We report an unusual case of sebaceous hyperplasia in an 18-year-old male manifestated clinically as yellowish, grouped papules with a linear distribution, present on the right side of forehead since birth. Histopathologically, a large sebaceous gland composed of numerous lobules grouped around a centrally dilated duct was seen. The sebaceous lobules distributed in the upper dermis showed direct connection to the skin surface, which suggested a transepidermal elimination of sebaceous lobules.
Adolescent ; Dermis ; Forehead ; Humans ; Hyperplasia* ; Male ; Parturition ; Sebaceous Glands ; Skin

The peripheral blood eosinophil and serum IgE level in 53 patients with atopic dermatitis (AD) were measured. The patients were divided into 2 groups by severity(mild and severe grous) and into 3 groups by the associated respiratory atopic deseases and/or their family history : respiratory group(patient, with both AD and respiratory atopy), family history group (patient with both AD and family history of respiratory atopy), and atopic group(patient with neither respiratory atopy nor family history of respiratorv atopy). We designed to study which factors are important in the elevation of serum IgE and peripheral blood eosinophil level in AD, and to know possible relationships between the serum eosinophil and IgE level and the several groups of AD. The results are as follows : 1. Peripheral eosinophil counts were higher in severe group(224.8/mm) than in mild group (180.0/mm)(p<0.05). 2. Peripheral eosinophil counts were 220.0/mm in atopic group, l65.0/mm in family history group, and 332.4/mm in respiratory group, but there was no stitistically significant difference among 3 groups. This suggests that concomitant respiatitiry atopy or a family history of respiratory atopy is not an important factor in the elvation of peripheral blood eosinophil counts in AD. 3. Serum IgE was higher in severe group(443.2IU/ml) than in mild group(231.5IU/ml)(p<0.05). 4. Serum IgE level in respiratory group(754.6IU/ml) were signifiiantlly higher than in atopic (286.6IU/ml) or family history group(342.0IU/ml)(p<0,01). But there was no significant. difference between family and atopic group. This result suggests that concomittent respiratory atopy is a potential factor in elevation of serurn Igi in AD. 5. Slightly high correlation between peripheral blood and IgE level appeared in all 53 patients (r=0.434) and severe group(r=0.480). But, respiratory group(r=0.060), family history group(r=0.111) and atopic group(r=0.202) showed poor relationships.
Dermatitis, Atopic* ; Eosinophils* ; Humans ; Immunoglobulin E*

Because clinical course of the Legg-Calve'-Perthes disease (LCPD) is varied and unpredictable, it is important that pediatric orthopedists have to know prognostic factors of LCPD in order to choose proper method of treatment. The most universally accepted prognostic factor is the patient's age at the onset of the disease, and most patient's who are less than 5 years old have been treated non-operatively. However, we believe that the extent of involvement of the femoral head is more important in this age group and that operative treatment can get good results in cases of servere head involvement. The purpose of this study is to evaluate the efficacy of femoral varus osteotomy in patients before the age of 5 years with severe involvement. We reviewed 18 patients (23 hips) who were less than 5 years old with Catterall group III (5 patients, 7 hips) or IV (13 patients, 16 hips) involvement from June 1984 to June 1994. Femoral varus osteotomies were performed in all cases. We followed up more than 2 years (range, from 24 to 130 months) and analysed clinical and radiological results. The results were as follows: 1. The mean duration from onset of the disease to the stage of repair was 16 months (range, from 8 to 27 months). 2. 2 hips (28.6%) in group III and 12 hips (75%) in group IV showed radiographic head at-risk signs. 3. Clinically all hips in group III showed good result. However, among the 16 hips in group IV, 13 hips were rated good and 3 hips were fair. Overall, 20 hips (86.9%) showed good result. 4. Radiologically all hips in group III showed good result, whereas in group IV, 10 hips were rated good and 6 hips were fair. Overall, 17 hips (78.9%) showed good result. We concluded that femoral varus osteotomy in patients less than 5 years old with severe involvement might shorten the course of disease and might be effective method.
Child* ; Child, Preschool* ; Fibrinogen ; Head ; Hip ; Humans ; Legg-Calve-Perthes Disease* ; Osteotomy*

Recent advances in surgical techniques and equipment have made bone lengthening by callotasis both easier and safer, and many successful clinical cases have been reported. The callus formation, however, has often been very poor, and prolonged applied of the external jixator increases the risk of serious complications, such as pin tract infection. We reviewed 68 cases of limb lengthenings performed with callus distraction in 48 patients at Kang Nam St. Mary' s Hospital between January 1989 and May 1994. There were 29 female and 19 male patients, with an average age of 19 (6-50) years. Causes of limb shortening were short stature (14), poliomyelitis (8), fracture and physeal damage (6), osteomyelitis (6), Legg-Calve-Perthe's disease (4), bone tumor (3), congenital dislocation of the hip (3), leg length discrepancy (3), achondroplasia (2) and hip dysplasia (1). Sixty eight calluses were classified radiographically into 6 types: external, straight, attenuated, opposite, pillar, and scattered. The healing indexes and complications following the procedure were evaluated. The mean femoral lengthening was 6.2 (2-10) cm, the tibial 6.5 (3.3-15.7) cm, the forearm 1.8 (1.6- 2.2) cm and the humerus 10 cm. Fifteen cases classified as external type, 5 femur, 7 tibiae, 2 forearm and 1 humerus, with healing index of 34 days/cm and no major complications. Thirty one cases classified as straight type, 7 femur, 22 tibiae, 1 forearm and 1 humerus with healing index of 38 days/cm and 2 obstacles. Fourteen cases classified as attenuated type, 4 femur and 10 tibiae with healing index of 47 days/cm and 2 obstacles. Six cases classified as opposite type, 4 femur and 2 tibiae with healing index of 65 days/cm and 3 obstacles and 1 residual complications. Two cases classified as scattered type, 2 tibiae with healing index of 116 days/cm and 5 obstacles. The scattered type of the callus in two cases was suspected to be a result of poor callus formation due to K-wire breakage conditions that autogenous bone marrow transplantations were performed. This classification enabled us to estimate the intrinsic conditions, predict the healing index, incidence of complications, and decide to apply early bone marrow injection to the callus.
Achondroplasia ; Bone Lengthening ; Bone Marrow ; Bony Callus* ; Classification* ; Dislocations ; Extremities* ; Female ; Femur ; Forearm ; Hip ; Hip Dislocation ; Humans ; Humerus ; Incidence ; Leg ; Male ; Osteogenesis, Distraction ; Osteomyelitis ; Poliomyelitis ; Tibia

In 1941, Jaffe and coworkers studied a lesion with histologic appearance of fibrous stroma, pigmented deposition and histiocytic infiltration as well as giant cell, for which they named pigmented villonodullar synovitis, bursitis and tenosynovitis. Thereafter many authors have disscussed etiology, clinical and radiological features, pathology and treatment regarding the disease. Recently we experienced a case of pigmented villonodular synovitis involving an hip joint which was treated by synovectomy and total hip replacement with good result.
Arthroplasty, Replacement, Hip ; Bursitis ; Giant Cells ; Hip Joint ; Hip ; Pathology ; Synovitis ; Synovitis, Pigmented Villonodular ; Tenosynovitis

Adenoid basal cell tumor of the prostate is a rare tumorous lesion that can be misdiagnosed as adenocarcinoma of the prostate. The malignant potential of adenoid basal cell tumor remains uncertain due to small number of reported cases. This 66-year-old man presented with symptoms of urinary tract obstruction. Under the impression of benign prostatic hyperplasia, a transurethral resection of the prostate (TURP) was performed. The patient was alive with no evidence of recurrence or metastasis 15 months after TURP. Microscopically, most of the lesions were composed of nodular collections of small nests of basaloid cells with peripheral palisading, and clusters of tumor cells forming cribriform pattern. Multiple areas of basal cell hyperplasia and atypical basal cell hyperpalsia were also observed. The coexistence of basal cell hyperplasia, atypical basal cell hyperpalsia, and adenoid basal cell tumor with cribriform pattern in this case supports a morphologic continuum from the benign hyperplastic lesion to malignant neoplasia.
Adenocarcinoma ; Adenoids* ; Aged ; Humans ; Hyperplasia ; Neoplasm Metastasis ; Prostate* ; Prostatic Hyperplasia ; Recurrence ; Transurethral Resection of Prostate ; Urinary Tract

A case of contact dermatitis due to herb onintment is described in a 24 year-old female patient. After topical application of herb ointment, she developed erythematous papules and plaques on the face and neck. Patch test revealed positive reactions to ammoniated mercury, thimerosal, and the herb ointment. Energy-dispersive X-ray microanalysis of the herb ointment showed a striking peak for mercury.
Dermatitis, Contact* ; Electron Probe Microanalysis ; Female ; Humans ; Neck ; Patch Tests ; Strikes, Employee ; Thimerosal ; Young Adult

Recent investigations have revealed that autocrine growth factors and their receptors are closely related and play an important role in controlling cancer cell growth. We performed an immunohistochemical study on the expression of epidermal growth factor (EGF), transforming growth factor-alpha (TGF-alpha), epidermal growth factor receptor (EGF-R), c-erbB-2, and PCNA labelling index in 60 cases of human gastric carcinomas. TGF-alpha was detected in 38 cases (63.3%), EGF in 26 cases (43.3%), EGF-R in 44 cases (73.3%), and c-erbB-2 in 18 cases (30%). These growth factors, EGF-R and c-erbB-2, were found more often in advanced gastric cancers. The PCNA labeling index was significantly higher in tumors with the expression of EGF-R or c-erbB-2. Tumors with simultaneous expression of EGF, TGF-alpha, EGF-R and c-erbB-2 was associated with a high PCNA labeling index. A correlation was observed between the synchronous expression of growth factors and its receptors and histological differentiation. The results suggest that the expression of EGF, TGF-alpha, EGF-R and c-erbB-2 are closely related and plays an important role in the growth and progression of human gastric carcinoma.
Epidermal Growth Factor* ; Humans ; Intercellular Signaling Peptides and Proteins ; Peptides* ; Proliferating Cell Nuclear Antigen ; Receptor, Epidermal Growth Factor ; Stomach Neoplasms ; Transforming Growth Factor alpha

No abstract available.
Aspirin* ; Epithelial Cells*

PURPOSE: To investigate the clinical features of 7 cases (8 eyes) of normal-tension glaucoma with the temporal visual defect only. METHODS: Patient's age, gender, systemic disease, refractive error, intraocular pressure, stereo disc photograph, nerve fiber layer photograph and visual field were analyzed. RESULTS: Age was 32+/-5 years, male:female ratio was 2:5 and 6 eyes were unilateral. Refractive error was -8.80+/-3.80 D, intraocular pressure was 16.0+/-1.90 mmHg and cup:disc ratio was 0.66+/-0.09 (horizontal) X 0.58+/-0.10 (vertical). There was disc hemorrhage in 1 eye, nasal cup in 1 eye, beta-type peripapillary atrophy in 2 eyes and undermining of nasal cup edge in 5 eyes. Pattern of temporal visual field defect, corresponding to the retinal nerve fiber layer defect were horizontal in 1 eye, cecopetal in one eye and cecofugal in 6 eyes. CONCLUSIONS: It is recommend to carefully evaluate nerve fiber layer in the young, high myopic patients showing undermining of nasal cup edge.
Atrophy ; Glaucoma* ; Hemorrhage ; Humans ; Intraocular Pressure ; Nerve Fibers ; Refractive Errors ; Retinaldehyde ; Visual Fields*