Chromosome Mapping ; Genome-Wide Association Study ; methods ; Humans

OBJECTIVE:To discuss the economic efficiency of original equipment manufacture(OEM)on drugs.METH?ODS:The economic efficiency of OEM on drugs was evaluated on the basis of transaction cost theory by analyzing the realistic and economic significance of OEM on pharmaceuticals and combining the current situation of supervision.RESULTS&CONCLUSION:The OEM on drugs should be encouraged at the proper time,by which the problem of repeated construction and low percentage of utilization of asset will be solved,and the rationalization of pharmaceutical industrial organization should be realized.

To study anti-leukemic cell mechanism of quercetin, its effects on the proliferation activity of human leukemic cell (HL-60) in vitro were investigated by flow cytometric method and MTT assay.The studies indicated that quercetin showed strong suppression on the proliferation activity of leukmic cells in the time and dose-dependent manner. The value of IC50 and 95% confidence limit were 43. 1 (30. 5~60. 8)?mol/L after 48h. The flow cytometry indicated that it could induce programmed cell death of leukmia HL-60 ecll.

Surgical resection has been accepted as a radical therapy for patients with colorectal cancer, but most of them will develop regional recurrence or distant metastasis. With the development and improvement of novel drugs and methods, they will bring survival hope to patients. In this article, we review the developments in chemotherapy for patients with advanced colorectal cancer.

Serum C-reactive protein (CRP) levels and erythrocyte sedimentation rates (ESR) were measured in 46 patients treated with uncomplicated primary hip replacements, 39 total tip replacements and 7 bipolar hip replacements. In uncomplicated primary hip replacements, ESR levels were slightly elevated preoperatively and were variable postoperatively. But CRP was normal before surgery and elevated in postoperative course, but back to normal within three weeks in most cases. Early success of hip arthroplasty is in indicated by normalization of CRP within three weeks, regardless of ESR. Since ESR seems to react somewhat differently from the CRP, both methods are useful in the monitoring of complications after hip arthroplasty.
Arthroplasty* ; Blood Sedimentation* ; C-Reactive Protein* ; Erythrocytes* ; Hip* ; Humans

No abstract available.
Animals ; Rats* ; Urinary Bladder Neck Obstruction* ; Urinary Bladder*

Objective To investigate the micrometastases of No 13 lymph node in gastric carcinoma. Methods In this study, the expression of CK20mRNA, a specific tumor marker of gastric carcinoma, was detected by RQ-PCR for No. 13 group lymph node micrometastasis in 44 gastric carcinoma patients undergoing D2 radical gastrectomy plus No 13 lymph node dissection. Patient's survival was compared with those of 49 gastric cancer eases receiving standard D2 gastrectomy. Results No 13 lymph node micmmetastasis was detected in 11 out of the 44 gastric cancer cases (25%). Micrometastasis was correlated with tumor histological type (P < 0.01) such as mucoid adenocarcinoma and ring cell carcinoma, but not with age, sex, tumor location, tumor size, Bonnann type, depth of invasion (P > 0.05). Group No13 lymph node micrometastasis was detected in 2 out of 6 cases with positive No[2 lymph nodes and in 4 out of 11 cases with positive No14 lymph nodes, the differences were significant with P <0.01, and P < 0.01 respectively, when compared with those with negative No12 lymph nodes and No14 lymph nodes. After a respective median 448 and 419 days follow-up, no obstructive jaundice caused by No 13 lymph node metastasis was detected after No 13 lymph node dissection in radical gastrectomy for gastric carcinoma and such obstructive jaundice was found in one case in the control group. However, there was no significant difference in tumor recurrence between the two groups (Log Rank x2 = 0.426, P = 0.514). Conclusions Dissection of No 13 lymph node in D2 gastrectomy for gastric carcinoma is recommended in patients with poor-differentiation adenocarcinoma, mucous-cell cancer and signet-ring cell cancer, or when No 12 and No 14 lymph node metastasis is suspected.

Human cytomegalovirus(HCMV)infection is quite prevalent in population. HCMV triggers important disorders in pregnant women,immune-compromised individuals and organ-transplant patients. For dec-ades,more and more scholars believe that NK cells are important immune cells against HCMV. The activity of NK cells largely depends on the balance between the signals transducted by inhibitory receptors and activatory re-ceptors,therefore the study of NK receptors is of great importance. It may be helpful to the basic research and clinical treatment of HCMV infection. Here,this paper reviews the changes and the molecular mechanism of NK receptors in the control of HCMV infection.

Objective To evaluate the clinical efficacy of external biplanar mini-fixator and limited internal fixation in treatment of severe midfoot fracture-dislocation.Methods Eight patients with severe midfoot fracture-dislocation were admitted from May 2009 to August 2012.They were 6 men and 2 women,28 to 57 years of age (average,35.4 years).According to the Gustilo classification,there were one type Ⅱand 7 cases of type Ⅲ.Two cases of midfoot fracture were complicated with dislocation of the transverse tarsal joint,4 with dislocation of the tarsometatarsal joint,and 2 with dislocation of both the transverse tarsal joint and the tarsometatarsal joint.The external biplanar mini-fixator was applied to stabilize and maintain lengths of the medial and lateral columns and normal geometry of the foot arch after reduction of the fracture-dislocation.K-wires were used if limited internal fixation was necessary.The external fixator was removed at 12 to 16 weeks postoperatively.The clinical treatment efficacy was assessed by the American Orthopaedic Foot and Ankle Society (AOFAS) midfoot scale and the visual analogue scale (VAS).Results The patients were followed up for an average of 13.4 months (from 10 to 24 months).Postoperative radiological films showed fine reduction of the fractures and dislocations.No reduction was lost after removal of external and internal fixations.They were able to walk independently and had good functional recovery of the injured feet without traumatic arthritis during the follow-up period.Their average AOFAS scores were 65.8 at 3 months after operation,71.3 at 6 months and 80.6 at 12 months; the average VAS scores were 7.5 at 3 months,4.3 at 6 months,and 1.2 at 12 months,respectively.Conclusion In treatment of severe midfoot fracture-dislocation,external biplanar mini-fixator combined with limited internal fixation can perfectly reconstruct and maintain the medial and lateral columns and normal geometry of the foot arch,preventing functional disability caused by foot malformation.

The data of 173 cases with acute mastitis were collected and reviewed from January 2010 to October 2012.The liquor puris samples were collected for bacterial culture.And drug sensitive test was performed by Kirby-Bauer method.98 samples were cultured with a positive rate of 56.7％.A total of 98 bacterial strains were isolated,Gram-positive bacteria were 91 strains (92.9％) and Gram-negative 7 strains (7.1％).The most common bacteriun Staphylococcus aureus,accounted for 83.7％ was highly resistant to penicillin and erythromycin with resistant rates of 90.2％ and 86.6％ respectively.And there was no resistance to vancomycin and teicoplanin.