The fact that therapeutic hypothermia (TH) has lowered intracranial pressure and protected brain in severe traumatic brain injury (TBI) is well known throughout past sources and experimental data. In this paper, the result of TH in TBI needs to be confirmed. The result of North American Brain Injury Study; Hypothermia (NAVIS-H) 1 and 2, Eurotherm3235, Japan trauma society study was reviewed throughout randomized controlled study which performed recently. The prognosis was not confirmed throughout TH in NAVIS-H1; however, there was statistical significance among the group of 45 years or less and below 35 degree in celcius which checked when he or she visited initially. Hence, NAVIS-H2 study was preceded. In patient who had surgically removed hematoma, the effects of TH were proved compared to diffuse brain damage in NAVIS-H2 study. This was found in the result of Japan neurotrauma data bank. Eurotherm study has been doing, which leads to collect many data later on. The TBI of TH makes them better prognosis in patients who had surgically removed hematoma and lowered initial body temperature. Later on, it is considered further study is necessary.
Body Temperature ; Brain ; Brain Injuries* ; Hematoma ; Humans ; Hypothermia* ; Intracranial Pressure ; Japan ; Prognosis

No abstract available.

Dysregulation of TGF-beta that is a modulator of cell growth and differentiation can result in uncontrolled growth and tumor formation. Monitoring these pattern of genes and protein expression during tumor development will provide a basis for understanding normal growth and distortion of osteochondrogenesis. Our comparative studies on the experssion of TGF-beta protein indicate that TGF-beta may primarily be a regulator of epithelial differentiation during tooth development (between 4 weeks and 40 gestational weeks) and tumorigenesis of odontogenic neoplasm (ameloblastoma). In early human tooth germ (cap/early bell stage) TGF-beta protein was found in the epithelial dentallamina and enamel orgen. TGF-beta experessions were seen in inner and outer dental epithelium during bell stage. During enamel and cementum appositional stage, TGF-beta expression shifted from the ameloblast to the odontoblast. In eruption stage, TGF-beta expressions look like moderate positive pattern in odontoblast and rare pattern in enamel, dentin and cementum. TGF-beta expressions of follicular and plexiform amelobalstoma are moderate positive reaction in ectodermal tumor components and mild positive in vessels of stroma tissue. In acanthomatous type, TGF-beta expression was shown severely positive finding in stellate reticulum cell. TGF-beta expressions were noted moderate reaction in margin of tumor epithelium and stellate reticulum cell of granular ameloblastoma. In unicystic ameloblastoma, TGF-beta expression was rare feature in cystic luminal epithelium. With these result, I should be suggested that TGF-beta may play an important role in epithelial-mesenchymal interactions in human tooth morphogenesis and development of odontogenic epithelial tumors.
Ameloblastoma* ; Ameloblasts ; Carcinogenesis ; Dental Cementum ; Dental Enamel ; Dentin ; Ectoderm ; Embryonic Structures* ; Epithelium ; Fetus* ; Humans* ; Morphogenesis ; Odontoblasts ; Phenobarbital ; Reticulum ; Tooth Germ* ; Tooth* ; Transforming Growth Factor beta*

No abstract available.
Korea* ; Mortality* ; Statistics as Topic* ; Stomach*

The fact that therapeutic hypothermia (TH) has lowered intracranial pressure and protected brain in severe traumatic brain injury (TBI) is well known throughout past sources and experimental data. In this paper, the result of TH in TBI needs to be confirmed. The result of North American Brain Injury Study; Hypothermia (NAVIS-H) 1 and 2, Eurotherm3235, Japan trauma society study was reviewed throughout randomized controlled study which performed recently. The prognosis was not confirmed throughout TH in NAVIS-H1; however, there was statistical significance among the group of 45 years or less and below 35 degree in celcius which checked when he or she visited initially. Hence, NAVIS-H2 study was preceded. In patient who had surgically removed hematoma, the effects of TH were proved compared to diffuse brain damage in NAVIS-H2 study. This was found in the result of Japan neurotrauma data bank. Eurotherm study has been doing, which leads to collect many data later on. The TBI of TH makes them better prognosis in patients who had surgically removed hematoma and lowered initial body temperature. Later on, it is considered further study is necessary.
Body Temperature ; Brain ; Brain Injuries ; Hematoma ; Humans ; Hypothermia ; Intracranial Pressure ; Japan ; Prognosis

No abstract available.
Animals* ; Brain* ; Hypothermia* ; Models, Animal*

No abstract available.
Aneurysm* ; Bone Cysts* ; Spine*

CTDs have been a growing problems for US and European industries with higher incidence rate every year. In our country, we have just Started to recognize and to work on the problems in industry. In this respect, this would be the first ergonomic-based CTD study with medical data. Two automobile part plants were ergonomically and clinically surveyed for this study. Specifically,' 25 jobs from A industry and 51 jobs from B industry were matched with the clinical data. Two types of analysis were conducted. First, ergonomic job evaluation using CTD checklist was done for both industries to figure out the relative risks for each jobs. Second, comprehensive analysis for risk factors regarding CTDs was conducted. It produced mainly two results. First, multiple regression analysis of both worker and work-related factors on total scores based on the results of the'physical examination showed that there was no statistically significant relationships between total scores based on physical examinations and either worker or work-related risk factors. Second, logistic analyses for both factors were done. An user-friendly logistic program was developed for this analysis and for the future analysis of CTD study in the long-run. The program would have even non-expert in statistical package easily manipulate logistic analysis. Based on the logistic analysis, there was no significant relationships between worker related risk factors and all CTD types except marital status. However, there was some significant results in terms of work-related factors. Lateral pinch and ulnar deviations had significant relationship with both all CTD types and CTS. Power grip was associated with all types of CTDs, Tendinitis and Carpal Tunnel Syndrome. The cycle time had significant effects only on Carpal Tunnel Syndrome. In conclusion, the first ergonomic-based CTD study has been initiated in Korea. However, it was realized that good overall situation for CTD study in Korea has been before the right time yet. Therefore, futher research on the basis of the framework of this study is strongly suggested to have a complete CTD guidelines in the near future.
Automobiles ; Carpal Tunnel Syndrome ; Checklist ; Cumulative Trauma Disorders ; Hand Strength ; Human Engineering ; Incidence ; Korea ; Marital Status ; Physical Examination ; Risk Factors ; Tendinopathy

CTDs have been a growing problems for US and European industries with higher incidence rate every year. In our country, we have just Started to recognize and to work on the problems in industry. In this respect, this would be the first ergonomic-based CTD study with medical data. Two automobile part plants were ergonomically and clinically surveyed for this study. Specifically,' 25 jobs from A industry and 51 jobs from B industry were matched with the clinical data. Two types of analysis were conducted. First, ergonomic job evaluation using CTD checklist was done for both industries to figure out the relative risks for each jobs. Second, comprehensive analysis for risk factors regarding CTDs was conducted. It produced mainly two results. First, multiple regression analysis of both worker and work-related factors on total scores based on the results of the'physical examination showed that there was no statistically significant relationships between total scores based on physical examinations and either worker or work-related risk factors. Second, logistic analyses for both factors were done. An user-friendly logistic program was developed for this analysis and for the future analysis of CTD study in the long-run. The program would have even non-expert in statistical package easily manipulate logistic analysis. Based on the logistic analysis, there was no significant relationships between worker related risk factors and all CTD types except marital status. However, there was some significant results in terms of work-related factors. Lateral pinch and ulnar deviations had significant relationship with both all CTD types and CTS. Power grip was associated with all types of CTDs, Tendinitis and Carpal Tunnel Syndrome. The cycle time had significant effects only on Carpal Tunnel Syndrome. In conclusion, the first ergonomic-based CTD study has been initiated in Korea. However, it was realized that good overall situation for CTD study in Korea has been before the right time yet. Therefore, futher research on the basis of the framework of this study is strongly suggested to have a complete CTD guidelines in the near future.
Automobiles ; Carpal Tunnel Syndrome ; Checklist ; Cumulative Trauma Disorders ; Hand Strength ; Human Engineering ; Incidence ; Korea ; Marital Status ; Physical Examination ; Risk Factors ; Tendinopathy

Gestational trophoblastic tumors including choriocarcinoma bave become one of the most curable human malignancies with an overall cure rate exceeding 90%. Although systemic chemotherapy is the initial treatment for chorio- carcinoma, some patients with chemotherapy-resistant choriocarcinorna can be treated by integration of cbemotherapy, surgery and radio- therapy. We report two cases of persistent localized choriocarcinoma which was treated by surgical intervention.
Choriocarcinoma* ; Drug Therapy ; Female ; Humans ; Neoplasm Metastasis ; Pregnancy ; Trophoblastic Neoplasms