1.Three Cases of Congenital Adrenal Hyperplasia Owing to Multiple Mutations of CYP21 Gene.
Jun HEO ; Jae Hong YU ; Dong Ki JEONG
Journal of Korean Society of Pediatric Endocrinology 2001;6(2):176-181
Congenital adrenal hyperplasia(CAH) results from an inherited defect in enzymatic steps required to synthesize cortisol from cholesterol. 21-hydroxylase deficiency accounts for 95% cases of CAH. We have analyzed CYP21 genes of CAH by PCR direct sequencing. Our results shows three cases of CAH owing to multiple mutations of CYP21 gene; first case, IVS2AS, A/G, -13, Ile172Asn; second case, IVS2AS, A/G, -13, Ile236Asn, Val237Glu, Met239Lys; third case, Ile172Asn, C to G at 1590nt, Val281Leu, Arg484Pro, G to A at 2697nt. Mutations such as Ile236Asn, Val237Glu, Met239Lys, and Arg484Pro are first noted in Korea.
Adrenal Hyperplasia, Congenital*
;
Cholesterol
;
Hydrocortisone
;
Korea
;
Polymerase Chain Reaction
;
Steroid 21-Hydroxylase
2.An Experimentally Induced Fat Embolism in the Rabbit Lung: High-resolution CT and Pathologic Findings.
Dong Ho HA ; Ki Nam LEE ; Jin Sook JEONG
Journal of the Korean Radiological Society 2001;44(2):153-159
PURPOSE: To assess the high-resolution CT and pathologic findings of fat embolism experimentally induced in rabbit lung. MATERIALS AND METHODS: Twelve rabbits were divided into four groups, namely control, 2-hour, 24-hour, and 72-hour, with three rabbits in each, and closed tibiofibular fractures were induced. After the rabbits were sacrificed, high-resolution CT scanning of the artificially inflated lungs was performed, and the CT findings were analyzed by two radiologists. They determined the presence or absence of ground glass opacity or consolidation, the extent of the lesions (using a 10% grading scale), and their distribution, reaching a consensus. The pathologic findings were analyzed using the specimens prepared by H & E and Oil-red O staining. RESULTS: Although the high-resolution CT findings of pulmonary fat embolism were nonspecific, bilateral patchy ground glass opacity (100%), and focal air-space consolidation surrounding the bronchovascular bundle (89%) were most common. In all groups, the occlusion of vessels by fat globules was confirmed by Oil-red Ostaining. The microscopic findings included focal pulmonary hemorrhage, edema, alveolar collapse, and extensive infiltration of inflammatory cells in the lung parenchyma. The 24-hour group showed more extensive change in high-resolution CT and pathologic findings than did the others. CONCLUSION: Fat embolism in rabbit lung may occur after closed tibio-fibular fracture. The extent of the lesion revealed by high-resolution CT correlated closely with the pathologic findings. High-resolution CT may thus be helpful for the detection of pulmonary fat embolism and evaluation of its extent.
Consensus
;
Edema
;
Embolism, Fat*
;
Glass
;
Hemorrhage
;
Lung*
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Pulmonary Embolism
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Rabbits
;
Tomography, X-Ray Computed
3.Experimental Brain Edema.
Jeong Wha CHU ; Ki Chan LEE ; Ki Young JANG ; Dong Whee JUN
Journal of Korean Neurosurgical Society 1976;5(2):39-46
By the expansion of stalk of laminaria inserted into the right epidural space of the rabbit head, cerebral compression and edema were produced. The studies of the occurrence and changes of experimental brain edema have been observed by weighing the wet and dry brain tissue, and by calculating the percentage of water content and that of swelling, with rate of per cent water content to that of control group. The percentage of water content and swelling of cerebral gray and white matters in the compressed site showed higher values than those in control and in non-compressed groups. As compared with normal group, the rate of per cent water content of cerebral gray matter at the site of compression showed gradually increasing tendency as time elapsed by 12 hours, while that of white matter demonstrated a increase of it by 24 hours and decreased gradually thereafter. Cerebral edema induced by laminaria compression was more evident and severe in the white matter than in the gray. Oxygen and glucose that are utilized the brain are two of the most important substances and play very important roles in the brain to form high energy bond and nucleic acid. Authors have attempted to measure oxygen consumption in normal rabbit brain and diseased brain that are produced by the expansion of stalk of laminaria in the intracranial epidural space. The value of oxygen consumption of cerebral gray and white matters in the compressed hemispheres showed higher values than those in control group, and they revealed a tendency of rather rapid increases at early experimental stages, an of gradual decrease thereafter.
Brain Edema*
;
Brain*
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Edema
;
Epidural Space
;
Glucose
;
Head
;
Laminaria
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Oxygen
;
Oxygen Consumption
4.A Pemphigus Vulgaris with IgG1 and IgG4 Subclass Autoantibodies.
Suk Woo LEE ; Jeong Ki RHE ; Dong HOUH ; Young Jin OH ; Young Whan KIM ; Won HOUH
Annals of Dermatology 1990;2(1):35-38
The distribution of pemphigus subclass autoantibodies in a patient with pemphigus vulgaris (PV) has been investigated by semiquantitative indirect immunofluorescence (IIF), using the HP series monoclonal antibodies specific for four human IgG subclasses on human foreskins. IgG1 and IgG4 intercellular substance-specific autoantibodies were detected in the serum of the patient, whereas IgG2 and IgG3 autoantibodies were absent. In addition to foreskins, human tonsillar epithelia were used as substrates of IIF for detecting the PV autoantibodies and it was one of satisfactory substitutes for monkey esophagus.
Antibodies, Monoclonal
;
Autoantibodies*
;
Esophagus
;
Fluorescent Antibody Technique, Indirect
;
Foreskin
;
Haplorhini
;
Humans
;
Immunoglobulin G*
;
Pemphigus*
5.An unusual Cellular Blue Nevus involving Phalangeal Bone.
Jeong Ki RHEE ; Dong HOUH ; Hyung Ok KIM ; Chung Won KIM ; Seok Jin GANG
Korean Journal of Dermatology 1989;27(6):757-761
A 34-year-old female had an unusual case of cellular blue nevus which had behaved in a locally aggressive fashion. The lesion infiltrsted the adjacent soft tissue of left nail bed and extended into deep phalangeal bone. The involved left thumb was partially amputated because complete excision was impossible and we were quite concerned about malignant transformation. Histologically biphasic pattern without cellular atypism, a characteristic features of cellular blue nevus, was shown. About 2 years later, the lesion had not recurred.
Adult
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Female
;
Humans
;
Nevus, Blue*
;
Thumb
6.Intradural Extramedullary Tuberculoma of the Spinal Cord Following Tuberculous Meningitis.
Deok Ki JEONG ; Young Min KWON
Korean Journal of Spine 2015;12(2):107-110
Intradural extramedullary tuberculoma of the spinal cord (IETSC) is an uncommon disease which can occurs secondary to tuberculous meningitis. A 31-year-old woman was diagnosed as tuberculous meningitis after mental disorientation. Her mentality was recovered after antituberculous therapy. After 7 months of antituberculous therapy, paraplegia has developed. Magnetic resonance imaging (MRI) revealed a mass lesion between the T1 and T12 spinal levels with arachnoid thickening which results in the development of tuberculoma. She received surgical resection of IETSC followed by antituberculous therapy and neurological function has been improved. The two years after surgical treatment, spinal MRI showed syringomyelia between T1 to L1. But, her neurological outcome was not aggravated.
Adult
;
Arachnoid
;
Female
;
Humans
;
Magnetic Resonance Imaging
;
Paraplegia
;
Spinal Cord*
;
Syringomyelia
;
Tuberculoma*
;
Tuberculosis, Meningeal*
7.A Case of Localized Axillary Syringomas.
Seung Hyun SOHNG ; Jeong Young PARK ; Dong Hoon SHIN ; Jong Soo CHOI ; Ki Hong KIM
Korean Journal of Dermatology 2012;50(5):489-490
8.Factors Influencing Willingness for Human Papilloma Virus (HPV) Vaccination in Female Students at One University.
Jung Ho YUM ; Hwee Soo JEONG ; Dong Wook LEE ; Ki Heum PARK ; Nu Lee KIM
Korean Journal of Health Promotion 2011;11(2):100-105
BACKGROUND: This study was done to identify factors that influence the willingness to be vaccinated with the human papilloma virus (HPV) vaccine in female college students eligible for a catch-up vaccination program. METHODS: This cross-sectional study included 572 female students aged 18-26 years attending one selected university in the Gyeongbuk Province. From March 2 to 6, 2009, they completed a self-administered questionnaire on their HPV vaccination status. Thereafter, unvaccinated participants were educated about the vaccination program, and each participant's willingness to be vaccinated was assessed. RESULTS: Of the 572 participants, 18 (3.1%) were already vaccinated with the HPV vaccine. The number of participants advised to be vaccinated was 102 (17.8%). Of the 554 unvaccinated participants, 305 (55.1%) were willing to be vaccinated after being educated about the vaccination program. Of the remaining 249 unvaccinated participants, 116 (48.7%) refused the vaccine due to its high cost. Advice by family members was related significantly to the willingness to be vaccinated (odds ratio, 2.37; 95% confidence interval, 1.09-5.14). CONCLUSIONS: The results of this study suggest that the willingness to be vaccinated with the HPV vaccine could be increased in female college students if they are advised to do so by their family members after being educated about the vaccination program.
Aged
;
Cross-Sectional Studies
;
Female
;
Humans
;
Papilloma
;
Vaccination
;
Viruses
;
Surveys and Questionnaires
9.Activation of Caspase-3 During Photoreceptor Degeneration in rd Mouse Retina.
Dong Hwan KIM ; Jeong A KIM ; Choun Ki JOO
Journal of the Korean Ophthalmological Society 2001;42(2):365-372
Retinal degeneration caused by a hereditary defect in the genome is reported in a few animals and it leads to blindness. rd mouse is one of the well studied animal models for retinal degeneration. The retinal degeneration of rd mouse is caused by a mutation on cGMP-phosphodiesterase(PDE). Caspase activation has been implicated for apoptosis. In this study, we examined the activation of caspase-3 during photoreceptor degeneration in rdmouse. Photoreceptor degeneration of rd mouse occured at PD 9 and disappeared at PD 21.In addition, we observed the active form of caspase-3 in the retinal degeneration of rd mouse. In conclusion, the cell death pattern of photoreceptor degeneration in rd mouse seemed to be an apoptosis rather than necrosis.
Animals
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Apoptosis
;
Blindness
;
Caspase 3*
;
Cell Death
;
Genome
;
Mice*
;
Models, Animal
;
Necrosis
;
Retina*
;
Retinal Degeneration
10.Clinical Study of Cataract Surgery in Diabetics.
Dong Won JOO ; Sang Ki JEONG ; Byung II PARK
Journal of the Korean Ophthalmological Society 1992;33(3):216-222
We have retrospectively studied 118 eyes of 91 diabetic patients which underwent cataract surgery and followed up at least 3 months and the postoperative corrected visual acuity compared according to the degree of retinopathy, duration of diabetics and age of the patients The results were as follows: 1. Age distribution of the diabetic patients were 17-85 years old and 6th decade was most frequent group and the percentage of male patients were 64.8% and 82.4% of total patients were over 50 years of age. 2. The postoperative corrected visual acuity above 20/40 according to patient age was 100% in the 3rd decade and 1st decade, 87.5% in the 4th decade, 73.5% in the 5th decade, 80.9% in the 6th decade and 42.8% in the 2nd decade. The postoperative visual acuity was generally better in younger patients. 3. The postoperative corrected visual acutiy above 20/40 according to degree of diabetics was 94.2% in Non Diabetic Retinopathy, 78.5% in Background Diabetic Retinopathy, 11.1% in Proliferative Diabetic Retinophthy. The postoperative corrected visual acuity was worse in severe retinopthy group. 4. The postoperative corrected visual acuity above 20/40 according to duration of diabetics was 94.2% in under 5 years, 83.9% in 10 < -15 years, 56.1% in above 15 years and the result was better in short diabetic duraction group.
Age Distribution
;
Cataract*
;
Diabetic Retinopathy
;
Humans
;
Male
;
Retrospective Studies
;
Visual Acuity