A case of testicular embryonal carcinoma developed in s cryptorchid testis is presented with a review of the literature. According to Campbell's series, the incidence of malignant cryptorchid testis was 11.6%. and his statistical evaluation was similar to Gilbert and Hamilton's series of 7,000 cases of testicular neoplasms where 840 tumors were developed in undescended testes(12%). Both authors agree that the chance of neoplastic development in a cryptorchid testis is approximately 48 times greater then that developing in a normally descended testis. Several cases of testicular tumor were reported sporadically in Korea, but malignant tumors in cryptorchism were rarely seen in the literatures Only two cases of malignant cryptorchid testis were already reported in Korea.
Carcinoma, Embryonal* ; Cryptorchidism ; Incidence ; Korea ; Male ; Testicular Neoplasms ; Testis*

No abstract available.
Walking*

No abstract available.
Lipoma*

No abstract available.
Congenital Abnormalities* ; Spondylitis, Ankylosing*

Dupuytren's contracture is characterized by a proliferative fibroplasia and contracture of the palmar fascia with resultant deformity of hand and finger. It is most common in those of Scandinavian and Celtic origin but it is very rare in the orientals. We experienced 30 hands of 21 patients from January 1985 to December 1995 in Soonchunhyang University Hospital. Among 21 patients, operative treatment was done in 28 hands of 19 patients. Partial fasciectomy was done in 24 hands and complete fasciectomy was done in 4 hands. The longitudinal straight skin incision was done in 14 cases and the transverse or Zig-Zag incision was done in 12 cases. Average follow-up period was 24 months. The results of the operative treatment were classified by Honner's classification. Excellent result was obtained in 16 cases (57%), good in 8 (29%), fair in 3 (11%), poor in 1 (3%). The complications were 5 cases as follows; recurrence 2, skin defect 1, hypoesthesia 2. In conclusion, partial fasciectomy utilizing longitudinal straight incisions overlying diseased area is suggested as one of the good method for the treatment of Dupuytren s contracture.
Classification ; Congenital Abnormalities ; Contracture ; Dupuytren Contracture* ; Fascia ; Fingers ; Follow-Up Studies ; Hand ; Humans ; Hypesthesia ; Recurrence ; Skin

BACKGROUND: Elastic fibers are a major fibrillar component of the extracellular matrix of several organs, and their presence provides elastic properties to these tissues. Recent molecular biological studies also have revealed that accumulation of elastotic material in the skin reflects enhanced synthesis of not only elastin but also a fibrillin, an integral component of the elastic fibers, and steady-state levels of the elastin mRNA increased in photodamaged skin. Futhermore, a variety of cytokines, growth factors, and hormones have been shown to modulate elastin gene expression including transforming growth factor- beta, tumor necrosis factor-a, insulin-like growth factor-I, glucoreorticoids, cyclic AMP, and vitamin D3. Recently, interleukin-1 beta (IL-1 beta) and IL-10 has been shown to up-regulatory function in elastin gene expression. OBJECTIVE: The purpose of this study was to examine the effect of IL-1 beta and IL-10 on elastin gene expression in cultured human fibroblasts. METHODS: Fibroblasts cultures were produced with DMEM medium. Cells were treated with IL-1 p (1U/ml, 10U/ml) and IL-10(0.1ng/ml, 1ng/ml, 10ng/ml) nuclear proteins were extracted. Effect of IL-1 beta and IL-10 on elastin gene expression were measured by Northern blot analysis, chloram- phenicol acetyltransferase(CAT) assay, and laser confocal microscopy. RESULTS: In Northern blot analysis, IL-1 beta and IL-10 showed an up-regulatory effect on elastin mRNA steady-state levels compared with controls incubated without IL-1 p and IL-10. In CAT assay, the percentage of acetylation were increased in cultured fibroblasts. The promoter activities were increased 1.5 and 2.2-fold in IL-1 beta (1U/ml, 10U/ml) and 2.2-fold in IL-10(lng/ml, 10ng/ml) treated fibroblasts compared to control groups. In laser confocal microscopy, the results indicated significant increase in the elastin epitopes associated with the cells in cultured with IL-1 beta and IL-10. CONCLUSION: These results show that IL-1 p and IL-10 increase elastin gene expression on transcriptional and protein levels of cultured fibroblasts. It suggests that they may effect on elastin synthesis by a stage up-regulater in human skin.
Acetylation ; Animals ; Blotting, Northern ; Cats ; Cholecalciferol ; Cyclic AMP ; Cytokines ; Elastic Tissue ; Elastin* ; Epitopes ; Extracellular Matrix ; Fibroblasts ; Gene Expression ; Humans* ; Intercellular Signaling Peptides and Proteins ; Interleukin-1 ; Interleukin-10* ; Interleukin-1beta* ; Microscopy, Confocal ; Necrosis ; Nuclear Proteins ; RNA, Messenger ; Skin

BACKGROUND: Recent randomized studies have shown a reduction of restenosis rate after denovo coronary stenting as compared to classical PTCA. The purpose of this study was to evaluate a new medication protocol using antiplatelet therapy(ticlodipine, aspirin) and heparin in conjunction with routine high pressure ballooning after stenting. METHODS AND RESULTS: Seventy two patients(47 males and 25 females, mean age : 58+/-11 years) underwent Palmaz-Schatz coronary stenting in 76 coronary lesions. Their clinical characeristice were ; 38 cases(63%) of unstable angina, 14 cases(19%) of stable angina and 20 cases(28%) of acute myocardial infarction(MI, Q : 16 cases, non-Q : 4 cases). In 15 out of 20 acute MI cases, stents were implanted in the infarct-related arteries. Primary elective stenting was indicated for 40 lesions(53%) ; 34 for de novo and 6 for restenosis after PTCA. Stents were implanted in 27 lesions(35%) with suboptimal result after PTCA and 9 lesions(12%) as a bailout procedure ; 8 threatened closures and 1 acute closure. All patients were treated with heparin for 48 hours and antiplatelet agents(aspirin 100-200mg/day and ticlopidine 200-500mg/day) after the procedure. All stents were greater than 3.0mm in size. Postdilatation was obtained with a max balloon diameter of 3.5+/-0.6mm(balloon-to-vessel ratio of 1.12+/-0.20) at a max inflation pressure of 14.4+/-2.8 atm. Percent diameter stenosis decreased from 70.4+/-15.5% to -1.2+/-4.8%(p<0.0001), and minimal luminal diameter increased from 0.94+/-0.57mm to 3.15+/-0.51mm(p<0.0001) after stenting. During mean follow-up duration of 5.1+/-3.0 months there were 3 cases(4.2%) of myocardial infarction, 2(2.7%) of repeat angioplasty, 1(1.4%) of CABG and 1(1.4%) of death. CONCLUSION: Palmaz-Schatz coronary stenting with poststenting routine high pressure ballooning appears to be safe and feasibile without anticoagulation and without use of intravascular ultrasound in selected patients.
Angina, Stable ; Angina, Unstable ; Angioplasty ; Arteries ; Constriction, Pathologic ; Coronary Artery Disease ; Female ; Follow-Up Studies ; Heparin ; Humans ; Inflation, Economic ; Male ; Myocardial Infarction ; Phenobarbital ; Stents* ; Ticlopidine ; Ultrasonography

BACKGROUND: Epidermal cyst is a common disease. The clinical and histo pathologic findings in patients with epidermal cysts are described. OBJECTIVE: Our purpose is to identify the clinical and histopathologic feastures of epidermal cysts. MEHTODS: We ealuated the clinical and histopathologie features of 11 cases which were diagnosed with epidermal cysts at the department of dermatology in Wonju Chist.an Hospital and Jeju Severance Dermatologic clinic for 13 years, from January 1980 to June 1992. RESULTS: The ratio of males to females was 1.9: 1 with male predominance. Age distribution at first visit was variable, ranging from to 85 years old. The mean age was 3.5 years old. The Duration of lesions was variable, ranging from a 3 days to 20 years, with the mean duration of 2.4 years. The most common site of lesions was the face(36%), followed by the trunk(18%), neck(13%), leg(13%), arm (8%), scalp(3%), scrotum(3%), vagina(3%), palm(1%) and fingers(1%). Histopathologically, 46 cases(41%) were ruptured. The most common stromal change was fibrosi followed by granulation tissue formation, giant cell, calcifiration, pilomatricoma like change, pigment, squamous eddy, bone formation and vessel proliferation. The most common cystic content was keiatinous material followed by parakeratotic cell, bacterial colony, calcification, cholesterol cleft, pigment and RBC. The most common cystic wall change was acanthosis followed by atrophy, hyperplasia, hyergranulosis, basalioma like change, parakeratosis and reticulation. CONCLUSION: Epidermal cysts are slowly growing tumors. They occur nost commonly on the face, trunk, neck, legs and arms. Histopathologically, they have a wall compose 1 of true epidermis. When an epidermal cyst ruptures, a foreignbody reaction with numerous multinu leated giant cells occurs.
Age Distribution ; Aged, 80 and over ; Arm ; Atrophy ; Cholesterol ; Dermatology ; Epidermal Cyst* ; Epidermis ; Female ; Gangwon-do ; Giant Cells ; Granulation Tissue ; Humans ; Hyperplasia ; Leg ; Male ; Neck ; Osteogenesis ; Parakeratosis ; Pilomatrixoma ; Rupture

Multiple meningiomas are a seldom encountered neoplasm. Most authors report an incidence ranging from 1 to 3% of all meningioma prior to the introduction of computerized tomography(CT). The routine use of CT has resolved diagnostic problems involved with multiple meningiomas and the incidence was 8% since the introduction of CT scan. In fact, it may be difficult to differentiate "true multiple meningioma" from simple recurrences or the special variant(forme fruste) of Von Recklinghausen's disease, and the pathogenetic factors related to true multiple meningioma is unknown, but various theroies of the etiology are explored by literature reports. We report the rare case of multiple meningiomas which diagnosed by CT scan and confirmed by operation.
Incidence ; Meningioma* ; Neurofibromatosis 1 ; Recurrence ; Tomography, X-Ray Computed

The role of cerebral revascularization in the treatment of ischemic stroke has been incompletely investigated. Ten patients with middle cerebral artery occlusion or stenosis and four patients with internal carotic artery occlusion or stenosis underwent superficial temporal artery-middle cerebral artery(STA-MCA) bypass surgery in the setting of acute neurological deficits, crescendo transient ischemic attacks(TIA'S), or recent completed stroke(CS). Early STA-MCA anastomosis was remarkably helpful in the setting of acute cerebral ischemia and crescendo TIA'S for their symptomatic relief. In addition, low flow revascularization were performed safely and also contributed to stabilization or slight reduction of the neurological deficit enen in CS. However, further controlled randomized studies are indicated.
Arteries ; Brain Ischemia ; Cerebral Revascularization ; Constriction, Pathologic ; Humans ; Infarction, Middle Cerebral Artery ; Stroke*