No abstract available.
Leukemia*

Mutation in the p53 suppressor gene is the most common genetic alteration found in human cancers including primary brain tumors. Ki-67 labeling index(LI) is known to be a marker of proliferating activity. The purpose of this study was to verify whether an immunohistochemical expression of p53 antibody and Ki-67 LI could be related to different clinicopathologic parameters including histologic grade, size, invasiveness and recurrence of the brain tumors. Materials were based on the 147 surgically resected brain tumors during the last two years. Of the 147 brain tumors, there were 35 astrocytic tumors, 35 meningiomas, 10 oligodendrogliomas, 7 craniopharyngiomas, 5 dysembryoplastic neuroepithelial tumors, 4 medulloblastomas, 5 ependymomas, 23 pituitary adenomas, 9 schwannomas, and 14 other brain tumors. The p53 expression and Ki-67 LI were higher in malignant brain tumors including astrocytic tumors, medulloblastoma, PNET and gliosarcoma. The p53 positivity was correlated with histologic grades and tumor recurrence. The brain tumors with a high Ki-67 LI(>6%) also showed a close relationship to a higher histologic grading, radiological invasiveness and recurrence. There was no evident correlation with the age and tumor size with p53 expression and Ki-67 LI. These results suggest that p53 overexpression and high proliferation potential of the tumor cells are associated with the higher histologic grade and aggressive clinical course in the central nervous system tumors.
Brain Neoplasms* ; Brain* ; Central Nervous System Neoplasms ; Craniopharyngioma ; Ependymoma ; Genes, Suppressor ; Gliosarcoma ; Humans ; Medulloblastoma ; Meningioma ; Neoplasms, Neuroepithelial ; Neurilemmoma ; Neuroectodermal Tumors, Primitive ; Oligodendroglioma ; Pituitary Neoplasms ; Recurrence

OBJECTIVE: As the rapid progress of aged society, there must be solutions of preparation against unpredicted accidents for aged solitary people. The most important thing that we must consider is the unconstraint of daily life. So, we are to develop a system and algorithm which meet our objectives. METHODS: We have monitored the degree of activity of the aged solitary person. The CCD camera was used not to disturb the daily activity and we evaluated the degree of activity using image processing on personal computer. The activity monitoring during night was assumed by sleeping on the bed, so the major method was breath monitoring during sleeping. On the other hand, daily activity was monitored by wide viewing camera in the living room. To prevent the privacy trouble, the acquired image was converted to binary form and the degree of breath and moving factor was estimated. RESULTS: In this paper we propose a new processing algorithm to accurately measure breathing characteristics in sleep apnea sufferers. We improved the conventional center-of-mass method and further applied the projection-profile method. As a result, we have improved breath measurement accuracy. In a comparison with conventional polysomnography, our method was 92% effective in detecting apnea cases. CONCLUSION: As a result of this study, we can monitor sleep apnea more simply and with no sleep interference. In measuring the activity of daily life, these improved algorithms were applied. So, we established a monitoring method of no-constrained, quantitative measurement for the aged solitary people during the whole day.
Apnea ; Hand ; Humans ; Microcomputers ; Polysomnography ; Privacy ; Respiration ; Sleep Apnea Syndromes*

The aim of the study was to investigate the effect of surgical therapy combined with the usage of metronidazole gel in the treatment of juvenile periodontitis by comparing clinical indices of flap operation along with application of metronidazole gel and flap operation only. Comparing clinical indices of the baseline, 3 months after surgery, 6 months after surgery statistically, the results are as follows; 1. Bleeding on probing (BOP) was decreased significantly both in the experimental group and the control group at 3 months after surgery (p<0.05). BOP increased 0.9% in the control group 6 months after surgery, while in the experimental group, decreased 4.7% (p>0.05). However, there was no statistically significant difference in these groups (p>0.05). 2. Pocket probing depth (PPD) was decreased significantly both in the experimental group and the control group at 3 months after surgery (p<0.05). PPD increased 0.1mm in the control group 6 months after surgery, while in the experimental group, no increase of the depth could be observed (p>0.05). However, there was no statistically significant difference in these groups (p>0.05). 3. Loss of attachment level(LOA) was decreased significantly both in the experimental group and the control group at 3 months after surgery (p<0.05). LOA increased 0.2mm in the control group 6 months after surgery, while in the experimental group, increased 0.3mm However, there was no statistically significant difference in these groups (p>0.05). In conclusion, flap operation was effective on the treatment of juvenile periodontitis. However, combined therapy of metronidazole gel could not give rise to any significant adjunctive effect on the treatment outcome.
Aggressive Periodontitis* ; Hemorrhage ; Loa ; Metronidazole* ; Treatment Outcome

No abstract available.
Humans ; Risk Factors*

BACKGROUND: In recent years, estrogen has also been shown to modulate the development and function of the brain, bur not exclusively in areas involved with sexual behavior. Among the most novel and fascinating effects of estrogen are those on cognitive function and memory process and their alterations during aging and neurodegenarative disease like Alzheimer. Estrogen receptors distributed not only in the hypothalamus but many different areas, like cerebral cortex, hippocampus, basal forebrain, midbrain, spinal cord, and the diverse action of estrogen is supported by this fact. Numerous studies suggest thai estrogen may be beneficial in preserving cognitive function, but it is not clear yet. PURPOSE: In this study, we perform the immunohistochemical staining in the hippocampus of normal aged rat, and show the distribution of estrogen receptor compared with the neonatal rat. METHODS: we have used antibodies against a estrogen receptor(ER)-alpha to determine their distribution in neonatal and aged SD rat hippocampus. RESULTS: In neonatal rat hippocampus, ER-alpha immunoreactivity was observed in the nucleus of Purkinje cells, whereas in aged rat hippocampus, ER-a immunoreactivity was found mainly in the cytoplasm of Purkinje cells. CONCLUSION: We showed the age related intracellular differential distribution of ER-alpha immunoreactivity in the rat hippocampus. But, further investigations are required to establish whether functional relations like cognitive ability exist with this different intracellular expression of ER-alpha immunoreactivity.
Aging ; Animals ; Antibodies ; Asian Continental Ancestry Group ; Brain ; Cerebral Cortex ; Cytoplasm ; Estrogens* ; Hippocampus* ; Humans ; Hypothalamus ; Memory ; Mesencephalon ; Prosencephalon ; Purkinje Cells ; Rats* ; Receptors, Estrogen ; Sexual Behavior ; Spinal Cord

No abstract available.
Myelodysplastic Syndromes* ; Neutrophils* ; Pyoderma Gangrenosum* ; Pyoderma*

No abstract available.

No abstract available.
Paragonimiasis*

Infant Incubator is the most important equipment in a infant ICU. This maintain adequate temperature and humidity for survival of infants. The final object of this research is Web-based monitoring of several infant incubators in ICU. To realize these objects, we developed a temperature/humidity sensing module which is interfaced to Web server board via RS485 port. We used a small micro controller in each sensing module. So the size of this module is small enough to be attached to incubator. We can access each sensing module with RS485 port on Web server board via network. As a first trial, we networked 4 infant incubators. The operator can send alarms to each incubator and these alarms are indicated with sounds and lights on measurement module. Our system can increase the convenience by a intensive central monitoring, so instant handling to some kinds of accident is possible.
Humans ; Humidity ; Incubators ; Incubators, Infant* ; Infant*