1.A case of chronic mucocutaneous candidiasis associated with hypoparathyroidism.
Dong Won KIM ; Jun Kyu OH ; Kyu Han KIM ; Kyoung Chan PARK ; Hoan Jong LEE
Korean Journal of Dermatology 1993;31(5):755-759
Chronic mucocutaneous randidiasis is a clinical syndrome characte ized by chronic and reccurent superficial candidal infection of the skin, mucous membranes, and nails. This syndrome is frequently associated with immune deficiency or endocrinopathy, especially hypopar; thyroidism. We report a case of chrcinic mucocutaneous candidiasis associated with hypoparathyroidism in a 8- year-old girl.
Candidiasis
;
Candidiasis, Chronic Mucocutaneous*
;
Female
;
Humans
;
Hypoparathyroidism*
;
Mucous Membrane
;
Skin
;
Thyroid Gland
2.Serum Interleukin-6 Concentration in Carcinoma of the Cervix.
Yong Ju LEE ; Jae Wook KIM ; Ki Seok OH ; Oh Seung YANG ; Dong Kyu KIM
Korean Journal of Gynecologic Oncology and Colposcopy 1993;4(3):1-6
Interleukin-6(IL-6) is a multifunctional cytokine, and deregulated IL-6 gene expression has been implicated as being involved in the pathogenesis of a number of diseaaes. So we measured the serum level of IL-6 to find a relationahip between uterine cervical cancer and serum IL-6 level. The serum levels of IL-6 were meesured m 54 patients adrnitted to the Severance hospital, from August, 1992 to February, 1993, of whom 27 patients were diagnosed as invasive cancer of cervix, 17 as CIN, and also utilizing 10 patiente diagnosed as uterine myoma as a control group for matched age and parity. The average serum level of IL-6 in invasive cancer, CIN, and uterine myoma were respectively 30.33pg/ml, 37.27pg/ml, and 12.45pg Jml. In 22% af cervical cancer patients (6 of 27), and 27% of CIN patients (4 of 17) studied blood levels of II-6 were detected whereas only 10% of uterine myoma (1 of 10) shorved the same result. However, the difference does not seem to be statistically significant, There was no statistically significant difference among any of the groups, and age and stage did not show any significant cmrelation, and the results need furt,ber investigations.
Cervix Uteri*
;
Female
;
Gene Expression
;
Humans
;
Interleukin-6*
;
Leiomyoma
;
Parity
;
Uterine Cervical Neoplasms
3.A Case of Leflunomide Induced Vasculitis.
Kyu LEE ; Dong Gyu KIM ; Ji Hyun OH ; Dong Il LEE ; Choong Won LEE
The Journal of the Korean Rheumatism Association 2004;11(4):459-460
No abstract available.
Vasculitis*
4.Influence of left ventricular function on the pattern of left ventricular diastolic filling assessed by doppler echocardiography in dilated cardiomyopathy.
Dong Hun KIM ; Seong Wook HONG ; Kyeong A OH ; Jin Weon JEONG ; Yang Kyu PARK ; Ock Kyu PARK
Korean Circulation Journal 1993;23(2):262-272
BACKGROUND: Recently, Doppler echocardiography has been widely used to evaluate left ventricular(LV) diastolic filling. However, There are only limited date about the influence of LV systolic function on the pattern of left ventricular diastolic filling. METHODS: To evaluate the changes of Doppler echocardiographic parameters of left ventricular filling induced by variations in left ventricular systolic function in dilated cardiomyopathy(DC) with heart failure(HF), 25 patients(M : F=14 : 11) with DC and HF, and 21 age-matched normal subjects(M : F=13 : 8) were examined by ECG, phonocardiography and echocardiography. From the Doppler recording, A2D(time from second heart sound to the onset of early diastolic mitral flow), peak velocity at early diastole(E) and late diastole(A), ratio of E to A velocity(E/A) and flow velocity integral(FVI) were measured. RESULTS: In 22 patients with DC and HF without mitral regurgitation(MR), A2D was significantly prolonged(119.5+/-12.7 vs 92.4+/-14.1msec, p<0.01), and early diastolic peak velocity and E/A velocity ratio were decreased as compared with the normal subjects(E=0.39+/-0.08 vs 0.57+/-0.12m/sec, p<0.01, E/A : 0.87+/-0.19 vs 1.33+/-0.19 vs 1.33+/-0.18, p<0.05). There were significant correlations between A2D and FVI(r=+0.73, p<0.01), and between E/A velocity ratio and FVI(r=-0.78, p<0.01). However, in 3 patients with MR, A2D(88.7+/-12.1msec), E(0.56+/-0.05m/sec), and E/A(1.32+/-0.12) were similar to those in normal subjects, despite of decreased FVI(12.0+/-0.9cm). CONCLUSIONS: These data show that a change of left ventricular systolic function in patients without MR may influence a diastolic filling pattern of left ventricle but not in patient with MR, and suggest that MR masks left ventricular distolic filling abnormalities.
Cardiomyopathy, Dilated*
;
Echocardiography
;
Echocardiography, Doppler*
;
Electrocardiography
;
Heart
;
Heart Sounds
;
Heart Ventricles
;
Humans
;
Masks
;
Phonocardiography
;
Ventricular Function, Left*
5.A Clinical Evaluations of Trabeculectomy.
Journal of the Korean Ophthalmological Society 1976;17(4):443-446
The authors analysed 30 eyes that "Trabeculectomy ab externo" was performed in S.N.U.H. Trabeculectomy was preferable operation in simple glaucoma and even in chronic closed angle glaucoma, but in congenital glaucoma, goniotomy was more preferable than trabeculectomy. In its mode of action, trabeculectomy was regarded as a sort of filtering precedure.
Glaucoma
;
Glaucoma, Open-Angle
;
Trabeculectomy*
6.Expression of Glutathione S-Transferase Isoenzymes in Carcinoma of the Uterine Cervix.
Jung Pil LEE ; Jae Wook KIM ; Oh Seung YANG ; Dong Kyu KIM
Korean Journal of Gynecologic Oncology and Colposcopy 1993;4(4):10-19
Glutathione S-Tanaferase (GST) is tripeptide, which plays a central role in the detoxification of electrophilic xenobioticas, including cytotoxic drugs and carcinogens, by conjugation with redueed glutathione. There are four major claases af human GST : pi, alpha, mu and rnicrosomal, They are propoaed as a marker for human and experimental neoplasia iincluding liver, kidney, lung,colon, uterine cervix, etc. Expression of pi, alphn, mu form of GST in control (15 cases), CIN (14 cases), invasive carcinoma (28 cases) of human uterine cervix was investigated immunohistochemically. They were selected fram September, 1992, to,June, 1992, in the department of Obstetrics and Gynecology, Yonsei university College of medicine. In nucleus, the expresaion of GST pi was increased statistically significant in case of CIN and invasive Ca. of Cx. compared to control(p=0.018, p=0.002). But expression of GST alpha, mu has no significant difference in each case. In cytoplasms, the expvession of GST pi was increased statistically significani, in case of CIN and invasive Ca. of Cx. (p=0.001, p<0.001). But expreasion of GST alpha, mu has no significant differenrce in each case. There was no statistically significant diHerence in expression of GST isoenzymes oC each nucleua and cytoplasm according to stage and cell type in Ca. oC Cx. The further evaluation of survival and expression of GST pi in Ca. of Cx. in order to establish new prognostic factor in Ca. of Cx.
Carcinogens
;
Cervix Uteri*
;
Cytoplasm
;
Female
;
Glutathione Transferase*
;
Glutathione*
;
Gynecology
;
Humans
;
Isoenzymes*
;
Kidney
;
Liver
;
Obstetrics
7.Detection of human papilloma virus in normal, dysplastic and invasive cervical cancer tissue by the polymerase chain reaction.
Jae Wook KIM ; Dong Kyu KIM ; Ki Suk OH ; Chan Ho SONG ; Uik Mook CHOI
Korean Journal of Obstetrics and Gynecology 1993;36(7):1865-1874
No abstract available.
Humans*
;
Papilloma*
;
Polymerase Chain Reaction*
;
Uterine Cervical Neoplasms*
8.Relation between the Efficacy of Amiodarone on Chronic Atrial Fibrillation and Left Atrial Size and Fibrillatory Wave Form.
Young Kyu HONG ; Hong Seog SEO ; Dong Joo OH ; Young Moo RO
Korean Circulation Journal 1989;19(1):125-131
To assess the efficacy of amiodarone on chronic atral fibrillation(AF) and to evaluate the relation between the ability to convert AF to sinus rhythm (SR) with amiodarone therapy and left atrial(LA) size and atrial fibrillatory wave forms, 22 patients with AF, aged 40 to 60 years(mean 47.5 years), were studied. Nine patients(40.9%) had mitral valvaular heart disease, 6(27.3%) hypertension, 5(18.2%) lone AF and 2 (9.1%) cadiomyopathy. Amiodarone therapy with either 600mg for 1 week, 200mg for 4 weeks in 5 consecutive patients, or 800mg for 1 week, 400mg for 4 weeks and 200mg for 6 weeks in 17 patients, converted AF to SR in 9(40.9%) patients 3 to 6 weeks after amiodarone was started on. In either group, patients who achieved conversion had smaller LA size(mean 43.7mm) than those who failed conversion(mean50.2mm)(P<0.05). Those who had LA size less than 45mm achieved conversion of AF to SR in 70%, comparing to 16.7% in patients with LA size more than 46mm(P<0.05). Among patients who achieved conversion, LA size was less than 46mm in 77.8% comparing to 23.1% in patients who failed conversion on Amiodarone. Those with coarse AF(46.2mm), althogh the difference was not significant statistically. There was no converstion in patients with LA size greater then 58mm and in patients with coarse AF who concomittantly had MVD. These findings suggest that the efficacy of amiodarone was related to LA size, and to the atrial fibrillation wave form in patients with mitral valvular heart disease.
Amiodarone*
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Atrial Fibrillation*
;
Heart Diseases
;
Heart Valve Diseases
;
Humans
;
Hypertension
9.Prognostic Value of Somatosensory Evoked Potentials in Comatose Patients after Cardiopulmonary Resuscitation.
Se Min CHOI ; Dong Rul OH ; Seung Pil CHOI ; Kyu Nam PARK ; Se Kyung KIM
Journal of the Korean Society of Emergency Medicine 2000;11(4):450-456
BACKGROUND: The improved technique for cardiopulmonary resuscitation(CPR) has resulted in the survival of many patient who experienced cardiac arrest. However, mortality in resuscitated patients is high, and the survival rate without brain damage is very low. Various neurological examination models, neuro-imaging techniques, electrophysiological procedures, and biochemical tests have been studied with respect to the detection of cerebral damage and outcome, but an early, reliable prediction of individual outcomes is still uncertain. METHODS: We studied twenty patient who had been in a coma for more than 24 hours after CPR, Somatosensory evoked potentials(SEP) were measured within the first three days after CPR. RESULTS: Of the twenty patients, seven patients(35%) had a good outcome, and thirteen patients(65%) had a bad outcome. Of the eleven patients with loss of the cortical evoked potential's N20 peak, all had a bad outcome. CONCLUSION: SEPs are of great benefit in prognostic evaluation after CPR.
Brain
;
Cardiopulmonary Resuscitation*
;
Coma*
;
Evoked Potentials, Somatosensory*
;
Heart Arrest
;
Humans
;
Mortality
;
Neurologic Examination
;
Survival Rate
10.Expression of Apoptosis, bcl-2, and PCNA in Uterine Cervical Intraepithelial Neoplasia and Invasive Carcinoma.
Myoung Ja CHUNG ; Kyu Yun JANG ; Myoung Jae KANG ; Dong Geen LEE ; Byung Chan OH
Korean Journal of Pathology 1997;31(11):1180-1189
This study was undertaken to know the extent of apoptosis, expression of bcl-2 and proliferating cell nuclear antigen (PCNA) in uterine cervical intraepithelial neoplasia (CIN; 15 cases) and invasive carcinoma (27 cases) and to evaluate them as a prognostic marker. Apoptosis was analysed by using the in situ apoptosis detection kit and bcl-2 and PCNA were detected by the immunohistochemical method. The results were as follows: Apoptotic indices (AI) in the invasive carcinoma (mean: 4.3) were 10-times higher than that in the CIN (mean: 0.43). Bcl-2 was expressed 60% of the cases in the dysplastic cells of the CIN II and CIN III, 33.3% of cases in the invasive carcinoma and not expressed in the CIN I except basal cells. The expression of the PCNA was increased by the grades of CIN and was strong in invasive carcinoma. The mean survival time of the patient with invasive carcinoma was significantly decreased in the higher AI index (above 4.3) than in the lower AI index (below 4.3). There was no significant correlation between the extent of apoptosis and the expression of bcl-2. According to the above results, AI are able to be used as an independent prognostic marker in the invasive cervical carcinoma, and bcl-2 and PCNA have an important role in the tumorigenesis of uterine cervical carcinoma.
Apoptosis*
;
Carcinogenesis
;
Cervical Intraepithelial Neoplasia*
;
Humans
;
Proliferating Cell Nuclear Antigen*
;
Survival Rate