1.An experimental study on the effect of prostaglandin e1 on the random pattern flap survival in the rats.
Dong Hyeok SHIN ; Joon Buhm KIM
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1998;25(4):530-537
The survival of skin flap has vital importance in plastic surgery. Many clinical and experimental researches have been carried out to increase the survival of skin flap. As a result of these researches, many drugs have been used clinically and experimentally for increasing the survival of skin flap, and prostaglandin E1 is known to be used for improving peripheral circulatory disturbance. The pharmacophysiologic mechanisms of the effect of prostaglandin E1 are 1) increasing blood flow by dilatation of smooth muscle of small sized vessels, 2) inhibition of aggregation of platelets, 3) increasing arteriolar blood flow by improving fluidity of erythrocytes, 4) preclusion of free-radical formation, 5) decreasing the endothelial cell damage by down- regulation of sensitivity for eosinophils, 6) making the endothelial cell be refractory to adrenergic stimulation, and 7) promotion of secretion of erythropoietin in the kidney. In this terms, in order to validate effectiveness of preoperative administration of prostaglandin E1 as a pharmacological flap delay, following experimental study was performed. Forty male Sprague-Dawley rats were divided into 4 groups and caudally based 2x8 cmsized flap was elevated on dorsal surface. In group 1, normal saline (0.25 ml/kg) was injected intraperitoneally as control, in group 2, 1 microgram/kg of prostaglandin E1 was injected intraperitoneally for preoperative seven days, in group 3, 1 microgram/kg of prostaglandin E1 was injected intraperitoneally for seven preoperative days, and in group 4, 1 microgram/kg of prostaglandin E1 was injected intraperitoneally for seven days preoperatively and for seven postoperative days. On the seventh postoperative day, the animals were sacrificed and the flap survival area was measured. The following results were obtained. 1. On the seventh postoperative day, the flap survival rates of group 2, 3, 4 were higher than that of group 1 with a statistical significance. 2. On the seventh postoperative day, the flap survival rate of group 3 was higher than group 2, but there was no statistical significance. 3. On the seventh postoperative day, the flap survival rate of group 4 was higher than that of group 2 and 3 with a statistical significance.In conclusion, preoperative administrations of prostaglandin E1 increase flap survival equally as when it is administrated postoperatively, and the improvement in flap survival can be enhanced by continuous administration of prostaglandin E1 in preoperative and postoperative period. So it is expected that surgical flap delay procedure is replaced by pharmacological flap delay by the use of prostaglandin E1 preoperatively.
Alprostadil*
;
Animals
;
Dilatation
;
Endothelial Cells
;
Eosinophils
;
Erythrocytes
;
Erythropoietin
;
Humans
;
Kidney
;
Male
;
Muscle, Smooth
;
Postoperative Period
;
Rats*
;
Rats, Sprague-Dawley
;
Skin
;
Surgery, Plastic
;
Surgical Flaps
;
Survival Rate
2.Structure and Function of Hepatitis C Virus.
The Korean Journal of Hepatology 1997;3(1):1-8
No abstract available.
Hepacivirus*
;
Hepatitis C*
;
Hepatitis*
3.Sacoidosis in Korea.
Tuberculosis and Respiratory Diseases 2000;49(3):274-280
No abstract available.
Korea*
4.Elective and emergency operations renal transplant recipients.
Il Dong KIM ; Sang Joon KIM ; Soo Tae KIM
Journal of the Korean Surgical Society 1991;40(5):661-667
No abstract available.
Emergencies*
;
Transplantation*
5.Significance of temporal bone CT scan for exposure of the facial canal and the lateral semicircular canal in cholesteatoma.
Ki Joon SUNG ; Dong Jin KIM ; Myung Soon KIM ; Young Ju KIM ; Joon KWEON
Journal of the Korean Radiological Society 1991;27(5):603-606
No abstract available.
Cholesteatoma*
;
Semicircular Canals*
;
Temporal Bone*
;
Tomography, X-Ray Computed*
6.A case of Leiner's disease.
Nam Joon CHO ; Un Sun CHOI ; Dong Kun KIM
Korean Journal of Dermatology 1992;30(4):543-545
In 1908 Leiner described the peculiar skin condition among infants to which he applied the name erythroderma desquamativa. The four cardinal features of Leiners disease are generalized seborrheic dermatitis, intractable severe diarrhea, recurrent local and systemic infections usually of gram negative etiology, and marked wasting and cyst rophy. A 2-month-old female presented to our clinic with generalized seborrheic erythrodermic eruption and intractable diarrhea. She had sufferd from these symptoms since birth. Her body weight was 3.4kg (below 3rd percentile). Her scalp was covered with thick yellowish crsts. There was generalized erythroderma covered vith scales and crusts. Laboratory result; revealed gram negative sepsis and DIC. Chest X-ray showed the findings of minimal aspir ition pneumonia in the right upper lobe. She expired on the following day.
Body Weight
;
Dacarbazine
;
Dermatitis, Exfoliative
;
Dermatitis, Seborrheic
;
Diarrhea
;
Female
;
Humans
;
Infant
;
Parturition
;
Pneumonia
;
Scalp
;
Sepsis
;
Skin
;
Thorax
;
Weights and Measures
7.A Case of Congentital Leukemia.
Joon Sik KIM ; Chang Ik LEE ; Dong Hak SHIN
Journal of the Korean Pediatric Society 1984;27(8):802-807
No abstract available.
Leukemia*
8.Pharmacologic Therapy of Hepatic Fibrosis.
The Korean Journal of Hepatology 2001;7(1):6-11
No abstract availalbe.
Fibrosis*
9.Treatment of CDH in walking age.
Sung Joon KIM ; Kuhn Sung WHANG ; Il Dong SONG
The Journal of the Korean Orthopaedic Association 1991;26(3):819-824
No abstract available.
Walking*
10.Symptomatic epidural lipoma.
Chang Uk CHOI ; Joon Min SONG ; Dong Yeon KIM
The Journal of the Korean Orthopaedic Association 1992;27(4):1132-1136
No abstract available.
Lipoma*