The mutation of p53, a tumor suppressor gene, has been considered to play an important role in tumorigenesis in a variety of human cancers and the abnormal expression of p53 are frequently associated with poor prognosis. In order to examine the association of p53 overexpression with known prognostic factors including estrogen receptors (ER) and progesterone receptors (PR), we studied the status of p53 protein expression by immunohistochemical staining of paraffin sections of 29 endometrial carcinoma (25 endometrioid carcinoma, 2 clear cell carcinoma, and 2 serous carcinoma), obtained from hysterectomy. The results were as follows: The expression of p53, ER, and PR was present in 9/29 (31%), 3/29 (16%), and 12/29 (48%), respectively. The expression of p53 in endometrioid adenocarcinoma was present in 6/25 (24%) and showed significant correlation with histologic grade, nuclear grade, and myometrial invasion. The status of PR showed significant inverse correlation with histologic grade, nuclear grade and myometrial invasion. There was no significant correlation between ER status and these histologic factors. The expression of p53 was inversely associated with the status of PR, but statistically not significant. Our results indicate that p53 may be useful in predicting prognosis in endometrial carcinoma and will be able to provide helpful information in predetermination of aggressive behavior of the tumor in evaluation of curettage specimen.
Carcinogenesis ; Carcinoma, Endometrioid ; Curettage ; Endometrial Neoplasms* ; Female ; Genes, Tumor Suppressor ; Humans ; Hysterectomy ; Paraffin ; Prognosis ; Receptors, Estrogen ; Receptors, Progesterone

No abstract available.
Hepacivirus* ; Hepatitis C* ; Hepatitis* ; Humans ; Infant* ; Mothers* ; Pregnancy*

No abstract available.

No abstract available.

The brachial plexus block by interscalene approach is useful for any procedure on upper extremity, including the shoulder. Complications such as high epidural block, total spinal anesthesia, permanent neurologic damage, phrenic nerve block, cardiac arrest, pneumothorax and Horner's syndrome etc. were reported. Ipsilateral Horner' syndrome can be used for confirmation of the accompanying sympathetic block. We experienced a case of 35-year old male patient who developed ipsilateral Horner's syndrome following the injection of 40ml of 1% lidocaine with 1 : 200,000 epinephrine to brachial plexus by interscalene approach. This compication lasted for 10days after interscalene brachial plexus block.
Adult ; Anesthesia, Spinal ; Brachial Plexus* ; Epinephrine ; Heart Arrest ; Horner Syndrome* ; Humans ; Lidocaine ; Male ; Phrenic Nerve ; Pneumothorax ; Shoulder ; Upper Extremity

This study was investigated to assess the difference of facial height and occlusal plane inclination between normal occlusion group and class 11 malocclusion group. The subjects consisted of 50 normal occlusion (male 25, female 25) and 50 class II(male 25, female 25) malocclusion patients. All subjects are adult. lateral cephalogram was taken with standard method, traced, and digitized for each subjects. The computerized statiscal analysis was carried out with SPSS program. The results were as follows: 1. In class II malocclusion group, variables significant different from normal occlusion group were as follows SN-FOP, FH-BOP, MP-BOP, AB-BOP, AB-FOP, Facial plane-BOP, FP-FOP. 2. In class II malocclusion group, the posterior facial height -especially posterior lower facial height-was significantly smaller than normal occlusion group.( P < 0.05) 3. In class II malocclusion group, the angles bEStween occlusal plane and upper and lower incisor, the angle between upper molar and bisected occlusal plane we e significantly larger than those of normal occlusion group. (P < 0.05) 4. LI to Mandibular plane (mm) was a unique factor of occlusal plane position that showed significant difference in class -Il1 malocclusion group. 5. The correlation between overbite and occlusal plane inclination existed in class II malocclusion group, but the correlation didn't exist in normal occlusion group.
Adult ; Dental Occlusion* ; Female ; Humans ; Incisor ; Malocclusion ; Molar ; Overbite

Objective To assess the efficacy and safety of naloxone for treating cerebral infarction.Methods Randomized controlled trials(RCTs)and quasi-RCTs were identified from MEDLINE(1966-2005.4),EMBASE(1980-2005.4),Cochrane Controlled Trials Register(Cochrane Library issue 2,2005),CBMdisc(1978 -2005.4).We handsearched related published and unpublished data and their references.All naloxone treating for cerebral infarction were included.Data were extracted and evaluated by two reviewers independently with designed extraction form.RevMan 4.2.7 software was used for data analysis.Results Twelve RCTs involving 1075 patients were included.All the results of meta-analysis were listed as follows:(1)Total effective rate:compared with none control,5 studies showed that naloxone had a statistical difference with RR 1.24,95 %CI 1.05 to 1.46;(2)cure rate:compared with none control,naloxone had a statistical differences with RR 1.54,95%CI 1.09 to 2.18;(3)adverse effect:the number of accidence were few and representations were light.Conclusion Naloxone may increase the total effective rate and cure rate of cerebral infarction.More high quality trials are required.

Objective To explorer the clinical therapeutic effects of applying hyperbaric oxygen drenching(HOD) combined with microsurgical technique on peripheral nerve injuries induced in plateau military training.Methods Forty-one hospitalized patients(52 nerves) with peripheral nerve injuries induced in plateau military training from Jan.2000 to Dec.2007 were randomly divided into treatment group(21 patients,27 nerves injured) and control group(20 patients,25 nerves injured).Microsurgery and postoperative HOD treatment were performed to the patients in treatment group,only microsurgery was performed to the patients in the control group.The restorative procedures for injured nerves were adopted with direct end-to-end suture or sural nerve autograft according to the degree of injury.The recovery of nerve function was assessed and compared between the two groups.Results All patients were followed up for a mean period of 18 months(ranged 6-30 months) after operations.The recovery of nerve function was assessed according to the single nerve functional evaluation criteria.In treatment group,the excellent and fine results were obtained in 7 and 16 nerves,the fineness rate was 85.2%;while in control group,the excellent and fine results were obtained in 2 and 11 nerves,the fineness rate was 52.0%,a significant difference existed on the fineness rate between the two groups(?2=6.71,P

Objective To evaluate the possible protective effect of isoflurane and propofol on myocardium during off pump coronary artery bypass grafting (CABG) surgery. Methods Twenty-six patients undergoing elective CABG without cardiopulmonary bypass were allocated into propofol group (n=13) and isoflurane group (n=13). Anesthesia was performed in propofol group with propofol plus fentanyl, while isoflurane and fentanyl were used in isoflurane group. Artery blood samples were collected before induction of anesthesia, and during and after the surgery. Plasma troponin I (cTnI), creatine kinase-MB (CK-MB), interleukin-6 (IL-6), and lactate concentrations were determined respectively. Results At the 4 hours after operation, plasma level of cTnI was significantly increased in both groups, and no significant differences were found between them. Compared with baseline values, IL-6 in propofol group showed no significant changes at each endpoint. However, IL-6 values in isoflurane group were significantly higher than those in propofol group during and after surgery (P

ObjectiveTo compare the effects of patient-controlled epidural analgesia (PCEA) and patient-controlled intravenous analgesia (PCIA) on postoperative nausea and vomit (PONV) in gynecologic and obstetric patients. Methods56 gynecologic or obstetric patients (ASA Ⅰ～Ⅱ) scheduled for lower abdominal surgeries were randomly allocated to receive either 1 mg/ml morphine plus 0.1 mg/ml droperidol intravenously (group PCIA) or 0.1 mg/ml morphine plus 0.125% bupivacaine (group PCEA-Ⅰ) or 0.1 mg/ml morphine plus 0.1 mg/ml droperidol plus 0.125% bupivacaine (group PCEA-Ⅱ) epidurally. 4, 24, and 48 h after operation, pain scores with visual analogus scale (VAS), sedation scores with Ramesay and the incidences of nausea, vomiting, pruritus, respiratory depression were assessed. ResultsVAS scores in the two PCEA groups were much lower than that of PCIA (P<0.01). The incidences of nausea and vomiting in PCEA-Ⅱ group were significantly lower than those in PCIA group (P<0.05), incidences of other side-effects such as pruritus, respiratory depression etc. were similar between the three groups (P>0.05). ConclusionThe regimen morphine/droperidol/bupivacaine by PCEA shows superiorities in relieving pain and reducing postoperative nausea and vomiting in gynecologic and obstetric patients.