We investigated 260 patients with the purpose of verifting the risk factors that determine lesion location and lesion volume. All the patients were subdibided into six lacunar syndrome subgroups (LSS) according to the clinical features, and also, into five lesion location subgroups(LSS) by neuroradiology findings. The common clinical syndromes were pure motor hemiparesis (32%) and sensorimotor stroke (30%). The mean lesion volume was large in pure sensory skoke and pure motor hem.paresis, and small in ataxic hemilaresis The common sites of lesion were internal capsule(32%) and basal ganglia(27%) In contrast with LSS, the risk factors and lesion volume were different among LLS. Patients with infratentorial lesion showed higher blood pressure than those with supratentorial lesion(p<0.05j. Lesion volume of corona radiata was greater than that of thalamus or internal capsule (p<005). Muliple lacunar lesions were associated with higher seurum hemoglobin concentration, men, and smoking (p<0.05). We suggest that (1) vlood pressure is of the contributing factors in determining the lesion location, (2) lesion volume is largest in lacunar infarction involving corona radiata, and (3) smol; ing is one of the important cause of multiple lacunar infarction.
Blood Pressure ; Humans ; Internal Capsule ; Male ; Paresis ; Risk Factors* ; Smoke ; Smoking ; Stroke ; Stroke, Lacunar* ; Thalamus

We describe an analysis of 214 patients with CT-proven basal ganglia aor thalamic hemorrhage. Based on CT flndings and medical records, the volume of hematoma was correlated with degree of hypertension and clinical features. Patients were grouped into 4 groups; basal ganglia hemorrhage without intraventricular hemorrhage (IVH) (group 1, n&76), basal ganglia hemorrhage with IVH (group 2, n&68), thalamic hemorrhage without IVH (group 3, n&5), and thalamic hemorrhage with IVH (group 4, n&65). Among these groups, those with IVH (group 2 and 4) had higher systolic and diastolic blood pressure than patients without IVH (group 1, 3,P Basal Ganglia ; Basal Ganglia Hemorrhage ; Blood Pressure ; Hematoma* ; Hemorrhage* ; Humans ; Hypertension* ; Medical Records ; Strikes, Employee ; Stroke

Wernicke's encephalopathy is a neuropsychiatric condition generally caused by acute thiamine deficiency. Although it is common in the severe alcoholics, several other causes also have been identified, such as total parenteral nutrition (TPN) use, persistent vomiting, hyperemesis gravidarum, anorexia nervosa and malnutrition. The classic triad of Wernicke's encephalopathy are ataxia, altered mentation and ophthalmoplegia. A 19-year-old boy had been treated with high dose Ara-C and mitoxantrone for acute myelogenous leukemia and intravenous hyperalimentation due to persistent vomiting. He suddenly complained of diplopia, gait disturbance and generalized weakness at 36th day after chemotherapy. Physical examinations showed disorientated mentality, oculomotor palsy and horizental nystagmus. The diagnosis of Wernicke's encephalopathy was made with classical brain MRI and decreased thiamine level. The patient was successfully treated with vitamin B1. We presented a case of acute Wernicke's encephalopathy developed after high dose Ara-C chemotherapy followed by intravenous hyperalimentation in a patient with acute myelogenous leukemia.
Alcoholics ; Anorexia Nervosa ; Ataxia ; Brain ; Cytarabine ; Diagnosis ; Diplopia ; Drug Therapy* ; Female ; Gait ; Humans ; Hyperemesis Gravidarum ; Leukemia, Myeloid, Acute ; Magnetic Resonance Imaging ; Male ; Malnutrition ; Mitoxantrone ; Ophthalmoplegia ; Paralysis ; Parenteral Nutrition ; Parenteral Nutrition, Total* ; Physical Examination ; Pregnancy ; Thiamine ; Thiamine Deficiency ; Vomiting ; Wernicke Encephalopathy* ; Young Adult