1.Paget's disease of bone: one case report.
Woon Sik CHOY ; Chang Hyun BAEK ; Dong Hoo KOH
The Journal of the Korean Orthopaedic Association 1991;26(3):970-974
No abstract available.
Osteitis Deformans*
2.Clinical analysis of unstable thoracolumbar fractures and fracture-dislocation using transpedicular screws.
Won Sik CHOY ; Chang Hyun BAIK ; Sung Soo CHO ; Hyun Jong PARK ; Dong Hoo KOH
The Journal of the Korean Orthopaedic Association 1991;26(3):719-727
No abstract available.
3.Experiences of Endoscopic Ultrasonography in the 5 cases with Pancreatic Insulinoma.
Young Il MIN ; Sung Koo LEE ; Myung Hwan KIM ; Hae Ryun KIM ; Il Han SONG ; Moon Soo KOH ; Hoo Soon CHOI ; Joong Yeol PARK ; Seung Kwan HONG ; Ki Up LEE ; Dong Jin SEO
Korean Journal of Gastrointestinal Endoscopy 1996;16(1):103-113
Of the various endocrine tumors affecting the pancreas, insulinomas and gastrinomas are the most common. In order to facilitate surgery, the localization of tumor is important. However, at the first time of presentation, the localization of tumor was often difficult by CT or ultrasonography because the tumor was relatively too small. The introduction of endoscopic ultrasonography has allowed high-resolution imaging of the pancreas that distinguishes structures as small as 2 to 3 mm in diameter. Thus, it has became easier to detect the lesion site of pancreatic endocrine tumor by endoscopic ultrasonography. We report the 5 patients who had pancreatic insulinoma which were detected and localized by endoscopic ultrasonography.
Endosonography*
;
Gastrinoma
;
Humans
;
Insulinoma*
;
Pancreas
;
Ultrasonography
4.Experiences of Endoscopic Ultrasonography in the 5 cases with Pancreatic Insulinoma.
Young Il MIN ; Sung Koo LEE ; Myung Hwan KIM ; Hae Ryun KIM ; Il Han SONG ; Moon Soo KOH ; Hoo Soon CHOI ; Joong Yeol PARK ; Seung Kwan HONG ; Ki Up LEE ; Dong Jin SEO
Korean Journal of Gastrointestinal Endoscopy 1996;16(1):103-113
Of the various endocrine tumors affecting the pancreas, insulinomas and gastrinomas are the most common. In order to facilitate surgery, the localization of tumor is important. However, at the first time of presentation, the localization of tumor was often difficult by CT or ultrasonography because the tumor was relatively too small. The introduction of endoscopic ultrasonography has allowed high-resolution imaging of the pancreas that distinguishes structures as small as 2 to 3 mm in diameter. Thus, it has became easier to detect the lesion site of pancreatic endocrine tumor by endoscopic ultrasonography. We report the 5 patients who had pancreatic insulinoma which were detected and localized by endoscopic ultrasonography.
Endosonography*
;
Gastrinoma
;
Humans
;
Insulinoma*
;
Pancreas
;
Ultrasonography
5.A Case of Pancreatic Endocrine and Exocrine Tumor with MEN Type I.
Oh Wan KWON ; Ho Soon CHOI ; Jee Hyun KIM ; Won MOON ; Jung Mi KIM ; Dong Hee KOH ; Hang Rak LEE ; Oh Young LEE ; Byung Chul YOUN ; Joon Soo HAM ; Dong Hoo LEE ; Min Ho LEE ; Choon Suhk KEE
Korean Journal of Gastrointestinal Endoscopy 2006;33(5):326-332
An acinar cell carcinoma of the exocrine pancreas is a rare tumor with reported a incidence of 1% to 2% of pancreatic carcinomas. Cases of acinar cell carcinomas with amphicrine features have been reported in recent decades. However, there are no reports of two simultaneous pancreatic masses: an endocrine tumor and, an exocrine tumor. We encountered a 59-year-old female patient presenting with abdominal pain and melena. The acinar cell carcinoma was a 1x1 cm-sized round solid mass in the head of the pancreas. The islet tumor was a 2.5x1.5 cm-sized round mass in the body of the pancreas. The endocrine tumor was nonfunctioning. Melena resulted from the hemosuccus pancreaticus due to a ductal invasion of the acinar cell carcinoma. The patient had a parathyroid adenoma with hyperparathyroidism. Therefore, both the islet tumor and parathyroid adenoma with hyperparathyroidism were strongly suggestive of a MEN I.
Abdominal Pain
;
Acinar Cells
;
Carcinoma, Acinar Cell
;
Female
;
Head
;
Humans
;
Hyperparathyroidism
;
Incidence
;
Male
;
Melena
;
Middle Aged
;
Multiple Endocrine Neoplasia Type 1
;
Pancreas
;
Pancreas, Exocrine
;
Parathyroid Neoplasms
6.Association between Insulin, Insulin Resistance, and Gallstone Disease in Korean General Population.
Jung Mi KIM ; Hang Lak LEE ; Won MOON ; Dong Hee KOH ; Oh Young LEE ; Byoeng Chul YOON ; Ho Soon CHOI ; Joon Soo HAHM ; Min Ho LEE ; Dong Hoo LEE ; You Hern AHN
The Korean Journal of Gastroenterology 2007;50(3):183-187
BACKGROUND/AIMS: Diabetes is one of the risk factors of gallstone diseases. Many studies found a positive association between insulin and gallstones in individuals with diabetes. However, this association is unclear in non-diabetes. So we conducted a case-control study for the evaluation of the association between gallstone diseases and fasting serum insulin level, insulin resistance in non-diabetic Korean general population. METHODS: This study was a prospective case-control study on 118 Korean subjects which included clinical examination, abdominal ultrasound, and blood chemistries. Serum fasting insulin level were determined by radioimmunoassay and concentrations of cholesterol, glucose, and triglycerides by standard enzymatic colorimetric methods. Insulin resistance was determined by the homeostasis model assessment (HOMA-IR). Body mass index (BMI), percentage of body fat, and waist hip ratio were also measured. RESULTS: We studied 118 subjects with no clinical evidence of diabetes mellitus and serum glucose<126 mg/dL. Compared with controls (n=89), cases (n=29) had higher levels of serum insulin, glucose, triglyceride levels, and BMI. In t-test and chi-square test for variables, the association between gallstone disease and serum insulin, HOMA-IR index, and BMI were statistically significant (p<0.05). In multiple logistic regression analysis, gallstone disease risk increased with the level of serum insulin (p=0.024, odds ratio=1.376) and HOMA-IR index (p=0.013, odds ratio=2.006). CONCLUSIONS: We suggest that hyperinsulinemia and insulin resistance could be associated with gallstone formation in individuals without clinical diagnosis of diabetes mellitus and with normal serum glucose level.
Adult
;
Body Mass Index
;
Case-Control Studies
;
Female
;
Gallstones/*epidemiology/etiology
;
Humans
;
Hyperinsulinism/complications
;
Insulin/*blood
;
*Insulin Resistance
;
Korea
;
Male
;
Middle Aged
;
Regression Analysis
;
Risk Factors
7.Clinical Feature of Pseudomembranous Colitis with Ascites.
Oh Wan KWON ; Oh Young LEE ; Young Il KWON ; Jae Yoon JEONG ; Yoo Hum BAEK ; Won MOON ; Jung Mi KIM ; Dong Hee KOH ; Hang Lak LEE ; Byung Chul YOON ; Ho Soon CHOI ; Joon Soo HAHM ; Min Ho LEE ; Dong Hoo LEE ; Choon Suhk KEE
Korean Journal of Gastrointestinal Endoscopy 2007;35(1):14-18
BACKGROUND/AIMS: Ascites is a fairly common condition, but the clinical features of pseudomembranous colitis with ascites are not well-known. The aim of this study was to determine how the existence of ascites is related to the clinical factors. METHODS: Between March 2002 and June 2006, 67 pseudomembranous colits patients were diagnosed by performing lower endoscopy and biopsy. The patients' ascites was identified by abdominal plain radiography, ultrasonography or computerized tomography. The extension of colitis was evaluated by ultrasonography or computerized tomography. RESULTS: 16 patients (23.9%) had ascites. The serum WBC (p=0.01), hypoalbuminemia (p<0.01), CRP (p<0.01), recurrence (p<0.01), and extension of colitis (p<0.01) were associated with the existence of ascites. The four patients who had undergone paracentesis had a low SAAG level and PMN dominant ascites. CONCLUSIONS: There were correlations of ascities with leukocytosis, hypoalbuminemia, CRP, extension of colitis and recurrence of PMC.
Ascites*
;
Biopsy
;
Colitis
;
Endoscopy
;
Enterocolitis, Pseudomembranous*
;
Humans
;
Hypoalbuminemia
;
Leukocytosis
;
Paracentesis
;
Radiography
;
Recurrence
;
Ultrasonography
8.p53 Codon 72 and 16-bp Duplication Polymorphisms of Gastric Cancer in Koreans.
Jung Mi KIM ; Oh Young LEE ; Chun Geun LEE ; Sung Joon KWON ; Kyung Suk KIM ; Won MOON ; Dong Hee KOH ; Hang Lak LEE ; Byoeng Chul YOON ; Ho Soon CHOI ; Joon Soo HAHM ; Min Ho LEE ; Dong Hoo LEE
The Korean Journal of Gastroenterology 2007;50(5):292-298
BACKGROUND/AIMS: p53 gene plays an important role in cell cycle control in response to DNA damage which may increase the probability of mutations leading to carcinogenesis. The role of p53 gene polymorphisms [codon 72 (exon 4) and 16-bp duplication (intron 3)] as potential markers indicating cancer risk remains inconclusive, and the data on gastric cancer are very limited. The aim of this study was to assess the role of p53 gene polymorphisms in the risk of gastric cancer and in the determination of genetic susceptibility to gastric cancer in Koreans. METHODS: We analysed p53 genotypes using a polymerase chain reaction-based restriction fragment length polymorphism assay in a population-based case-control study in 120 gastric cancer patients and 145 cancer-free controls in Koreans. RESULTS: There was no specific genotype of p53 gene polymorphism in the gastric cancer patients compared to cancer-free controls. In p53 codon 72 and 16-bp duplication polymorphisms, the frequency and distribution of genotypes showed no statistical significance (p=0.7125 and p=0.1659). There was no difference in genotype by histologic subtypes, location of lesion, and age. However, the genotypic distribution in the patient subgroups with a history of heavy cigarette smoking of p53 16-bp duplication polymorphism were significantly different from those of cancer-free controls (p=0.0079). CONCLUSIONS: The p53 codon 72 and 16-bp duplication polymorphisms were not associated with the increased risk of gastric cancer and did not seem to contribute to gastric cancer susceptibility among Koreans. It is possible that p53 16-bp duplication polymorphism modulates the risk of smoking-induced gastric cancer development in Koreans. In order to clarify the associations between specific genotypes and gastric cancer risk, the evaluations of these polymorphisms in other ethnic backgrounds with larger number of patients would be needed.
Adult
;
Aged
;
Case-Control Studies
;
Codon
;
Data Interpretation, Statistical
;
Female
;
*Genes, p53
;
Genetic Predisposition to Disease
;
Genotype
;
Heterozygote
;
Homozygote
;
Humans
;
Korea
;
Male
;
Middle Aged
;
*Polymorphism, Restriction Fragment Length
;
Stomach Neoplasms/*genetics/pathology
;
Tandem Repeat Sequences/*genetics
9.The Results of Nation-Wide Registry of Age-related Macular Degeneration in Korea.
Kyu Hyung PARK ; Su Jeong SONG ; Won Ki LEE ; Hee Sung YOON ; Hyoung Jun KOH ; Chul Gu KIM ; Yun Young KIM ; Se Woong KANG ; Ha Kyoung KIM ; Byung Ro LEE ; Dong Heun NAM ; Pill Young LEE ; Hyoung Su KIM ; Hyeoung Chan KIM ; Si Yeol KIM ; In Young KIM ; Gwang Su KIM ; Kuhl HUH ; Jae Ryung OH ; Shin Dong KIM ; Sang Jun LEE ; Young Duk KIM ; Soon Hyun KIM ; Tae Gon LEE ; Sung Won JOE ; Dong Cho LEE ; Mu Hwan CHANG ; Si Dong KIM ; Young Wok JOE ; Sun Ryang BAE ; Ju Eun LEE ; Boo Sup OUM ; Ill Han YOON ; Soon Ill KWON ; Jae Hoon KANG ; Jong In KIM ; Sang Woong MOON ; Hyeong Gon YU ; Young Hee YOON ; Gwang Yul CHANG ; Sung Chul LEE ; Sung Jin LEE ; Tae Kwan PARK ; Young Hun OHN ; Oh Woong KWON ; Woo Hyok CHANG ; Yeon Sik YANG ; Suk Jun LEE ; Su Young LEE ; Chang Ryong KIM ; Jung Hee LEE ; Yeon Sung MOON ; Jae Kyoun AHN ; Nam Chun JOE ; Gwang Ju CHOI ; Young Joon JOE ; Sang Kook KIM ; Sung Pyo PARK ; Woo Hoo NAM ; Hee Yoon JOE ; Jun Hyun KIM ; Hum CHUNG
Journal of the Korean Ophthalmological Society 2010;51(4):516-523
PURPOSE: To evaluate the incidence and clinical features of age-related macular degeneration (AMD) in Korea. METHODS: Web-based (www.armd-nova.or.kr) registration was conducted for AMD patients aged 50 or more who were newly diagnosed by retinal specialists in Korea from August 20, 2005 to August 20, 2006. Patient data including ophthalmologic examination, fundus photography, fluorescein angiogram and/or indocyanin green angiogram (ICG), past medical history, behavioral habit, combined systemic diseases were up-loaded. RESULTS: Among finally enrolled 1,141 newly diagnosed AMD patients, 690 patients (60.5%) were male and 451 patients (39.5%) were female. The average age of AMD patients was 69.7+/-8.0. Early AMD was observed in 190 patients and 951 patients had late AMD. Classic choroidal neovascular membrane (CNVM) was observed in 18.6% of exudative AMD patients and 63.4 % had occult CNVM. Subfoveal CNVM was observed in 80.4% of the patients with CNVM. Among the 580 exudative AMD eyes that performed indocyanin green angiography (ICG), 184 eyes (31.7%) had polypoidal choroidal vasculopathy (PCV) and 36 eyes (6.2%) showed retinal angiomatous proliferation (RAP). Age, male gender, smoking, diabetes and hypertension significantly increased the risk of the AMD among Koreans. CONCLUSIONS: Because of the low rate of participation by retinal specialists, definite incidence of AMD was not obtainable. However, the estimated 1-year AMD incidence in the Pusan area of Korea is at least 0.4%. In contrast to Western people, 31.7% of exudative AMD cases were revealed to be PCV and 6.2% were revealed to be RAP. This discrepancy between ethnic groups should be considered in the diagnosis and treatment modality selection of Korean AMD patients.
Aged
;
Angiography
;
Choroid
;
Ethnic Groups
;
Eye
;
Female
;
Fluorescein
;
Humans
;
Hypertension
;
Incidence
;
Korea
;
Macular Degeneration
;
Male
;
Membranes
;
Photography
;
Retinaldehyde
;
Smoke
;
Smoking
;
Specialization