1.Polycystic ovary in torsion combined with stage in endometrial carcinoma.
Jung In YANG ; Suk Jung KIM ; Byung Seok LEE ; Dong Jei CHO ; Kook LEE ; Chan Ho SONG
Korean Journal of Obstetrics and Gynecology 1991;34(10):1481-1487
No abstract available.
Endometrial Neoplasms*
;
Female
;
Ovary*
2.Clinical application of diagnosis laparoscopy in gynecology.
Woo Hyun JEONG ; Tai Ho CHUNG ; Jung Hyun CHO ; Yoon Ho LEE ; Dong Jei CHO ; Chan Ho SONG
Korean Journal of Obstetrics and Gynecology 1991;34(9):1302-1312
No abstract available.
Diagnosis*
;
Gynecology*
;
Laparoscopy*
3.N-Terminal Pro-B-Type Natriuretic Peptide in Overweight and Obese Patients With and Without Diabetes: An Analysis Based on Body Mass Index and Left Ventricular Geometry.
Seung Jei PARK ; Kyoung Im CHO ; Sun Jae JUNG ; Sung Won CHOI ; Jae Won CHOI ; Dong Won LEE ; Hyeon Gook LEE ; Tae Ik KIM
Korean Circulation Journal 2009;39(12):538-544
BACKGROUND AND OBJECTIVES: Several recent studies have shown that there is an inverse relationship between plasma B-type natriuretic peptide (BNP) and body mass index (BMI) in subjects with and without heart failure. Obesity frequently coexists with diabetes, so it is important to consider the relationship between diabetes and natriuretic peptide levels. We evaluated the influence of diabetes on the correlation of BNP and BMI. SUBJECTS AND METHODS: We examined 933 patients with chest pain and/or dyspnea undergoing cardiac catheterization between Feb. 2006 and Nov. 2007 in the Maryknoll cardiac center who had creatinine levels <2.0 mg/dL and normal systolic heart function. BMI was checked, transthoracic echocardiography was performed, and aminoterminal pro-brain natriuretic peptide (NT-proBNP) was sampled at the start of each case. RESULTS: In 733 non-diabetic patients, mean plasma NT-proBNP levels of non obese individuals (BMI <23 kg/m2), overweight individuals (23< or = BMI <25 kg/m2), and obese individuals (BMI > or =25 kg/m2) showed a significant negative correlation with increasing BMI (856.39+/-237.3 pg/mL, 601.69+/-159.6 pg/mL, 289.62+/-164.9 pg/mL, respectively, p<0.0001). However, in 200 diabetic patients, the correlation between BMI and NT-proBNP was not significant (r=-0.21, p=0.19), and NT-proBNP did not correlate with mitral E/Ea in obese diabetic patients (r=0.14, p=0.56). NT-proBNP was significantly correlated with mitral E/Ea in the non-obese (r=0.24, p=0.008) and non diabetic (r=0.32, p=0.003) groups. Left ventricular (LV) mass index was significantly correlated with NT-proBNP in all BMI groups (r=0.61, p<0.001), and patients with concentric cardiac hypertrophy showed the highest NT-proBNP levels. CONCLUSION: The present study demonstrates that obese patients have reduced concentrations of NT-proBNP compared to non obese patients despite having higher LV filling pressures. However, NT-proBNP is not suppressed in obese patients with diabetes. This suggests that factors other than cardiac status affect NT-proBNP concentrations.
Body Mass Index
;
Cardiac Catheterization
;
Cardiac Catheters
;
Cardiomegaly
;
Chest Pain
;
Creatinine
;
Dyspnea
;
Echocardiography
;
Heart
;
Heart Failure
;
Humans
;
Natriuretic Peptide, Brain
;
Obesity
;
Overweight
;
Peptide Fragments
;
Plasma
4.A case of left main NSTEMI with ST segment elevation in lead aVR.
Choi Jae WON ; Choi Sung WON ; Park Seung JEI ; Dong Won LEE ; Hyeon gook LEE ; Kyoung Im CHO ; Tae Ik KIM
Korean Journal of Medicine 2009;77(Suppl 1):S82-S86
The 12-lead electrocardiogram (ECG) is an inexpensive bedside tool that most physicians use to make rapid diagnoses such as acute myocardial infarction (AMI), arrhythmia, and conduction abnormalities. Although each lead in the ECG represents electronic information from specific portions of the heart, lead aVR, an augmented unipolar limb lead, is frequently ignored. The aVR lead provides excellent information from the right portion of the heart, including the outflow tract of the right ventricle and basal portion of the septum. In this report, we discuss ST segment elevation changes in lead aVR of serial ECGs in emergency room patients with chief complaints of syncope and chest discomfort.
Acute Coronary Syndrome
;
Arrhythmias, Cardiac
;
Coronary Vessels
;
Electrocardiography
;
Electronics
;
Electrons
;
Emergencies
;
Extremities
;
Heart
;
Heart Ventricles
;
Humans
;
Myocardial Infarction
;
Syncope
;
Thorax
5.Clinical Effects of Hypertension on the Mortality of Patients with Acute Myocardial Infarction.
Dong Goo KANG ; Myung Ho JEONG ; Yongkeun AHN ; Shung Chull CHAE ; Seung Ho HUR ; Taek Jong HONG ; Young Jo KIM ; In Whan SEONG ; Jei Keon CHAE ; Jay Young RHEW ; In Ho CHAE ; Myeong Chan CHO ; Jang Ho BAE ; Seung Woon RHA ; Chong Jin KIM ; Yang Soo JANG ; Junghan YOON ; Ki Bae SEUNG ; Seung Jung PARK
Journal of Korean Medical Science 2009;24(5):800-806
The incidence of ischemic heart disease has been increased rapidly in Korea. However, the clinical effects of antecedent hypertension on acute myocardial infarction have not been identified. We assessed the relationship between antecedent hypertension and clinical outcomes in 7,784 patients with acute myocardial infarction in the Korea Acute Myocardial Infarction Registry during one-year follow-up. Diabetes mellitus, hyperlipidemia, cerebrovascular disease, heart failure, and peripheral artery disease were more prevalent in hypertensives (n=3,775) than nonhypertensives (n=4,009). During hospitalization, hypertensive patients suffered from acute renal failure, shock, and cerebrovascular event more frequently than in nonhypertensives. During follow-up of one-year, the incidence of major adverse cardiac events was higher in hypertensives. In multi-variate adjustment, old age, Killip class > or =III, left ventricular ejection fraction <45%, systolic blood pressure <90 mmHg on admission, post procedural TIMI flow grade < or =2, female sex, and history of hypertension were independent predictors for in-hospital mortality. However antecedent hypertension was not significantly associated with one-year mortality. Hypertension at the time of acute myocardial infarction is associated with an increased rate of in-hospital mortality.
Acute Disease
;
Age Factors
;
Aged
;
Cerebrovascular Disorders/etiology
;
Diabetes Mellitus/etiology
;
Female
;
Heart Failure/etiology
;
Hospital Mortality
;
Humans
;
Hyperlipidemias/etiology
;
Hypertension/*complications
;
Male
;
Middle Aged
;
Myocardial Infarction/complications/*mortality/therapy
;
Peripheral Vascular Diseases/etiology
;
Predictive Value of Tests
;
Registries
;
Sex Factors
6.Application of Diagnostic Microarray Technique in Subtyping and Pathotyping of Avian Influenza Viruses Isolated in Mongolia.
Jung Hoon KWON ; Ji Hoon KIM ; Dong hun LEE ; Hyunseok CHO ; Seung Yong HWANG ; Seong Su YUK ; Tseren Ochir ERDENE-OCHIR ; Jin Yong NOH ; Woo Tack HONG ; Jei Hyun JEONG ; Sol JEONG ; Gyeong Bin GWON ; Sang Won LEE ; In Soo CHOI ; Chang Seon SONG
Journal of Bacteriology and Virology 2016;46(1):22-26
Asian-lineage H5 highly pathogenic avian influenza (HPAI) viruses have caused continuous outbreaks in poultry and wild birds. Development of rapid and accurate diagnostic methods is needed for preventing further spread of the virus and reducing the time required for eradication of the virus. We developed a low-density microarray for the rapid detection and identification of avian influenza virus subtypes H5, H7, and H9 and their pathotypes in a previous study. In the present study, we evaluated previously developed diagnostic microarray using avian influenza viruses isolated in Mongolia, including H5 HPAI viruses. All H5 HPAI viruses isolated in Mongolia were shown as H5-specific and highly pathogenic pattern in the microarray. H2, H3 and H12 viruses isolated in Mongolia used in this study did not show any H5, H7 and H9 patterns. These results indicated that this diagnostic microarray has enormous potential for the rapid subtyping and pathotyping of influenza viruses, including viruses isolated in Mongolia.
Animals
;
Birds
;
Disease Outbreaks
;
Influenza in Birds*
;
Mongolia*
;
Orthomyxoviridae
;
Poultry
7.Safety and Efficacy of the Endeavor Resolute® Stent in Patients with Multivessel Disease: The HEART (Honam EndeAvor ResoluTe) Prospective, Multicenter Trial
Doo Sun SIM ; Myung Ho JEONG ; Young Joon HONG ; Ju Han KIM ; Youngkeun AHN ; Keun Ho PARK ; Sun Ho HWANG ; Dong Goo KANG ; Seung Uk LEE ; Joon Woo KIM ; Jong Pil PARK ; Jay Young RHEW ; Sang Rok LEE ; Jei Keon CHAE ; Kyeong Ho YUN ; Seok Kyu OH ; Won You KANG ; Su Hyun KIM ; Jang Hyun CHO
Chonnam Medical Journal 2018;54(1):55-62
The Endeavor Resolute® (ER) is a zotarolimus-eluting stent (ZES) with a biocompatible BioLinx polymer. This study prospectively compared the clinical outcomes of 2 versions of ZES, ER and Endeavor Sprint® (ES), in patients with multivessel disease. A total of 488 patients who underwent multivessel percutaneous coronary intervention (PCI) were divided into 2 groups the ER group (n=288) and the ES group (n=200). The primary endpoint was a composite of major adverse cardiac events (MACE) consisting of death, myocardial infarction, and target vessel revascularization after 12 months. In all patients, the prevalence of diabetes was higher in the ER group (42.7% vs. 31.0%, p=0.009). The rate of post-PCI Thrombolysis in Myocardial Infarction flow grade 3 was higher in the ER group (100.0% vs. 98.0%, p=0.028). There were no between-group differences in the in-hospital, 1-month and 12-month clinical outcomes. In the propensity score matched cohort (n=200 in each group), no differences were observed in the baseline and procedural characteristics. There were no statistical differences in the rates of in-hospital, 1-month and 12-month events (12-month MACE in the ER and ES groups: 6.0% vs. 3.5%, p=0.240, respectively). The safety and efficacy of both versions of ZES were comparable in patients with multivessel disease during a 12-month clinical follow-up.
Cohort Studies
;
Coronary Artery Disease
;
Drug-Eluting Stents
;
Follow-Up Studies
;
Heart
;
Humans
;
Multicenter Studies as Topic
;
Myocardial Infarction
;
Percutaneous Coronary Intervention
;
Polymers
;
Prevalence
;
Propensity Score
;
Prospective Studies
;
Stents
8.Intensity of Statin Treatment in Korean Patients with Acute Myocardial Infarction and Very Low LDL Cholesterol
Doo Sun SIM ; Myung Ho JEONG ; Hyo Soo KIM ; Hyeon Cheol GWON ; Ki Bae SEUNG ; Seung Woon RHA ; Shung Chull CHAE ; Chong Jin KIM ; Kwang Soo CHA ; Jong Seon PARK ; Jung Han YOON ; Jei Keon CHAE ; Seung Jae JOO ; Dong Ju CHOI ; Seung Ho HUR ; In Whan SEONG ; Myeong Chan CHO ; Doo Il KIM ; Seok Kyu OH ; Tae Hoon AHN ; Jin Yong HWANG ;
Journal of Lipid and Atherosclerosis 2019;8(2):208-220
OBJECTIVE: Data on the intensity of statin therapy for patients with acute myocardial infarction (MI) and very low baseline low-density lipoprotein (LDL) cholesterol level are lacking. We sought to assess the impact of statin intensity in patients with acute MI and LDL cholesterol <70 mg/dL. METHODS: A total of 1,086 patients with acute MI and baseline LDL cholesterol <70 mg/dL from the Korea Acute Myocardial Infarction Registry-National Institute of Health database were divided into less intensive statin (expected LDL reduction <40%, n=302) and more intensive statin (expected LDL reduction ≥40%, n=784) groups. The primary endpoint was major adverse cardiac and cerebrovascular events (MACCEs), a composite of cardiac death, MI, revascularization occurring at least 30 days after admission, and stroke, at 12 months. RESULTS: After 1:2 propensity matching, differences were not observed between less intensive (n=302) and more intensive statin (n=604) groups in incidence of cardiac death (0.3% vs. 0.3%) and hemorrhagic stroke (0.3% vs. 0.5%, p=0.727) at 12 months. Compared with the less intensive statin group, the more intensive statin group showed lower target-vessel revascularization (4.6% vs. 1.8%, p=0.027) and MACCE (11.6% vs. 7.0%, p=0.021). Major bleeding was not different between less intensive and more intensive statin groups (1.0% vs. 2.6%, p=0.118). CONCLUSION: More intensive statin therapy was associated with significantly lower major adverse cardiovascular events in patients with acute MI and very low LDL cholesterol compared with less intensive statin therapy.
Cholesterol
;
Cholesterol, LDL
;
Death
;
Hemorrhage
;
Humans
;
Hydroxymethylglutaryl-CoA Reductase Inhibitors
;
Incidence
;
Korea
;
Lipoproteins
;
Myocardial Infarction
;
Stroke
9.Clopidogrel versus Aspirin after Dual Antiplatelet Therapy in Acute Myocardial Infarction Patients Undergoing Drug-Eluting Stenting
Doo Sun SIM ; Myung Ho JEONG ; Hyo Soo KIM ; Hyeon Cheol GWON ; Ki Bae SEUNG ; Seung Woon RHA ; Shung Chull CHAE ; Chong Jin KIM ; Kwang Soo CHA ; Jong Seon PARK ; Jung Han YOON ; Jei Keon CHAE ; Seung Jae JOO ; Dong Ju CHOI ; Seung Ho HUR ; In Whan SEONG ; Myeong Chan CHO ; Doo Il KIM ; Seok Kyu OH ; Tae Hoon AHN ; Jin Yong HWANG ;
Korean Circulation Journal 2020;50(2):120-129
BACKGROUND AND OBJECTIVES: There is a paucity of data regarding the benefit of clopidogrel monotherapy after dual antiplatelet therapy (DAPT) in patients treated with drug-eluting stents (DES). This study compared outcome between clopidogrel versus aspirin as monotherapy after DES for acute myocardial infarction (MI).METHODS: From Korea Acute Myocardial Infarction Registry-National Institute of Health database, 1,819 patients treated with DES who were switched to monotherapy with clopidogrel (n=534) or aspirin (n=1,285) after uneventful 12-month DAPT were analyzed. The primary endpoint was net adverse clinical events (NACE), defined as a composite of death from any cause, MI, repeat percutaneous coronary intervention (PCI), stent thrombosis, ischemic stroke, or major bleeding during the period from 12 to 24 months.RESULTS: After adjustment using inverse probability of treatment weighting, patients who received clopidogrel, compared with those treated with aspirin, had a similar incidence of NACE (0.7% and 0.7%; hazard ratio, 1.06; 95% confidence interval, 0.31–3.60; p=0.923). The 2 groups had similar rates of death from any cause (0.1% in each group, p=0.789), MI (0.3% and 0.1%, respectively; p=0.226), repeat PCI (0.1% and 0.3%, respectively; p=0.548), stent thrombosis (0.1% and 0%, respectively; p=0.121), major bleeding (0.2% in each group, p=0.974), and major adverse cardiovascular and cerebrovascular events (0.5% in each group, p=0.924).CONCLUSIONS: Monotherapy with clopidogrel, compared to aspirin, after DAPT showed similar clinical outcomes in patients with acute MI treated with DES.
Aspirin
;
Drug-Eluting Stents
;
Hemorrhage
;
Humans
;
Incidence
;
Korea
;
Myocardial Infarction
;
Percutaneous Coronary Intervention
;
Platelet Aggregation Inhibitors
;
Stents
;
Stroke
;
Thrombosis
10.Clopidogrel versus Aspirin after Dual Antiplatelet Therapy in Acute Myocardial Infarction Patients Undergoing Drug-Eluting Stenting
Doo Sun SIM ; Myung Ho JEONG ; Hyo Soo KIM ; Hyeon Cheol GWON ; Ki Bae SEUNG ; Seung Woon RHA ; Shung Chull CHAE ; Chong Jin KIM ; Kwang Soo CHA ; Jong Seon PARK ; Jung Han YOON ; Jei Keon CHAE ; Seung Jae JOO ; Dong Ju CHOI ; Seung Ho HUR ; In Whan SEONG ; Myeong Chan CHO ; Doo Il KIM ; Seok Kyu OH ; Tae Hoon AHN ; Jin Yong HWANG ;
Korean Circulation Journal 2020;50(2):120-129
BACKGROUND AND OBJECTIVES:
There is a paucity of data regarding the benefit of clopidogrel monotherapy after dual antiplatelet therapy (DAPT) in patients treated with drug-eluting stents (DES). This study compared outcome between clopidogrel versus aspirin as monotherapy after DES for acute myocardial infarction (MI).
METHODS:
From Korea Acute Myocardial Infarction Registry-National Institute of Health database, 1,819 patients treated with DES who were switched to monotherapy with clopidogrel (n=534) or aspirin (n=1,285) after uneventful 12-month DAPT were analyzed. The primary endpoint was net adverse clinical events (NACE), defined as a composite of death from any cause, MI, repeat percutaneous coronary intervention (PCI), stent thrombosis, ischemic stroke, or major bleeding during the period from 12 to 24 months.
RESULTS:
After adjustment using inverse probability of treatment weighting, patients who received clopidogrel, compared with those treated with aspirin, had a similar incidence of NACE (0.7% and 0.7%; hazard ratio, 1.06; 95% confidence interval, 0.31–3.60; p=0.923). The 2 groups had similar rates of death from any cause (0.1% in each group, p=0.789), MI (0.3% and 0.1%, respectively; p=0.226), repeat PCI (0.1% and 0.3%, respectively; p=0.548), stent thrombosis (0.1% and 0%, respectively; p=0.121), major bleeding (0.2% in each group, p=0.974), and major adverse cardiovascular and cerebrovascular events (0.5% in each group, p=0.924).
CONCLUSIONS
Monotherapy with clopidogrel, compared to aspirin, after DAPT showed similar clinical outcomes in patients with acute MI treated with DES.