1.Clinical and pathologic study of dysfunctional uterine bleeding.
Sung Bae KIM ; Moon Hyun BOO ; Chia Chen DONG ; Kuch Hwan BAE
Korean Journal of Obstetrics and Gynecology 1993;36(8):3312-3316
No abstract available.
Female
;
Metrorrhagia*
2.Developing a Computerized Reminder System and Evaluating the Effects on the Improvemtent of Cancer Screening.
Ihn Sook JEONG ; Dong Hwan CHEN ; Eun Sook BAE ; Il KIM ; Eun Ok CHOI
Journal of Korean Academy of Nursing 2004;34(3):400-411
PURPOSE: This study was aimed to develop a computerized reminder system and evaluate it's effect in terms of percent age change of screening, and satisfaction. METHOD: It was conducted through 6 phases : Analyzing the job and defining the basic input data, developing the information system, collecting and inputting data, testing the system, working with the system, and evaluating it's effect. Participants were 787 people (female 30-69 years, and males 40-49 years) in 2 dong of Suyoung gu, Busan, who haven't had cancer screening for the stomach, breast, or cervix since Dec. 2000. There were three experimental groups: a letter; calling and calling after the letter reminder, and a non-equivalent control group. To determine whether services were obtained, a telephone survey was done after two months of follow-up. RESULT: A cancer screening information system with five DB modules was develped. Overall compliance with screening was not statistically significantly changedbefore and after applying computerized reminders for all three screening sites. Only 16% were satisfied with the reminder. CONCLUSION: This data didn't show that a reminder effort was effective of screening. However, because the evaluation interval was too short to find a difference in screening rate, we recommend additional longer prospective follow up studies.
Adult
;
Aged
;
Female
;
Humans
;
Male
;
Middle Aged
;
Neoplasms/*diagnosis
;
Patient Compliance
;
*Reminder Systems
;
Risk Factors
3.Trends of Mortality and Cause of Death among HIV-Infected Patients in Korea, 1990-2011.
Sun Hee LEE ; Kye Hyung KIM ; Seung Geun LEE ; Dong Hwan CHEN ; Dong Sik JUNG ; Chi Sook MOON ; Ji Young PARK ; Joo Seop CHUNG ; Ihm Soo KWAK ; Goon Jae CHO
Journal of Korean Medical Science 2013;28(1):67-73
Although a decrease in acquired immunodeficiency syndrome (AIDS)-related mortality has been documented in highly active antiretroviral therapy (HAART) era, there are no published data comparing specific causes of death between pre-HAART and HAART era in Korea. Mortality and cause of death were analyzed in three treatment periods; pre-HAART (1990-1997), early-HAART (1998-2001), and late-HAART period (2002-2011). The patients were retrospectively classified according to the treatment period in which they were recruited. Although mortality rate per 100 person-year declined from 8.7 in pre-HAART to 4.9 in late-HAART period, the proportion of deaths within 3 months of initial visit to study hospital significantly increased from 15.9% in pre-HAART to 55.1% in late-HAART period (P < 0.001). Overall, 59% of deaths were attributable to AIDS-related conditions, and Pneumocystis pneumonia (PCP) was the most common cause of death (20.3%). The proportion of PCP as cause of death significantly increased from 8.7% in pre-HAART to 31.8% in late-HAART period (P < 0.001). Despite of significant improvement of survival, there was still a high risk of early death in patients presenting in HAART era, mainly due to late human immunodeficiency virus (HIV) diagnosis and late presentation to care.
Acquired Immunodeficiency Syndrome/mortality
;
Adult
;
*Antiretroviral Therapy, Highly Active
;
Cause of Death/*trends
;
Female
;
HIV Infections/drug therapy/*mortality
;
Humans
;
Kaplan-Meier Estimate
;
Male
;
Middle Aged
;
Pneumonia, Pneumocystis/mortality
;
Republic of Korea
;
Retrospective Studies
4.Causes of Death and Risk Factors for Mortality among HIV-Infected Patients Receiving Antiretroviral Therapy in Korea.
Sun Hee LEE ; Kye Hyung KIM ; Seung Geun LEE ; Heerim CHO ; Dong Hwan CHEN ; Joo Seop CHUNG ; Ihm Soo KWAK ; Goon Jae CHO
Journal of Korean Medical Science 2013;28(7):990-997
A retrospective study was conducted to determine the mortality, causes and risk factors for death among HIV-infected patients receiving antiretroviral therapy (ART) in Korea. The outcomes were determined by time periods, during the first year of ART and during 1-5 yr after ART initiation, respectively. Patients lost to follow-up were traced to ascertain survival status. Among 327 patients initiating ART during 1998-2006, 68 patients (20.8%) died during 5-yr follow-up periods. Mortality rate per 100 person-years was 8.69 (95% confidence interval, 5.68-12.73) during the first year of ART, which was higher than 4.13 (95% confidence interval, 2.98-5.59) during 1-5 yr after ART. Tuberculosis was the most common cause of death in both periods (30.8% within the first year of ART and 16.7% during 1-5 yr after ART). During the first year of ART, clinical category B and C at ART initiation, and underlying malignancy were significant risk factors for mortality. Between 1 and 5 yr after ART initiation, CD4 cell count < or = 50 cells/microL at ART initiation, hepatitis B virus co-infection, and visit constancy < or = 50% were significant risk factors for death. This suggests that different strategies to reduce mortality according to the time period after ART initiation are needed.
Anti-Retroviral Agents/*adverse effects/*therapeutic use
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Antiretroviral Therapy, Highly Active/adverse effects
;
CD4 Lymphocyte Count
;
Cause of Death
;
Coinfection
;
Female
;
HIV Infections/*drug therapy/*mortality/virology
;
Humans
;
Male
;
Middle Aged
;
Republic of Korea
;
Retrospective Studies
;
Risk Factors
;
Treatment Outcome
5.Predictors of Poor Retention in Care of HIV-infected Patients Receiving Antiretroviral Therapy in Korea: Five-Year Hospital-based Retrospective Cohort Study.
Shinwon LEE ; Sun Hee LEE ; Su Jin LEE ; Kye Hyung KIM ; Jeong Eun LEE ; Heerim CHO ; Seung Geun LEE ; Dong Hwan CHEN ; Joo Seop CHUNG ; Ihm Soo KWAK
Journal of Korean Medical Science 2016;31(3):376-381
Poor retention in care (RIC) is associated with higher antiretroviral therapy (ART) failure and worse survival. Identifying high risk patients for poor RIC is important for targeted intervention. A retrospective cohort study was conducted at a tertiary care hospital in Korea. HIV-infected patients initiating ART during 2002-2008 were included. 5 year-RIC was measured by hospital visit constancy (HVC) at 5 years after initiating ART. Among 247 enrolled patients, 179 (72.5%) remained in care, 20 (8.1%) were transferred to other hospitals, 9 (3.6%) died and 39 (15.8%) were lost to follow-up. We compared the demographic, psychosocial, and clinical characteristics between the groups with 100% HVC (n = 166, 67.2%) and < or = 50% HVC (n = 33, 13.4%). In multivariable analysis, ART-starting age < or = 30 years (odds ratio [OR] 4.08 vs. > 50; 95% confidence interval [CI] 1.10-15.15, P = 0.036), no non-HIV related comorbidity (OR 2.94 vs. comorbidity > or = 1; 95% CI 1.02-8.49, P = 0.046), baseline CD4 cell count > 300 cells/muL (OR 3.58 vs. < or = 200; 95% CI 1.33-9.65, P = 0.012) were significant predictable factors of poor RIC. HIV/AIDS care-givers should pay attention to young patients with higher baseline CD4 cell counts and no non-HIV related comorbidity.
Adult
;
Anti-HIV Agents/*therapeutic use
;
CD4 Lymphocyte Count
;
CD4-Positive T-Lymphocytes/cytology
;
Cohort Studies
;
Comorbidity
;
Demography
;
Female
;
HIV Infections/*drug therapy/mortality/psychology
;
Hospitals
;
Humans
;
Male
;
*Medication Adherence/psychology
;
Middle Aged
;
Multivariate Analysis
;
Odds Ratio
;
Republic of Korea
;
Retrospective Studies
6.Evolutionary changes in metabolic dysfunction-associated steatotic liver disease and risk of hepatocellular carcinoma: A nationwide cohort study
Seogsong JEONG ; Yun Hwan OH ; Joseph C AHN ; Seulggie CHOI ; Sun Jae PARK ; Hye Jun KIM ; Gyeongsil LEE ; Joung Sik SON ; Heejoon JANG ; Dong Hyeon LEE ; Meng SHA ; Lei CHEN ; Won KIM ; Sang Min PARK
Clinical and Molecular Hepatology 2024;30(3):487-499
Background/Aims:
To determine the association between evolutionary changes in metabolic dysfunction-associated steatotic liver disease (MASLD) status and the risk of hepatocellular carcinoma (HCC) in a nationwide population-based cohort.
Methods:
Information on study participants was derived from the Korea National Health Insurance Service database. The study population consisted of 5,080,410 participants who underwent two consecutive biennial health screenings between 2009 and 2012. All participants were followed up until HCC, death, or 31 December 2020. The association of evolutionary changes in MASLD status, as assessed by the fatty liver index and cardiometabolic risk factors, including persistent non-MASLD, resolved MASLD, incident MASLD, and persistent MASLD, with HCC risk was evaluated using multivariable-adjusted Cox proportional hazards regression.
Results:
Among the 5,080,410 participants with 39,910,331 person-years of follow-up, 4,801 participants developed HCC. The incidence of HCC in participants with resolved, incident, and persistent MASLD was approximately 2.2-, 2.3-, and 4.7-fold higher, respectively, than that in those with persistent non-MASLD among the Korean adult population. When stratifying the participants according to the evolutionary change in MASLD status, persistent (adjusted hazard ratio [aHR], 2.94; 95% confidence interval [CI], 2.68–3.21; P<0.001), incident (aHR, 1.85; 95% CI, 1.63–2.10; P<0.001), and resolved MASLD (aHR, 1.33; 95% CI, 1.18–1.50; P<0.001) had an increased risk of HCC compared to persistent non-MASLD.
Conclusions
The evolutionary changes in MASLD were associated with the differential risk of HCC independent of metabolic risk factors and concomitant medications, providing additional information on the risk of HCC stratification in patients with MASLD.