Possible seasonal differences in serum Insulin-Like Growth Factor-I (IGF-I) concentrations have not been studied in newborn infants. Recently we demonstrated sea- sonal differences in bone mineral content (BMC) in newborn infants: lower BMC was present in summer vs. winter-born infants (J Pediatr Gastroenterol Nutr 1992; 15: 285). In a second stduy, higher serum osteocalcin, an index of bone formation, and lower BMC were found in summer vs. winter (J Pediatr Gastroenterol Nutr 1994; 19: 2207). We speculated that increased serum osteocalcin in summer could be an adaptive response to decreased bone mass. Since growth factors such as IGFs are local regulators of bone formation, we hypothesized that in summer-born infants, serum IGF-I will be higher than in winter, associated with high bone formation activity. Fifty-nine healthy, term appropriate for gestational age (AGA) infants were studied prospectively in winter (Jan-Mar, 29) and in summer (July-Sept., 30). Thirty infants were male, and 29 infants were female. Gestational ages and birth weights were not different by season(in summer, mean+SD, 39.61.1 wk, 3,471360 g,' in winter, 39.31.4 wk, 3,402 392 g). Cord serum IGF-I was measured by radioimmunoassay, modified from Furlanetto et al (1977), after acidification and sep-pack extraction of serum, and osteocalcin concentrations were determined by a kit radio-immunoassay. Cord serum IGF-I concentrations were not different by season of birth(summer vs. winter, 20.11.83 vs. 16.5 1.75 ng/mL, p=0.2). No gender differences were found: 18.21.8 vs. 18.2+1.8 ng/ mL in males vs. females. Serum osteocalcin was higher in summer vs. winter-born infants (8.22.3 vs. 4.951.58 ng/mL, p=0.009). BMC was different by season (87.2+ 14.5 vs. 94.1+16.4 mg/cm, p=0.02). Cord serum IGF-I was not related to serum osteocalcin and BMC. We conclude that serum IGF-I concentrations are not different by season or gender, and are not related to bone formation activity and BMC. Thus, IGF -I concentrations in serum are not seasonally regulated, nor associated with an index of bone formation activity.
Birth Weight ; Bone Density ; Female ; Gestational Age ; Humans ; Infant ; Infant, Newborn* ; Insulin-Like Growth Factor I ; Intercellular Signaling Peptides and Proteins ; Male ; Osteocalcin ; Osteogenesis ; Prospective Studies ; Radioimmunoassay ; Seasons*

PURPOSE: To define the histologic correlation of the ultrsonic gastric wall layers of resected human gastric specimens. MATERIALS AND METHODS: UItrasound images of the gastric wall by using 5 or 7.5 MHz linear transducer were compared with the corresponding histologic sections of 30 surgically resected human gastric specimens. RESULTS: Five layers seen from within on ultrasound images of the normal gastric wall corresponded to (1) the acoustic interface between fluid bathing the surgical specimen and the mucosal surface and a portion of the superficial mucosa, (2) the deep mucosa including the muscularis mucosae and most of the superficial mucosa, (3) the submucosa plus the acoustic interface between the submucosa and the muscularis propria, (4) the muscularis propria minus the acoustic interface between the submucosa and the muscularis propria, and (5) the serosa and the subserosal tissue plus the acoustic interface between the serosa and the fluid bathing the surgical specimen. Ultrasonic findings in gastric carcinomas corresponded to their histopathologic findings. CONCLUSION: Histologic correlation of the ultrasonic gastric wall layers will provide us with a very useful and objective basis of gastric ultrasonography.
Acoustics ; Baths ; Humans ; Mucous Membrane ; Serous Membrane ; Transducers ; Ultrasonics* ; Ultrasonography

Transmitral left ventricular diastolic inflow velocities determined by pulsed Doppler in 47 normotensives, 80 hypertensives and 44 age-matched hypertensives were measured to evaluate the effects of age and left ventricular hypertrophy on left ventricular diastolic fuction in normotensives and hypertensives. The results were as follows: 1) The peak E velocity in normotensives(77.82+/-13.53cm/sec) was significantly different from those of hyeprtensives(58.13+/-11.80cm, p<0.01) and age-matched hypertensives(59.31+/-10.94cm/sec, p<0.01). The peak E/A in normotensives(1.31+/-0.45) was significantly different from those of hypertensives(0.83+/-0.21,p<0.01) and age-matched hypertensives(0.83+/-0.20, p<0.01). 2)In normotensives, simple linear regression analysis revealed strong inverse correlations of peak E with age(r=-0.758, p<0.01), peak E/A with age(r=-0.748, p<0.01), but no significant correlation of peak E and peak E/A with LVMI(p>0.05). Stepwise regression analysis revealed that age was the most important correlate of peak E and peak E/A in normotensives(peak E: R
Heart Diseases ; Hypertrophy, Left Ventricular* ; Linear Models

No abstract available.
Anti-Bacterial Agents* ; Sepsis*

No abstract available.
Polyhydramnios*

No abstract available.
Infant, Newborn ; Meconium Aspiration Syndrome* ; Meconium*

No abstract available.
Hepatitis B virus* ; Hepatitis B* ; Hepatitis* ; Humans ; Infant, Newborn*

No abstract available.
Humans ; Hyalin* ; Hyaline Membrane Disease* ; Infant, Newborn

No abstract available.
Humans ; Infant, Very Low Birth Weight* ; Critical Care*

No abstract available.
Humans ; Infant* ; Infant, Very Low Birth Weight*