1.Changes of c-Fos Protein Expression in Rat Brain Neurons after Formalin Induced Pain.
Kyu Geun HWANG ; Myeong Dong SHIN ; Ki Soo YOO
Journal of the Korean Child Neurology Society 1999;7(1):29-41
PURPOSE: The effects of pain on brain is not well known. Also, differences between somatic and visceral pains have not been fully elucidated. This study was conducted to investigate changes in the expression of c-Fos protein after somatic and visceral pains were induced by formalin. METHODS: Male rats(n=65) were underwent one of three procedures : (i) Control group, rats were left undisturbed in their cages; (ii) Somatic pain group, rats were injected subcutaneously with 0.1 ml of 10% formalin in the plantar surface of right hindpaw; (iii) Visceral pain group, rats were administered with same amount of formalin, as described above, in the rectum. Rats were sacrificed at increasing times(30 minutes, 1 hour, 2 hours, 6 hours, 1 day, 3 days and 7 days) after noxious formalin stimuli to hindpaws and rectums. Rat brains were removed and sliced in rat brain matrix. Brain slices were coronal sectioned at interaural 5.70-6.70mm. Serial sections were immunohistochemically reacted with polyclonal c-Fos antibody. The numbers of c-Fos protein immunoreactive neurons in cingulate cortex, primary somatosensory area, and hippocampus were examined and analyzed statistically with Mann-Whitney U test. RESULTS: 1) The numbers of c-For protein immunoreactive neurons in cingulate cortex, primary somatosensory area and hippocampus peaked at 2 hours after somatic pain stimuli and reached almost normal conditions at 7 days. 2) The numbers of c-Fos protein immunoreactive neurons in cingulate cortex, primary somatosensory area and hippocampus peaked at 1 day after visceral pain stimuli and reached almost normal conditions at 7 days. 3) The numbers of c-Fos protein immunoreactive neurons of somatic pain groups were higher than that of visceral groups at all times and the difference of numbers peaked at 2 hours after pain stimuli. CONCLUSION: Reactions of somatic pain stimuli influenced more changable than visceral pain stimuli to brain. Conduction velocities of somatic pain were more faster than those of visceral pain. Higher numbers of c-Fos protein immunoreactive neurons were found in specific regions. These results provide some basic knowledge in understanding the mechanism and control of pain.
Animals
;
Brain*
;
Formaldehyde*
;
Gyrus Cinguli
;
Hippocampus
;
Humans
;
Male
;
Neurons*
;
Nociceptive Pain
;
Rats*
;
Rectum
;
Visceral Pain
2.The comparative study of the surgical treatment of axillary osmidrosis by inaba's manual, and combined subcutaneous tissue shaving method.
Dong Ha HWANG ; Ki Young AHN ; Dae Hwan PARK
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1993;20(6):1310-1316
No abstract available.
Subcutaneous Tissue*
3.A Case of Gastroenteritis Complicated with Empyema of Gall Bladder Caused by Salmonella Serogroup B.
Dong Soo KIM ; Ki Sup CHUNG ; Dong Shik CHIN ; Seung Hoon CHOI ; Eui Ho HWANG
Journal of the Korean Pediatric Society 1986;29(2):103-106
No abstract available.
Empyema*
;
Gastroenteritis*
;
Salmonella*
;
Urinary Bladder*
4.Clinical application of helium-neon laser & diode laser for acceleration of wound healing.
Dong Ha HWANG ; Dong Gil HAN ; Ki Young AHN ; Dae Hwan PARK
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1993;20(6):1216-1223
No abstract available.
Acceleration*
;
Lasers, Semiconductor*
;
Wound Healing*
;
Wounds and Injuries*
5.A case of Addison's disease.
Cheol Hee HWANG ; Dong Kui LEE ; Myung Sug NAM ; Mun Ki CHO
Journal of the Korean Pediatric Society 1991;34(8):1169-1174
No abstract available.
Addison Disease*
6.The effect of zonisamide in children with refractory epilepsies.
Ki Joong KIM ; Soo Ahn CHAE ; Tae Sung KO ; Dong Wook KIM ; Yong Seung HWANG
Journal of the Korean Pediatric Society 1993;36(8):1139-1145
Zonisamide was administered to 20 patients with refractory epileptic seizures. The mean duration of the administration was 6 months, and the mean dosage was 7.2 mg/kg/day. The efficacy of zonisamide was rated remarkable in 15% of the cases, improvement in 40%, and no change in 45%. The response rates of zonisamide were 62.5% for myoclonic seizures, 50% for tonic-clonic seizures, 80% for atonic seizures and 33.3% for atypical absence seizures. There was no correlation between the clinical response and dose or serum concentration of the drug. The adverse effects were observed in 35% of the cases which were drowsiness, dizziness, ataxia, nausea, and vomiting. In all cases, however, the administration of zonisamide could be continued.
Ataxia
;
Child*
;
Dizziness
;
Epilepsy*
;
Epilepsy, Absence
;
Humans
;
Nausea
;
Seizures
;
Sleep Stages
;
Vomiting
7.A asymptomatic rectal endometriosis with endometrial cyst.
Hyoung Min CHOI ; Sung Ki LEE ; Yoon Ho LEE ; Dong Hoon HWANG ; So Yeon PARK
Korean Journal of Obstetrics and Gynecology 1992;35(11):1679-1685
No abstract available.
Endometriosis*
;
Female
8.A case of testicular feminization syndrome.
Dong Hoon KIM ; Jin Wan PARK ; Tai Young HWANG ; Hyun Ho KIM ; Won Ki LEE
Korean Journal of Obstetrics and Gynecology 1993;36(7):2377-2382
No abstract available.
Androgen-Insensitivity Syndrome*
;
Male
9.A case of testicular feminization syndrome.
Dong Hoon KIM ; Jin Wan PARK ; Tai Young HWANG ; Hyun Ho KIM ; Won Ki LEE
Korean Journal of Obstetrics and Gynecology 1993;36(7):2377-2382
No abstract available.
Androgen-Insensitivity Syndrome*
;
Male
10.Chlamydial infection in women with tubal pregnancy.
Woo Sik LEE ; Dong Hoon HWANG ; Byung Suk LEE ; Ki Hyun PARK ; Chan Ho SONG
Korean Journal of Obstetrics and Gynecology 1993;36(4):534-542
No abstract available.
Female
;
Humans
;
Pregnancy
;
Pregnancy, Tubal*