1.Genetic Polymorphism in Proteins of the Complement System.
Hyori KIM ; Dobeen HWANG ; Jungwon HAN ; Hwa Kyoung LEE ; Won Jun YANG ; Junyeong JIN ; Ki Hyun KIM ; Sang Il KIM ; Duck Kyun YOO ; Soohyun KIM ; Junho CHUNG
The Journal of the Korean Society for Transplantation 2016;30(2):59-68
The complement system is a part of the innate immune system that potentiates the ability of antibodies and phagocytic cells to clear microbes and damaged cells. The complement system consists of a number of proteins circulating as inactive precursors. It is stimulated mainly by three pathways: the classical pathway, the alternative pathway, and the lectin pathway. There are many genetic polymorphisms in this system, which can over-activate the immune system. In this study, we collected the polymorphisms reported to over-activate complement cascades that affect the immune system and induce autoimmune diseases.
Antibodies
;
Autoimmune Diseases
;
Complement System Proteins*
;
Immune System
;
Phagocytes
;
Polymorphism, Genetic*
Result Analysis
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