1.Comparative study of ravitch's operation and sternal evernal operation for pectus excavatum.
Jin Myung LEE ; Seung Il PARK ; Meong Gun SONG ; Kwang Hyun SOHN ; Cahng Dong HYUN
The Korean Journal of Thoracic and Cardiovascular Surgery 1993;26(10):787-790
No abstract available.
Funnel Chest*
2.NETosis in Autoimmune Diseases.
Journal of Rheumatic Diseases 2016;23(2):82-87
Neutrophils are the major antimicrobial cells of the innate immune system, which are recruited rapidly to the sites of infection and provide the primary defense against pathogens. Recent evidence suggests that neutrophils undergo a distinct cell death mechanism called NETosis, which not only contributes to the host defense, but also leads to severe pathological immune responses in cases of dysregulation. Here, we review the general features of NETosis as well as the generation of autoantigens and damage-associated molecular patterns by NETosis in autoimmune diseases. This review discusses the pathogenic role of NETosis in rheumatoid arthritis and systemic lupus erythematosus, where neutrophils may play a key role in the pathogenesis of these diseases, and suggest the possibility of neutrophil extracellular traps as biomarkers and therapeutic targets for the treatment of autoimmune diseases.
Arthritis, Rheumatoid
;
Autoantigens
;
Autoimmune Diseases*
;
Biomarkers
;
Cell Death
;
Immune System
;
Lupus Erythematosus, Systemic
;
Neutrophils
3.Effects of Interleukin-6 on mRNA Expression of Alkaline Phosphatase, Osteopontin, Decorin and a1(1)-collagen in Human Bone Marrow Stromal Cells
Chul Hee KIM ; Dong Kwan KIM ; Seung Il PARK ; Kwang Hyun SOHN ; Ghi Su KIM
Journal of Korean Society of Endocrinology 1996;11(2):156-162
Background: Inter1eukin-6(IL-6) is known to be produced by osteoblastic cells and to have impartant role in regulation of bone remodelling, Most previous studies indicated that IL-6 bas a major role in stimulating osteoclastic resorption by increasing recruitment and proliferation of preosteoclasts. But its autocrine effect on osteoblastic cells has not been well established yet. Therefore, we studied the effects of IL-6 on messenger RNA (mRNA) expression of proteins that are characteristic of osteoblastic cells in human bone marrow stromal (osteoprogenitor) cells (hRMSC). Methods: The expression of mRNAs for alkaline phosphatase, al(1)-collagen, osteopontin and decorin were studied by northern blot analysis after 3 7 days' treatrnent with IL-6 in the concenttation range of 101,000 U/ml. Results: The mRNA levels for any of the osteoblastic proteins studied did not change significantly by IL-6 treatment up to the concentration of 1,000 U/ml. Conclusion: These results suggest that IL-6 does not have a significant role in differentiatian or activities of human bone rnarrow stromal.
Alkaline Phosphatase
;
Blotting, Northern
;
Bone Marrow
;
Decorin
;
Humans
;
Interleukin-6
;
Mesenchymal Stromal Cells
;
Osteoblasts
;
Osteoclasts
;
Osteopontin
;
RNA, Messenger
4.Gene Expression of Surfactant Protein B and C in Endotoxin and Thiourea Treated Rats.
Dong Hyun SOHN ; Jang Won SOHN ; Ho Joo YOON ; Dong Ho SHIN ; Sung Soo PARK
Tuberculosis and Respiratory Diseases 2003;54(5):510-521
BACKGROUND: The surfactant specific proteins, SP-B and SP-C are believed to be important regulators of the surfactant function and homeostasis. Since acute respiratory distress syndrome(ARDS) is usually viewed as the functional and morphological expression of a similar underlying lung injury caused by a variety of insults, and since abnormalities in the surfactant function have been described in ARDS, the authors investigated the different effects of endotoxin and thiourea on the accumulation of mRNA encoding SP-B and SP-C. METHODS: Sprague-Dawley rats were given 5 mg/kg of an intraperitoneal endotoxin from Salmonella enteritidis and 3.5 mg/kg intraperitoneal thiourea and were sacrificed at different time periods. RESULTS: 1. The SP-B mRNA levels 6 and 24 hours after the 5 mg/kg endotoxin treatment was significantly reduced by 26.1% and 50%, respectively(P<0.01, P<0.001). 2. The SP-B mRNA levels 24 hours after the 3.5 mg/kg thiourea treatment was reduced by 9.8% and 12.5%, respectively. 3. The SP-C mRNA levels 6 and 24 hours after the 5 mg/kg endotoxin treatment was significantly reduced by 38.7% and 53.6%, respectively(P<0.01, P<0.001). 4. The SP-C mRNA level 6 hours after the 3.5 mg/kg thiourea treatment was reduced by 22.8%(P<0.05). CONCLUSION: These results indicate that the differential regulation of the hydrophobic surfactant proteins in vivo is evident, and suggest that the hydrophobic surfactant proteins might be differentially regulated during lung injury at different time periods without altering the lung wet to dry ratios. The mechanism of these alternations at the different time periods and the different kinds of etiology remain to be determined.
Animals
;
Gene Expression*
;
Homeostasis
;
Lung
;
Lung Injury
;
Rats*
;
Rats, Sprague-Dawley
;
RNA, Messenger
;
Salmonella enteritidis
;
Thiourea*
5.Two cases of successful pregnancy outcome with hemodialysis and continuous ambulatory peritoneal dialysis patient.
Sung Wook SOHN ; Dong Yeon LEE ; Suk Young AHN ; In Bae CHUNG ; Dong Soo CHA ; Dae Hyun KIM
Korean Journal of Perinatology 1993;4(3):408-414
No abstract available.
Female
;
Humans
;
Peritoneal Dialysis, Continuous Ambulatory*
;
Pregnancy
;
Pregnancy Outcome*
;
Pregnancy*
;
Renal Dialysis*
6.Endothelium-Independent Effect of Fisetin on the Agonist-Induced Regulation of Vascular Contractility.
Hyun Dong JE ; Uy Dong SOHN ; Hyen Oh LA
Biomolecules & Therapeutics 2016;24(1):57-61
Fisetin, a natural flavonoid found in a variety of vegetables and fruits, has been shown to possess many biological functions. The present study was undertaken to investigate the influence of fisetin on vascular smooth muscle contractility and to determine the mechanism involved. Denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments. Fisetin significantly relaxed fluoride-, thromboxane A2- or phorbol ester-induced vascular contraction suggesting as a possible anti-hypertensive on the agonist-induced vascular contraction regardless of endothelial nitric oxide synthesis. Furthermore, fisetin significantly inhibited fluoride-induced increases in pMYPT1 levels and phorbol ester-induced increases in pERK1/2 levels suggesting the mechanism involving the inhibition of Rho-kinase activity and the subsequent phosphorylation of MYPT1 and MEK activity and the subsequent phosphorylation of ERK1/2. This study provides evidence regarding the mechanism underlying the relaxation effect of fisetin on agonist-induced vascular contraction regardless of endothelial function.
Animals
;
Fluorides
;
Fruit
;
Humans
;
Isometric Contraction
;
Male
;
Muscle, Smooth, Vascular
;
Nitric Oxide
;
Phosphorylation
;
Rats
;
Relaxation
;
rho-Associated Kinases
;
Vegetables
7.Three Cases of Hepatitis Related to the Use of Famotidine and Ranitidine.
Joo Hyun SOHN ; Young Woo SOHN ; Yong Cheol JEON ; Dong Soo HAN ; Joon Soo HAHM ; Ho Soon CHOI ; Kyung Nam PARK ; Choon Suhk KEE
The Korean Journal of Hepatology 1998;4(2):194-199
H2-receptor blockers are widely used for therapy of peptic ulcer disease and gastroesophageal reflux disease. H2-receptor blockers infrequently cause adverse hepatic effects, and when they occur they are usually asymptomatic. There are several previous reports of liver injury related to ranitidine. Until now, only two cases of acute hepatitis associated with the use of famotidine were reported in the world. We report three cases of clinical hepatitis that followed administration of famotidine (2 cases) and ranitidine (1 case). First, a 54-year-old woman received famotidine, 40mg, daily for treatment of erosive gastritis. After 6 weeks of treatment with famotidine, jaundice and itching sense developed. Second, a 45-year-old man was hospitalized for jaundice. He had a long history of duodenal ulcer and had been intermittently treated with famotidine. He had 6 weeks of treatment with famotidine prior to admission. Third, a 19-year-old woman was hospitalized for nausea, vomiting and urticaria. She had a history of acute hepatitis B virus infection and was discharged 4 weeks prior to readmission. She had been received ranitidine, 300 mg, daily for treatment of gastritis. After 17 days of drug ingestion, whenever she had taken her medication, she developed these symptoms of nausea, vomiting and urticaria. Other causes of hepatitis were ruled out and all patients recovered after discontinuation of drug ingestion.
Duodenal Ulcer
;
Eating
;
Famotidine*
;
Female
;
Gastritis
;
Gastroesophageal Reflux
;
Hepatitis B virus
;
Hepatitis*
;
Humans
;
Jaundice
;
Liver
;
Middle Aged
;
Nausea
;
Peptic Ulcer
;
Pruritus
;
Ranitidine*
;
Urticaria
;
Vomiting
;
Young Adult
8.Three Cases of Hepatitis Related to the Use of Famotidine and Ranitidine.
Joo Hyun SOHN ; Young Woo SOHN ; Yong Cheol JEON ; Dong Soo HAN ; Joon Soo HAHM ; Ho Soon CHOI ; Kyung Nam PARK ; Choon Suhk KEE
The Korean Journal of Hepatology 1998;4(2):194-199
H2-receptor blockers are widely used for therapy of peptic ulcer disease and gastroesophageal reflux disease. H2-receptor blockers infrequently cause adverse hepatic effects, and when they occur they are usually asymptomatic. There are several previous reports of liver injury related to ranitidine. Until now, only two cases of acute hepatitis associated with the use of famotidine were reported in the world. We report three cases of clinical hepatitis that followed administration of famotidine (2 cases) and ranitidine (1 case). First, a 54-year-old woman received famotidine, 40mg, daily for treatment of erosive gastritis. After 6 weeks of treatment with famotidine, jaundice and itching sense developed. Second, a 45-year-old man was hospitalized for jaundice. He had a long history of duodenal ulcer and had been intermittently treated with famotidine. He had 6 weeks of treatment with famotidine prior to admission. Third, a 19-year-old woman was hospitalized for nausea, vomiting and urticaria. She had a history of acute hepatitis B virus infection and was discharged 4 weeks prior to readmission. She had been received ranitidine, 300 mg, daily for treatment of gastritis. After 17 days of drug ingestion, whenever she had taken her medication, she developed these symptoms of nausea, vomiting and urticaria. Other causes of hepatitis were ruled out and all patients recovered after discontinuation of drug ingestion.
Duodenal Ulcer
;
Eating
;
Famotidine*
;
Female
;
Gastritis
;
Gastroesophageal Reflux
;
Hepatitis B virus
;
Hepatitis*
;
Humans
;
Jaundice
;
Liver
;
Middle Aged
;
Nausea
;
Peptic Ulcer
;
Pruritus
;
Ranitidine*
;
Urticaria
;
Vomiting
;
Young Adult
9.The Clinical Significance of Serum Hyaluronic Acid and Type IV Collagen Level in Chronic Hepatitis and Early Liver Cirrhosis.
Joo Hyun SOHN ; Young Woo SOHN ; Dong Soo HAN ; Yong Cheol JEON ; Choon Suhk KEE ; Won Mi LEE ; Se Jin JANG ; Yong Wook PARK
The Korean Journal of Hepatology 1999;5(3):190-199
BACKGROUND/AIMS: Liver biopsy has been used to evaluate the degree of hepatic fibrosis in patients with chronic liver diseases. It is important to assess liver fibrosis when following the course of chronic liver diseases. Histopathological examination of percutaneous biopsy specimens is invasive and is also of questionable value because of the heterogenous distribution of pathological changes in the liver. Therefore, non-nvasive methods to determine the progress of liver fibrosis are needed. Serum hyaluronic acid and type IV collagen are known to be related to hepatic fibrosis. This study was performed to evaluate the clinical usefulness of serum hyaluronic acid and type IV collagen measurement as a differential point in patients with chronic liver diseases and early cirrhosis. METHODS: This study included 109 patients with chronic liver diseases caused by various etiologies. Liver biopsy and histopathological classification were done in all patients. Serum hyaluronic acid and type IV collagen were measured by one-tep sandwich binding protein assay and one-tep sandwich enzyme immunoassay. RESULTS: The concentrations of hyaluronic acid and type IV collagen in the early cirrhosis group (208.5+/-186.4 ng/mL, 242.1+/-162.8 ng/mL) were significantly higher (p<0.01) than those in the normal and fatty liver group (26.3+/-21.7 ng/mL, 79.2+/-28.8 ng/mL), mild chronic hepatitis group (22.8+/-15.4 ng/mL, 125.5+/-79.7 ng/mL), moderate to severe hepatitis group (66.3+/-60.5 ng/mL, 148.5+/-78.7 ng/mL). At the cutoff value of 100 ng/mL for hyaluronic acid and 200 ng/mL for type IV collagen, the sensitivities were 66.7% and 55.6%, and specifities were 82.9% and 89%, and diagnostic efficiencies were 78.9% and 80.7% respectively for discriminating patients with cirrhosis (4 points) from the mild to severe fibrosis (0~3 points). CONCLUSIONS: The serum levels of hyaluronic acid and type IV collagen may be sensitive markers of fibrotic process in chronic liver diseases and useful biochemical markers in differentiation of the patients with early cirrhosis from those with chronic liver diseases.
Biomarkers
;
Biopsy
;
Carrier Proteins
;
Classification
;
Collagen Type IV*
;
Fatty Liver
;
Fibrosis
;
Hepatitis
;
Hepatitis, Chronic*
;
Humans
;
Hyaluronic Acid*
;
Immunoenzyme Techniques
;
Liver Cirrhosis*
;
Liver Diseases
;
Liver*
10.Cystic lymphangioma of the pancreas.
Bok Kyung SOHN ; Chang Ho CHO ; Hyun Dong CHAE
Journal of the Korean Surgical Society 2011;81(2):141-145
Lymphangioma is a benign form of neoplasm arising from the lymphatic system. It occurs as a result of congenital malformations of the lymphatics leading to the obstruction of local lymph flow and the development of lymphangiectasia. Lymphangiomas are common in pediatric patients, in the soft tissues of the neck and the axillae, but lymphangioma of the pancreas is extremely rare, accounting for less than 1% of these tumors. It occurs more frequently in females and is often located in the distal pancreas. Although extremely rare, cystic lymphangioma of the pancreas should be taken into consideration as a differential diagnosis of pancreatic cystic or retroperitoneal lesions, especially in women. Herein, we report on a case of cystic lymphangioma of the distal pancreas in a 37-year-old woman who was treated with complete surgical resection with a review of the literature.
Accounting
;
Adult
;
Axilla
;
Diagnosis, Differential
;
Female
;
Humans
;
Lymphangioma
;
Lymphangioma, Cystic
;
Lymphatic System
;
Neck
;
Pancreas
;
Pancreatic Cyst
;
Retroperitoneal Space