Ethanol extract of the mixture of Ligusticum wallichii and Angelica acutiloba exerts significant anticoagulant effect on human blood in in vitro experiments. At concentration of 1:25 in the serum, the extract prolongs the prothrombin, thromboplastin and thrombin times, thus inhibits all the three steps of the coagulation process, i.e, the exogenous, the endogenous precoagulation steps and the formation of fibrins. Finally, at concentration of 1:50 in the serum, the mixture significantly reduces theplatelet aggregation blocking the clotting process.
Anticoagulants ; Blood ; Biochemistry