1.Epidermolysis Bullosa Acquisita: A Complete Remissions versus Patients with Long-term Persistent Activities.
Dong Kyu HWANG ; Chang Woo LEE
Korean Journal of Dermatology 1999;37(6):715-718
BACKGROUND: In epidermolysis bullosa acquisita, it has been recognized that there exists heterogeneity in the clinical and serologic/immunopathologic features. OBJECTIVE: We examined patients with epidermolysis bullosa acquisita to see if there were any associated clinical and serological features which may predict disease activity or prognosis in the disease. METHODS: Clinical and some serologic features were compared. between 2 groups of patients with epidermolysis bullosa acquisita; one with complete remission of the symptoms and signs of the disease for more than 2 years and the other group with persistent disease activities of longer than 5 years.
Epidermolysis Bullosa Acquisita*
;
Epidermolysis Bullosa*
;
Humans
;
Population Characteristics
;
Prognosis
2.Biologic Significance of Hepatocyte Hepatitis B Core Antigen Expression in Chronic Hepatitis B Virus Infection II.
Hye Kyung LEE ; Kwang Min LEE ; Dong Kyu CHUNG
Korean Journal of Pathology 1992;26(4):355-359
Routine use of commercially available antisera against hepatitis B core antigen(HBcAg) has permitted a reevaluation of the histochemical distribution of the antigen in liver tissue. HBcAg, classically described almost exclusively in the nucleus, was found with a very high frequency in the cytoplasm of liver cells as well. To elucidate the biologic significance of HBcAg expression and its relation to the natural course of hepatitis B virus(HBV) infection, the patterns of activity in 33 needle liver biopsies of HBsAg carriers were analysed. A good correlation of liver HBcAg with disease activity was demonstrated. HBcAg was present in the hepatocyte nuclei(nHBcAg) or cytoplasm(cHBcAg), or in both(mixed). Pure nHBcAg was seen mainly in non-aggressive reactive liver tissue and cHBcAg was predominantly associated with chronic active hepatitis(95%). The results suggest that expression of HBcAg correlates with the liver pathology and the possibility of HBcAg to be an immunological target for T cell mediated hepatocyte damage.
Biopsy
3.The Imfacts of School Life and Home Surroundings on Adolescent's Smoking.
Kyu Sik LEE ; Ju Kyeong KIM ; Dong Hyun LEE
Journal of Korean Academy of Community Health Nursing 2006;17(2):263-272
No abstract available.
Adolescent
;
Humans
;
Personal Satisfaction
;
Smoke*
;
Smoking*
4.Neonatal Mortality Rate.
Byung Kyu SUH ; Dong Ku LEE ; Byung Churl LEE
Journal of the Korean Pediatric Society 1984;27(5):425-432
No abstract available.
Humans
;
Infant
;
Infant Mortality*
5.The mechanism of Arginine-stimulated growth hormone secretion.
Wan Kyu LEE ; Dong Goo LEE ; Duk Hi KIM
Journal of the Korean Pediatric Society 1991;34(4):544-552
No abstract available.
Arginine
;
Growth Hormone*
;
Growth Hormone-Releasing Hormone
;
Somatostatin
6.Study on the lead exposure of workers in a litharge making industry.
Sang Bok LIM ; Jung Kyu LIM ; Sung Soo LEE ; Kyu Dong AHN ; Byung Kook LEE
Korean Journal of Preventive Medicine 1995;28(4):875-884
In order to investigate the level of lead exposure of workers in litharge making industry and to evaluate how lead exposure, personal habit such as smoking and drinking affect the prevalence of lead related symptoms and other study variables, we investigate 114 workers(24 office workers and 90 lead exposed workers) in a litharge making industry. Study variables chosen were blood lead(PbB), zinc protoporphyrin in whole blood(ZPP), Hemoglobin(Hb), hematocrit (Hct), SGOT and SGPT. symptom questionnaires which had 15 lead exposure related symptoms were provided to all workers and filled up by themselves and reconfirmed by physician. The results obtained were as follows; 1. The mean value of PbB, ZPP and SGOT in lead exposed group were higher than those of non-exposed group, and there were no differences of means in other study variables. 2. The smoking and drinking rate of study subjects were 65.8% and 71.0% as a whole. Smoking rates were lower in non-exposed group than exposed group, but drinking rate were not. 3. There were no differences of mean values of study variables between smoker and non-smoker in non-exposed and exposed group, but there was a difference of mean value of SGOT between drinker and non-drinker in lead exposed group. 4. while the symptom prevalence of lead exposed group were higher in neuromuscular category than non-exposed group, those of non-exposed group were higher or same with exposed group in gastrointestinal and general symptom category. 5. The symptom prevalence of smoker were higher than non-smoker regardless of exposure. 6. The symptom prevalence of drinker were only higher in gastrointestinal symptom category than non-drinker. 7. In multiple stepwise regression analysis of lead related symptoms as dependent variable and blood lead, smoking habit, drinking habit and work duration as independent variables, drinking habit contributed to the gastrointestinal symptom category, whereas blood lead and smoking contributed to the neuromuscular symptom category. For the total symptoms work duration and smoking habit contributed significantly.
Alanine Transaminase
;
Aspartate Aminotransferases
;
Drinking
;
Hematocrit
;
Humans
;
Prevalence
;
Surveys and Questionnaires
;
Smoke
;
Smoking
;
Zinc
7.A Case of Leflunomide Induced Vasculitis.
Kyu LEE ; Dong Gyu KIM ; Ji Hyun OH ; Dong Il LEE ; Choong Won LEE
The Journal of the Korean Rheumatism Association 2004;11(4):459-460
No abstract available.
Vasculitis*
8.Pseudoatrophoderma Colli.
Min Geol LEE ; Kyu Kwang WHANG ; Dong Kun KIM
Korean Journal of Dermatology 1985;23(4):471-474
Pseudoatrophoderma colli is a symptomless, persistent, persistent, pigmentary disorder involving the neck and upper thorax first described by Becker and Muir in. 1934 The lesion is usually localized to the neck and upper part of the thorax. It consists of macules or papules which show pigmentation or papules which show pigmentation or depigmentation and look atrophic. Histological examination shows hyperkeratosis, hypogranulosis, focal acanthosis and perivascular lymphocytic infiltration. We present herein a case of pseudoatrophoderma colli which showed symptomless, mottled, pigmentated macules involving the neck clinically and compatible findings histopathologically.
Neck
;
Pigmentation
;
Thorax
9.Two-Dimensional Echocardiographic Diagnosis of Cornary Aneurysms in Children with the Mucocutaneous Lymphnode Syndrome.
Jun Hee SUL ; Sung Kyu LEE ; Dong Shik CHIN
Journal of the Korean Pediatric Society 1987;30(12):1363-1367
No abstract available.
Aneurysm*
;
Child*
;
Diagnosis*
;
Echocardiography*
;
Humans
10.The Development of a Wound Healing Model Using Nerve Growth Factor(NGF) Expression in Raft Culture.
Kyu Han KIM ; Dong Youn LEE ; Kyoung Chan PARK
Annals of Dermatology 2000;12(2):106-113
BACKGROUND: The wound healing process is impaired or delayed in aged patients. The development of a new wound healing model is needed. Nerve growth factor (NGF) plays a special role in wound healing because NGF is expressed only in proliferating tissues such as wounds. OBJECTIVE: The aim of our study was to develop a wound healing model using a 3-dimensional culture system, raft culture, by comparing the level of NGF expression according to the wound stage after an artificial wound was made to the raft samples. We tried to specifically localize the site of NGF expression both in mRNA and protein level. METHODS: Raft culture using normal human keratinocytes was done and a 2 mm slit wound was made in the center of the raft samples. Raft samples of no wound, 4 d, 7 d, and 9 d after wounding were prepared. In situ RT-PCR and immunohistochemistry were performed to detect and localize NGF expression after making wounds and the addition of substance P (SP). RESULTS: We failed to localize NGF mRNA expression in raft samples by in situ RT-PCR. Immunohistochemistry showed NGF staining throughout the epidermis although a little more dense staining was found in the basal layer. NGF(+) cells tended to increase until 7 d after wounding, but there were no significant differences according to the wounding days. There was `a tendency that the SP(+) group showed more NGF(+) cells than the SP(-) group, but there were no statistical differences. CONCLUSION: We think that our in vitro raft wound model using NGF expression could be used, at least in part, as an objective indicator for wound healing. In our raft model lacking nerve, NGF may not be suitable for representing wound healing process because this model can not reflect the interaction between the skin and the nervous system. Expression of growth factors or cytokines other than NGF need to be applied to our raft culture system.
Cytokines
;
Epidermis
;
Humans
;
Immunohistochemistry
;
Intercellular Signaling Peptides and Proteins
;
Keratinocytes
;
Nerve Growth Factor
;
Nervous System
;
RNA, Messenger
;
Skin
;
Substance P
;
Wound Healing*
;
Wounds and Injuries*