1.Primary lung cancer presenting initially as spontaneous pneumothorax .
Seung Dong YEO ; Myung In KIM ; Eung Joong KIM ; Seung Pyung LIM ; Young LEE
The Korean Journal of Thoracic and Cardiovascular Surgery 1991;24(6):631-635
No abstract available.
Lung Neoplasms*
;
Lung*
;
Pneumothorax*
2.Differential Diagnosis of Breast Mass and Staging of Breast Cancer Using F-18-FDG PET.
Jeong Seok YEO ; Dong Soo LEE ; Keon Wook KANG ; Dong Young NOH ; June Key CHUNG ; Myung Chul LEE
Korean Journal of Nuclear Medicine 1999;33(6):502-511
PURPOSE: F-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) has been proven to be useful in the differential diagnosis of breast mass and staging of breast cancer. This study assessed the diagnostic accuracy of F-18-FDG PET in the differentiation of breast mass and staging of breast cancer. MATERIALS AND METHODS: Total 42 patients who had breast mass underwent F-18-FDG PET (all female, 40+/-10 year old). We compared F-18 FDG PET results with pathologic findings in 24 patients RESULTS: In the differentiation of breast mass, sensitivity and specificity were 95% (19/20) and 77% (7/9) respectively. Three false positive cases were due to inflammation and one false negative patient had small tumor less than 1 cm. In the assessment of axillary lymph node status, sensitivity and specificity were 73% (8/11) and 100% (7/7) respectively. We found distant metastasis that were not suspected before F-18-FDG PET in 2 patients. CONCLUSION: F-18-FDG PET shows good diagnostic performance in differentiation of breast mass and staging of breast cancer.
Breast Neoplasms*
;
Breast*
;
Diagnosis, Differential*
;
Female
;
Humans
;
Inflammation
;
Lymph Nodes
;
Neoplasm Metastasis
;
Positron-Emission Tomography
;
Sensitivity and Specificity
3.Influence of Gating and Attenuation-correction for Diagnostic Performance of Usual Rest/stress Myocardial Perfusion SPECT in Coronary Artery Disease.
Myung Chul LEE ; June Key CHUNG ; Dong Soo LEE ; Kyeong Min KIM ; Young SO ; Jeong Seok YEO ; Gi Jeong CHEON
Korean Journal of Nuclear Medicine 1999;33(2):131-142
PURPOSE: Either gated myocardial perfusion SPECT or attenuation corrected SPECT can be used to improve specificity in the diagnosis of coronary artery disease. We investigated in this study whether gating or attenuation correction improved diagnostic performance of rest/stress perfusion SPECT in patients having intermediate pre-test likelihood of coronary artery disease. MATERIALS AND METHODS: Sixty-eight patients underwent rest attenuation-corrected T1-20l/dipyridamole stress gated attenuation-corrected Tc-99m-MIBI SPECT using an ADAC vertex camera (M:F=29:39, aged 59+/-12 years, coronary artery stenosis> or =70%. one vessel: 13, two vessel: 18, three vessel: 8, normal: 29). Using a five-point scale, three physicians graded the post-test likelihood of coronary artery disease for each arterial territory (1 normal, 2: possibly normal 3:equivocal, 4: possibly abnormal, 5: abnormal). Sensitivity, specificity and area under receiver-operating-characteristic curves were compared for each operator between three METHODS: (A) non-attenuation-corrected SPECT; (B) gated SPECT added to (A); and (C) attenuation-corrected SPECT added to (B). RESULTS: When grade 3 was used as the criteria for coronary artery disease, no differences in sensitivity and specificity were found between the three methods for each operator Areas under receiver- operating-characteristic curves for diagnosis of coronary artery disease revealed no differences between each modality (p>005). CONCLUSION: In patients at intermediate risk of coronary artery disease, gated SPECT and attenuation-corrected SPECT did not improve diagnostic performance.
Coronary Artery Disease*
;
Coronary Vessels*
;
Diagnosis
;
Humans
;
Perfusion*
;
ROC Curve
;
Sensitivity and Specificity
;
Tomography, Emission-Computed, Single-Photon*
4.The effect and side effect of dipyridamole in myocardial SPECT.
Hyung In YANG ; Dong Soo LEE ; Jeong Suk YEO ; Sang Kyun BAE ; Chang Woon CHOI ; June Key CHUNG ; Myung Chul LEE ; Chang Soon KOH
Korean Journal of Nuclear Medicine 1993;27(2):203-209
No abstract available.
Dipyridamole*
;
Tomography, Emission-Computed, Single-Photon*
5.Comparison of Diagnostic Performance between Interictal F-18-FDG PET and Ictal Tc-99m-HMPAO SPECT in Occipital Lobe Epilepsy.
Myung Chul LEE ; June Key CHUNG ; Dong Soo LEE ; Jae Min JEONG ; Sang Kun LEE ; Jeong Seok YEO ; Seok Ki KIM ; Joo Yong KIM
Korean Journal of Nuclear Medicine 1999;33(3):262-272
PURPOSE: Interictal F-18-fluorodeoxyglucose (FDG) PET and ictal Tc-99m-HMPAO SPECT are found to be useful in localizing epileptogenic zones in neocortical lateral temporal or frontal lobe epilepsy. We investigated whether interictal F-18-FDG PET or ictal Tc-99m-HMPAO SPECT was useful to find epileptogenic zones in occipital lobe epilepsy (OLE). MATERIALS AND METHODS: We reviewed patterns of hypometabolism in interictal F-18-FDG PET and of hyperperfusion in ictal Tc-99m-HMPAO SPECT in 17 OLE patients (mean age=27+/-6.8 year, M:F=10:7, injection time=30+/-17 sec). OLE was diagnosed based on invasive electroencephalography (EEG) study, surgery and post-surgical outcome (Engel class I in all for average 14 months). RESULTS: Epileptogenic zones were correctly localized in 9 (60%) out of 15 patients by interictal F-18-FDG PET. Epiletogenic hemispheres were correctly lateralized in 14 patients (93%). By ictal Tc-99m-HMPAO SPECT, epileptogenic hemispheres were correctly lateralized in 13 patients (76%), but localization was possible only in 3 patients (18%). Among patients who showed no abnormality with MR imaging and no correct localization with ictal Tc-99m-HMPAO SPECT, interictal F-18-FDG PET was helpful in 2 patients. CONCLUSION:: Ictal Tc-99m-HMPAO SPECT was helpful in lateralization but not in localization in OLE. Interictal F-18-FDG PET was helpful for localization of epileptogenic zones even in patients with ambiguous MR or ictal SPECT findings. Key KW: Occipital lobe epilepsy, Tc-99m-HMPAO, Ictal perfusion SPECT, F-18-FDG, PET, SPECT
Electroencephalography
;
Epilepsies, Partial*
;
Epilepsy, Frontal Lobe
;
Humans
;
Magnetic Resonance Imaging
;
Occipital Lobe*
;
Perfusion
;
Tomography, Emission-Computed, Single-Photon*
6.NT-proBNP as a useful tool in diagnosing incomplete Kawasaki disease.
Dong Won LEE ; Yeo Hyang KIM ; Myung Chul HYUN ; Tae Chan KWON ; Sang Bum LEE
Korean Journal of Pediatrics 2010;53(4):519-524
PURPOSE: To determine the efficacy of the N-terminal fragment of B-type natriuretic peptide (NT-proBNP) as a useful diagnostic method in children with incomplete Kawasaki disease (KD). METHODS: Ninety-six patients who were diagnosed as having KD between January 2008 and June 2009 were enrolled in the study. American Heart Association recommendations for diagnosis were used, and patients were divided into the complete KD and incomplete KD groups. Blood tests including NT-proBNP were performed on admission day. Nineteen patients who had other febrile diseases other than KD were enrolled as control. RESULTS: Thirty-three patients (34%) had incomplete KD. Change in the lips and oral cavity and conjunctivitis were the most common clinical features, but their frequency was lower than complete KD (76% vs 98%, 76% vs 90%). Patients with incomplete KD exhibited significantly higher NT-proBNP level than that of control (1,407.7+/-1633.5 pg/mL vs 126.2+/-135.5 pg/mL, p<0.001). An NT-proBNP cutoff value of 158 pg/mL provided a sensitivity of 81% and a specificity of 74% for diagnosis of incomplete KD. CONCLUSION: NT-proBNP assay can be clinically useful for the diagnosis of incomplete KD, if the patient has persistent fever, change in the lips and oral cavity, and conjunctivitis, and if the patient with those symptoms is suspected to have incomplete KD.
American Heart Association
;
Child
;
Conjunctivitis
;
Fever
;
Hematologic Tests
;
Humans
;
Lip
;
Mouth
;
Mucocutaneous Lymph Node Syndrome
;
Natriuretic Peptide, Brain
;
Peptide Fragments
;
Sensitivity and Specificity
7.Difference of Time Course of Functional Recovery after Revascularization According to Preoperative Reversibility of Perfusion Impairment in Ischemic Myocardial Dysfunction.
Jin Chul PAENG ; Dong Soo LEE ; Ki Bong KIM ; Yu Kyeong KIM ; Jeong Seok YEO ; June Key CHUNG ; Myung Chul LEE
Korean Journal of Nuclear Medicine 2001;35(6):364-370
No abstract available.
Perfusion*
8.Echocardiographic Parameters of Pulmonary Atresia with Intact Ventricular Septum(PA/IVS).
Young Seok LEE ; Yeo Hyang KIM ; Myung Chul HYUM ; Sang Bum LEE
Journal of the Korean Pediatric Society 2003;46(5):484-489
PURPOSE: To understand morphologic and hemodynamic variations in patients with pulmonary atresia with intact ventricular septum(PA/IVS), and to decide the best treatment modalities, we measured right ventricular volume, inflow, and outflow valvular annulus size in these patients and compared them with those of normal newborns. METHODS: Eight patients with PA/IVS diagnosed by echocardiography from January to December 2001 were enrolled in this study. Among the total eight patients, five were male and three were female. The mean age of patients was 6.9 days(1-34 days), and the mean body weight was 3,343 gm (2,970-4,000 gm). Ten fullterm newborn infants with sepsis or hyperbilirubinemia without heart disease were enrolled as a control group. Echocardiographic and Doppler studies using Acuson Aspen (7Mh probe) were recorded on super-VHS videotape and later on, with review mode. We measured volumes of right and left ventricles, aortic, pulmonic, mitral and tricuspid valvular annulus sizes using an installed program, and then these parameters were compared with those of the control group. RESULTS: Mean Z-value of tricuspid valvular annulus in PA/IVS was -3.69+/-2.80(-8.4--0.45), and tricuspid/mitral valvular annulus size ratio 0.68+/-0.15(0.43--0.84). The more the tricuspid/mitral valvular annulus size ratio, the more Z-value of tricuspid valvular annulus(P=0.003, r=0.885). Those patients who underwent pulmonary valvuloplasty(balloon or surgical) had a tendency toward larger volume of the right ventricle, more Z-value of pulmonic and tricuspid valvular annulus, and more tricuspid/mitral valvular annulus size ratio than those patients who underwent a shunt operation. CONCLUSION: Compared to a measurement of the volume of the right ventricle, measurements of tricuspid/mitral valvular annulus size ratio and Z-value of tricuspid valvular annulus may be easier and better parameters to decide the treatment method and to predict prognosis in PA/IVS patients.
Body Weight
;
Echocardiography*
;
Female
;
Heart Diseases
;
Heart Ventricles
;
Hemodynamics
;
Humans
;
Hyperbilirubinemia
;
Infant, Newborn
;
Male
;
Prognosis
;
Pulmonary Atresia*
;
Sepsis
;
Videotape Recording
9.Factors Influencing Outcome of Surgical Treatment for Primary Aldosteronism.
Myung Chul CHANG ; Dong Young NOH ; Yeo Kyu YOUN ; Kuk Jin CHOE ; Seung Keun OH
Korean Journal of Endocrine Surgery 2003;3(2):141-146
PURPOSE: Primary aldosteronism due to an adrenal cortical adenoma is a surgically curable disease. However, hypertension is known to persist postoperatively in many patients. The aim of this study was to determine the factors influencing the long-term outcome of blood pressure after an adrenalectomy for a primary aldosteronism and to evaluate the changing pattern of renin and aldosterone. METHODS: Forty-two cases of primary aldosteronism, which were operated on and followed up at the Department of Surgery, Seoul National University Hospital from January 1986 to June 2001 were included in this study. The subjects were classified into a normotensive group and a hypertensive group and the two groups were compared according to the clinical, biochemical and pathological parameters. RESULTS: After surgery, the aldosterone concentration was decreased and the plasma renin activity was increased. During a mean follow-up period of 28 months, 31 patients (73.8%) had a normal blood pressure without an antihypertensive treatment. The significant risk factors for persistent hypertension were a family history of hypertension, a long duration of preoperative hypertension, a poor response of preoperative spironolactone. The hypertensive group had a higher level of postoperative plasma renin activity and an aldosterone concentration in the long-term follow-up period after surgery. CONCLUSION: A family history of hypertension, the duration of hypertension and the response to spironolactone were factors influencing persistent hypertension after surgery for a primary aldosteronism. A high level of plasma renin activity and aldosterone during the follow-up period is related to the persistent hypertension. Therefore, early detection and surgery for a primary aldosteronism would reduce the preoperative cardiovascular changes and improve the postoperative outcome.
Adrenalectomy
;
Adrenocortical Adenoma
;
Aldosterone
;
Blood Pressure
;
Follow-Up Studies
;
Humans
;
Hyperaldosteronism*
;
Hypertension
;
Plasma
;
Renin
;
Risk Factors
;
Seoul
;
Spironolactone
10.Detection of Osteomylitis Using a Tc-99m Labeled Antigranulocyte Antibody Immunoscintigraphy.
Won Jun KANG ; June Key CHUNG ; Jeong Seok YEO ; Mee Kyoung HONG ; Jae Min JEONG ; Dong Soo LEE ; Sang Hoon LEE ; In Ho CHOI ; Myung Chul LEE
Korean Journal of Nuclear Medicine 1998;32(4):344-353
PURPOSE: The purpose of this study was to evaluate the diagnostic accuracy of Tc-99m labeled antigranulocyte antibody immunoscintigrapy in the diagnosis of osteomyelitis and compare with the results of triphasic bone scan. MATERIALS AND METHODS: The study population was 39 patients (22 male, 17 female) who had uncertain diagnoses of osteomyelitis. Fifteen patients had history of orthopedic surgery, and 5 had previous fracture. One milligram of monoclonal antibody against NCA-95 was labeled with 370 MBq of Tc-99m, injected intravenously, and 4 hour images were obtained. Triphasic bone scan images were obtained in 30 p;tients. The final diagnosis was confirmed by bacteriologic culture, biopsy or long term clinical follow up. RESULTS: Twenty one patients were confirmed to have osteomyelitis (1 acute, 20 chronic). Eighteen patients were without osteomyelitis. Antigranulocyte antibody immunoscintigraphy had a sensitivity of 71% (15/21), and a specificity of 89% (16/18), while the sensitivity and specificity of triphasic bone scan was 93% (13/14) and 38% (6/16), respectively. Antigranulocyte antibody scan showed higher specificity of 100% (11/11) in comparison with 33% (3/9) of triphasic bone scan in patients with history of orthopedic surgery or fracture. CONCLUSION: Antigranulocyte antibody immunoscintigraphy is more specific than that of triphasic bone scan and may be helpful in patients with history of surgery or fracture. However, sensitivity is lower than triphasic bone scan in the detection of chronic osteomyelitis.
Biopsy
;
Diagnosis
;
Follow-Up Studies
;
Humans
;
Male
;
Orthopedics
;
Osteomyelitis
;
Sensitivity and Specificity