1.Acute leukemian in patients with juvenile rheumatoid arthritis displaysing multiply osteolytic lesions and compression fracture.
Mi Kyoung LIM ; Dong Hyuk SHEEN ; Seoung Cheol SHIM
Korean Journal of Medicine 2002;63(1):103-104
No abstract available.
Arthritis, Juvenile*
;
Fractures, Compression*
;
Humans
2.Retinal Detachment Associated with Probable Zonular Traction Tufts.
Hyuk AHN ; Jin Ok LIM ; Dong Eul SHIN
Journal of the Korean Ophthalmological Society 1993;34(10):1050-1054
Zonular traction tufts, which exist in 15% of normal population, do not cause retinal detachment by themselves but they can cause traction retinal detaehment when there is traction force added. It is thought that the possibility of development of retinal detaehment increases especially when zonular traetion tufts originate posterior to the vitreous base No case of traction retinal detachment caused by zonular traction tufts has been reported. Here, we report one suspected case of traction retinal detachment induced by zonular traction tufts and lens subluxation.
Lens Subluxation
;
Retinal Detachment*
;
Retinaldehyde*
;
Traction*
3.Intraneural Ganglion of the Peroneal Nerve: A Case of Report
Hong Chul LIM ; Seok Hyun LEE ; Soon Hyuk LEE ; Dong Joo CHAE
The Journal of the Korean Orthopaedic Association 1990;25(6):1790-1792
Intrsneural ganglion cysts of the peroneal nerve are rare. The precise etiology and pathological changes remain obscure. We have experienced recently a case of intraneural ganglion cyst developed in the sheath of the peroneal nerve. A 28 year old male had suffered from lump producing pain over the posterolateral aspect of the upper portion of the fibula, weakness of dorsiflexion of the ankle and of extension of the toes and diminution of sensation on the dorsum of the foot. He underwent excision of the ganglion and the prognosis for recovery of function is good.
Ankle
;
Fibula
;
Foot
;
Ganglion Cysts
;
Humans
;
Male
;
Peroneal Nerve
;
Prognosis
;
Recovery of Function
;
Sensation
;
Toes
4.Analysis of Heavy Metals in 201TlTlCl Injection Using Polarography.
Kwon Soo CHUN ; Yong Sup SUH ; Seung Dae YANG ; Soon Hyuk AHN ; Sang Wook KIM ; Kang Hyuk CHOI ; Dong Hoon LEE ; Sang Moo LIM ; Kook Hyun YU
Korean Journal of Nuclear Medicine 2000;34(4):336-343
PURPOSE: Thallous-201 chloride produced at Korea Cancer Center Hospital(KCCH) is used in detecting cardiovascular disease and cancer. Thallium impurity can cause emesis, catharsis and nausea, so the presence of thallium and other metal impurities should be determined. According to USP and KP, their amounts must be less than 2 ppm in thallium and 5 ppm in total. In this study, the detection method of trace amounts of metal impurities in [201Tl]TlCl injection with polarography was optimized without environmental contamination. MATERALS AND METHODS: For the detection of metal impurities, Osteryoung Square Wave Stripping Voltammetry method was used in Bio-Analytical System (BAS) 50W polarograph. The voltammetry was composed of Dropping Mercury Electrode (DME) as a working electrode, Ag/AgCl as a reference electrode and Pt wire as a counter electrode. Square wave stripping method, which makes use of formation and deformation of amalgam, was adopted to determine the metal impurities, and pH 7 phosphate buffer was used as supporting electrolyte. RESULTS: T1, Cu and Pb in thallous-201 chloride solution were detected by scanning from 300 mV to -800 mV. Calibration curves were made by using TlNO3, CuSO4 and Pb(NO3)2 as standard solutions. Tl was confirmed at -450 mV peak potential and Cu at -50 mV. Less than 2 ppm of Tl and Cu was detected and Pb was not detected in KCCH-produced thallous-201 chloride injection. CONCLUSION: Detection limit of thallium and copper is approximately 50 ppb with this method. As a result of this experiment, thallium and other metal impurities in thallous-201 chloride injection, produced at Korea Cancer Center Hospital, are in the regulation of USP and KP. Polarograph could be applied for the determination of metal impurities in the quality control of radiopharmaceuticals conveniently without environmental contamination.
Calibration
;
Cardiovascular Diseases
;
Catharsis
;
Copper
;
Electrodes
;
Hydrogen-Ion Concentration
;
Korea
;
Limit of Detection
;
Metals, Heavy*
;
Nausea
;
Polarography*
;
Quality Control
;
Radiopharmaceuticals
;
Thallium
;
Vomiting
5.Role of T lymphocyte in the pathogenesis of rheumatoid arthritis.
Seung Cheol SHIM ; Mi Kyoung LIM ; Dong Hyuk SHEEN
Hanyang Medical Reviews 2005;25(2):26-35
PURPOSE OF REVIEW: Rheumatoid arthritis (RA) is characterized by a chronic T-cell response that has escaped normal control mechanisms. This review summarizes recent insights in pathways that are functional in RA and that favor continuous and pathogenic T-cell activation. RECENT FINDINGS: T-cell activation is ultimately determined by positive signals from costimulatory molecules and negative signals from regulatory T cells. Blockade of the classic costimulatory pathway, CD28-CD80 or CD86, is beneficial in RA. Additional pathways that predominantly control the activation of memory and effector T cells are functionally important in synovial inflammation. Some of these costimulatory molecules(such as stimulatory killer cell immunoglobulin-like receptors and NKG2D) appear to be relatively specific for RA and not to play a role in normal immune responses. In addition to this predominance of positive signals, age-disproportionate decline in thymic activity in RA may lead to a diminution of regulatory T cells and loss of their negative signals. SUMMARY: The successful treatment trial of RA with CTLA-4Ig clearly documents the importance of T-cell costimulation in RA disease activity. Novel costimulatory pathways may be of even greater significance than CD28 in RA and may represent promising new therapeutic targets. The finding of reduced thymic activity in RA is exciting and will stimulate further studies of T-cell homeostasis and the function of regulatory cells.
Arthritis, Rheumatoid*
;
Autoimmunity
;
Homeostasis
;
Inflammation
;
Lymphocytes*
;
Memory
;
Receptors, KIR
;
T-Lymphocytes
;
T-Lymphocytes, Regulatory
;
United Nations
6.Comparison of Dobutamine Echocardiography and Contrast Echocardiograph in Patients with Myocardial Infarction.
Wan Joo SHIM ; Woo Hyuk SONG ; Dong Kuy JIN ; Do Sun LIM ; Chang Gyu PARK ; Young Hoon KIM ; Dong Joo OH ; Young Moo RO
Korean Circulation Journal 1996;26(1):62-68
BACKGROUND: Dobutamine echocardiography is a useful method to detect myocardial viability in ischemic heart disease. Recently myocardial contrast echocardiography(MCE) is reported to be a new method to evaluate myocardial viability by assessing microvascular integrity of dysfunctional myocardium. We hypothesized if the microvascular integrity is maintained, the dysfunctional myocardium would improve its function by dobutamine infusion. METHOD: 10 myocardial infarction patients (acute : old=8 : 2, M : F=7 : 3, mean age=61+/-11yr) were included in the study. 2 dimensional echocardiography was performed before and during dobutamine infusion and after contrast injection to right and left coronary arteries in the catheterization laboratory. Echocardiographic analysis was done in parasternal short, apical 4 and 2 chamber views. Left ventricule was devided by 20 segments from 3 views. In each segment, will motion score(graded 1, normal, to 5, dyskinesia) before and after dobutamine infusion and opacification grade(0, 0.5, 1 denoting no, intermediate and normal opacification respectively) was compared. RESULTS: The number of segments with abnormal wall motion at baseline were 57 segments. 5 segments was exciuded due to poor image quality. Among 52 segments, 25 segments improved it's function during dobutamine infusion. Improvement of regional function was more frequent in hypokinetic segments than akinetic or dyskinetic segments (69% vs 15%). The improvement of dysfunctional regional wall motion by dobutamine infusion was observed in 80%(19/24), 67%(6/9) and 5%(1/19) of normally, intermediately and none opacified segment respectively. The correlation between wall motion score with opacification grade was 0.598 at baseline and increased to 0.766 after dobutamine infusion. CONCLUSION: In patients with myocardial infarction the dysfunctional segments but intact microvasculature assessed myocardial contrast echocardiography improves function by dobutamine infusion. These findings myocardial contrast echocardiography would be a useful method to detect myocardial viability.
Catheterization
;
Catheters
;
Coronary Vessels
;
Dobutamine*
;
Echocardiography*
;
Humans
;
Microvessels
;
Myocardial Infarction*
;
Myocardial Ischemia
;
Myocardium
7.Surgical Treatment for Acute, Severe Brain Infarction.
Je On PARK ; Dong Hyuk PARK ; Sang Dae KIM ; Dong Jun LIM ; Jung Yul PARK
Journal of Korean Neurosurgical Society 2007;42(4):326-330
OBJECTIVE: Stroke is the most prevalent disease involving the central nervous system. Since medical modalities are sometimes ineffective for the acute edema following massive infarction, surgical decompression may be an effective option when medical treatments fail. The present study was undertaken to assess the outcome and prognostic factors of decompressive surgery in life threatening acute, severe, brain infarction. METHODS: We retrospectively analyzed twenty-six patients (17 males and 9 females; average age, 49.7yrs) who underwent decompressive surgery for severe cerebral or cerebellar infarction from January 2003 to December 2006. Surgical indication was based on the clinical signs such as neurological deterioration, pupillary reflex, and radiological findings. Clinical outcome was assessed by Glasgow Outcome Scale (GOS). RESULTS: Of the 26 patients, 5 (19.2%) showed good recovery, 5 (19.2%) showed moderate disability, 2 (7.7%) severe disability, 6 (23.1%) persistent experienced vegetative state, and 8 (30.8%) death. In this study, the surgical decompression improved outcome for cerebellar infarction, but decompressive surgery did not show a good result for MCA infarction (30.8% overall mortality vs 100% mortality). The dominant-hemisphere infarcts showed worse prognosis, compared with nondominant-hemisphere infarcts (54.5% vs 70%). Poor prognostic factors were diabetes mellitus, dominant-hemisphere infarcts and low preoperative Glasgow Coma Scale (GCS) score. CONCLUSION: The patients who exhibit clinical deterioration despite aggressive medical management following severe cerebral infarction should be considered for decompressive surgery. For better outcome, prompt surgical treatment is mandatory. We recommend that patients with severe cerebral infarction should be referred to neurosurgical department primarily in emergency setting or as early as possible for such prompt surgical treatment.
Brain Edema
;
Brain Infarction*
;
Brain*
;
Central Nervous System
;
Cerebral Infarction
;
Decompression
;
Decompression, Surgical
;
Diabetes Mellitus
;
Edema
;
Emergencies
;
Female
;
Glasgow Coma Scale
;
Glasgow Outcome Scale
;
Humans
;
Infarction
;
Infarction, Middle Cerebral Artery
;
Male
;
Mortality
;
Persistent Vegetative State
;
Prognosis
;
Reflex, Pupillary
;
Retrospective Studies
;
Stroke
8.Coronary Angiography with Multidetector row Computed Tomography: Part II - Clinical Aspects.
Dong Hun KIM ; Sang Il CHOI ; Kyung Won LEE ; Hyuk Jae CHANG ; Woo Young CHUNG ; In Ho CHAE ; Dong Ju CHOI ; Cheong LIM ; Joong Haeng CHOH ; Jae Hyung PARK
Journal of the Korean Radiological Society 2004;51(4):409-416
An application of the multi-detector computed tomography (MDCT) for cardiac imaging is the non-invasive CT angiographic assessment of the cardiac morphology and the coronary arteries. The most important application is for the non-invasive diagnosis of coronary artery disease, and this includes assessment of coronary artery anomaly and stenosis, the evaluation of non-calcified atherosclerotic plaque and the follow-up examinations after stent deployment and bypass surgery. In the study, we have illustrated a variety of diseases of the coronay artery by using MDCT. These may facilitate the understanding of MDCT features of coronary artery lesions.
Arteries
;
Constriction, Pathologic
;
Coronary Angiography*
;
Coronary Artery Disease
;
Coronary Vessels
;
Diagnosis
;
Follow-Up Studies
;
Multidetector Computed Tomography*
;
Plaque, Atherosclerotic
;
Stents
9.Coil Embolization of a Ruptured Basilar Tip Aneurysm Associated with Bilateral Cervical Internal Carotid Artery Occlusion: A Case Report and Literature Review.
Sang Shin KIM ; Dong Hyuk PARK ; Nam Jun LEE ; Shin Hyuk KANG ; Dong Jun LIM ; Yong Gu CHUNG
Journal of Cerebrovascular and Endovascular Neurosurgery 2012;14(1):44-49
We report here on a rare case of a ruptured basilar tip aneurysm that was successfully treated with coil embolization in the bilateral cervical internal carotid artery (ICA) occlusions with abnormal vascular networks from the posterior circulation. A 43-year old man with a familial history of moyamoya disease presented with subarachnoid hemorrhage. Digital subtraction angiography demonstrated complete occlusion of the bilateral ICAs at the proximal portion and a ruptured aneurysm at the basilar artery bifurcation. Each meningeal artery supplied the anterior cranial base, but most of both hemispheres were supplied with blood from the basilar artery and the posterior cerebral arteries through a large number of collateral vessels to the ICA bifurcation as well as the anterior cerebral and middle cerebral arteries. The perfusion computed tomography (CT) scans with acetazolamide (ACZ) injection revealed no reduction of cerebral blood flow and normal cerebrovascular reactivity to ACZ. An abdominal CT aortogram showed no other extracranial vessel abnormalities. A ruptured basilar tip aneurysm was successfully treated with coil embolization without complications. Endovascular embolization may be a good treatment option with excellent safety for a ruptured basilar tip aneurysm that accompanies proximal ICA occlusion with vulnerable collateral flow.
Acetazolamide
;
Aneurysm
;
Aneurysm, Ruptured
;
Angiography, Digital Subtraction
;
Basilar Artery
;
Carotid Artery, Internal
;
Collateral Circulation
;
Glycosaminoglycans
;
Meningeal Arteries
;
Middle Cerebral Artery
;
Moyamoya Disease
;
Perfusion
;
Posterior Cerebral Artery
;
Skull Base
;
Subarachnoid Hemorrhage
10.Angiographic Features and Clinical Outcomes of Intra-Arterial Nimodipine Injection in Patients with Subarachnoid Hemorrhage-Induced Vasospasm.
Sang Shin KIM ; Dong Hyuk PARK ; Dong Jun LIM ; Shin Hyuk KANG ; Tai Hyoung CHO ; Yong Gu CHUNG
Journal of Korean Neurosurgical Society 2012;52(3):172-178
OBJECTIVE: The aim of this study was to determine the role of intra-arterial (IA) nimodipine injections for cerebral vasospasm secondary to ruptured subarachnoid hemorrhage (SAH) and to investigate the factors that influence vasodilation and clinical outcomes. METHODS: We enrolled 29 patients who underwent aneurysm clipping for ruptured cerebral aneurysms between 2009 and 2011, and who received IA nimodipine after subsequently presenting with symptomatic vasospasm. The degree of vasodilation shown in angiography was measured, and the correlation between the degree of vasodilation and both the interval from SAH to cerebral vasospasm and the interval from clipping to cerebral vasospasm was determined. The change in blood flow rate after IA injection was assessed by transcranial Doppler ultrasound. Multiple clinical parameters were completed before and after IA nimodipine injection to evaluate any improvements in clinical symptoms. RESULTS: For eight patients, Glasgow Coma Scale (GCS) scores increased by two or more points. The regression analysis demonstrated a positive correlation between the change in GCS scores after IA nimodipine injection and the change in blood vessel diameter (p=0.025). A positive correlation was also observed between the interval from SAH to vasospasm and the change in diameter (p=0.040); and the interval from clipping to vasospasm and the change in diameter (p=0.022). CONCLUSION: IA nimodipine injection for SAH-induced vasospasm led to significant vasodilation in angiography and improvement in clinical symptoms without significant complications. Our findings suggest that IA nimodipine injection should be utilized when intractable vasospasm develops despite rigorous conservative management.
Aneurysm
;
Aneurysm, Ruptured
;
Angiography
;
Blood Vessels
;
Glasgow Coma Scale
;
Glycosaminoglycans
;
Humans
;
Injections, Intra-Arterial
;
Intracranial Aneurysm
;
Nimodipine
;
Subarachnoid Hemorrhage
;
Vasodilation
;
Vasospasm, Intracranial