The effect of intravesical formalin instillation as a therapeutic modality for intractable bladder hemorrhage in well known. And despite clear evidence of therapeutic efficacy of intravesical cytotoxic drugs and / or BCG immunotherapy, there have been substantial recurrences during follow up after transurethral resection for superficial bladder tumor. If formalin injected at the bed of superficial bladder tumor is able to coagulate and necrotize the tumor, it will be greatly helpful to the patients with recurrent bladder tumor developed during follow up. Since this technique is applicable on outpatient basis, an economical as well as a psychological burden of the patients can be reduced considerably. The purpose of this study is to evaluate the effect of submucosal formalin injection on rat bladder wall. 36 healthy adult male Sprague-Dawley rats (weighing 350 gm in average) were divided into 3 groups: In Group I (control group), 0.01ml of normal saline was injected submucosally at the left posterolateral wall of the bladder opened under intraperitoneal Nembutal anesthesia; In Group II and III, 0.01 ml of 10% and 4% formalin, respectively, were administered at the same site as in the Group I, two rats in each group were sacrificed at day 1, 2, and 3, and week 1, 2, and 4 after injection, respectively. Gross and microscopic examination of the cystectomized specimen were done in each group. In the Group II, bladder stones were formed at week 1, and in both the Group I and III, stones were seen at week 2 post injection. There was no significant difference in histologic findings of the bladder between the group II and III. Mucosal ulcer and/or prominent mucosal disruption was observed at 24 hours after injection in both Group II and III. Epithelial regeneration began at day 2, and was marked at day 3, and epithelial lining was almost normalized one week after injection. Subepithelial edema, telangiectasia and inflammatory reaction were prominent at 24 hours post formalin injection. Subepithelial edema persisted in moderate degree for 1 week. Telangiectasia and inflammatory reaction were noted for 4 weeks. Mild degree of these findings also appeared in the control group. Fibroblastic proliferation appeared at day 2 and persisted in moderate degree for 4 weeks. There has been no mortality or bladder perforation. These results suggest that clinical application of this technique is feasible for the selected cases of recurrent, solitary superficial bladder tumor. However, optimal dosage of formalin in relation to the size of the lesion remains to be investigated.
Adult ; Anesthesia ; Animals ; Edema ; Fibroblasts ; Follow-Up Studies ; Formaldehyde* ; Hemorrhage ; Humans ; Immunotherapy ; Male ; Mortality ; Mycobacterium bovis ; Outpatients ; Pentobarbital ; Rats* ; Rats, Sprague-Dawley ; Recurrence ; Regeneration ; Telangiectasis ; Ulcer ; Urinary Bladder Calculi ; Urinary Bladder Neoplasms ; Urinary Bladder*

No abstract available.
Arthroplasty, Replacement, Knee*

No abstract available.
Arthroplasty* ; Carbon* ; Knee*

The anterior cruciate ligament(ACL) is one of the main structures which have a stabilizing function of the knee. If a knee with a complete tear of ACL is not treated operatively, progressive instability develops, and the knee has a high risk of incurring meniscal is required. From March, 1989 to December 1992, we reconstructed ACL using patellar tendon with Kennedy-ligament augmentation device(LAD) in 26 patients. Nine patients had acute injuries and 17 patients had chronic rupture. In eleven patients operation was done arthroscopically, and in fifteen patients operation was done by arthrotomy. We used quadriceps tendon-patellar periosteum-patellar tendon in 16 cases and bone-patellar tendon-bone in ten cases. The length of follow-up ranged from 6 month to 33 months (mean; 10 months). We obtained satisfactory results in 22 cases.
Anterior Cruciate Ligament Reconstruction ; Anterior Cruciate Ligament ; Follow-Up Studies ; Humans ; Knee ; Patellar Ligament ; Rupture ; Tears ; Tendons

The peripheral blood eosinophil and serum IgE level in 53 patients with atopic dermatitis (AD) were measured. The patients were divided into 2 groups by severity(mild and severe grous) and into 3 groups by the associated respiratory atopic deseases and/or their family history : respiratory group(patient, with both AD and respiratory atopy), family history group (patient with both AD and family history of respiratory atopy), and atopic group(patient with neither respiratory atopy nor family history of respiratorv atopy). We designed to study which factors are important in the elevation of serum IgE and peripheral blood eosinophil level in AD, and to know possible relationships between the serum eosinophil and IgE level and the several groups of AD. The results are as follows : 1. Peripheral eosinophil counts were higher in severe group(224.8/mm) than in mild group (180.0/mm)(p<0.05). 2. Peripheral eosinophil counts were 220.0/mm in atopic group, l65.0/mm in family history group, and 332.4/mm in respiratory group, but there was no stitistically significant difference among 3 groups. This suggests that concomitant respiatitiry atopy or a family history of respiratory atopy is not an important factor in the elvation of peripheral blood eosinophil counts in AD. 3. Serum IgE was higher in severe group(443.2IU/ml) than in mild group(231.5IU/ml)(p<0.05). 4. Serum IgE level in respiratory group(754.6IU/ml) were signifiiantlly higher than in atopic (286.6IU/ml) or family history group(342.0IU/ml)(p<0,01). But there was no significant. difference between family and atopic group. This result suggests that concomittent respiratory atopy is a potential factor in elevation of serurn Igi in AD. 5. Slightly high correlation between peripheral blood and IgE level appeared in all 53 patients (r=0.434) and severe group(r=0.480). But, respiratory group(r=0.060), family history group(r=0.111) and atopic group(r=0.202) showed poor relationships.
Dermatitis, Atopic* ; Eosinophils* ; Humans ; Immunoglobulin E*

Paroxysmal Nocturnal Hemoglobinuria (PNH) is an uncommon hematologic disease characterized by an abnormal sensitivity of blood cells to the lytic action of serum complement. We experienced one case of PNH in Yeungnam University Hospital from May 1983 to May 1989. The patients was followed up without severe complications of 4 years since diagnosis with the only conservative treatments such as washed blood transfusion, adrenal corticosteroids, androgens, folate and iron preparation, intermittently.
Adrenal Cortex Hormones ; Androgens ; Blood Cells ; Blood Transfusion ; Complement System Proteins ; Diagnosis ; Folic Acid ; Hematologic Diseases ; Hemoglobinuria, Paroxysmal* ; Humans ; Iron

A case of epidermodysplasia verruciformis associated with squamous cell carcinoma occurred in 21 years old male. He had extensive flat-topped papules on the face, neck and the upper trunk, and verrucous lesions on the extremities, especially on the dorsa of hands and feet for 15 years. Several peanut sized ulcerative lesions on the forehead were noticed for 1 year and identified as squarnous cell carcinomi. The akin test with dinitrochlorobenzene, tuberculin, phytohemagglutinin, candidin and dermatophytin showed alI negative. T and B-cell counts were within norrnal limits, but IgG and IgD levels in serurn were incresed.
B-Lymphocytes ; Carcinoma, Squamous Cell* ; Dinitrochlorobenzene ; Epidermodysplasia Verruciformis ; Extremities ; Foot ; Forehead ; Hand ; Humans ; Immunoglobulin D ; Immunoglobulin G ; Male ; Neck ; Tuberculin ; Ulcer ; Young Adult

We experienced a case of Reiter's syndrome. A 20-year-old Korean male patient of Reiter's syndrome was reported. He had been suffered from mucopurulent urethral discharge, followed by white scaly patches on the skin, fever, transient conjunctivitis and arthralgia. Initially he was treated with sodium salicylic acid (Aspirin), indomethacin 150 mg/day for arthralgia and prednisolone 30mg/day. In accordance with improvement of symptom., prednisolone was tapered to 12. 5mg, when methotrexate 20mg/wk was added for the prevention of side effects of long term use of corticosteroids, Conjunctivitis, arthritis, and skin lesions cleared within 7 months. With improvement of symptoms, prednisolone was tapered and methotrexate also was tapered slowly. Physical therapy for joint stiffness was done.
Adrenal Cortex Hormones ; Arthralgia ; Arthritis ; Conjunctivitis ; Fever ; Humans ; Indomethacin ; Joints ; Male ; Methotrexate* ; Prednisolone* ; Salicylic Acid ; Skin ; Sodium ; Young Adult

Menetrier's disease is characterized by enlarged gastric folds with foveolar hyperplasia and cystic dilatation of gastric glands. The additional biochemical features of hypoproteinemia, hypochlorhydria, and increased gastric mucus are often encountered. The pathogenesis and etiologic factors have not been clearly defined. In this report, we present two cases of Menetrier's disease in the stomach, one occurring in a 38-year-old male, associated with massive hematemesis, and the other in a 39-year-old male. Grossly, both cases showed marked giant gastric rugal folds resembling cerebral convolutions, sparing the antral portion. Microscopically, the giant gastric rugal folds consisted of the striking foveolar hyperplasia accompanied by an occasional presence of the smooth muscle fibers from the muscularis mucosa. The immunohistochemical stain revealed an intense positive reaction for transforming growth factor-alpha (TGF-alpha) and epidermal growth factor receptor (EGF-R) in the majority of mucous cells throughout the gastric mucosa and parietal cells, but did not reveal for epidermal growth factor (EGF). We suggested that TGF-alpha and EGF-R might be involved in the pathogenesis of Menetrier's disese.
Achlorhydria ; Adult ; Dilatation ; Epidermal Growth Factor ; Gastric Mucosa ; Gastritis, Hypertrophic* ; Hematemesis ; Humans ; Hyperplasia ; Hypoproteinemia ; Immunohistochemistry ; Male ; Mucous Membrane ; Mucus ; Muscle, Smooth ; Rabeprazole ; Receptor, Epidermal Growth Factor ; Stomach ; Strikes, Employee ; Transforming Growth Factor alpha

We report an unusual case of sebaceous hyperplasia in an 18-year-old male manifestated clinically as yellowish, grouped papules with a linear distribution, present on the right side of forehead since birth. Histopathologically, a large sebaceous gland composed of numerous lobules grouped around a centrally dilated duct was seen. The sebaceous lobules distributed in the upper dermis showed direct connection to the skin surface, which suggested a transepidermal elimination of sebaceous lobules.
Adolescent ; Dermis ; Forehead ; Humans ; Hyperplasia* ; Male ; Parturition ; Sebaceous Glands ; Skin