1.Gyrate Atrophy of the Choroid and Retina Diagnosed by Ornithine-delta-aminotransferase Gene Analysis: A Case Report.
Sang Jin KIM ; Dong Hui LIM ; Jae Hui KIM ; Se Woong KANG
Korean Journal of Ophthalmology 2013;27(5):388-391
A pair of 19-year-old female identical twins was referred to our hospital with progressive visual loss. They exhibited bilateral chorioretinal atrophy involving the midperiphery on fundoscopy and fluorescein angiography. Bilateral visual field constriction was noted on dynamic Goldmann perimetry, and a markedly impaired response was observed on both photopic and scotopic electroretinograms. Cystoid macular edema was identified in both eyes on optical coherence tomography. Plasma levels of ornithine were elevated. Based on these observations, the patients were diagnosed with gyrate atrophy of the choroid and retina. The clinical diagnosis was confirmed by mutation analysis of the ornithine-delta-aminotransferase (OAT) gene. Patients were treated with a pyridoxine supplement (300 mg/day) and an arginine-restricted diet to lower plasma levels of ornithine, which were successfully reduced without progression of chorioretinal atrophy for 15 months. Our report describes the first case of gyrate atrophy in the Korean population diagnosed by OAT gene analysis and treated with vitamin B6 dietary supplementation.
DNA/*analysis
;
DNA Mutational Analysis
;
Diagnosis, Differential
;
Electroretinography
;
Female
;
Fluorescein Angiography
;
Fundus Oculi
;
Gyrate Atrophy/*diagnosis/enzymology/genetics
;
Humans
;
*Mutation
;
Ornithine-Oxo-Acid Transaminase/*genetics/metabolism
;
Tomography, Optical Coherence
;
Visual Acuity
;
Young Adult
2.The Incidence and Risk Factors of Lens-iris Diaphragm Retropulsion Syndrome during Phacoemulsification.
Dong Hui LIM ; Dong Hoon SHIN ; Gyule HAN ; Eui Sang CHUNG ; Tae Young CHUNG
Korean Journal of Ophthalmology 2017;31(4):313-319
PURPOSE: In the present study, the incidence and risk factors of lens-iris diaphragm retropulsion syndrome (LIDRS) were evaluated. METHODS: Patients who underwent cataract surgery using phacoemulsification between June 2014 and December 2014 were included in the study. The preoperative ocular biometric and intraoperative surgical parameters were examined. The incidence of LIDRS and various risk factors were analyzed using an independent t-test, Pearson's chi-square test, and univariable and multivariable logistic regression analyses. RESULTS: Among 124 eyes of 124 patients, 100 (80.6%) had no LIDRS and 24 (19.4%) had LIDRS. LIDRS occurred in 13 of 31 vitrectomized eyes (41.9%) and 11 of 93 non-vitrectomized eyes (11.8%). Based on univariable analysis, age (odds ratio [OR], 0.920; p = 0.001), vitrectomized eye (OR, 5.038; p = 0.001), spherical equivalent (OR, 0.778; p < 0.001), axial length (OR, 1.716; p < 0.001), anterior chamber depth (OR, 3.328; p = 0.037), and 3.0 mm vs. 2.2 mm incision size (OR, 4.964; p = 0.001) were statistically significant risk factors associated with the development of LIDRS. Conditional multivariable logistic regression showed that vitrectomized eye (OR, 3.865; 95% confidence interval [CI], 1.201 to 12.436; p = 0.023), long axial length (OR, 1.709; 95% CI, 1.264 to 2.310; p = 0.001), and 3.0 vs. 2.2 mm incision size (OR, 3.571; 95% CI, 1.120 to 11.393; p = 0.031) were significant independent risk factors associated with LIDRS. CONCLUSIONS: LIDRS is a relatively common occurrence and was found to be associated with vitrectomized eye, long axial length, and larger incision size. Evaluating risk factors prior to cataract surgery can help reduce associated morbidity.
Anterior Chamber
;
Cataract
;
Diaphragm*
;
Humans
;
Incidence*
;
Iris
;
Logistic Models
;
Phacoemulsification*
;
Risk Factors*
3.Formula Comparison for Intraocular Lens Power Calculation Using IOL Master and Ultrasound for the ZCB00 IOL.
Dong Hoon SHIN ; Dong Hui LIM ; Ja Young YOU ; Eui Sang CHUNG ; Tae Young CHUNG
Journal of the Korean Ophthalmological Society 2014;55(4):527-533
PURPOSE: To evaluation the accuracy of the IOL power calculation formulae measured by IOL Master(R) and applanation ultrasonography for the Tecnis ZCB00 IOL. METHODS: We performed a retrospective study of 170 eyes in 121 patients who underwent cataract surgery in our hospital with AMO Tecnis ZCB00 IOL.s. The SRK/T formula was used to predict the patient's implanted IOL power. Differences in the predicted refractive errors between IOL Master(R) and ultrasonography were analyzed and factors attributed to the differences were also analyzed. Three months after cataract surgery, mean numeric error and mean absolute error were analyzed. RESULTS: SRK/II and SRK/T formulas calculated using ultrasonography showed differences compared to the same formulas calculated using IOL Master(R), in which hyperopic shift was also demonstrated. No definite factor was attributed to the differences between the 2 methods. Although the 3 formulas of IOL Master(R) showed no significant difference in refractive errors, the SRK/T formula calculated using IOL Master(R) showed the least mean absolute and numeric errors. CONCLUSIONS: IOL Master(R) is considered more suitable when determining proper AMO Tecnis ZCB00 IOL power in cataract surgery. The hyperopic shift should be considered when calculating the IOL power using only ultrasonography.
Cataract
;
Ultrasonography*
;
Humans
;
Lenses, Intraocular*
;
Refractive Errors
;
Retrospective Studies
;
Ultrasonography
4.A Comparison of Bioimpedance and Echocardiography in Measuring Cardiac Output in Healthy Male Volunteers.
Gyu Chong CHO ; Won KIM ; Yoo Dong SOHN ; Hui Dong KANG ; Bum Jin OH ; Kyoung Soo LIM
Journal of the Korean Society of Emergency Medicine 2006;17(3):225-230
PURPOSE: To manage a critically ill patient effectively, an emergency physician must make an accurate assessment of the patient's hemodynamic status. Although the hemodynamic status can be accurately measured through the use of a pulmonary artery catheter, this device has significant limitations in the emergency department. Instead, the most commonly used method of measuring cardiac output (CO) in the emergency department is transthoracic echocardiography (TTE). However, TTE has been reported to underestimate the CO. Impedance cardiography (ICG) is an established and accurate technique for noninvasive determination of hemodynamic parameters. Thus, this study aimed to assess the agreement between CO measurements made by using TTE and ICG. METHODS: In 20 healthy volunteers, the hemodynamic parameters (stroke volume and CO) obtained by TTE were compared with the parameters derived from simultaneous measurements by ICG. RESULTS: The mean stroke volumes and COs were 63.9+/-11.6 ml and 4.1+/-0.7 L/min, respectively, by TTE, and 77.2+/-10.2 ml and 5.0+/-0.6 L/min by ICG. The correlation coefficients for stroke volume and CO between TTE and ICG were 0.77 and 0.64. The mean difference in stroke volume between TTE and ICG was -13.3+/-6.4 ml (-19.5+/-10.5 %), and the mean difference in CO was -0.88+/-0.48 L/min (-20.1+/-11.6 %). CONCLUSION: In healthy volunteers, the comparison between TTE and ICG showed a good correlation for stroke volume and CO. However, the mean differences in stroke volume and CO between TTE and ICG were -19.5+/-10.5 % and -20.1+/-11.6 %, respectively.
Cardiac Output*
;
Cardiography, Impedance
;
Catheters
;
Critical Illness
;
Echocardiography*
;
Emergencies
;
Emergency Service, Hospital
;
Healthy Volunteers
;
Hemodynamics
;
Humans
;
Male*
;
Pulmonary Artery
;
Stroke Volume
;
Volunteers*
5.A Case of Toxic Keratitis due to Chronic Use of Sodium Hyaluronate Eyedrops.
Eun Jung LEE ; In Jeong LYU ; Joo HYUN ; Dong Hui LIM ; Tae Young CHUNG
Journal of the Korean Ophthalmological Society 2015;56(2):291-295
PURPOSE: To report a case of toxic keratitis due to chronic use of sodium hyaluronate eyedrops. CASE SUMMARY: A 74-year-old female visited our clinic with severe ocular pain and decreased vision in both eyes. She had received refractive surgeries in both eyes 10 years prior. She had been using sodium hyaluronate eyedrops for the treatment of dry eye symptoms for 10 years. Slit-lamp examination revealed inferior punctate erosions in the inferior part of the cornea in both eyes. With her history of chronic use of sodium hyaluronate and after ophthalmologic examination, we suspected keratitis medicamentosa due to sodium hyaluronate eyedrops. We discontinued the eyedrops she was using and prescribed autologous serum. One month later, ocular discomfort and decreased vision were improved and corneal erosions were decreased. CONCLUSIONS: In the present case, toxic keratitis was assumed to be associated with the use of sodium hyaluronate eyedrops and corneal erosions improved after the eyedrops were discontinued. We suggest sodium hyaluronate eyedrops are potentially hazardous and recommend a regular follow-up should be performed by a qualified ophthalmologist.
Aged
;
Cornea
;
Female
;
Humans
;
Hyaluronic Acid*
;
Keratitis*
;
Ophthalmic Solutions*
;
Refractive Surgical Procedures
6.Clinical Outcome of Retreatment after Refractive Surgery.
Eun Jung LEE ; Dong Hui LIM ; Ja Young YOU ; Tae Young CHUNG ; Eui Sang CHUNG
Journal of the Korean Ophthalmological Society 2015;56(2):180-189
PURPOSE: To evaluate the clinical outcome of retreatment after refractive surgery. METHODS: Retrospective analysis of 38 eyes of 24 patients who received retreatment surgery after refractive surgery from August 2008 to May 2013 was performed. Pre-initial surgery characteristics and the reason for retreatment were investigated, and preand post-retreatment uncorrected visual acuity, best corrected visual acuity, safety index, efficacy index, predictability, and postoperative complication were also investigated. RESULTS: Age at initial refractive surgery and retreatment were 28.50 +/- 7.29 years (17-49 years) and 31.21 +/- 6.49 years (21-49 years). Reasons for retreatment were myopic regression in 36 eyes (94.7%) and overcorrection in two eyes (5.3%). Methods of retreatment were laser subepithelial keratomileusis (LASEK) in 31 eyes (81.6%) and laser-assisted in situ keratomileusis (LASIK) in seven eyes (18.4%). Safety index values for all were above 1.0 and efficacy index values were 0.92, 0.93, and 0.95 in postoperative examination at 1 month, 3 months, and 6 months, respectively. No eye showed a decrease in best corrected visual acuity. One eye had transient hyperopia after retreatment, and two eyes had postoperative corneal opacity, but no eye experienced significant alteration in visual prognosis. CONCLUSIONS: Retreatment after refractive surgery was an efficient and safe clinical course in our clinic. No long-term complications were observed, and uncorrected visual acuity and refractive errors significantly improved after retreatment. In particular, LASEK can be considered as a safe and efficient retreatment modality without risk of keratectasia.
Corneal Opacity
;
Humans
;
Hyperopia
;
Keratectomy, Subepithelial, Laser-Assisted
;
Keratomileusis, Laser In Situ
;
Postoperative Complications
;
Prognosis
;
Refractive Errors
;
Refractive Surgical Procedures*
;
Retreatment*
;
Retrospective Studies
;
Visual Acuity
7.Effects and Prognostic Factors of Automated Thermodynamic System Treatment for Meibomian Gland Dysfunction.
Seung Wan NAM ; Dong Hui LIM ; Joo HYUN ; Tae Young CHUNG
Journal of the Korean Ophthalmological Society 2016;57(5):724-733
PURPOSE: To evaluate the effect and prognostic factors of automated thermodynamic treatment (thermal compression therapy device [KCL 1100®]) for Meibomian gland dysfunction (MGD). METHODS: Patients (48 eyes of 24 subjects) with MGD were recruited for a prospective clinical trial. Patients received 15-minute treatments twice a day using the KCL 1100®. Severity of dry eye symptoms were evaluated using the Standard Patient Evaluation for Eye Dryness (SPEED) and Ocular Surface Disease Index (OSDI), and severity of Meibomian gland function was evaluated using the Meibomian gland expressibility (MGE), Meibomian gland secretion (MGS) score and lipid layer thickness measured by LipiView®. To evaluate ocular surface, we measured tear break-up time (BUT) and fluorescein corneal staining score (Oxford scale). Data were presented for baseline and at 2 weeks and 1 month post-treatment. RESULTS: Dry eye symptom (SPEED, OSDI), Meibomian gland function (MGE, MGS), and ocular surface index (BUT, Oxford scale) of patients were significantly improved from baseline to 2 weeks (p < 0.05) and 1 month post-treatment (p < 0.05). In addition, patients with more severe dry eye symptom and Meibomian gland index at baseline examination achieved improvement in mild to moderate MGD (p < 0.05). Improvement of Meibomian gland function (MGE) was associated with improvement of ocular surface index (BUT, Oxford scale) (p < 0.05), but not with improvement of dry eye symptom (SPEED, OSDI) (p > 0.05). There were no significant adverse events during the treatment. CONCLUSIONS: KCL 1100® automated thermodynamic treatment is an effective and safe treatment for MGD. Additionally, KCL 1100® is more effective in patients with moderate dry eye symptom and MGD.
Fluorescein
;
Humans
;
Meibomian Glands*
;
Prospective Studies
;
Tears
;
Thermodynamics*
8.Predisposing Factors and Surgical Outcomes of Intraocular Lens Dislocation after Phacoemulsification.
Je Moon YOON ; Joo HYUN ; Dong Hui LIM ; Eui Sang CHUNG ; Tae Young CHUNG
Journal of the Korean Ophthalmological Society 2016;57(1):36-42
PURPOSE: To report the predisposing factors and surgical outcomes of intraocular lens dislocation (IOL) after phacoemulsification. METHODS: We performed a retrospective study of 131 eyes in 120 patients who were diagnosed with IOL dislocation after phacoemulsification between January 2008 and December 2013. The main outcomes are possible predisposing factors, characteristics of IOL dislocation, and outcomes of rectification surgery, including visual acuity (VA), and refractive status before and at 3 months after surgery. RESULTS: The main conditions associated with IOL dislocation were as follows: status after vitrectomy (27.5%), long axial length (9.2%), neodymium-doped yttrium aluminium garnet (Nd:YAG) posterior capsulotomy (8.4%), uveitis (6.1%), trauma (5.3%), mature cataract (3.8%), and pseudoexfoliation (2.3%). Mean uncorrected VA improved significantly after rectification surgery (p = 0.00), and best-corrected VA also improved significantly (p = 0.01). Mean value of spherical equivalent tended to decrease, although the decrease was not significant (p = 0.07). Whereas astigmatism showed a significant increase (p = 0.01). 6 eyes (4.6%) were associated with recurrence of IOL dislocation. CONCLUSIONS: Possible major predisposing factors for IOL dislocation are status after vitrectomy, long axial length, Nd:YAG posterior capsulotomy, uveitis, and trauma. The surgical outcome and improvement of postoperative visual acuity were satisfactory.
Astigmatism
;
Cataract
;
Causality*
;
Dislocations*
;
Humans
;
Lenses, Intraocular*
;
Phacoemulsification*
;
Posterior Capsulotomy
;
Recurrence
;
Retrospective Studies
;
Uveitis
;
Visual Acuity
;
Vitrectomy
;
Yttrium
9.The Relations Between Progression of Peripapillary Chorioretinal Atrophy and Progression of Normal Tension Glaucoma.
Jong Chul HAN ; Wool SUH ; Dong Hui LIM ; Changwon KEE
Journal of the Korean Ophthalmological Society 2012;53(6):807-812
PURPOSE: To evaluate the relations between progression of glaucoma in visual field and peripapillary area change in normal tension glaucoma (NTG). METHODS: We respectively evaluated 66 patients (66 eyes) with normal tension glaucoma; these patients were classified as progressive glaucoma group and non-progressive glaucoma group by visual field test. Interobserver and intraobserver agreement was evaluated for qualitative assessment. Zone beta change was measured by Image J (National Institute of Health, Bethesda, USA) by two methods. One method used paired t-test and the other method used CV (correlation of variation) to define significant progression of zone beta. RESULTS: 46 patients (46 eyes) were classified as progressive glaucoma and 20 patients (20 eyes) were classified as non-progressive glaucoma. There was no statistically significant different change of zone beta between two groups and there were no changes of zone beta over coefficient of variation (CV). CONCLUSIONS: The measurement of change of zone beta seems to be of no use in recognition of progression in normal tension glaucoma.
Atrophy
;
Glaucoma
;
Humans
;
Low Tension Glaucoma
;
Visual Field Tests
;
Visual Fields
10.Clinical Outcomes of Descemet's Membrane Endothelial Keratoplasty: A 1-Year Retrospective Study.
Gyu Le HAN ; Joo HYUN ; Dong Hui LIM ; Eui Sang CHUNG ; Tae Young CHUNG
Journal of the Korean Ophthalmological Society 2015;56(10):1489-1496
PURPOSE: To evaluate the 1-year results of Descemet's membrane endothelial keratoplasty (DMEK) in Korea. METHODS: The medical records of 9 patients (10 eyes) with endothelial disease who underwent DMEK from January 2012 to December 2013, and were followed up for more than 12 months were reviewed retrospectively. RESULTS: In 8 eyes with successful results after surgery, best corrective visual acuity (BCVA) was significantly improved from 1.64 +/- 0.21 (log MAR, mean) to 0.35 +/- 0.22 at 1 month and was maintained at 12 months (p = 0.012, Wilcoxon signed ranks test). BCVA at postoperative 3, 6 and 12 months were gradually increased (0.25 +/- 0.23, 0.20 +/- 0.17 and 0.16 +/- 0.17 log MAR). Endothelial cell counts were 1,996 +/- 528/mm2, 1,564 +/- 174/mm2 and 1,463 +/- 541/mm2, 1,205 +/- 358/mm2 at 1, 3, 6, and 12 months after surgery, tended to decrease but showed no statistical significance. There was no statistical difference in astigmatism before and 3 months after the operation (3.32 +/- 2.36 diopter and 2.57+/- 1.44 diopter). Primary graft failure occurred in 2 eyes and 1 received reoperation. Total detachment was found in 1 eye. CONCLUSIONS: The 1-year results of DMEK showed fast visual recovery which was maintained for 12 months. DMEK may be a very efficient option for the surgical management of corneal endothelial disease.
Astigmatism
;
Cornea
;
Corneal Transplantation*
;
Descemet Membrane*
;
Endothelial Cells
;
Humans
;
Korea
;
Medical Records
;
Reoperation
;
Retrospective Studies*
;
Transplants
;
Visual Acuity