The optic canal fracture has been recognized as a clinical entity for quite sometime, and is, by no means, a rare condition. We were aware of it for last several years, and have collected five radiographically proved cases from the records. Interestingly enough, two of these patients were involved in motor-cycle accidents and revealed abrasion over the lateral end of the homolateral eye brow. Only one of these five patients had partial recovery of his vision.
Humans

The antimicrobial agents reduced infectious diseases significantly. However, antibiotic resistance has followed for almost every antimicrobial agent. Especially, Staphylococcus aureus was one of the most notorious for the multidrug resistance. Streptomyces sp. 681 has been selected for antibiotic-producing strain against methicillin-resistant Staphylococcus aureus (MRSA) from 1,000 strains of Actinomycetales which had been isolated from soil. In antimicrobial susceptibility test, all of the test strains were susceptible to vancomycin. However, most strains of Staphylococcus aureus were found to be resistant to methicillin. Ninety eight (75%) strains out of 129 strains showed multiple resistance pattern to more than 5 antimicrobial agents. The MIC values of the purified antibiotic (K-681) were 1-32 ug/ml against Gram-positive bacteria compared to >128 ug/ml against Grarn-negative bacteria or fungi. The MIC was 8 ug/ml for 90% of the 129 clinical isolates of S. aureus. The antibiotic showed no cytotoxicity against P 388, HeLa, and S180 at the concentration of 500 ug/ml.
Actinomycetales ; Anti-Infective Agents ; Bacteria ; Communicable Diseases ; Drug Resistance, Microbial ; Drug Resistance, Multiple ; Fungi ; Gram-Positive Bacteria ; Methicillin ; Methicillin-Resistant Staphylococcus aureus ; Soil ; Staphylococcus aureus* ; Staphylococcus* ; Streptomyces* ; Vancomycin

The fibrillar coat of Candida albicans is of interest as its significance in antigenicity, antiphagocytosis, and adherence to host tissues. The partial biochemical properties and ultrastructure of fibrillar coat induced by rabbit sera were examined. The induced fibrillar layer was destroyed by treatments of lyticase, proteinase K and dithiothreitol. The total protein concentration of fibrillar cell wall lysate was higher than that of non-fibrillar cell wall lysate, but the total sugar concentration was similar. On SDS-PAGE analysis, the protein profiles between in fibrillar cells and in non-fibrillar cells were shown to be different. In fibrillar cells, the major bands of cell wall lysate were 83, 66, 54, 47, 33, and 26 kDa in dithiothreitol-treated lysate. The proteins of 26 and 19 kDa were predominant in lyticase-treated lysate. Although the fibrillar thickness and protein amount of cell wall lysate were increased in according to the incubation time, the protein profiles did not changed. These results suggest that the proteins of 83, 66, 54, 47, 33, 26, and 19 kDa may be major constituents of fibrillar coat in C. albicans.
Candida albicans* ; Candida* ; Cell Wall ; Dithiothreitol ; Electrophoresis, Polyacrylamide Gel ; Endopeptidase K

Exploratory analysis was conducted in a health screening data which had been collected in residents of Taegu city in 1986 to seek out items of serum chemistry associated with hypertension. Six-hundred residents mere than 20 years of age were sampled by the multistage cluster sampling method. Because blood sampling and blood pressure measurements were possible in 384 residents of 600, the rest of 216(36%) were replaced with the healthy visitors to the Department of Health checkup, matched with age and sex. Fivehundred eighty subjects were used in the defined above systolic blood pressure 141mmHg and/or diastolic pressure 91mmHg. The most common age group was under 29 years of age in both sexes, with 103(38.3%) in males and 125(40.2%) in females. Mean body weight of males was Hypertensives were 24(8. in males and 21(6.8%) in females. The items of serum chemistry which showed p values less than 0.25 were glucose, albumin, total cholesterol, ALP and AST in males and glucose, creatinine, albumin, total cholesterol, AST and ALT in females. After controlling age and body weight, glucose and AST showed slightly decreased regression coefficients(beta=0.030, S.E.=0.018, beta= 0.021, S.E.=0.012, respectively) and p values 0.09, 0.08 respectively while albumin, total cholesterol and ALP showed substantially larger p values than unadjusted ones in males. After controlling age and body weight, total cholesterol only remained statistically significant (beta=0.015, S. E. =0. 007, p=0.04). These results suggested that certain items of serum chemistry might be associated with hypertension.
Blood Pressure ; Body Weight ; Chemistry* ; Cholesterol ; Creatinine ; Daegu ; Female ; Glucose ; Humans ; Hypertension* ; Male ; Mass Screening

We reported a case of nontraumatic cerebrospinal fluid fistula who had concomittantly CSF rhinorrhea, pneumocephalus and bacterial meningitis. By metrizamide CT cisternography, we found her CSF fistula was likely to be on the right lateral wall of sphenoidal sinus. She was recovered from her symptoms by medical treatment and has been free of CSF rhinorrhea or meningitis without surgical repair of CSF fistula during recent 1 year follow up.
Cerebrospinal Fluid* ; Fistula* ; Follow-Up Studies ; Meningitis ; Meningitis, Bacterial ; Metrizamide ; Pneumocephalus

We have reported on a case of craniopharyngioma of 11 year old korean who had diabetes insipidus and the other typical symptoms. X-ray finding. Hormonal therapeutic study and review of literature for a case were made friefly.
Child ; Craniopharyngioma* ; Diabetes Insipidus ; Humans

There was decreasment of the domestic animal rabies, but increasment of the sylvatic animal rabies now a days in the world. We could see stable statistics of the ministry of health and social affairs annuala report, however, only rabies we could occationally find out suggestive human rabies by domestic animal for the slight more incidence in Korea. Now, we report on the three cases of sugg. Rabies in our children and review of literature. We think the improvement should be needed for postmortem examination that isn't taking by the Korean custom.
Animals ; Animals, Domestic ; Autopsy ; Child ; Humans ; Incidence ; Korea ; Rabies*

We have reported on a case of hemophilia B (Christmas disease) of 6 month old Korean who was have admitted to our hospital in duration of 7 days on Aug. 1974. Clinical study review of literature for a case were made briefly.
Hemophilia B ; Humans ; Infant

This study was performed to analyse the expression of VEGF and it's receptor(VEGFR) in the tension side of the periodontal ligament following orthodontic tooth movement. Upper first molars of Sprague-Dawley rats were moved medially using closed coil spring for 1, 2, 24 hours and 3, 7, 14 days. H&E staining, immunohistochemical staining and in situ hybridization methods were used to analyse the change of the expression of VEGF and VEGFR. The results from this study were as follows : 1. Following tensional force, periodontal ligament showed elongation of fibers, compression and congestion of vessels and regional hemorrhage. These tissue changes were recovered within 3 days of force application. New bone formation was seen after 3 days of force application and continued for the remaining experimental periods. 2. Following tensional force, VEGF and VEGF mRNA expression was increased in the periodontal ligament cells, osteoblasts and cementoblasts. This change was followed by increased vasculature in the periodontal ligament. 3. After 3 days of tensional force, VEGF and VEGF mRNA expression was confined mainly to the osteopaths and the periodontal ligament cells adjacent to the alveolar bone. After 2 weeks of force application, VEGF and VEGF mRNA expression was reduced to the level of control sample. 4. VEGFRs(Flt-1, Flk-1) showed similar expression pattern and it's expression was mainly seen in the endothelial cells and osteoblasts. Following tensional force VEGFR expression was increased in the endothelial cells and osteoblasts. In conclusion, in the tension side of the periodontal ligament, ligament cells, osteoblast and cementoblast showed increased expression of VEGF & VEGF mRNA. It preceded the increase of vasculature and new bone formation. The increased expression of VEGF mRNA in cementoblast may induce periodontal vessels, which distribute mainly the bone side half of periodontal ligament, grow in the direction of tensional force. Increased expression of VEGFR & VEGFR mRNA not only in endothelial cell but in osteoblast, osteocyte and periodontal cells showed VEGF acts not only in paracrine manner but in autocrine one.
Animals ; Dental Cementum ; Endothelial Cells ; Estrogens, Conjugated (USP) ; Hemorrhage ; Humans ; In Situ Hybridization ; Ligaments ; Molar* ; Osteoblasts ; Osteocytes ; Osteogenesis ; Osteopathic Physicians ; Periodontal Ligament* ; Rats* ; Rats, Sprague-Dawley ; RNA, Messenger ; Tooth Movement* ; Tooth* ; Vascular Endothelial Growth Factor A*

OBJECTIVE: The purpose of this study was to evaluate whether clusterin expression is significantly correlated with paclitaxel resistance in cervical cancer cell lines. METHODS: The expressions of clusterin in cervical cancer cell lines were validated with western blotting. And subsequently, the correlation between clusterin expression levels and the IC50 of paclitaxel in several cervical cancer cell lines was evaluated. After transfection of clusterin siRNA into HeLaS3, which expressed high level of clusterin, their effect on chemo-resistance was evaluated by XTT assay. RESULTS: Clusterin expression levels were correlated with paclitaxel resistance in cervical cancer cell lines. And after transfection of clusterin siRNA into HeLa-S3 significantly decreased paclitaxel resistance (P<0.05). CONCLUSION: These findings suggest that clusterin expression may correlate with paclitaxel resistance.
Blotting, Western ; Cell Line* ; Clusterin* ; Drug Resistance ; Inhibitory Concentration 50 ; Paclitaxel* ; RNA, Small Interfering ; Transfection ; Uterine Cervical Neoplasms*