No Abstract Available.
Allografts* ; Posterior Cruciate Ligament*

Two 4-day-old Thoroughbred foals with acute clinical signs of depression, elevated pulse and respiratory rates, anemia, and jaundice were referred to the equine hospital of Korea Racing Authority. The foals were seemingly normal at birth, but showed clinical signs such as abnormal behavior, jaundice and anemia suddenly after ingestion of the mare's colostrum, followed by death at 4 days after birth. According to the results of the hematology, serum chemistry analysis, jaundice foal agglutination test, and blood groups test, the foals were diagnosed as neonatal isoerythrolysis (NI) caused by the mare's antibodies. These results suggested that the pregnant mares have a potential for NI.
Agglutination Tests ; Anemia ; Antibodies ; Blood Group Antigens ; Colostrum ; Continental Population Groups ; Depression ; Eating ; Hematology ; Humans ; Jaundice ; Korea ; Parturition ; Respiratory Rate

The pathologic spectrums of the tennis elbow are varies as lateral epicondylitis, degenerative partial tear of extensor tendon origin, annular ligament lesion, synovial fringe between radio-capitellar joint, bursitis and posterior interosseous nerve pathology. So it is difficult to perform separate treatments for each different pathologic conditions. Conservative treatments for the tennis elbow are consisted of rest, immobilization, non-steroidal anti-inflammatory drugs (NSAID), and local injection of the steroid. Usual success rates of the conservative treatment have been reported approximately more than 90%. Several methods of surgical treatm nt of the resistant tennis elbow have been reported. Authors performed surgical treatment for twelve cases of the resistant tennis elbow from Jan. 1989 to Jan. 1994. Authors modified the Nirschl's technique; flap retraction of the extensor carpi radilais brevis (ECRB) and common extensor tendon to expose the radio-capitellar joint and no reattachment of detached tendons to the lateral epicondyle and side-to-side suture with maximal stretching of the ECRB tendon. Identified pathologic conditions were the degenerative partial tear and friable granulation tissues at the ECRB origin, sclerosis of the lateral epicondyle (ten cases), synovial fringe bewteen the radio-capitellar joint (two cases). In one case, authors couldn't find any abnormal pathologic conditions. Microscopic examinations (two cases) showed angioblastic proliferation, fibrosis, degeneration of the collagen fiber. Among these patients, eleven patients were industrial worker (eight painter, two welder and one carpenter). They have something in common with using hammer mainly. The hammering might be a possible cause of the tennis elbow. After the surgery, the functional recoveries were satisfactory. The final results were four excellent (33.3%) and good (66.6%) by Nirsh & ettrone grading system. The time required to return to the original job were varied from one month to eight months (average 4.3 months).
Bursitis ; Collagen ; Elbow ; Fibrosis ; Granulation Tissue ; Humans ; Immobilization ; Joints ; Ligaments ; Pathology ; Sclerosis ; Sutures ; Tendons ; Tennis Elbow* ; Tennis*

Purpose: This study was performed to evaluate the incidence of vasovagal reactions (VVRs) and the efficacy of lidocaine injection for prevention. Methods: One hundred seventeen patients diagnosed with hemorrhoids and scheduled to undergo a stapled hemorrhoidopexy (SH) were randomly divided according to submucosal injection to the rectum: lidocaine group (n = 53, lidocaine injected just before full closure of the stapler) and control group (n = 58). Outcomes included baseline patient characteristics (American Society of Anesthesiologists physical status classification, body mass index, diabetes mellitus, hypertension, and previous VVR history), vital signs during the operation, incidence of VVRs (hypotension, bradycardia, dizziness, diaphoresis, and nausea/vomiting), and postoperative complications (pain, bleeding, and urinary retention). Results: Baseline characteristics were similar between groups. The number of patients with lower abdominal pain after firing the stapler and incidence of dizziness were lower for the lidocaine group than for the control group (9.4% vs. 25.9%, P = 0.017; 0% vs. 8.6%, P = 0.035, respectively). However, there were no significant between-group differences in incidence of nausea and diaphoresis (0% vs. 3.4%, P = 0.172) and syncope (1.9% vs. 3.4%, P = 0.612). Fewer patients in the lidocaine group complained of postoperative pain (41.5% vs. 58.6%, P = 0.072), and these patients used analgesics less frequently than those in the control group (28.3% vs. 36.2%, P = 0.374). Conclusion Patients who received a submucosal lidocaine injection prior to SH experienced less lower abdominal pain and dizziness compared with those who received standard treatment. A larger, more detailed prospective study is needed for further analysis.

PURPOSE: We studied the clinical outcome of nasolacrimal probing according to the age and silicone tube intubation for congenital nasolacrimal duct obstruction. METHODS: We analyzed a total of 76 patients (99 eyes) who had undergone nasolacrimal duct probing performed in the office under topical anesthesia and 18 patients (20 eyes) who had undergone silicone tube intubation under general anesthesia between February 1997 and March 2001. Patients who had undergone probing were grouped according to their age at the time of probing: 6 months or less (group 1), 7 to 12 months (group 2) and 13 months or older (group 3). RESULTS: The overall success rate by probing was 84%. The success rate of probing in those under 6 months of age was 88%; in those from age 7 to 12 months, 86%; and in those 13 months or older, the rate decreased to 76%. The decrease in success rate after 13 months was statistically significant (P<0.05). The success rate of silicone tube intubation was 95%. CONCLUSION: We concluded that early office probing under 12 months of age for congenital nasolacrimal duct obstruction is an effective method for treatment of symptomatic nasolacrimal duct obstruction. In case over 13 months of age, probing is also considered as the first choice of treatment although its success rate is lower than the former. Silicone tube intubation is an effective method in case of failure of repeated probing and over 20 months of age.
Anesthesia ; Anesthesia, General ; Humans ; Intubation* ; Nasolacrimal Duct* ; Silicones*

OBJECTIVES: Cord blood stem cells have been widely used as donor cells for bone marrow transplantation recently. These cells can give rise to a variety of hematopoietic lineages to repopulate the blood. Recent observations reveal that some bone marrow cells and bone marrow stromal cells(MSCs) can grow to become either neurons or glial cells. It is, however, unclear whether or not there exists stems cells which can differentiate into neurons in the blood during the early stages of postnatal life. METHODS: Human cord blood stem cells were prepared from human placenta after full term delivery. To induce neuronal differentiation of stem cells, beta-mercaptoethanol was treated. To confirm the neuro-glial characteristics of differentiated stem cells, immunocytochemical stain for NeuN, neurofilament, glial fibrillary acidic protein(GFAP), microtubule associated protein2(MAP2) was performed. RT-PCR was performed for detecting nestin mRNA and MAP2 mRNA. RESULTS: We showed in this experiment that neuro-glial markers(NeuN, neurofilament, MAP2, GFAP) were expressed and axon-like cytoplasmic processes are elaborated in the cultured human cord blood stem cells prepared from new born placenta after full term delivery. Nestin mRNA was also detected in fresh cord blood monocytes. Conclusions: These results suggest that human cord blood derived stem cells may be potential sources of neurons in early postnatal life.
Bone Marrow ; Bone Marrow Cells ; Bone Marrow Transplantation ; Cytoplasm ; Fetal Blood* ; Humans* ; Microtubules ; Monocytes ; Nestin ; Neural Stem Cells ; Neuroglia ; Neurons ; Placenta ; RNA, Messenger ; Stem Cells ; Tissue Donors ; Umbilical Cord*

BACKGROUND: We evaluated the prevalence of thyroid cancer in patients with cold thyroid nodules and the impact of sex, age, hardness of nodule, and multinodularity as factors able to predict the probability of malignancy in patients with nodular thyroid diseases. METHODS: We examined a 728 patients who visited Seoul National University Hospital with one or more cold thyroid nodules between Jan. 1996 and Dec. 1997. After clinical evaluations including medical history, physical examinations(size, hardness and multiplicity of nodule), fine needle aspiration biopsies and cytologic examinations were carried out. RESULTS: Among the 728 cases, 76 cases(10.4%) were diagnosed as cancer and 602 cases (82.6%) were diagnosed as benign nodule. The prevalence of cancer was significantly lower in female patients with cold nodules(9.4%, 62/662) than in males(17.5%, 11/63)(p=0.041). Age was an important factor in both sexes. The proportion of nodules that were malignant was lower in patients of 20-60 years old(8,9%, 56/632) than patients younger than 20 years old(1S.1%, 2/11) or older than 60 years old(18.3%, 15/82)(p=0.019). The prevalence of cancer was significantly higher in hard nodules(36.3%, 41/113) than firm(5.2%, 30/574) or soft nodules(5.3%, 2/38)(p= 0.001). There was no size difference between malignant(25.2 +- 13.7mm) and benign nodules(25.3 +- 8.9mm)(p=0.9425). The prevalence of thyroid cancer in solitary nodule(10.6%, 63/593) was not different from that in multiple nodules(7.6%, 10/132)(p=0.293). CONCLUSION: Our data suggest that thyroid nodules of the patients who are younger than 20 years old or older than 60 years old, male, as well as hard nodule require more careful evaluation for the risk of thyroid malignancies.
Biopsy ; Biopsy, Fine-Needle ; Female ; Hardness ; Humans ; Male ; Middle Aged ; Prevalence* ; Seoul ; Thyroid Diseases ; Thyroid Gland* ; Thyroid Neoplasms* ; Thyroid Nodule* ; Young Adult

We report herein the case of a 38-year-old woman with Cushings syndrome caused by bilateral adrenocortical adenomas. The adrenal tumor on the left side hypersecreted cortisol and no findings of cortisol hypersecretion from the adrenal tumor on the right side were observed on bilateral adrenal vein samplings. Both adrenal tumors were resected and histologically without any findings of nodular hyperplasia. The left adrenal tumor was histologically diagnosed as a so-called black adenoma. These data imply that the adrenal adenomas developed primarily from the adrenal gland itself, and that one of the tumors was well differentiated and secreted excess hormones, while the other remained in cell proliferation without hypersecretion.
Adenoma* ; Adrenal Glands ; Adrenocortical Adenoma* ; Adult ; Cell Proliferation ; Cushing Syndrome* ; Female ; Humans ; Hydrocortisone ; Hyperplasia ; Veins

BACKGROUND: Leptin, produced in the adipose tissue, is involved in the regulation of body weight. The release of the leptin is increased in obese adults even in children. This study investigated whether the serum leptin in cord blood was related to babys birth weight and metabolic parameters. METHODS: 71 pairs of singleton pregnancy babies and their mother were studied. Babies are classified in LGA (large for gestational age), AGA (appropriate for gestational age), SGA (small for gestational age) three groups. After delivery, cord blood and maternal venous blood samples were drawn. We measured the plasma leptin, insulin-like growth factor (IGF)-1, insulin and proinsulin in cord and maternal serum. RESULTS: The concentration of leptin from cord blood was increased in LGA babies and decreased in SGA babies compued with the level in AGA babies. There was positive correlatian (r=0.55, p<0.01) between the plasma leptin level in cord and birth weight. There were positive correlatian between both the plasma proinsulin (r=0.37, p<0.01) and IGF-1 (r=0.32, p<0.01) and birth weight, too. But there was no difference between female and male baby's cord blood leptin level. In multiple regression analysis, cord blood leptin level was found independent factor related to birth weight ( p=0.001) CONCLUDION : The plasma leptin, proinsulin and IGF-1 is correlates to the birth weight. These data provide evidence that leptin and proinsulin are highly related to the nutritional status already during the fetal periods, and effect on the intrauterine fetal growth.
Adipose Tissue ; Adult ; Birth Weight* ; Body Weight ; Child ; Female ; Fetal Blood* ; Fetal Development ; Humans ; Insulin ; Insulin-Like Growth Factor I ; Leptin* ; Male ; Mothers ; Nutritional Status ; Parturition* ; Plasma ; Pregnancy ; Proinsulin

BACKGROUND: Among the various factors affecting bone mass and bone metabolism, aging and menopause play a major role. After the disappearance of the menstrual cycle, estrogen deficiency is the most important factor in bone loss. It is still unclear whether women with early menopause have a rate of bone loss different from women whose menopause has occurred later. Various biochemical bone markers are increased after menopause but it is still unclear whether women with early menopause have biochemical bone markers different from women whose menopause has occurred later. The aim of this study was to establish whether healthy women with early or normal menopause have different bone mass, biochemical bone markers and rates of bone loss. METHODS: Postmenopausal healthy women were divided into two groups according to their age at menopause(AAM): one group with AAM > 43 years, and the other group with AAM 50 years. Bone mass was measured using a dual energy X-ray absorptiometry(DEXA) in the lumbar, femur neck, femur trochanter, and Wards triangle. Serum levels of bone alkaline phosphatase and osteocalcin, and urine levels of calcium, deoxypyridinoline and type I collagen N-telopeptide were measured using a commercial kit. RESULTS: Age and body mass index in the early menopause group were different from those in the normal menopause group. All the bone mass and the biochemical bone markers in the early menopause group were not different from those in the normal menopause group. We selected 15 subjects from the two groups matched by age and BML Bone mass of femur neck in the early menopause group was lower than in the normal menopause group matched by age and BMI. Bone mass in lumbar, femur trochanter, and Wards triangle was lower in the early menopause group than in the normal menopause group, but the difference between the two groups was not significant. After adjusting years since menopause, we didnt find the difference of bone mass between the two groups. All the bone biochemical markers were not different in the two groups matched by age and BMI. CONCLUSION: Our data suggest that women with early menopause dont lose bone faster than women with normal menopause.
Aging ; Alkaline Phosphatase ; Biomarkers ; Body Mass Index ; Bone Density* ; Calcium ; Collagen Type I ; Estrogens ; Female ; Femur ; Femur Neck ; Humans ; Menopause* ; Menstrual Cycle ; Metabolism ; Osteocalcin