No abstract available.
Lung*

No abstract available.
Follow-Up Studies* ; Stomach Neoplasms* ; Stomach*

Congenital constricting band of the trunk is a rare malformation with a wide spectrum of associated congenital anomalies. A 3-year-old boy with a congenital constricting band around the waist and anterior thigh and clubfoot deformity is reported. Laboratory test and chest and abdominal X-ray examination were within normal limits and unremarkable. Histopathologic examination revealed compact fibrocollagenous bundles in deep dermis. The compact fibrocollagenous bundles are parallel to the skin surface and have thin wavy nuclei. We think these bundles caused annular constriction on the trunk. We follow up the patient regularly without specific treatment because the constricting band caused no functional impairment and hypertrophic scar had developed at the biopsy site.
Biopsy ; Child, Preschool ; Cicatrix, Hypertrophic ; Clubfoot ; Congenital Abnormalities ; Constriction ; Dermis ; Follow-Up Studies ; Humans ; Male ; Skin ; Thigh ; Thorax

OBJECTIVES: Health is closely related to an individual's assessment of their quality of life and their subjective level of happiness. The aim of this study was to investigate the association between happiness index and self-rated health by utilizing a community health survey in Korea. METHODS: The study participants were 17,937 people living in Gyeongsangnam-do, Korea, who completed a community health survey in 2014. The non-subjective variables included in the statistical analysis were sex, age, region, education, income, and economic activity. The subjective awareness variables included self-rated health, self-rated oral health, chewing difficulty, pronunciation difficulty, and happiness index. Statistical analysis of the data was done using the SPSS 21.0 program. RESULTS: Evaluation of the subjective awareness levels revealed that the respondents that were better educated, whose income levels were higher, and those who engaged in an economic activity found themselves to be in better physical health and oral health. In contrast, the respondents that were female, older, and with residence in the counties reported a higher incidence of chewing difficulty. There was a positive correlation between happiness index and subjective awareness level, and a negative correlation between chewing difficulty and pronunciation difficulty. Happiness index was influenced the most by subjective health levels, followed by income, age, pronunciation difficulty, subjective oral health, chewing difficulty, academic credential, region, and sex. CONCLUSIONS: Therefore, in order to improve the happiness index of community residents, regular health checkups and systematic oral health education should be prepared in order to improve awareness of subjective health and reduce discomfort in the oral cavity, and efforts should be made to reduce the gap between regions.
Diagnostic Self Evaluation* ; Education ; Female ; Gyeongsangnam-do ; Happiness* ; Health Surveys* ; Humans ; Incidence ; Korea ; Mastication ; Mouth ; Oral Health ; Quality of Life ; Surveys and Questionnaires

PURPOSE: Bacillus Calmette-Guerin (BCG) is the most effective intravesical agent for patients with superficial bladder cancer, but the long-term efficacy of BCG has not been established. We report our long-term experience of intravesical BCG therapy in the recurrence and progression for superficial bladder cancer. PATIENTS AND METHODS: Between 1985 and 1993. high risk patients with superficial bladder cancer were received complete TURB plus intravesical BCG (n=77). 120mg Tice-Chicago strain BCG was administered weekly for 6 weeks and then monthly for 3 months. Patients were considered treatment failure if either urinary cytology or biopsy results were positive for tumor on every 3 to 6 months followup examination. All patients reported have had a minimum 2-year followup, with the mean of 63 months. RESULTS: The 1st course of BCG was successful in 47 (6696) of 71 patients treated for prophylaxis and 3 (50%) of 6 treated for carcinoma in situ. Subsequent progression of disease occurred in 6 patients (8%) and cystectomy was performed in 2 patients (3%). The response rate for the total patients population treated with the 1st course was 65% (50 of 77). Of 27 patients who failed the 1st treatment course 21 patients were given the 2nd BCG treatment course. Of the 2nd BCG course, subsequent progression of disease occurred in 3 patients (14%), and cystectomy was performed in 2 patients (9%). Thirteen (68%) had complete response and 5 (26%) had new tumors, who had rendered free of disease after TURB plus intravesical therapy (mitomycin and/ or BCG). Although serious BCG complications (hepatitis, miliary Tbc, sepsis) were observed in 2 patients, side-effects were self-limiting and well controlled in the majority of patients (fever, bladder irritability, and hematuria). CONCLUSIONS: Intravesical BCG therapy seems to be effective to prevent recurrence and progression of superficial bladder cancer with long-term follow-up. However, we must note the possibility of fatal generalized complications in patients with grossly trauma of lower urinary tract.
Bacillus* ; Biopsy ; Carcinoma in Situ ; Cystectomy ; Follow-Up Studies* ; Humans ; Mycobacterium bovis ; Recurrence ; Treatment Failure ; Urinary Bladder Neoplasms* ; Urinary Bladder* ; Urinary Tract

PURPOSE: We report a case of a recurrent, non-tender mass on the right upper eyelid, which was completely excised and histologically diagnosed as mucinous adenocarcinoma from the eccrine gland. METHODS: A 67-year-old man presented with a non-tender subcutaneous mass on the right upper eyelid, which had developed 6 months prior to presentation. A similar eyelid mass had also been removed one year earlier. We surgically removed some skin and the mass and conducted a biopsy. During the operation, the biopsy revealed it to be mucinous adenocarcinomas, and thus it was removed by Mohs' excision technique with a clean margin. RESULTS: A mucinous adenocarcinoma from the eccrine gland was diagnosed by a histologic examination of the removed mass. A whole-body examination was conducted to determine if the lesion was primary or metastatic, and the results indicated it was primary lesion. There was no evidence of other malignant lesions, and a 21-month follow-up is currently being conducted in case of recurrence. CONCLUSIONS: Primary mucinous adenocarcinoma occuring on an eyelids is a very rare malignant tumor. Complete mass removal is well known to be the best treatment. For differential diagnosis, various examinations of the entire body are required in case the lesion had metastasized from the breast, gastrointestinal tract, kidneys, ovaries, lacrimal glands and so on. Periodical postoperative examinations must be thoroughly performed, since the probability of recurrence is about 30%.
Adenocarcinoma, Mucinous* ; Aged ; Biopsy ; Breast ; Diagnosis, Differential ; Eccrine Glands ; Eyelids* ; Female ; Follow-Up Studies ; Gastrointestinal Tract ; Humans ; Kidney ; Lacrimal Apparatus ; Mucins* ; Ovary ; Recurrence ; Skin

PURPOSE: The authors have experienced various lesions that simulate ganglion of the foot on the ultrasonography. The purpose of this study is to evaluate ultrasonographic findings of soft tissue lesions, which were interpreted as ganglion but confirmed as different lesions in the foot. MATERIALS AND METHODS: We reviewed a database of patients with ganglion on the ultrasonography from two different institutions. There were 109 patients who underwent both ultrasonography and surgical confirmation. Twenty one lesions were identified, of which initial interpretation on the ultrasonography included ganglion which pathology revealed to be different lesions. All images were evaluated by one musculoskeletal radiologist, regarding size, margins, internal echogenicity of lesions, and presence of posterior enhancement. RESULTS: Of 21 lesions, there were 6 fibrous tumors including fibroma, giant cell tumor of tendon sheath, and fibromatosis, 3 hemangiomas, 2 epidermal inclusion cysts, 2 chondromas, 2 angioleiomyomas, 1 trichilemal cyst, 1 neurofibroma, 1 granular cell tumor, 1 neurilemmoma, 1 neuromyxoma, and 1 nodular hidradenoma. Mean size of the lesion was 1.1 cm. Margins were smooth in 10, mild lobulation in 8 and marked lobulation in 3 lesions. Lesions were hypoechoic in 16, anechoic in 4 and isoechoic in 1 case. Posterior acoustic enhancement was definitely present in 5 lesions. CONCLUSION: On the ultrasonography, various soft tissue lesions of the foot may be confused with ganglion. During surgical resection care should be given even to a simple ganglion as it might turn up to be a solid lesions such as fibrous tumors.
Acoustics ; Acrospiroma ; Angiomyoma ; Chondroma ; Fibroma ; Foot ; Ganglion Cysts ; Giant Cell Tumors ; Granular Cell Tumor ; Hemangioma ; Humans ; Neurilemmoma ; Neurofibroma ; Tendons

It is well known that hypertension is associated with left ventricular diastolic dysfunction which frequently precede systolic dysfunction. To determine whether nifedipine could improve left ventricular diastolic function in hypertensive patients, we studied 15 hypertensive patients and 15 normotensive subjects matched for sex, age with Doppler echocardiography. After oral administration of 10mg of nifedipine, there were no significant changes in Doppler-derived transmitral diastolic filling indexes of normotensive subjects. On the other hand, although peak flow velocity in atrial systole(PFVA), time velocity integral in atrial systole(TVIA) did not change significantly after nifedipine, nifedipine significantly increased peak flow velocity in early diastole(PFVE) from 40.2+/-6.4cm/sec to 46.5+/-10.9cm/sec(p<0.005), time velocity integral in early diastole(TVIE) from 5.24+/-1.2cm to 5.97+/-1.43cm(p<0.001), the ratio of PFVE/PFVA from 0.69+/-0.11 to 0.76+/-0.12(p<0.05), the ratio of TVIE/TVIA from 1.18+/-0.21 to 1.29+/-0.24(p<0.05), deceleration slope(DS) from 244.9+/-51.9cm/sec2 to 289.9+/-49.1cm/sec2 (p<0.001) and decreased isovolumic relaxation time(IVRT) from 132.3+/-10.3msec to 117.2+/-13.5msec(p<0.001), deceleration time(DT) from 168.8+/-30.3msec to 154.9+/-29.8msec(p<0.05) in hypertensive patients. These fimdings indicated that nifedipine improves Doppler-derived early diastolic filling indexes in hypertensive patients and may be related to improvement of active relaxation of left ventricle in early diastole.
Administration, Oral ; Deceleration ; Diastole ; Echocardiography, Doppler* ; Hand ; Heart Ventricles ; Humans ; Hypertension ; Nifedipine* ; Relaxation

A 32-year-old multiparous woman (gravida 2, para 2) with a history of previous cesarean section had acute abdominal pain and collapsed at 21 weeks of gestation. Exploratory laparotomy was performed because of the patient's worsening condition; ultrasound examination results were suggestive of massive hemoperitoneum, and fetus in vertex presentation with bradycardia. Uterine rupture between the left lower segment and borderline of the cervix in the anterior wall with active bleeding was confirmed. An uncomplicated classical cesarean section was performed, but the fetus was stillborn due to preterm birth. Hysterectomy was performed after the cesarean section. The patient was admitted to intensive care units for 3 days and was discharged in 12 days following delivery. Placenta percreta at the anterior lower segment of the uterus was confirmed in the pathology report.
Abdominal Pain ; Adult ; Bradycardia ; Cervix Uteri ; Cesarean Section ; Female ; Fetus ; Hemoperitoneum ; Hemorrhage ; Humans ; Hysterectomy ; Intensive Care Units ; Laparotomy ; Pathology ; Placenta Accreta* ; Placenta* ; Pregnancy ; Pregnancy Trimester, Second* ; Pregnancy* ; Premature Birth ; Ultrasonography ; Uterine Rupture* ; Uterus

PURPOSE: To establish new in vitro model systems that better reflect in vivo condition, multicellular tumor spheroids(MTS) and raft culture were developed using cell lines of squamous cell carcinoma(SCCHN) of the head and neck. In these 3-dimensional systems, the expression of cell surface molecules which are important for modulation of physiology of tumor cells were studied with or without the treatment of interferon(IFN)-gamma. MATERIALS AND METHODS: Four SCCHN cell lines were used for MTS and raft culture. The effects of interferon-gamma on SCCHN cells were examined by immunohistochemistry. RESULTS: All cell lines formed MTS, but only Tu-138 showed a good stratification at the air-liquid interface in the raft culture system. Immunohistochemical studies of MTS using monoclonal antibodies revealed a strong staining for MHC class I, no staining for MHC-DR, a weak patch expression of ICAM-1 and a central strong staining for integrin a 6. Staining patterns were similar for the raft cultures except integrin a 6(intense full-thickness positivity). In both systems, IFN-gamma enhanced the expression of MHC-DR and ICAM-1. No significant change was found in the expression of MHC class I and integrin a 6. CONCLUSIONS: MTS and raft culture system were established successfully from the SCCHN cell lines. IFN-gamma can modulate the surface molecules of tumor cells in the 3-dimensional culture systems.
Antibodies, Monoclonal ; Carcinoma, Squamous Cell* ; Cell Line ; Head* ; Immunohistochemistry ; Intercellular Adhesion Molecule-1 ; Interferon-gamma ; Neck* ; Physiology