The effects of skeletal muscle relaxants on skeletal muscle have been well known, but not effects of those drugs on smooth muscle have intensively studied. In an attempt to study the effects of pancuronium, gallamine, succinylcholine and d-tubocurarine on isolated tracheal preparation of mongrel dog. The writters have performed a set of experiment, of which results can be summarized as follow: 1) Pancuronium in dose of 3ug, 10ugi 30ug, 100ug produced dose-dependent relaxation on contraction. 2) Gallamine in dose of 100ug, 300ug, 1,000ug and 3,000ug produced dose dependent relax histamine action on histamine contraction. 3) Succinylocholine in dose of 10ug, 30ug, 100ug and 300ug produced dose dependent contraction on histamine contraction. 4) d-Tubocurarine in dose of 30ug, 100ug, 300ug and 1,000ug produced dose dependent contraction on histamine contraction. From the results described above, it can be concluded that pancuronium and gallamine have bronchodilating character and succinylcholine and d-Tubocurarine have bronchospastic character.
Dogs ; Animals

Three beagle dogs aged over one and half years were used in this study. All mandibular premolars were carefully extracted. Two AVANA implants(Sumin, Korea) and two 3i implants(Implant Innovation, USA) were installed at each right and left side respectively. Each dog was sacrificed at 4, 8. 12 weeks. Non-decalcified specimens were made and stained for a light microscopic study. The results were as follows; 1. Inflammation was not observed in the area of bone tissue adjacent to the implant body. 2. With time, quantity of osseointegration increased in each type of dental implant. There was no difference between AVANA implant and 3i implant. 3. Maturation of the bone around each type of the dental implant increased with time. 12 weeks after implant installation, the bone around dental implant represented compact bone-like appreance. 4. In case implants were located adjacent to a root, newly-formed periodontal ligament tissue was observed around the implant. And the direction of the periodontal ligament fiber was parallel to the surface of the implant. Within the results of this study, AVANA implants represented similar osseointegration in comparision with 3i implants.
Dogs ; Animals

The ultimate goal of periodontal therapy is the regeneration of periodontal tissue and repair of function. For more than a decade there have been many efforts to develop materials and bioactive molecule(such as growth factor and differentiation factors) to promote periodontal wound healing. Among the bioactive molecules, bone morphogenetic protein(BMP) was studied for periodontal wound healing. Since Urist demonstrated that demineralized bone matrix could induce the formation of cartilage and bone in ectopic site, many studies on BMP have been reported. Among those BMPs, it was reported that rhBMP-2 enhanced the healing of bone defects in animal studies and clinical studies. However, its efficacy in periodontal regeneration, especially 1-wall intrabony defects is still unknown. The purpose of this study was to examine the effect of rhBMP-2/ACS on the epithelial migration, gingival connective tissue adhesion, cementum formation, alveolar bone regeneration in intrabony defects of dogs. Four millimeter deep and four millimeter wide 1-wall defects were surgically created in the mesial aspects of the 3rd incisors. The test group received rhBMP-2/ACS with a flap procedure and the control underwent buffer/ACS with a flap procedure. Histologic analysis after 8 weeks of healing revealed the following results: 1. The length of epithelial growth(the distance from alveolar crest to the apical end of JE) was 0.9+/-1.5mm in the control group and 1.2+/-1.4mm in the test group. There was no statistically significant difference between the two groups. 2. The length of connective tissue adhesion was 2.4+/-1.3mm in the control group and 1.2+/-1.1mm in the test group. The control group showed significantly enhanced adhesion(P<0.05). 3. The length of new cementum was 0.9+/-1.0mm in the control group and 1.7+/-0.8mm in the test group. The test group showed significantly enhanced cementum regeneration(P<0.05). 4. The length of new bone height was 1.9+/-0.6mm in the control group and 2.4+/-0.9mm in the test group. There was no statistically significant difference between the two groups. 5. The new bone area was 4.7+/-1.7mm2 in the control group and 8.0+/- 2.0mm2 in the test group. The test group showed significantly enhanced bone formed area(P<0.05). 6. The new bone density was 73.0+/-8.6% in the control group and 66.6+/- 15.3% in the test group. There was no statistically significant difference between the two groups. These results suggest that the use of rhBMP-2 in 1-wall intrabony defects has significant effect on new cementum and new bone formation area, but doesn't have any significant effect on the prevention of junctional epithelium migration and new bone formation height.
Dogs ; Animals

No abstract available.
Dogs ; Animals

No abstract available.
Animals ; Dogs*

No abstract available.
Animals ; Dogs* ; Magnolia* ; Periodontitis*

No abstract available.
Animals ; Calcium* ; Dogs* ; Glass*

Rabies is a fetal viral encephalitis to which all mammals, including man are susceptible. This virus, the genus of Rhabdovirus, is usually present in the saliva of infected animals and is transmitted by their bite. As a rule the virus enter the CNS by ascending along peripheral nervous system and extremely variable in extent. Negri bodies are appear in about 75% of cases. These bodies are eosinophilic, usually rounded inclusions and is located in the cystoplasm of the neurons, most frequently in the pyramidal neurons of the Hippocampus and the Purkinje cells of the cerebellum. We have experienced a case of canine rabies that showed Negri bodies in the Purkinje cells along with diffuse degenerative encephalitis and perivascular mononuclear cells infiltration. The Negri bodies were best demonstrated by Negri body staining although routine H-E staind was also useful. There inclusion bodies were located exclusively in the cytoplasm, and were found occasionally. Electron microscopic findings of the Negri bodies showed aggregates of bulletshaped nucleocapsids. We report a Negri body found in the brain of rabid dog with the light and electron microscopic findings.
Male ; Humans ; Dogs ; Animals

No abstract available.
Animals ; Dogs* ; Membranes* ; Periodontitis*

No abstract available.
Animals ; Dogs* ; Iodopyracet*