No abstract available.
Animals ; Antibody Formation* ; Bone Marrow Cells* ; Bone Marrow* ; Culture Media, Conditioned* ; Mice* ; Thymocytes*

No abstract available.
Culture Media, Conditioned* ; Thymocytes*

The ligamentum nuchae is a midline structure extending from the occiput to the spinous process of the 7th cervical vertebra. Radio-opaque formations in the soft tissues behind the processes of the cervical spine has been known to radiologists since Barsony's description in 1929. It may actually be a normal sesamoid, or it may have developed as a result of previous trauma. But this remains hypothetical in that histological endochondral ossification sequence has not yet been demonstrated. These are generally asymptomatic and of clinical significance only in so far as they may be confused with fracture or tumors. Two patients who had clinical symptoms with or without previous trauma visited and they were relieved of their clinical symptoms by surgical excision. Then, we report on two unusual cases which were symptomatic.
Humans ; Spine

Glomangiosarcoma is a histopathologically defined extremely rare malignant tumor that accompanies a glomus tumor usually, but its has benign clinical course characteristically. It shares common ultrastructural and immunohistochemical features with glomus tumor, and transformed possibly from glomus tumor". Glomangiosarcoma shows more sarcomatous appearance histologically than glomus tumor, however with no malignant behavior(i.e. recurrence or metastasis) was expressed. We experienced a case of glomangiosarcoma form subungual region treated by marginal excision and no recurrence or metastasis was developed untill 1 year and 6 months postoperatively.
Glomus Tumor ; Neoplasm Metastasis ; Recurrence

The effect of intravenous immune globulin (IVIG) on the lymphocyte phenotypes in acute Kawasaki disease (KD) was studied in a random trial of IVIG-and-aspirin versus aspirin-alone. Before therapy, patients in each treatment group had an increased percentage of B cells, and a decreased percentage of T cells, CD4 T cells, CD8 T cells and CD5+ B cells. There was no significant difference in immunologic parameters between the two groups measured before therapy. Patients treated with IVIG-and-aspirin had by the fourth day developed a highly-significant increase in T cells, CD4 T cells and CD8 T cells and a decrease in B cells. Despite the decrease of B cells, there were significant increases in CD5+ B cells in both treatment groups. However, the degree of increase in the IVIG-and-aspirin treated group was significantly more noticeable than that in the aspirin-alone treated group. These findings indicate that treatment with IVIG restores the T- and B- cell abnormalities, especially CD5+ B-cell abnormalities found in patients with acute KD.
Child, Preschool ; Female ; Human ; Immunoglobulins, Intravenous/*therapeutic use ; Immunophenotyping ; Infant ; Lymphocyte Subsets/*immunology ; Male ; Mucocutaneous Lymph Node Syndrome/immunology/*therapy ; Support, Non-U.S. Gov't

The effect of intravenous immune globulin (IVIG) on the lymphocyte phenotypes in acute Kawasaki disease (KD) was studied in a random trial of IVIG-and-aspirin versus aspirin-alone. Before therapy, patients in each treatment group had an increased percentage of B cells, and a decreased percentage of T cells, CD4 T cells, CD8 T cells and CD5+ B cells. There was no significant difference in immunologic parameters between the two groups measured before therapy. Patients treated with IVIG-and-aspirin had by the fourth day developed a highly-significant increase in T cells, CD4 T cells and CD8 T cells and a decrease in B cells. Despite the decrease of B cells, there were significant increases in CD5+ B cells in both treatment groups. However, the degree of increase in the IVIG-and-aspirin treated group was significantly more noticeable than that in the aspirin-alone treated group. These findings indicate that treatment with IVIG restores the T- and B- cell abnormalities, especially CD5+ B-cell abnormalities found in patients with acute KD.
Child, Preschool ; Female ; Human ; Immunoglobulins, Intravenous/*therapeutic use ; Immunophenotyping ; Infant ; Lymphocyte Subsets/*immunology ; Male ; Mucocutaneous Lymph Node Syndrome/immunology/*therapy ; Support, Non-U.S. Gov't

PURPOSE: To compare the outcomes of bilateral lateral rectus recession between 20 and 25 prism diopters (PD) for intermittent exotropia. METHODS: A retrospective study was performed with a total of 584 patients who underwent surgery for intermittent exotropia and were followed up for more than 12 months. The patients were classified into either the 20 PD group (5 mm bilateral rectus muscle recession [BLR]) or the 25 PD group (6 mm BLR). Successful postoperative motor alignment was defined as within 10 PD of exotropia and 4 PD of esotropia. RESULTS: Cumulative probabilities of surgical success rates for 24 months were 77.9% in the 20 PD group and 54.8% in the 25 PD group, respectively (p < 0.001). Postoperative deviations in recurrence patients were 13.41 +/- 3.64 PD and 14.66 +/- 3.87 PD (p = 0.062) at postoperative 12 months. CONCLUSIONS: All patients with relatively small angle of exodeviation such as 20 PD had a higher success rate and small postoperative exodaviation at 12 months. Therefore, surgery could be considered when the eye is exodeviated with a relatively small angle. However, in the group with the exotropic drift, approximately 2/3 of the preoperative angle of deviation is measured with similar outcomes between preoperative and postoperative angles of deviation.
Esotropia ; Exotropia* ; Humans ; Recurrence ; Retrospective Studies

PURPOSE: Atopic dermatitis is characterized by reduced IFN-gamma production and increased IL-4 production. As a result, IgE production increases in atopic dermatitis. In the previous studies, it was reported that recombinant IFN-gamma therapy is effective in treatment of severe atopic dermatitis. In this study, changes of plasma IFN-gamma, IL-4, IL-5 and IL-10 concentration by IFN-gamma therapy were studied in atopic dermatitis. Changes of plasma IgE levels and eosinophil counts were also investigated in the present report. METHODS: Sixty-five atopic dermatitis patients were studied. Diagnostic criteria for atopic dermatitis were those used by Hanifin and Rajka. Patients received 2x106 units/m2 IFN-gamma by subcutaneous injection eighteen times for six weeks. The following investigations were performed : complete blood cell count, total IgE, eosinophil percentage and total eosinophil count in addition to plasma IFN-gamma, IL-4, IL-5 and IL-10 concentration. RESULTS: Plasma concentrations of IL-4, IL-5 and IL-10 decreased by IFN-gamma therapy in atopic dermatitis. However, plasma IFN-gamma concentration was not changed. No significant correlations among the changes of IgE, eosinophil counts and plasma cytokine concentrations were detected. CONCLUSION: Plasma concentrations of Th2 cytokine such as IL-4, IL-5 and IL-10 decreased by IFN-gamma therapy. This study suggests that Th2 cytokines might not be produced simulaneously. and that changes of Th2 cytokines might not affect the quantitiative changes of IgE and of eosinophil count.
Blood Cell Count ; Cytokines* ; Dermatitis, Atopic* ; Eosinophils ; Humans ; Immunoglobulin E ; Injections, Subcutaneous ; Interferons* ; Interleukin-10 ; Interleukin-4 ; Interleukin-5 ; Plasma*

PURPOSE: Atopic dermatitis is characterized by reduced IFN-gamma production and increased IL-4 production. As a result, IgE production increases in atopic dermatitis. In the previous studies, it was reported that recombinant IFN-gamma therapy is effective in treatment of severe atopic dermatitis. In this study, changes of plasma IFN-gamma, IL-4, IL-5 and IL-10 concentration by IFN-gamma therapy were studied in atopic dermatitis. Changes of plasma IgE levels and eosinophil counts were also investigated in the present report. METHODS: Sixty-five atopic dermatitis patients were studied. Diagnostic criteria for atopic dermatitis were those used by Hanifin and Rajka. Patients received 2x106 units/m2 IFN-gamma by subcutaneous injection eighteen times for six weeks. The following investigations were performed : complete blood cell count, total IgE, eosinophil percentage and total eosinophil count in addition to plasma IFN-gamma, IL-4, IL-5 and IL-10 concentration. RESULTS: Plasma concentrations of IL-4, IL-5 and IL-10 decreased by IFN-gamma therapy in atopic dermatitis. However, plasma IFN-gamma concentration was not changed. No significant correlations among the changes of IgE, eosinophil counts and plasma cytokine concentrations were detected. CONCLUSION: Plasma concentrations of Th2 cytokine such as IL-4, IL-5 and IL-10 decreased by IFN-gamma therapy. This study suggests that Th2 cytokines might not be produced simulaneously. and that changes of Th2 cytokines might not affect the quantitiative changes of IgE and of eosinophil count.
Blood Cell Count ; Cytokines* ; Dermatitis, Atopic* ; Eosinophils ; Humans ; Immunoglobulin E ; Injections, Subcutaneous ; Interferons* ; Interleukin-10 ; Interleukin-4 ; Interleukin-5 ; Plasma*

PURPOSE: This study was carried out to survey the serum anti-PRP titers after the completion of a primary series with 3 doses of the PRP-T conjugate vaccine(ACT-HIBTM), to evaluate the necessity of booster vaccination. METHODS: One hundred twenty healthy infants who went for consultations at Moon Hwa hospital between December 1999 to May 2001 were vaccinated at two, four and six months after birth. The serum antibody levels were measured at 7-8 months and 19-20 months of age by the "Farr" type of radioimmunological method at Aventis Pasteur International in France. RESULTS: The geometric mean of Anti-PRP titers were 24.6 microgram/mL at 7-8 months and then fell to 2.10 microgram/mL at 19-20 months. Minimum Anti-PRP titer was 0.75 microgram/mL at 7-8 months, and 0.1 microgram/mL at 19-20 months. Maximum Anti- PRP titer was 99.2 microgram/mL at 7-8 months, and 9.1 microgram/mL at 19-20 months. Subjects of Anti-PRP titers more than 0.15 microgram/mL were 100% at 7-8 months, and 97.0% at 19-20 months, and subjects of Anti-PRP titers more than 1.0 microgram/mL were 98.3% at 7-8 months, and 61.6% at 19-20 months. CONCLUSION: The Anti-PRP titers at 7-8 months were very high but rapidly decreased at 19-20 months of age, so the necessity of booster vaccination could be considered in Korean children.
Child ; France ; Haemophilus influenzae* ; Haemophilus* ; Humans ; Infant ; Parturition ; Referral and Consultation ; Vaccination*