1.A Case of Raymond-Cestan Syndrome Caused by Inferior Petrosal Sinus Sampling.
Journal of Korean Society of Endocrinology 2003;18(1):73-78
Inferior petrosal sinus sampling (IPSS) plays an important role in the assessment of patients with ACTH-dependent Cushing's syndrome. IPSS has been described as an innocuous, essentially risk-free procedure. Neurological complications associated with IPSS are rare. Previously reported neurological complications include brain stem infraction, pontine hemorrhage and subarachnoid hemorrhage. A 26-year-old woman was admitted to the hospital because of a moon face and a buffalo hump. A MRI showed a suspicious, but uncertain, area on the left side of the sella turcica. IPSS was performed as an appropriate means of providing more information about the side of the ACTH source. Immediately after the procedure, the woman experienced double vision, caused by a complete sixth nerve palsy of the left eye, together with a contralateral hemiparesis. From a clinical point of view, abducens nerve palsy and contralateral hemiparesis corresponded to Raymond-Cestan syndrome. I report a case of Raymond-Cestan syndrome, following petrosal sinus sampling in a female patient with ACTH-dependent Cushing's syndrome. To the best of our knowledge, this complication associated with petrosal sinus sampling has only been described in one previous case report. Although IPSS may provide essential information in the investigation of Cushing's syndrome, the possibility of very occasional but devastating complications should be remembered.
Abducens Nerve Diseases
;
Adrenocorticotropic Hormone
;
Adult
;
Brain Stem
;
Buffaloes
;
Cushing Syndrome
;
Diplopia
;
Female
;
Hemorrhage
;
Humans
;
Magnetic Resonance Imaging
;
Paresis
;
Petrosal Sinus Sampling*
;
Sella Turcica
;
Subarachnoid Hemorrhage
3.Intermittent Fasting in Diabetic Patients.
Journal of Korean Diabetes 2013;14(4):163-165
Obesity is becoming increasingly prevalent worldwide. It is linked to health problems including cardiovascular disease, diabetes, cancer, musculoskeletal problems and even psychiatric problems. Intermittent fasting is an interventional strategy wherein individuals are subjected to varying periods of fasting. Intermittent fasting has recently attracted attention because experimental studies have highlighted its potential for correcting metabolic abnormalities. Preliminary findings indicate that intermittent fasting may be associated with increased lifespan, decreased mortality from cancers and cardiovascular diseases, improved insulin sensitivity, and reduced oxidative stress and inflammation. However, some of the data still remain controversial. No human studies have examined the effects of intermittent fasting in diabetics. Studies examining intermittent fasting in diabetic patients have encountered problems with compliance, malnutrition, and hypoglycemia rather than seeing benefits of weight loss. Regular meals (at least three meals each day) and a balanced diet are crucial in the management of blood sugar levels in diabetic patients.
Blood Glucose
;
Caloric Restriction
;
Cardiovascular Diseases
;
Compliance
;
Diabetes Mellitus
;
Diet
;
Fasting*
;
Humans
;
Hypoglycemia
;
Inflammation
;
Insulin Resistance
;
Malnutrition
;
Meals
;
Mortality
;
Obesity
;
Oxidative Stress
;
Weight Loss
4.Value of PAPAN score as parameter of subrenal capsule tumor implant assay in gynecological malignant tumors.
Soon Beom KANG ; Jong Hyeok KIM ; Dong Geun CHUNG ; Kyoung Hoon CHO ; Seung Chul KIM ; Hyo Pyo LEE
Journal of the Korean Cancer Association 1991;23(4):728-739
No abstract available.
5.Clinical Review of Positive Antinuclear Antibody(ANA) Test in Pediatric Patients.
Dong Jin CHOI ; Kye Sik SHIM ; Hyeok CHOI ; Byoung Soo CHO ; Sung Ho CHA ; Jin Tae SUH
Journal of the Korean Pediatric Society 1994;37(10):1397-1404
The antinuclear antbody (ANA) test have been used to screen the patients with systemic lupus erythematosus (SLE) and other autoimmune diseases. We had retrospectively reviewed the 263 records of pediatric patients with doing ANA tests who admitted at Department of Pediatrics, Kyung Hee University Hospital, from January 1988 to May 1993. The following results were obtained. 1) The positive rate of ANA test in patients with connective tissue diseases is 16 out of 40(40%).In patients with SLE, the positive rate of ANA test is 9 out of 11 (82%). 2) The positive predictivity for SLE is 9 out 36 (25%). 3) The positive predictivity for connective tissue disease and possible immune disease is 28 out of 36 (78%). 4) The false positive rate is 8 0ut of 36 (22%), Thus, the pediatric patients with positive ANA test should be applicable for diagnosis with prudence. 5) The positive anti-dsDNA in patients with the positive ANA is shown in 4 cases and these patients are all SLE. In conclusion, the patients who had repeated positive ANA should be tested Anti-dsDNA antibody, and further clinical and diagnostic evaluation of other ANA associated diseases.
Autoimmune Diseases
;
Connective Tissue Diseases
;
Diagnosis
;
Humans
;
Immune System Diseases
;
Lupus Erythematosus, Systemic
;
Pediatrics
;
Retrospective Studies
6.Recent Advances in Sodium Glucose Cotransporter-2 Inhibitors
Journal of Korean Diabetes 2021;22(2):113-125
Sodium glucose cotransporter-2 inhibitors (SGLT2i) block SGLT2 in the renal proximal tubule and increase the excretion of glucose into the urine, thereby decreasing serum glucose concentrations. These glucose-lowering effects are independent of insulin action. SGLT2i has been demonstrated to reduce cardiovascular complications and hospitalization for heart failure. SGLT2i has also shown remarkable inhibition effects on the progression of renal complications, decreasing serum creatinine, reducing albuminuria, and decreasing death from renal disease. These cardiorenal protective effects appear to be independent of glycemic control efficacy, and in view of these results, SGLT2i is recommended in type 2 diabetes patients at high risk of cardiovascular or renal disease. This review aims to provide an update on the mechanisms, efficacy, cardiorenal protective effects, and adverse effects of SGLT2i.
7.Blood Sugar Control in Alcohol-Consuming Diabetics.
Journal of Korean Diabetes 2012;13(2):91-94
Alcohol influences glucose metabolism in both diabetic and non-diabetic individuals. Moderate alcohol consumption significantly decreases fasting glucose levels, but does not affect postprandial glucose levels. However, acute alcohol intake without food may provoke hypoglycemia. Moderate alcohol consumption may inhibit gluconeogenesis and enhance insulin sensitivity, but excessive alcohol intake (three or more drinks per day) may contribute to hyperglycemia. Daily alcohol intake in diabetics should be limited to a moderate amount (one drink per day or less for women and two drinks per day or less for men). Moderate alcohol intake may have cardiovascular benefits for patients with diabetes, but the trade-off between the cardiovascular benefits versus the potential risk of lower adherence associated with self-care behaviors should be considered.
Alcohol Drinking
;
Blood Glucose
;
Diabetes Mellitus
;
Fasting
;
Female
;
Gluconeogenesis
;
Glucose
;
Humans
;
Hyperglycemia
;
Hypoglycemia
;
Insulin Resistance
;
Self Care
8.Inflammatory Myofibroblastic Tumor of the Thyroid Gland: A Brief Case Report.
Hye Jeong KIM ; Jong In NA ; Ji Shin LEE ; Dong Hyeok CHO ; Jin Seong CHO
Korean Journal of Pathology 2014;48(4):319-322
No abstract available.
Myofibroblasts*
;
Thyroid Gland*
9.A case of Graves' disease associated with Turner's syndrome.
Jin Ook CHUNG ; Dong Hyeok CHO ; Dong Jin CHUNG ; Min Young CHUNG
Korean Journal of Medicine 2008;74(3):325-329
It is becoming increasingly evident that adults with Turner's syndrome are susceptible to endocrine autoimmunity. An increased prevalence of thyroid autoantibodies and hypothyroidism in patients with Turner's syndrome has been reported, but the involvement of Graves' disease in these patients is relatively rare. We describe a case of Graves' disease associated with Turner's syndrome. A 28-year-old woman was referred for diffuse anterior neck swelling and palpitation. She had been diagnosed with Turner's syndrome with monosomy 45,X before the age of 9 years and she took estrogen together with progesterone. The physical examination revealed a firm, non-tender goiter. The T3 level was 632 ng/dL, the free T4 level was 5.68 ng/dL, the TSH level was 0.02 microIU/mL, the % of TSH-binding inhibiting immunoglobulin was 24% and the anti-thyroid autoantibodies were positive. The radioactive iodine uptake was increased. Therefore, she was diagnosed as having Graves' disease.
Adult
;
Autoantibodies
;
Autoimmunity
;
Estrogens
;
Female
;
Goiter
;
Graves Disease
;
Humans
;
Hypothyroidism
;
Immunoglobulins
;
Iodine
;
Monosomy
;
Neck
;
Physical Examination
;
Prevalence
;
Progesterone
;
Thyroid Gland
;
Turner Syndrome
10.Association between Diabetic Polyneuropathy and Cardiovascular Complications in Type 2 Diabetic Patients.
Jin Ook CHUNG ; Dong Hyeok CHO ; Dong Jin CHUNG ; Min Young CHUNG
Diabetes & Metabolism Journal 2011;35(4):390-396
BACKGROUND: Diabetes mellitus is a major independent risk factor for cardiovascular disease (CVD), but high cardiovascular risk in diabetes mellitus patients is not completely explained by clustering traditional risk factors. Recently, associations between diabetic polyneuropathy (DPN) and macrovasculopathy have been suggested. We aimed to assess associations between DPN and cardiovascular complications in type 2 diabetic patients. METHODS: Microvascular and cardiovascular complications were evaluated in 1,041 type 2 diabetic patients. RESULTS: In patients with DPN, the age, prevalence of hypertension, diabetes duration, systolic blood pressure, pulse pressure, and hemoglobin glycation (HbA1c) levels were significantly higher, while the high density lipoprotein cholesterol (HDL-C) levels were lower than in those without DPN. The prevalence of CVD was higher in patients with DPN. In multivariate analysis, DPN was independently associated with CVD (odds ratio, 1.801; 95% confidence interval, 1.009 to 3.214). CONCLUSION: Our results showed that DPN was associated with a high prevalence of cardiovascular disease in type 2 diabetic patients, but further studies are needed to investigate the causative nature of associations between DPN and CVD.
Blood Pressure
;
Cardiovascular Diseases
;
Cholesterol
;
Cholesterol, HDL
;
Diabetes Mellitus
;
Diabetes Mellitus, Type 2
;
Diabetic Neuropathies
;
Hemoglobins
;
Humans
;
Hypertension
;
Lipoproteins
;
Multivariate Analysis
;
NAD
;
Prevalence
;
Risk Factors