1.A case of chronic mucocutaneous candidiasis associated with hypoparathyroidism.
Dong Won KIM ; Jun Kyu OH ; Kyu Han KIM ; Kyoung Chan PARK ; Hoan Jong LEE
Korean Journal of Dermatology 1993;31(5):755-759
Chronic mucocutaneous randidiasis is a clinical syndrome characte ized by chronic and reccurent superficial candidal infection of the skin, mucous membranes, and nails. This syndrome is frequently associated with immune deficiency or endocrinopathy, especially hypopar; thyroidism. We report a case of chrcinic mucocutaneous candidiasis associated with hypoparathyroidism in a 8- year-old girl.
Candidiasis
;
Candidiasis, Chronic Mucocutaneous*
;
Female
;
Humans
;
Hypoparathyroidism*
;
Mucous Membrane
;
Skin
;
Thyroid Gland
2.Clinical Study on Chronic Granulomatous Disease(CGD) -Occurrence in Siblings-.
Yong Hoon JUN ; Sung Won YANG ; Dong Wook KIM ; Hoan Jong LEE ; Joong Gon KIM
Journal of the Korean Pediatric Society 1994;37(6):794-803
To analyse the age of onset, etiologic microorganisms, clinical manifestations, managements and genetic variation of chromic granulomatous disease, the authors reviewed four patients who were diagnosed as CGD at Department of Pediatrics, Seoul National Univesity Children's Hospital. They were siblings in relationship-two of them were brothers, the others were brother-sister. @ES The results were as follows; 1) Initial manifestations developed within 1 year old, and lymphadenopathy associated with BCG vaccination was the most common. 2) In culture study of micro-organism, catalase positive microorganisms such as Staphylococcus aureus, Serratia marcescens, Coagulase (-) Staphylococcus, Enterococcus, Proleus vulgaris, Klebsiella pneumoniae, E. coli and fungus such as Candida albicans were isolated. In 2 cases, culture study revealed no growth. 3) Fever, lymphadenopathy, hepatomegaly, suppurative dermatitis and pneumonia were the most common manifestations. In most of cases, antituberculous medications were administered under the impression of tuberculosis without response. 4) Immunologic screening tests including B-cell system, T-cell system, and complement system were within normal limit except NBT test. 5) In spite of severe infections, NBT scores of all the cases were less than those of controls. Liver biopsies of 3 cases showed granuloma formation with characteristic yellow brown pigment-laden macrophages.
Age of Onset
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B-Lymphocytes
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Biopsy
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Candida albicans
;
Catalase
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Coagulase
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Complement System Proteins
;
Dermatitis
;
Enterococcus
;
Fever
;
Fungi
;
Genetic Variation
;
Granuloma
;
Hepatomegaly
;
Humans
;
Klebsiella pneumoniae
;
Liver
;
Lymphatic Diseases
;
Macrophages
;
Mass Screening
;
Mycobacterium bovis
;
Pediatrics
;
Pneumonia
;
Seoul
;
Serratia marcescens
;
Siblings
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Staphylococcus
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Staphylococcus aureus
;
T-Lymphocytes
;
Tuberculosis
;
Vaccination
3.Classification of the Carbohydrate using pectin Binding Characteristics and PAS Reaction in Human Gingiva.
Bong Soo PARK ; Jin Jeong KIM ; Jae Bong KIM ; Ju Hee KIM ; Sik YOON ; Dong Hoan KIM
Korean Journal of Physical Anthropology 1988;1(1):17-27
This study was performed in order to recognize the identifications of the glycoproteins containing oligosaccharides in human gingiva. After made paraffin sections of human gingiva at 4µm, the sections were incubated with 7 lectins (UEA-I, BS-I, SBA, DBA, WGA, PNA, PNA after neuraminidase treated, Con-A). In order to increase specificity of reactions, the sections were applicated with ABC system. And then the sections were incubated with DAB and were counterstained with hematoxylin. Using the same sections, the sections were done H-E and PAS stains. In WGA, DBA and Con-A, plasma membranes of the layers of all epithelium and connective tissue were stained. In BS-I ; In the epithelium of marginal gingiva, plasma membranes of upper layer of the spinous cell layer and granular cell layer were stained. And in epithelium of sulcular gingiva, plasma membranes of the all spinous cell layer and granular cell layer were stained. In SBA ; Plasma membranes of the granular cell layer were stained. In PNA ; In the epithelium of marginal gingiva, plasma membranes of the basal cell layer and lower layer of spinous cell layer were stained. But lectin reactions were not occurred in thc sulcular gingiva. In PNA treated neuraminidase, plasma membranes of the all epithelial layer except basal cell layer membranes especially cytoplasms of upper layer at the sulcular gingiva and connective tissue were reacted. 1. By the above results, authors could know the identification of oligosaccharides existing g1ycoproteins in the human gingiva. 1) All epithelial layer ; α-D-N-Acetyl-Galactosamine, Sialic acid, D-Glucosamine, α-D-Mannose 2) Basal cell layer ; Galactose-β-(1-3)-N-Acetyl-Galactosamine 3) Spinous cell layer ; α-D-Galactose, Galactose-β-(1-3)-N-Acetyl-Galactosamine 4) Granular cell layer ; α-D-Galactose 5) Connective tissue ; α-D-N-Acetyl-Galactosamine, Siallic acid, β-(1-4)-D-Acetyl-Glucosamine, α-D-Glucosamine, α-D-Mannose 2. The Galactose-β-(1-3)-N-Acetyl-Galactosamine was not existed in the basal cell layer and spinous cell layer in the sulcular gingiva.
Cell Membrane
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Classification*
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Coloring Agents
;
Connective Tissue
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Cytoplasm
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Dronabinol
;
Epithelium
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Gingiva*
;
Glycoconjugates
;
Glycoproteins
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Hematoxylin
;
Humans*
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Lectins
;
Membranes
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N-Acetylneuraminic Acid
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Neuraminidase
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Oligosaccharides
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Paraffin
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Periodic Acid-Schiff Reaction*
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Sensitivity and Specificity
4.Cloning of the hyphantrica cunea nuclear polyhedrosis virus partial EcoRI genome DNA fragments in plasmid vectors pUC8 and pBR322.
Hyung Hoan LEE ; Jin Wook KIM ; Hee Kyung KIM ; Sung Sook PARK ; Yong Chull LEE ; Dong Chull OK
Journal of the Korean Society of Virology 1991;21(1):35-40
No abstract available.
Clone Cells*
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Cloning, Organism*
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DNA*
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Genome*
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Nucleopolyhedrovirus*
;
Plasmids*
5.Localized Paroxysmal Pruritus in Multiple Sclerosis.
Jung Hoan YOO ; Hong Suk KIM ; Dong Seung KANG ; Kee Yang CHUNG
Korean Journal of Dermatology 2000;38(3):410-412
Paroxysmal itching is a rare symptom in multiple sclerosis and it was first reported in 1975 by Osterman and Westerberg. It has been suggested that paroxysmal itching may be due to the activation of axons in CNS via abnormal synapses between demyelinated axons. Carbamazepine, phenytoin, and ibuprofen are known to be effective in the treatment of paroxysmal itching. We report a case of paroxysmal itching of 4 months' duration in a 41-year-old female with multiple sclerosis who suffered from severe paroxysmal itching on the left side of her neck and chest. The itching did not respond to carbamazepine, but it was partially controlled with ibuprofen.
Adult
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Axons
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Carbamazepine
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Female
;
Humans
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Ibuprofen
;
Multiple Sclerosis*
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Neck
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Phenytoin
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Pruritus*
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Synapses
;
Thorax
6.A Clinical Study of Periappendiceal Abscess.
Dong Hoan KIM ; Woo Shik CHUNG ; Seong Ryul RYU ; Tae Soo CHANG
Journal of the Korean Society of Coloproctology 1997;13(2):215-222
This is a clinical analysis and review of one-hundred ninety-four patients with periappendiceal abscesses who were treated at the Departmeat of Surgery, Masan Samsung Hospital over a ten year period from January 1985 to December 1994. The following results were obtained. The incidence of periappendiceal abscesses was 7.24% of the total cases of appendicitis operated on during the same period, and most of the patients(43.8%) were over fifty years old. The male to female ratio was 1:1.02. 41.2% of the patients had operations within four days after their symptoms occurred. On admission, the most common physical finding was tenderness on the right lower quadrant of the abdomen (92.9%) and leukocytosis(> OR = 10,000/mm3) was noted on CBC in 82% of the patients. Abdominal sonograms revealed periappendiceal abscesses in 88% of the patients, 83% were revealed with barium enema and 88% with abdominal CT scan. Many patients(75.5%) visited the local clinic and were treated under the diagnosis of gastritis or enteritis instead of appendicitis. One-hundred eighty-three patients(94.3%) had appendectomies with drainages(94.3%), two patients had drainages of abscesses without appendectomy, six patients had ileocecal resections and three patients had right hemicolectomies. Microbiologically, E. coli was the most frequently cultured species(63%) from abscess, and Klebsiella, Enterococcus and Proteus were isolated in some cases. Postoperative complication occurred in seventy-five patients(38.6%) and the most frequent complication was wound infection(28.8%). There was no mortality and the mean hospital stay was fifteen days.
Abdomen
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Abscess*
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Appendectomy
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Appendicitis
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Barium
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Diagnosis
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Enema
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Enteritis
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Enterococcus
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Female
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Gastritis
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Humans
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Incidence
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Klebsiella
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Length of Stay
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Male
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Mortality
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Postoperative Complications
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Proteus
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Tomography, X-Ray Computed
;
Wounds and Injuries
7.Risk Factors Associated with Stroke Recurrence.
Moo Kyum KIM ; Min Jeong KANG ; Hoan Nyoung LEE ; Kyoung Min LEE
Journal of the Korean Academy of Rehabilitation Medicine 2000;24(5):857-863
OBJECTIVE: This study was done to evaluate the risk factors associated with recurrence after first-ever stroke. METHOD: We retrospectively studied 256 first-ever stroke patients treated in Dong-Eui hospital from March 1997 to February 1998. Telephone or out-patient interviews were performed with these patients regarding stroke recurrence and treatment for hypertension and diabetes mellitus. These were divided into two groups, those with recurrence and those without. Evaluated risk factors for stroke recurrence were the following: history of diabetes mellitus, hypertension, heart disease, smoking, alcohol drinking, and transient ischemic attack; clinical findings at admission of hypertension, diabetes mellitus, hyperlipidemia, heart disease, type and location of stroke; treatment compliance for diabetes mellitus and hypertension after discharge. RESULTS: The recurrence rate after first-ever stroke was 12.9%. In univariate analysis, significant risk factors for stroke recurrence were history of smoking, clinical findings at admission of diabetes mellitus, atrial fibrillation, ischemic heart disease, and non-compliance with therapy for diabetes mellitus and hypertension after discharge (p<0.05). In multivariate analysis, significant risk factors for stroke recurrence were atrial fibrillation at admission (odds ratio=3.43) and non-compliance with therapy for hypertension after discharge (odds ratio=7.51)(p<0.05). CONCLUSION: History of smoking, clinical findings at admission of diabetes mellitus, atrial fibrillation, ischemic heart disease, and non-compliance with therapy for diabetes mellitus and hypertension after discharge are considered to be important factors for recurrence of stroke. So treatment and education for those factors associated with stroke recurrence are needed during rehabilitation program.
Alcohol Drinking
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Atrial Fibrillation
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Compliance
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Diabetes Mellitus
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Education
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Heart Diseases
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Humans
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Hyperlipidemias
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Hypertension
;
Ischemic Attack, Transient
;
Multivariate Analysis
;
Myocardial Ischemia
;
Outpatients
;
Recurrence*
;
Rehabilitation
;
Retrospective Studies
;
Risk Factors*
;
Smoke
;
Smoking
;
Stroke*
;
Telephone
8.Patterns of Voiding Dysfunction of Stroke Patients during Rehabilitation.
Moo Kyum KIM ; Hoan Nyoung LEE ; Ki Rim KIM ; Kyoung Min LEE ; In Kil LEE ; Eun Ho CHOI
Journal of the Korean Academy of Rehabilitation Medicine 2001;25(4):551-558
OBJECTIVE: The purpose of this study is to evaluate the patterns of voiding dysfunction of stroke patients during rehabilitation. METHOD: We evaluated 53 patients with complaints of voiding dysfunction following the strokes. After the comprehensive history and physical examination, all patients underwent cystometric study and males underwent the transrectal ultrasound. RESULTS: The incidences of detrusor hyperreflexia, detrusor areflexia, and normal finding on the cystometry were 50.9%, 32.1%, and 17.0%, respectively (p<0.05). There was a significantly high incidence of detrusor hyperreflexia in the groups of subcortical lesion, large lesion, and the over 3 months after stroke (p<0.05). However, there was no statistical difference on cystometric findings according to the other characteristics of the stroke such as the age, sex, type of stroke, cognition, aphasia, and diabetes mellitus. The incidences of irritative, obstructive, and mixed symptoms according to the presenting voiding complaints were 49.1%, 32.1%, and 18.9%, respectively (p<0.05). There was no significant statistical difference on the cystometric findings according to the 3 voiding symptom groups as well as none of significant statistical difference on prostate enlargement in males in according to the 3 voiding symptom groups. CONCLUSION: Only with the pattern of voiding, we could not predict the cystometric finding or the presence of bladder outlet obstruction. Thus, we recommend the further studies including cystometry and evaluation of the bladder outlet obstruction for the treatment of voiding dysfunction of stroke patients during rehabilitation.
Aphasia
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Cognition
;
Diabetes Mellitus
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Humans
;
Incidence
;
Male
;
Physical Examination
;
Prostate
;
Reflex, Abnormal
;
Rehabilitation*
;
Stroke*
;
Ultrasonography
;
Urinary Bladder Neck Obstruction
9.Recurrent rhinocerebral mucormycosis: A case report.
Ho Sung KIM ; Jin Young PARK ; Bo Young YUN ; Eun Sil DONG ; Hee Young SHIN ; Hoan Jong LEE ; Hyo Seop AHN
Journal of the Korean Pediatric Society 1993;36(4):589-595
A case of recurrent rhinocerebral mucormycosis that has occurred during an induction chemotherapy for acute megakaryocytic leukemia in a 10 year-old boy is reported. He had suffered from high fever, proptosis, right eye ball pain and necrotic inflammation of hard palate during the chemotherapy of leukemia. CT scan of the paranasal sinus showed inflammatory change of right ethmoid and maxillary sinuses, and right orbital cystic mass which displaced medial rectus muscle. Pathologic examination of the inflammatory mass revealed mucormycosis with characteristic hyphae invading vessel walls. He was managed with 2 times of extensive debridement of necrotic tissue and currettage of cystic mass, and intravenous amphotericin-B for 80 days with apparent improvement. Seven months after discharge from the hospital, necrosis of posterior nasal septum and hard palate was noted for second time. It was managed again with 2 times of extensive debridement. Since this last operation he is on follow-up for 16 months uneventfully and is on therapy with low dose Ara-C in continuous remission.
Child
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Cytarabine
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Debridement
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Drug Therapy
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Exophthalmos
;
Fever
;
Follow-Up Studies
;
Humans
;
Hyphae
;
Induction Chemotherapy
;
Inflammation
;
Leukemia
;
Leukemia, Megakaryoblastic, Acute
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Male
;
Maxillary Sinus
;
Mucormycosis*
;
Nasal Septum
;
Necrosis
;
Orbit
;
Palate, Hard
;
Tomography, X-Ray Computed
10.Three-Dimensional Approach to Stem Cell Therapy.
Journal of Korean Medical Science 2002;17(2):151-160
Recent progress in stem cell research is opening a new hope for cell therapy in regenerative medicine. Two breakthroughs were made in the stem cell era, one, new discoveries in multipotentiality of adult stem cells beyond the traditionally appreciated extent, and the other, establishment of pluripotent stem cell from human embryo. In addition to the newly identified multipotentiality of adult stem cells, their ability to be trans-differentiated toward other tissue types (stem cell plasticity) as well as to migrate toward the site of tissue damage make adult stem cells particularly attractive choice for stem cell based therapy. Stem cell therapy for organ regeneration, therefore, could be approached from three distinct dimensions: first, direct differentiation of multi-potent stem cells toward desired tissue types; secondly, regeneration of specific tissues through in vivo stem cell plasticity, and lastly, by tissue-specific stem cells from many types of organs. While each approach in stem cell therapy poses distinctive limitations for their success-ful clinical applications, understanding regulatory mechanisms of stem cell selfrenewal and their in vivo engraftment will mostly extend their medical efficacy of stem cell based therapy.
Animals
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*Hematopoietic Stem Cell Transplantation
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Humans
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Stem Cells/*physiology
;
Umbilical Cord