1.Protective effects of astragalosides on pancreatic tissue in diabeticrats
International Journal of Traditional Chinese Medicine 2016;38(3):242-246
Objective To investigate the protective effects of astragalosides on pancreatic tissue in diabetic rats.Methods The experimental diabetic rat models were made by feeding with high fat and sugar and injecting STZ, and according to blood glucose level, the rat models were randomly devided into five groups: a diabetic model control group, an astragalosides low (30 mg/kg), a medium (60 mg/kg), a high (120 mg/kg) dose treated groups and a metformin hydrochloride 200 mg/kg treated group (n=16), and selected another 16 same-aged rats as a normal control group. 72 h after the models were made, the drugs were given by intragastric administration for 4 weeks, once a day. Before and after the drugs were given 7, 14, 21, 28 days, the level of plasma glucose (FPG) and insulin (FINS) were determined, and the ISI and HOMA-IR were calculated, the level of T-AOC and the content of ROS in serum were detected, the activity of SOD, CAT and the content of MDA in pancreatic tissue were detected, the histopathological changes of pancreatic tissue and pancreatic cells apoptosis were observed, and the apoptosis index were analyzed.Results Four weeks later, compared with the diabetic model control group, the FINS (9.34 ± 1.67 mIU/ml, 10.46 ± 1.51 mIU/mlvs.7.37 ± 1.39 mIU/ml) and the level of ISI (6.82 ± 0.96, 6.52 ± 0.79vs.7.35 ± 0.84) in astragalosides medium and high dose treated groups were significantly increased (P<0.05 orP<0.01), the level of HOMA-IR (43.62 ± 5.26, 29.37 ± 4.51vs.61.70 ± 5.85) were significantly decreased (P<0.05 orP<0.01). The level of FPG (9.32 ± 2.57 mmol/Lvs.17.15 ± 2.54 mmol/L) in astragalosides high dose treated group was significantly decreased (P<0.01), the level of T-AOC (12.20 ± 3.36 U/L vs.9.34 ± 2.59 U/L) in serum was significantly increased (P<0.01). The activity of SOD (11.52 ± 2.31 U/mg, 15.29 ± 2.50 U/mgvs.7.53 ± 1.86 U/mg) in serum of astragalosides medium and high dose treated groups were significantly increased (P<0.05 orP<0.01). The content of MDA (2.83 ± 0.37 nmol/mg, 1.92 ± 0.31 nmol/mgvs. 4.08 ± 0.42 nmol/mg) in pancreatic tissue of astragalosides medium, high dose treated groups were significantly decreased (P<0.05 orP<0.01); the activity of SOD (11.52 ± 2.31 U/mg, 15.29 ± 2.50 U/mgvs.7.53 ± 1.86 U/mg) and CAT (392.28 ± 38.05 U/g, 461.73 ± 42.52 U/gvs. 280.46 ± 29.61 U/g) were significantly increased (P<0.05 orP<0.01).Conclusion Astragalosides had protective effects on pancreatic tissue in diabetic rats.
2.The Critical Text from Boramae's Medical Dispute.
Journal of the Korean Medical Association 2004;47(9):814-817
No abstract available.
Dissent and Disputes*
3.The Critical Text from Boramae's Medical Dispute.
Journal of the Korean Medical Association 2004;47(9):814-817
No abstract available.
Dissent and Disputes*
4.Peumomediastinum in the Newborn.
Journal of the Korean Pediatric Society 1985;28(3):217-224
No abstract available.
Humans
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Infant, Newborn*
5.New start.
Journal of Korean Academy of Oral Health 2017;41(2):71-72
No abstract available.
Dental Research
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Journalism, Dental
;
Periodicals as Topic
;
Peer Review
;
Publishing
6.Spontaneous Pneumothorax in the Newborn.
Journal of the Korean Pediatric Society 1985;28(1):16-24
No abstract available.
Humans
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Infant, Newborn*
;
Pneumothorax*
7.A case of delivery in paroxysmal noctumal hemoglobinuria.
Korean Journal of Obstetrics and Gynecology 1991;34(6):865-870
No abstract available.
Hemoglobinuria*
8.Oral health and the war crisis.
Journal of Korean Academy of Oral Health 2017;41(3):163-164
No abstract available.
Oral Health*
9.Some Future-oriented Roles and Phases for the Ethics Committee of KMA.
Journal of the Korean Medical Association 2001;44(9):938-940
No abstract available.
Ethics Committees*
;
Ethics*