology 2002;40(5):551-554
Localized scleroderma(LS) is sclerosis of the skin characterized by one or multiple circumscribed ivory-white, indurated, sometimes confluent plaques. It has been reported that LS might result from the unbalance between synthesis and degradation of collagen in the dermis. Recently, treatment of LS with long wave UVA1, which can induce mRNA of matrix metalloproteinase-1 from dermal fibroblast and can cause apoptosis of infiltrating T lymphocytes, showed promising results. In this case, a 14-year-old girl had a 6 month history of linear, brown colored, indurated plaque on her left thigh compatible with LS histopathologically. UVA1(2.4-10.8J/cm2) was irradiated to the skin lesion at each visit, a total of 68 times for 18 months with the cumulative dose of 533J/cm2 UVA1. Her fibrotic skin lesion was resolved during treatment, but became hardened with cessation of phototherapy. She remains disease free for 11 months. We report a case of LS with improvement with low-dose UVA1 phototherapy.
Adolescent
;
Apoptosis
;
Collagen
;
Dermis
;
Female
;
Fibroblasts
;
Humans
;
Matrix Metalloproteinase 1
;
Phototherapy*
;
RNA, Messenger
;
Scleroderma, Localized*
;
Sclerosis
;
Skin
;
T-Lymphocytes
;
Thigh
4.Multiple Pilomatricomas Associated with Myotonic Muscular Dystrophy in Brother and Sister.
Dong O YOO ; Jung Dae KANG ; So Jin KIM ; Seok Don PARK
Korean Journal of Dermatology 2002;40(11):1419-1422
Pilomatricoma is a tumor with differentiation toward hair cortex cells. There have been a few cases of multiple familial pilomatricomas in association with myotonic muscular dystrophy. We report two members of the family(brother and sister) with association of multiple pilomatricomas and myotonic muscular dystrophy. Multiple familial pilomatricomas may be a cutaneous manifestation of the myotonic syndrome.
Hair
;
Humans
;
Muscular Dystrophies*
;
Pilomatrixoma*
;
Siblings*
5.Lumbar Spinal Stenosis in Vertebral Ankylosing Hyperostosis: A Case Report.
Rae O KIM ; Chang Ho KIM ; Kwan Uk YOO ; Dong Sup CHUNG ; Young Sup PARK ; Ki Jun KIM ; Joon Ki KANG
Journal of Korean Neurosurgical Society 1999;28(3):378-383
Vertebral ankylosing hyperostosis is a systemic rheumatological abnormality of unknown etiology whose hallmark is luxurious flowing ossification of the anterior longitudinal ligament. It has been regarded as asymptomatic ankylosis requiring no medical or surgical treatment. However, dyspnea, dysphagia, spinal cord compression, and peripheral nerve entrapment have all been documented in association with this disorder. On the other hand, reports on spinal stenosis at lumbar level are extremely rare. We present a case of spinal stenosis assosiated with vertebral ankylosing hyperostosis.
Ankylosis
;
Deglutition Disorders
;
Dyspnea
;
Hand
;
Hyperostosis, Diffuse Idiopathic Skeletal*
;
Longitudinal Ligaments
;
Peripheral Nerves
;
Spinal Cord Compression
;
Spinal Stenosis*
6.Endovascular Treatment of Bilateral Cavernous Sinus Dural Arteriovenous Fistula: Therapeutic Strategy and Follow-Up Outcomes.
Jong Kook RHIM ; Young Dae CHO ; Dong Hyun YOO ; Hyun Seung KANG ; Won Sang CHO ; Jeong Eun KIM ; Min Jae CHO ; Gyojun HWANG ; O Ki KWON ; Moon Hee HAN
Korean Journal of Radiology 2018;19(2):334-341
OBJECTIVE: Bilateral cavernous sinus dural arteriovenous fistula (CSdAVF) is very rare, even in Asian countries. The research intended to present clinical and radiologic outcomes of treating such fistulas through endovascular embolization. MATERIALS AND METHODS: Data was obtained from 220 consecutive patients, with CSdAVF, who were treated from January 2004 to December 2015. Bilateral CSdAVF was identified in 17 patients (7.7%). The clinical and radiologic outcomes of the fistulas were assessed with an emphasis on the technical aspects of treatment. RESULTS: At the time of treatment, 7 and 10 patients presented with bilateral and unilateral symptoms, respectively. In the former cases, 4 patients had progressed from unilateral to bilateral symptoms. Bilateral fistulas were treated with a single-stage transvenous embolization (TVE) in 15 patients, via bilateral inferior petrosal sinuses (IPS) (n = 9) and unilateral IPS (n = 6). In the other 2 patients with one-sided dominance of shunting, only dominant fistula was treated. Two untreated lesions were found on follow-up to have spontaneously resolved after treatment of the dominant contralateral fistula. Of the 34 CSdAVF lesions, complete occlusion was achieved in 32 lesions after TVE. Seven patients (41.2%) developed worsening of cranial nerve palsy after TVE. During the follow-up period, 4 patients obtained complete recovery, whereas the other 3 remained with deficits. CONCLUSION: With adjustments of endovascular procedures to accommodate distinct anatomical configurations, endovascular treatment for bilateral CSdAVF can achieve excellent angiographic occlusion results. However, aggravation of symptoms after TVE may occur frequently in bilateral CSdAVF. In the patients with one-sided dominance of shunt, treatment of only dominant fistula might be an alternative option.
Arteriovenous Fistula
;
Asian Continental Ancestry Group
;
Cavernous Sinus*
;
Central Nervous System Vascular Malformations*
;
Cranial Nerve Diseases
;
Endovascular Procedures
;
Fistula
;
Follow-Up Studies*
;
Humans
7.A Case of Panhypopituitarism with Rhabdomyolysis.
Sung Wook HONG ; Eun Jung LEE ; Ji Young PARK ; Ji Sung YOON ; Ji O MOK ; Yeo Joo KIM ; Hyeong Kyu PARK ; Jae Woo KIM ; Chul Hee KIM ; Sang Jin KIM ; Dong Won BYUN ; Kyo Il SUH ; Myung Hi YOO
Journal of Korean Society of Endocrinology 2005;20(2):174-178
Rhabdomyolysis is the consequence of extensive muscle injury with the release of muscle cell constituents into plasma. It can arise from trauma and also from a variety of nontraumatic causes. Trauma, drugs, toxins and infection are the major causes of rhabdomyolysis, but it is rarely associated with metabolic disorders such as severe electrolyte disturbance, diabetic ketoacidosis, hyperosmolar nonketotic coma, hypothyroidism and thyrotoxicosis. There have been several reported cases of metabolic rhabdomyolysis, but panhypopituitarism as a cause has never been identified. We experienced a case of acute rhabdomyolysis associated with panhypopituitarism. Thus, So we report this case with the review of related literature. Metabolic disorder is a rare cause of rhabdomyolysis, but it should always be considered in a patient having and unexplained increased of the creatine kinase concentration
Coma
;
Creatine Kinase
;
Diabetic Ketoacidosis
;
Humans
;
Hypothyroidism
;
Muscle Cells
;
Plasma
;
Rhabdomyolysis*
;
Thyrotoxicosis
8.Increased Expression of Focal Adhesion Kinase in Thyroid Cancer: Immunohistochemical Study.
Sang Jin KIM ; Jin Woo PARK ; Ji Sung YOON ; Ji O MOK ; Yeo Joo KIM ; Hyeong Kyu PARK ; Chul Hee KIM ; Dong Won BYUN ; Yong Jin LEE ; So Young JIN ; Kyo Il SUH ; Myung Hi YOO
Journal of Korean Medical Science 2004;19(5):710-715
Focal adhesion kinase (FAK) is a tyrosine kinase that is found in cellular structures called focal adhesions. FAK appears to be a key element in signal transduction pathways involved in cell adhesion and locomotion. FAK is overexpressed in various tumors, including tumors derived from regions of the head and neck, colon, breast, prostate, and liver. In this study, we investigated immunohistochemically whether FAK expression was increased in thyroid cancers. FAK staining was not seen in any of the 20 normal thyroid tissues or the 6 nodular hyperplasia specimens. In contrast, FAK staining was observed in all of 17 papillary carcinomas, 9 follicular carcinomas, 8 medullary carcinomas, and 2 anaplastic carcinomas. Nine of 17 follicular adenomas showed FAK immunoreactivity. FAK was not expressed in normal tissue and nodular hyperplasia, but was expressed in some of the follicular adenoma, and all of the follicular, papillary, medullary and anaplastic thyroid carcinoma. This result indicates that the up-regulation of FAK may play a role in the development of thyroid carcinogenesis.
Adenoma/*metabolism/pathology
;
Adult
;
Aged
;
Carcinoma, Papillary/*metabolism/pathology
;
Female
;
Humans
;
Immunohistochemistry
;
Male
;
Middle Aged
;
Protein-Tyrosine Kinase/*metabolism
;
Research Support, Non-U.S. Gov't
;
Thyroid Neoplasms/*metabolism/pathology
;
Tumor Markers, Biological/*metabolism
9.Immunohistochemical Expression of COX-2 in Thyroid Nodules.
Sang Jin KIM ; Jae Hak LEE ; Ji Sung YOON ; Ji O MOK ; Yeo Joo KIM ; Hyeong Kyu PARK ; Chul Hee KIM ; Dong Won BYUN ; Kyo Il SUH ; Myung Hi YOO
The Korean Journal of Internal Medicine 2003;18(4):225-229
BACKGROUND: Recent evidence indicates that elevated COX-2 expression is associated with the carcinogenesis of numerous neoplasms. In this study, we investigated COX-2 expression in various thyroid specimens in order to elucidate its physiological role in pathologic conditions, and to evaluate the efficiency of COX-2 protein expression as a molecular marker of malignancy in the thyroid gland. METHODS: COX-2 expression was studied immunohistochemically in 19 papillary carcinomas, 8 follicular carcinomas, 14 follicular adenomas, 2 H rthle cell carcinomas, 4 H rthle cell adenomas, 8 nodular hyperplasias, 3 Graves' diseases, 3 Hashimoto's thyroiditis, 2 medullary carcinomas, 1 anaplastic carcinoma, and 20 normal thyroid tissues. RESULTS: COX-2 staining was not seen in any of the normal thyroid, Graves' disease, or nodular hyperplasia specimens. In contrast, COX-2 staining was observed in all of papillary carcinomas, Hashimoto's thyroiditis, H rthle cell carcinomas, and H rthle cell adenomas tissues. Moreover, 7 of 8 follicular carcinomas and 11 of 14 follicular adenomas showed COX-2 staining. CONCLUSION: These results indicate that COX-2 is not useful as a marker of malignancy. Since COX-2 expression was evident in follicular adenomas and in papillary and follicular carcinomas. Thus, the enzyme may be involved in the early process of thyroid tumorigenesis.
Human
;
*Immunohistochemistry
;
Isoenzymes/*analysis
;
Prostaglandin-Endoperoxide Synthase/*analysis
;
Thyroid Nodule/*enzymology/*pathology
;
Tumor Markers, Biological/*analysis
10.A Case of Kallmann's Syndrome with Unilateral Renal Aplasia and Diabetes Mellitus.
En Jung LEE ; Sung Wook HONG ; Yun Ki HONG ; Ji Sung YOON ; Ji O MOK ; Yeo Joo KIM ; Hyeong Kyu PARK ; Chul Hee KIM ; Sang Jin KIM ; Dong Won BYUN ; Won Kyung BAE ; Kyo Il SUH ; Myung Hi YOO
Journal of Korean Society of Endocrinology 2005;20(1):96-102
Kallmann's syndrome is defined as the combination of hypogonadotropic hypogonadism and anosmia/hyposmia. The syndrome is a result of defect in the embryonic migratory pathway of gonadotropin-releasing hormone, which synthesizes neurons and olfactory axons. The hypogonadotropic hypogonadism results due to absence of or incomplete pubertal development and may be associated with anosmia, hyposmia, midline defect(color blindness, cleft-lip, cleft-palate, unilateral renal agenesis, sensorineural deafness), cryptorchidism and skeletal anomaly. Till date in Korea, few cases of Kallmann's syndrome have been reported but there are no available reports on cases of Kallmann's syndrome with unilateral renal aplasia and diabetes mellitus. We handled a case of Kallmann's syndrome associated with unilateral renal agenesis and diabetes mellitus. In the current work, we present a peculiar case as afore mentioned with the review of related literature.
Axons
;
Blindness
;
Cryptorchidism
;
Diabetes Mellitus*
;
Gonadotropin-Releasing Hormone
;
Hypogonadism
;
Kallmann Syndrome*
;
Korea
;
Male
;
Neurons
;
Olfaction Disorders