1) The effectiveness of azathioprine (Imuran) in suppressing the immunogenic rejection of corneal grafts was studied by pathology. 2) The method of conjunctival implantation was used to produce neovascularization of the host cornea and the rejection of interlamellar allgraft and xenograft (rooster to rabbit) provided the experimental model against which the therapeutic efficacy of the drug was evaluated. There is almost same pathological finding between interlamellar homograft and heterograft. but the rejection phenomena of the heterograft group is slightly severer than homograft group. 3) On comparing the graft rejection between control and treated group in homograft and heterograft, the reaction in control group is severer than treated group. Microscopically, tbe cornea of treated group is almost transparent, but there are fibrosis of graft border, thickening of the host tissues and irregular arragement of corneal lamellae, by microscopically 4) On comparing between sensitized and non-sensitized group, no specific difference was observed by microspically.
Allografts ; Azathioprine* ; Cornea ; Fibrosis ; Graft Rejection ; Heterografts ; Immunosuppression* ; Models, Theoretical ; Pathology ; Transplants*

Author analysed the postexercise electrocardiogram of 139 cases of normal group and 106 cases of cardiovascular disease according to Rhee's criteria, Master's criteria and Lepeschkin's criteria. following results were obtained: 1. 8.7% of normal group was revealed positive by Rhee's criteria of analysis of double Masters'2 step excrcise test, 9.3% by Master's criteria and 27.3% by Lepeschkin's criteria, were as 35.8% of cardiovascular cases was revealed positive by Rhee's criteria, 38.6% by Master's criteria, and 43.3% by Lepeschkin's criteria. 2. Almost the same positive ratio was revealed both when by UP segment of Master and when by O point of Lepeschkin were considered to be the baseline. 3. Determination of QT ratio and the QX/QT fraction had no diagnostic value of ischemic heart disease. 4. No significant relationship was found between abnormal response of exercise electrocardiogram and coronary risk factors. 5. After exercise test, T wave changes were found in few cases, where as U wave changes were found in many cases, but both changes had no diagnostic value of ischemic heart disease.
Cardiovascular Diseases ; Diagnosis* ; Electrocardiography* ; Exercise Test ; Myocardial Ischemia* ; Risk Factors

No abstract available.

No abstract available
Cholangiopancreatography, Endoscopic Retrograde* ; Pancreas*

1. Alkali burns of rabbit corneas were produced by 5.0 N NaOH swabbing the cornea and surrounding sclera. 2. Collagenolytic activity of alkali burned corneas, and the effectiveness of collagenase inhibitors (0.2 M cysteine sol. and 0.5% zinc sulfate sol.) in preventing the perforation of corneas were studied by pathology. 3. In control group, almost 85% of coreas were perforated, but in treated group, no corneal perforations were found. 4. In control group, epithelial and endothelial thickenings are evident and no neovascularization could be seen, in treated group neovascularization is evident and slight cellular reactions were visualized.
Alkalies* ; Burns* ; Cornea* ; Corneal Perforation ; Cysteine ; Matrix Metalloproteinase Inhibitors ; Pathology ; Sclera ; Zinc Sulfate

No abstract available.
Humans ; Immunity, Humoral* ; Sputum*

No abstract available.
Adolescent* ; Humans

No abstract available.

No abstract available.
Arm*

A prospective study of vitamin B6, B12, folate, and homocysteine levels was carried out in 7 kidney transplant(KT) recipients. The first sample for the basal level was drawn on the morning of the KT day before the start of cyclosporine injection. Thereafter, serial blood samples were taken every day until the serum creatinine level decreased below 1.5 mg/dl and then every 2 or 3days until discharge. The serum creatinine level decreased to below 1.5 mg/dl within 3days except for cases 4 and 6. The homocysteine levels decreased markedly in synchronisation with serum creatinine levels increased during the first 7days and then declined together with serum creatinine levels but went up again after a few days. The levels of B6, and vitamin B12 do not continue to decrease after the levels of serum creatinine have decreased to 1.5mg/dl, while homocysteine levels go up progressively. In conclusion, contrary to our expectation, the level of homocysteine rebounds a few days after KT following a transient decline. A deficiency of folic acid, vitamin B6 and vitamin B12 does not seem to cause hyperhomocysteinemia in KT recipients. It is necessary to pay attention to hyperhomocysteinemia in KT recipients, especially when the recipients have an atherosclerosis-related complication.
Creatinine ; Cyclosporine ; Folic Acid ; Homocysteine* ; Hyperhomocysteinemia ; Kidney ; Kidney Transplantation* ; Plasma* ; Prospective Studies ; Vitamin B 12 ; Vitamin B 6