OBJECTIVE: The purpose of this study was to review the clinical features, treatments and prognosis of the borderline malignant tumors of the ovary. METHODS: Thirty-two patients with borderline malignant tumors of the ovary were admitted, operated and confirmed with postoperative histopathological study at department of obstetrics and gynecology, Yonsei University Wonju Christian Hospital. The data were collected retrospectively and all charts were reviewed. RESULTS: The incidence of borderline malignant ovarian tumor was 19.2% (32/167). Age distribution revealed between 18 and 77 years old, the mean age was 43.1 years old. As for the parity distribution of borderline malignant tumor, nulliparity was most common (43.8%). The most common chief complaint was abdominal distension (34.4%). Histologic subtypes were mucinous in 19 cases (59.4%), serous in 13 cases (40.6%). According to FIGO classification, 28 cases (87.5%) were stage I, 1 case (3.1%) was stage II, 3 cases (9.4%) were stage III. Sixteen cases (50%) underwent conservative surgery (unilateral salpingooophorectomy or cystectomy). Sixteen cases (50%) were treated with total abdominal hysterectomy and bilateral salpingooophorectomy. Fifteen cases (46.9%) received adjuvant postoperative chemotherapy. Excluding 5 cases lost to follow up, patients were alive and were followed from 9 months to 100 months. (mean 36 months).
Age Distribution ; Aged ; Classification ; Drug Therapy ; Female ; Gangwon-do ; Gynecology ; Humans ; Hysterectomy ; Incidence ; Lost to Follow-Up ; Mucins ; Obstetrics ; Ovary* ; Parity ; Prognosis ; Retrospective Studies

OBJECTIVE: The purpose of this study was to review the clinical features, treatments and prognosis of the borderline malignant tumors of the ovary. METHODS: Thirty-two patients with borderline malignant tumors of the ovary were admitted, operated and confirmed with postoperative histopathological study at department of obstetrics and gynecology, Yonsei University Wonju Christian Hospital. The data were collected retrospectively and all charts were reviewed. RESULTS: The incidence of borderline malignant ovarian tumor was 19.2% (32/167). Age distribution revealed between 18 and 77 years old, the mean age was 43.1 years old. As for the parity distribution of borderline malignant tumor, nulliparity was most common (43.8%). The most common chief complaint was abdominal distension (34.4%). Histologic subtypes were mucinous in 19 cases (59.4%), serous in 13 cases (40.6%). According to FIGO classification, 28 cases (87.5%) were stage I, 1 case (3.1%) was stage II, 3 cases (9.4%) were stage III. Sixteen cases (50%) underwent conservative surgery (unilateral salpingooophorectomy or cystectomy). Sixteen cases (50%) were treated with total abdominal hysterectomy and bilateral salpingooophorectomy. Fifteen cases (46.9%) received adjuvant postoperative chemotherapy. Excluding 5 cases lost to follow up, patients were alive and were followed from 9 months to 100 months. (mean 36 months).
Age Distribution ; Aged ; Classification ; Drug Therapy ; Female ; Gangwon-do ; Gynecology ; Humans ; Hysterectomy ; Incidence ; Lost to Follow-Up ; Mucins ; Obstetrics ; Ovary* ; Parity ; Prognosis ; Retrospective Studies

A male, 5-year-old Jindo dog underwent enterectomy and enteroanastomosis due to ileus of the intestine at a local veterinary hospital. Grossly, the excised intestine showed markedly thickened multinodular masses in the serosal layer of the upper part, and soft-to-firm, creamcolored neoplastic masses that displayed extensive nodular mucosal protuberances into the lumen. The neoplastic masses were filled with large round cells that were ovoid in shape and they had pale and/or hyperchromatic nuclei. The neoplastic cells had mainly infiltrated into the mucosal and submucosal layers, and they had diffusely invaded the muscular and serosal layers. Therefore, the diagnosis of canine multiple intestinal malignant lymphomatous polyposis was made based on the gross and histopathological findings. The origin of these tumor cells was determined to be B-cells since they were positive for anti-CD20.
Animals ; Antigens, CD20/metabolism ; Dog Diseases/*pathology/surgery ; Dogs ; Immunohistochemistry/veterinary ; Intestinal Neoplasms/pathology/surgery/*veterinary ; Intestinal Polyps/*pathology/surgery ; Lymphoma, Mantle-Cell/pathology/surgery/*veterinary ; Male

BACKGROUND: Malignant pleural effusion is a common condition in neoplastic patients and palliative therapy is the usual treatment. Talc has been generally accepted to be the most effective sclerosant for chemical pleurodesis, but the optimal route of administration remains controversy. We compared the results of video-assisted thoracoscopic talc poudrage (VTP) with administering a bedside talc slurry through a chest tube (BTS) for the treatment of malignant pleural effusion. MATERIAL AND METHOD: From December 2004 to May 2006, 20 patients with malignant pleural effusion underwent chemical pleurodesis via VTP (group A, n=10), and BTS (group B, n=10). RESULT:The durations of chest tube placement after the procedure were 7.0+/-4.0 days (group A) and 6.7+/-3.6 days (group B). The hospital stays were 24.3+/-9.4 days (group A) and 30.7+/-21.5 days (group B), respectively. The symptoms of dyspnea were much more improved in group A (p-value=0.014) after discharge (mean f/u group A=8.5+/-2.2 months, group B 8.0+/-7.4 months). The collapsed portions of lung were better expanded in group A than in group B (p-value= 0.011). CONCLUSION: We recommend VTP for the selected patients with malignant pleural effusion because of the advantages of dissecting the fibrous peel to relieve the atelectasis and dyspnea, and excising the pleura for diagnosis with direct viewing of the lesion.
Chest Tubes ; Diagnosis ; Dyspnea ; Humans ; Length of Stay ; Lung ; Palliative Care ; Pleura ; Pleural Effusion ; Pleural Effusion, Malignant* ; Pleurodesis ; Pulmonary Atelectasis ; Talc* ; Thoracoscopy

BACKGROUND AND OBJECTIVES: Dentigerous cysts arise from the reduced enamel epithelium and expand into the surrounding bone. They grow unnoticed to such extensive sizes as to occupy a considerable portion of the maxillary sinus. This study was designed to clarify the clinical, radiological and histopathological features of ten cases of the dentigerous cyst involving the maxillary sinus. MATERIALS AND METHODS: Medical records of ten patients, who were diagnosed with dentigerous cyst, were analyzed from June 1990 to May 2000 retrospectively. RESULTS: The greatest incidence of dentigerous cyst occurred between the ages of 10 and 30 years old (average age 29.6 years). Facial swelling and pain were the most common com-plaints, followed by oro-antral fistula, headache and facial numbness. CT scan of paranasal sinuses showed a slightly nonhomogeneous soft tissue density surrounded by an incomplete bony wall which occupied partially antral space. In the middle of the cyst, the isolated high density of unerupted tooth was seen. In the lining epithelium, the stratified squamous epitheliums were the most frequent. Six patients underwent cyst removal via Caldwell-Luc approach and four patients underwent cyst removal via intraoral approach. The postoperative course has been gone well without recurrence. CONCLUSIONS: The differential diagnosis and early detection of the dentigerous cyst in involving maxillary sinus are important. Rhinologist should be aware of this disease entity when encountered with patients presented with unilateral painful swelling of cheek.
Adult ; Cheek ; Dental Enamel ; Dentigerous Cyst* ; Diagnosis, Differential ; Epithelium ; Fistula ; Headache ; Humans ; Hypesthesia ; Incidence ; Maxillary Sinus* ; Medical Records ; Paranasal Sinuses ; Recurrence ; Retrospective Studies ; Tomography, X-Ray Computed ; Tooth, Unerupted

BACKGROUND AND OBJECTIVES: Dentigerous cysts arise from the reduced enamel epithelium and expand into the surrounding bone. They grow unnoticed to such extensive sizes as to occupy a considerable portion of the maxillary sinus. This study was designed to clarify the clinical, radiological and histopathological features of ten cases of the dentigerous cyst involving the maxillary sinus. MATERIALS AND METHODS: Medical records of ten patients, who were diagnosed with dentigerous cyst, were analyzed from June 1990 to May 2000 retrospectively. RESULTS: The greatest incidence of dentigerous cyst occurred between the ages of 10 and 30 years old (average age 29.6 years). Facial swelling and pain were the most common com-plaints, followed by oro-antral fistula, headache and facial numbness. CT scan of paranasal sinuses showed a slightly nonhomogeneous soft tissue density surrounded by an incomplete bony wall which occupied partially antral space. In the middle of the cyst, the isolated high density of unerupted tooth was seen. In the lining epithelium, the stratified squamous epitheliums were the most frequent. Six patients underwent cyst removal via Caldwell-Luc approach and four patients underwent cyst removal via intraoral approach. The postoperative course has been gone well without recurrence. CONCLUSIONS: The differential diagnosis and early detection of the dentigerous cyst in involving maxillary sinus are important. Rhinologist should be aware of this disease entity when encountered with patients presented with unilateral painful swelling of cheek.
Adult ; Cheek ; Dental Enamel ; Dentigerous Cyst* ; Diagnosis, Differential ; Epithelium ; Fistula ; Headache ; Humans ; Hypesthesia ; Incidence ; Maxillary Sinus* ; Medical Records ; Paranasal Sinuses ; Recurrence ; Retrospective Studies ; Tomography, X-Ray Computed ; Tooth, Unerupted

BACKGROUND AND OBJECTIVES: Guanylin and uroguanylin are small, heat-stable peptides that were originally isolated from the small intestine and urine, respectively. Functionally, it has been proposed that these peptides can regulate the ion and water transport in various fluid-transporting epithelia. The present study evaluated the presence of mRNAs for the human guanylin and uroguanylin in human inferior turbinate mucosa and nasal polyp. MATERIALS AND METHOD: The expression and localization of mRNA for both peptides were investigated in inferior turbinate tissues and nasal polyp using reverse transcriptase polymerase chain reaction (RT-PCR) and in situ hybridization. RESULTS: The mRNAs for both peptides were detected in human turbinate mucosa and nasal polyp. In situ hybridization revealed that they were localized in the epithelial layer and submucosal glands of inferior turbinate mucosa and in the epithelial layer of nasal polyp. However, their expression in the superficial epithelium of nasal polyp was noted at lower levels than in the inferior turbinate mucosa. CONCLUSION: These results indicate that guanylin and uroguanylin in the nasal mucosa may participate in normal physiological processes, but also suggest that altered expression of these genes in nasal polyp may cause impaired electrolyte and water transport across the epithelial cells.
Epithelial Cells ; Epithelium ; Humans* ; In Situ Hybridization ; Intestine, Small ; Mucous Membrane ; Nasal Mucosa* ; Nasal Polyps* ; Peptides ; Physiological Processes ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger* ; Turbinates ; Water

BACKGROUND AND OBJECTIVES: Electrolyte transport by nasal epithelia has been suggested to be important for controlling the quantity and composition of the nasal fluid and may play an important role in the development of nasal polyps. Transepithelial transport of ion and water in various fluid-transporting epithelia is strictly dependent on the localization of specific membrane proteins in the polarized epithelial cells. Na+ : HCO3-cotransporter (NBC) transports Na+ and HCO3- into the intracellular from extracellular space and induces the evacuation of H+, regulating pH. K+ : Cl- cotransporter (KCC) controls the cell volume and resorption of NaCl which is associated with the extracellular transport of K+ and Cl-. The present study evaluated the presense of mRNA for NBC and KCC in human inferior turbinate and nasal polyp. MATERIALS AND METHOD: The expression of NBC and KCC mRNA isoforms in inferior turbinate mucosa and nasal polyp was evaluated, using RT-PCR and in situ hybridization. RESULTS: RT-PCR revealed that the inferior turbinate and nasal polyp mucosa expressed kNBC, KCC1 and 4 mRNA. In in situ hybridization, their distribution was noted in the epithelial layer and submucosal glands of both mucosa. CONCLUSION: These results indicate that these types of ion transporters are expressed in human nasal mucosa and nasal polyp, controlling the fluid and ion transport in nasal epithelium and submucosal glands.
Cell Size ; Epithelial Cells ; Extracellular Space ; Humans* ; Hydrogen-Ion Concentration ; In Situ Hybridization ; Ion Transport ; Membrane Proteins ; Mucous Membrane ; Nasal Mucosa* ; Nasal Polyps* ; RNA Isoforms ; RNA, Messenger* ; Turbinates ; Water