No abstract available.
Korea* ; Mortality* ; Statistics as Topic* ; Stomach*

Schonlein-Henoch purpura is a generalized small vessel vasculitis characterized by nonthrombocytopenic purpura, arthritis, abdominal pain and nephritis. In 1914 Osler described an allergic purpura associated with hemiplegia. After then Lewis et al. reported the cases of Schonlein-Henoch purpura associated with convulsion, coma, confusion, intracranial hemorrhage, and chorea, CNS complication has been reported in 1-8% of children and subsided spontaneously in most cases. Headache is a remarkable sympton and appears nonspecific nature. In 1991 Ostergaard and Storm reported that headache occured during the first week following skin rash and frequently showed abnormal EEG findings. We investigated prospectively the presence of a possible cerebral and renal involvement in the case of Schonlein-Henoch purpura. EEG abnormality demonstrated in 52.6% of all cases, and headache or irritability in 47.4% of all cases. A significant association was found between abnormal EEG finding and presence of headache, but was not found between EEG findings and presence of renal involvement and hypertension. Patients with abnormal EEG had no Past or famity history of febrile convulsion or ididopathic epilepsy.
Abdominal Pain ; Arthritis ; Child ; Chorea ; Coma ; Electroencephalography* ; Epilepsy ; Exanthema ; Headache ; Hemiplegia ; Humans ; Hypertension ; Intracranial Hemorrhages ; Nephritis ; Prospective Studies ; Purpura, Schoenlein-Henoch* ; Seizures ; Seizures, Febrile ; Vasculitis

Fifty patients with mild essential hypertension were studied to evaluate the efficacy of once-daily regimen of nitrendipine, 10~20mg daily for 12 weeks. 1) Thirty-Seven patients completed the study and showed -9% change in mean arterial headache etc. 2) Eight patients were dropped out because of side reaction, namely flushing, palpitation, headache etc. 3) Ambulatory blood pressure monitoring before and after treatment in 3 patients confirmed the drug efficacy revealing 9% decrement in mean blood pressure and 46% decrease in % elevated BP. 4) Twenty patients who were controlled with other hypotensive drugs were well controlled & maintained the blood pressure in normal range after switching to nitrendpine 10~20mg daily. In conclusion, citrendipine is a safe and good antihypertensive calcium antagonist in the treatment of mild hypertensives with 10~20mg of once-daily dosage.
Blood Pressure Monitoring, Ambulatory ; Blood Pressure* ; Calcium ; Flushing ; Headache ; Humans ; Hypertension ; Nitrendipine* ; Reference Values

A new hypolipidemic agent, lovastatin, hydroxy-methyl-gultaryl coenzyme A reductase inhibitor was administred to 25 patients with primary hyperlipidemia 20 to 40 mg daily for 12 weeks and sequential changes of serum lipid profile were analysed as follow. 1) Mean average at baseline period of serum total cholesterol, triglyceride, HDL and low desity lipoprotein cholesterol were 271, 179, 51 and 185 mg/dl respectively. 2) Total cholesterol showed 20% decrease at 4th week and 23% decrease at the end of 12th week while low density lipoprotein cholesterol decreased 31% and 33% respectively. 3) Triglyceride dropped 7% at 8th week and 3% at 12th week. High density lipoprotein cholesterol increased 4% at 4th week and showed 2% decrease at the end of study. 4) Only one patient complained of moderate abdominal pain, which subsided after 2 weeks drug withdrawal. In conclusion, lovastatin was well tolerated and effective, in the treatment of primary hyperlipidemia.
Abdominal Pain ; Cholesterol ; Cholesterol, HDL ; Cholesterol, LDL ; Coenzyme A ; Humans ; Hyperlipidemias* ; Lipoproteins ; Lovastatin ; Oxidoreductases ; Triglycerides

Lymphangioma circumscriptum is a benign disorder of lymphatic channels. The pathologic findings consist of a collection of deep, sequestered subcutaneous lymphatic cisterns which are encircled by smooth muscle. The lymphatic cisterns are communicating with superficial clusters of vesicles through dilated lymphatic channels. The etiology of this lesion is unclear ; however, lymphatic obstruction has been suggested as a possible cause. It is characterized clinically by grouped vesicles, some of which may be filled with serosanguinous fluid. It is an unpleasant, but benign condition conventionally managed by wide local excision, which provides symptom control and often prevents recurrence. Neither long term complication nor association with squamous cell carcinoma has been previously documented. Some cases were reported following mastectomy and radiation therapy or radiation therapy for squamous cell carcinoma of the cervix. We present a 17-year-old patient with lymphangioma circumscriptum developed on buccal mucosa, which developed 3 months after innervated serratus anterior muscle free flap for functional reconstruction of cheek. We suppose that it was caused not only by lymphatic blockage resulted from wide operation but also by chronic masticating local irritation. In review of literatures, we didn't have found any report of lymphangioma circumscriptum developed on buccal mucosa.
Adolescent ; Carcinoma, Squamous Cell ; Cervix Uteri ; Cheek ; Female ; Free Tissue Flaps ; Humans ; Lymphangioma* ; Mastectomy ; Mouth Mucosa* ; Muscle, Smooth ; Recurrence

Lymphangioma circumscriptum is a benign disorder of lymphatic channels. The pathologic findings consist of a collection of deep, sequestered subcutaneous lymphatic cisterns which are encircled by smooth muscle. The lymphatic cisterns are communicating with superficial clusters of vesicles through dilated lymphatic channels. The etiology of this lesion is unclear ; however, lymphatic obstruction has been suggested as a possible cause. It is characterized clinically by grouped vesicles, some of which may be filled with serosanguinous fluid. It is an unpleasant, but benign condition conventionally managed by wide local excision, which provides symptom control and often prevents recurrence. Neither long term complication nor association with squamous cell carcinoma has been previously documented. Some cases were reported following mastectomy and radiation therapy or radiation therapy for squamous cell carcinoma of the cervix. We present a 17-year-old patient with lymphangioma circumscriptum developed on buccal mucosa, which developed 3 months after innervated serratus anterior muscle free flap for functional reconstruction of cheek. We suppose that it was caused not only by lymphatic blockage resulted from wide operation but also by chronic masticating local irritation. In review of literatures, we didn't have found any report of lymphangioma circumscriptum developed on buccal mucosa.
Adolescent ; Carcinoma, Squamous Cell ; Cervix Uteri ; Cheek ; Female ; Free Tissue Flaps ; Humans ; Lymphangioma* ; Mastectomy ; Mouth Mucosa* ; Muscle, Smooth ; Recurrence

It is known that TGF-beta induces scar in fetal wound healing. The fact gives us that inhibition of TGF-beta can reduce scar formation. It has been reported that neutralizing antibody of TGF-beta reduced scar in rat incisional wounds. Meanwhile decorin, which is main proteoglycan of extracellular matrix, has been known as other antagonist against TGF-beta. However there has been no report about effects of decorin on scar formation. This study examined the histologic findings and width of incisional wound of rat, which was treated with decorin, compsring with non treated wound. We found that scar width was narrower in wounds 2 and 8 weeks after incision and the amount of collagen fiber is less in wounds treated with decorin than in control group. The collagen fibers, especially in wound 8 weeks after incision, were thick and regularly arranged and similar to no dermis in wounds treated with decorin. These results suggest that decorin reduces scar formation and facilitates maturation in wound healing. Even though this study cannot confirm its mechanism, the effect of decorin might be due to inhibition of TGF-beta.
Animals ; Antibodies, Neutralizing ; Cicatrix ; Collagen ; Decorin* ; Dermis ; Extracellular Matrix ; Proteoglycans ; Rats* ; Transforming Growth Factor beta* ; Wound Healing* ; Wounds and Injuries*

Inflammation is the characteristics of scar formation which is abscent in fetal wound healing. The adhesion molecules such as selectin groups are believed to have key roles for migration of inflammatory cells through the microvascular endothelial cells to the wound 77re purpose of this study was to evaluate the expression of E-selectin on the cultured human fetal and neonate dermal microvascular endothelial cells. The back skin of spontaneously delivered dead fetus (IUP 18-22 wks) and circumcised prepuce skin of neonate were used Human fetal dermal microvascular endothelial cells (HFDMEC) were isolated by extracting microvascular segment pom trypsin treated fetal and neonate skin tissue and isolated by sieving with nylon mesh and then by 35% Perocoll gradient centrifugation. Further purification was done with the Ulex europaeus I coated magnetic dynabead To confirm the fetal and neonatal endothelial cells, expression of factor VIII antigen on cell surface and uptake of acetylated low-density lipoprotein were checked Expression of E-selectin on cultured fetal and neonatal endothelial cells in response to IL-1alpha TNF-alpha INF-gamma was examined by ELISA. And the expression of E-selectin on fetal and neonatal dermal microvascular endothelial cells was examined by immunohistochemical study using monoclonal 3B7 anti E-selectin antibody in cultured fetal and neonatal skin. The expression of E-selectin on endothelial cells was not significantly digerent between fetal and neonatal endothelial cells. This expression was augmented 10 times more by IL-1alpha, TNF-alpha, INF-gamma. Augmented endothelial E-selectin expression by IL-1alpha, TNF-alpha, INF-gamma showed peak level 4 hours after stimulation and return to baseline level after 48 hrs. This time course was similar in both fetal and neonatal endothelial cells. Immunohistochemically, the expression of E-selectin molecule of unstimulated fetal and neonatal tissue was not observed However, on both fetal and neonatal tissue cultured for 4 hours after stimulation by 100 u/ml of IL-1 and 100 u/ml of TNF, expression of E-selectin molecule in microvasculature of upper dermis was observed and this expression persisted for up to 16 hours of culture. Also after culturing for 48hrs with 500 qlml of IFN, expression of E-selectin was observed in the microvessels of upper dermis. In conclusion, we could not find any digerences between the fetal and neonate skin in the expression of E-selectin on the endothelial cells spontaneously or stimulated by IL-1alpha, TNF-alpha or INF-gamma in vivo and vitro which means the expression of E-selectin vny not be an important mechanism of scarless wound healing in fetus.
Centrifugation ; Cicatrix ; Dermis ; E-Selectin* ; Endothelial Cells* ; Enzyme-Linked Immunosorbent Assay ; Factor VIII ; Fetus ; Humans ; Infant, Newborn ; Inflammation ; Interleukin-1 ; Lipoproteins ; Microvessels ; Nylons ; Skin* ; Trypsin ; Tumor Necrosis Factor-alpha ; Ulex ; Wound Healing ; Wounds and Injuries

BACKGROUND: It is known that nonsynostotic plagiocephaly does not spontaneously improve, and the craniofacial deformities that result from it. This study was conducted to analyze the effectiveness of helmet therapy for the nonsynostotic plagiocephaly patient, and to suggest a new treatment strategy based on this analysis. METHODS: A total of 108 pediatric patients who had undergone helmet therapy after being diagnosed with nonsynostotic plagiocephaly were included in this study. The patients were classified according to the initiation age of the helmet therapy, severity, and helmet wearing time. The treatment effect was compared using cranial vault asymmetry (CVA) and the cranial vault asymmetry index (CVAI), which were obtained from diagonal measurements before and after therapy. RESULTS: The discrepancy of CVA and CVAI of all the patients significantly decreased after helmet therapy. According to the initiation time of helmet therapy, the treatment effect was best at 5 months old or less. The helmet wearing time per day was proportional to the treatment effect up to 20 hours. In addition, the rate of the successful treatment (final CVA < or =5 mm) significantly decreased when the initiation age was 9.1 months or older and the treatment period was less than 7.83 months. CONCLUSIONS: This study showed the effectiveness of the helmet therapy for nonsynostotic plagiocephaly patients. Based on analysis of this study, helmet therapy should be started at the age of 9 months or younger for 7.83 months or more, and the helmet wearing time should be more than 20 hours a day.
Congenital Abnormalities ; Fungi ; Head Protective Devices ; Humans ; Plagiocephaly, Nonsynostotic ; Treatment Outcome

PURPOSE: This study aimed to evaluate the validity of chest auscultation and oxygen saturation measurement in the assessment of bronchial hyperreactivity to inhaled methacholine in preschool children who were thought to be asthmatic clinically. METHODS: Seventy-two children with a history of more than three wheezing episodes in the previous year were considered the asthma group and underwent methacholine bronchial challenges. Provocation concentration at wheezing (PCw), at 5% fall of oxygen saturation (PCSat), and at 50% increase in respiratory rate (PCRR) were determined in each subject. One hundred and eighteen children who have had less than two wheezing episodes in their life served as control group. RESULTS: The geometric means of PCw, PCSat, and PCRR of asthma group were significantly lower than those of the control group. The optimal cut-off level for PCw was 8 mg/mL, giving a sensitivity of 63% and a specificity of 78%. Corresponding values for PCSat and PCRR were 8 mg/mL (72%, 67%) and 16 mg/mL (49%, 86%), respectively. The area under the receiver operating characteristic (ROC) curve for PCw, PCSat, and PCRR were 0.80, 0.88, and 0.70 respectively. The discriminative capacity of PCSat as judged by ROC curve analysis exceed those of PCw and PCRR. CONCLUSION: These findings provide support for the use of chest auscultation and oxygen saturation measurement as a tool in the assessment of bronchial hyperreactivity. The cut-off level of 8 mg/mL for PCSat, owing to its highest discriminative capacity, may be useful for the diagnosis of asthma in preschool children.
Asthma ; Auscultation* ; Bronchial Hyperreactivity* ; Bronchial Provocation Tests ; Child ; Child, Preschool* ; Diagnosis ; Humans ; Methacholine Chloride ; Oxygen* ; Respiratory Rate ; Respiratory Sounds* ; ROC Curve ; Sensitivity and Specificity ; Thorax*