1.A Case of Congenital Intrahepatic Portosystemic Venous Shunt.
Do Yeon KIM ; Dong Jin LEE ; Jung Hyeok KWON
Journal of the Korean Pediatric Society 2000;43(2):283-287
Intrahepatic portosystemic venous shunt(IPVS) is an uncommon pathologic condition which occurs mostly in adult patients with portal hypertension and cirrhosis of the liver with only scattered reports are on children. However, asymptomatic IPVS have been detected in an increasing number of patients with recent advances in imaging techniques, such as sonography, CT, MR imaging, and color Doppler sonography. The cause of IPVS remains unknown, but two probable origins have been proposed, congenital and acquired origin. In the congenital origin, it has been proposed that the IPVS develops from embryologic vascular remnants. Acquired IPVS can develop into intrahepatic collateral pathway in the presence of portal hypertension and cirrhosis of the liver. We report a case of congenital IPVS with suspicious sepsis in a 6-day-old female patient. An abdominal ultrasonography and color Doppler sonography demonstrated an aneurysmal type of anomalous shunt connecting the right portal vein to the right hepatic vein. The patient continued to be symptomatic after discharge and a follow-up ultrasonography 3 months later revealed the disappearance of the previous IPVS.
Adult
;
Aneurysm
;
Child
;
Female
;
Fibrosis
;
Follow-Up Studies
;
Hepatic Veins
;
Humans
;
Hypertension, Portal
;
Liver
;
Magnetic Resonance Imaging
;
Portal Vein
;
Sepsis
;
Ultrasonography
2.Survival benefits of warfarin in Korean patients with idiopathic pulmonary arterial hypertension.
Byung Ju KANG ; Yeon Mok OH ; Sang Do LEE ; Jae Seung LEE
The Korean Journal of Internal Medicine 2015;30(6):837-845
BACKGROUND/AIMS: Idiopathic pulmonary arterial hypertension (IPAH) is an incurable disease with high mortality. Although most studies recommend anticoagulation treatment for IPAH, the benefits are uncertain, particularly in Korea, where it has not been studied. The purpose of this study was to evaluate survival outcomes of Korean patients with IPAH treated with warfarin. METHODS: We performed a retrospective cohort study of patients diagnosed previously with pulmonary arterial hypertension (PAH) at the Asan Medical Center in Korea, between January 1994 and February 2013. We excluded patients with associated PAH, patients who did not undergo right heart catheterization (RHC), and patients with a positive vasoreactivity test. Patients in the study cohort were classified into a "warfarin group" and a "non-warfarin group," according to the treatment they received during the first year after diagnosis. RESULTS: We identified 31 patients with IPAH and a negative vasoreactivity test on RHC. Median patient age was 36.0 years, and 23 patients (74.2%) were female. The median time from the onset of symptoms to diagnosis was 19.0 months, and the most common presenting symptom was dyspnea. Survival rates of the patients at 1, 3, 5, and 10 years were 90.2%, 79.5%, 62.7%, and 34.8%, respectively. The mean survival period was 12.0 years in the warfarin group and 6.1 years in the non-warfarin group. Warfarin treatment had significant survival benefits in patients with IPAH (p = 0.023). CONCLUSIONS: Warfarin treatment substantially improved survival outcomes in Korean cases of IPAH.
Adult
;
Anticoagulants/*therapeutic use
;
Asian Continental Ancestry Group
;
Familial Primary Pulmonary Hypertension/diagnosis/*drug therapy/ethnology/mortality
;
Female
;
Humans
;
Kaplan-Meier Estimate
;
Male
;
Proportional Hazards Models
;
Protective Factors
;
Republic of Korea
;
Retrospective Studies
;
Risk Factors
;
Time Factors
;
Treatment Outcome
;
Warfarin/*therapeutic use
3.Primary MALT(mucosa-associated lymphoid tissue) Type Lymphoma of the Liver.
Do Youn PARK ; Jee Yeon KIM ; Hyo Jeong CHAE ; Jin Sook LEE ; Chang Hun LEE ; Mee Young SOL ; Kang Suek SUH ; Sun Kyung LEE
Korean Journal of Pathology 1997;31(12):1317-1319
Primary non-Hodgkin' lymphomas of the liver, an organ normally devoid of a native lymphoid tissue, are very rare. We recently experienced a case of a primary low-grade hepatic B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type in a 36-year-old woman. The ultrasonography revealed a 5 cm sized mass in the right lobe of the liver. A right segmentectomy of the liver was done and showed a relatively well-circumscribed brownish yellow lobulated homogenous mass, measuring 5.5x4.5 cm in size. Histologic sections of liver mass revealed large lymphoid follicles with reactive germinal centers, follicular colonization by centrocyte-like cells (CCL cells), and lymphoepithelial lesions. The CCL cells were positive for B-cell (CD20), LCA (CD45RA), Bcl-2 oncoprotein, and lambda light chain.
Adult
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B-Lymphocytes
;
Colon
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Female
;
Germinal Center
;
Humans
;
Liver*
;
Lymphoid Tissue
;
Lymphoma*
;
Lymphoma, B-Cell
;
Mastectomy, Segmental
;
Ultrasonography
4.Dose-Dependent Inhibitory Effect of Nitric Oxide on Embryo Development.
Sea Hee PARK ; Bo Sun JOO ; Hwa Sook MOON ; Yoon Yeon KIM ; Jae Dong CHO ; Ho Sung KANG ; Han Do KIM
Korean Journal of Fertility and Sterility 1999;26(2):203-211
No abstract available.
Embryonic Development*
;
Embryonic Structures*
;
Female
;
Nitric Oxide*
;
Pregnancy
5.CT Evaluation of Postoperative Pericardal Adhesion in Patients Receiving Redo-Valve Surgery.
Yeon Hee LEE ; Do Yun LEE ; Kyu Ok CHOI ; Byung Chul CHANG ; Meyun Shick KANG ; Bum Koo CHO ; Sung Nok HONG
Journal of the Korean Radiological Society 1994;30(4):681-686
PURPOSE: To evaluate the efficacy of computed tomography(CT) in detecting pericardial adhesion. MATERIALS AND METHODS: CT of 32 patients with 'redo-valve surgery' was retrospectively evaluated for the location and appearance of their surgically confirmed pericardial adhesion. CT of 20 cases without cardiac or pericardial disease was reviewed as normal control. RESULTS: Nodular increased density at the site of adhesion between the sternum and the right atrium(RA) or ascending aorta(n=10), retrosternal dirty fat(n=10), obliteration of the pericardial fat(n=28), cardiac contour change with or without nodular epicardial fat accumulation(n=10), diffuse pericardial thickening(n=14), and pericardial calcification(n=13) were considered to be important findings. We also noticed an additional findings of beak-like projection of RA appendage(n=13), but was considered less significant because they were also observed in 4 normal subjects. CONCLUSION: CT scan is an effective, simple, and noninvasive method for predicting pericardial adhesion that may be occurred after redo-valve surgery.
Humans
;
Retrospective Studies
;
Sternum
;
Tomography, X-Ray Computed
6.Tooth Loss Is Associated with Brain White Matter Change and Silent Infarction among Adults without Dementia and Stroke.
Yang Ki MINN ; Seung Han SUK ; Hyunyoung PARK ; Jin Sung CHEONG ; Hyunduk YANG ; Sungik LEE ; Seung Yeon DO ; Ji Sook KANG
Journal of Korean Medical Science 2013;28(6):929-933
Periodontal disease is a predictor of stroke and cognitive impairment. The association between the number of lost teeth (an indicator of periodontal disease) and silent infarcts and cerebral white matter changes on brain CT was investigated in community-dwelling adults without dementia or stroke. Dental examination and CT were performed in 438 stroke- and dementia-free subjects older than 50 yr (mean age, 63 +/- 7.9 yr), who were recruited for an early health check-up program as part of the Prevention of Stroke and Dementia (PRESENT) project between 2009 and 2010. In unadjusted analyses, the odds ratio (OR) for silent cerebral infarcts and cerebral white matter changes for subjects with 6-10 and > 10 lost teeth was 2.3 (95% CI, 1.38-4.39; P = 0.006) and 4.2 (95% CI, 1.57-5.64; P < 0.001), respectively, as compared to subjects with 0-5 lost teeth. After adjustment for age, education, hypertension, diabetes mellitus, hyperlipidemia, and smoking, the ORs were 1.7 (95% CI, 1.08-3.69; P = 0.12) and 3.9 (95% CI, 1.27-5.02; P < 0.001), respectively. These findings suggest that severe tooth loss may be a predictor of silent cerebral infarcts and cerebral white matter changes in community-dwelling, stroke- and dementia-free adults.
Age Factors
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Aged
;
Alzheimer Disease/diagnosis
;
Brain/*radiography
;
Cross-Sectional Studies
;
Dementia/pathology/prevention & control
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Diabetes Complications/diagnosis
;
Female
;
Humans
;
Hyperlipidemias/complications
;
Hypertension/complications
;
Interviews as Topic
;
Male
;
Middle Aged
;
Odds Ratio
;
Periodontal Diseases/complications/*diagnosis
;
Predictive Value of Tests
;
Risk Factors
;
Stroke/pathology/prevention & control
;
Tomography, X-Ray Computed
;
Tooth Loss
7.Comparison of Laparoscopic with Open Resections in Colorectal Cancer: Analysis of Short-term Results.
Yong Won KANG ; Seo Gu YOON ; Eu Gene KIM ; Chang Mok LEE ; Kwang Yeon KIM
Journal of the Korean Society of Coloproctology 2007;23(2):93-100
PURPOSE: This study aimed to compare the results of laparoscopic resection with those of open resection for consecutive colorectal cancer patients who underwent surgery at a single center. METHODS: During the thirty-month period between January 2003 and August 2005, patients with a colorectal adenocarcinoma admitted to our hospital were assessed. Cancers related with FAP or HNPCC, cancers treated with endoscopy or local excision, and recurrent cancers were excluded from the study. Three hundred two laparoscopic resection patients were matched to 302 open resection patients. RESULTS: The mean age of the laparoscopic resection group was 59.5 years while that of the open resection group was 59.4 years. Patients in two groups were similar in terms of gender distribution, level of CEA and ASA, and location and size of tumor. The modified Dukes' stages showed 51 patients in stage A, 33 in stage B1, 62 in stage B2, 17 in stage C1, and 139 in stage C2 for the laparoscopic resection group and 33 in stage A, 52 in stage B1, 82 in stage B2, 18 in stage C1, and 117 in stage C2 for the open resection group (P=0.024). The operative time averaged 9.6 minutes longer in the laparoscopic group (188.9 vs. 179.3 min, P<0.0001). The rate of stoma formation for protection of anastomosis in the laparoscopic group was 4.9% (5.8% in open group). There were significant differences in blood loss (556.2 vs. 952.8 ml, P<0.0001), the amount of intraoperative blood transfusion (1.6 vs. 2.3 unit, P=0.004), the number of harvested lymph nodes (21.1 vs. 16.9, P<0.0001), and the rate of high ligation of IMA (91.7 vs. 75.5%, P<0.0001). The length of the distal resection margins from cancer was longer in the open group (2.9 vs. 3.5 cm, P=0.037). Patients in the laparoscopic group had a faster recovery of bowel function (P<0.0001) and a significant reduction in the mean length of hospital stay (11.5 vs. 16.8 days, P<0.0001). There was no mortality in either group. Early and late complications were comparable. The conversion rate was 1.6 percent. CONSLUSIONS: The benefits of a laparoscopic resection for colorectal cancers are less blood loss and transfusion, faster postoperative bowel motion, a shorter hospital stay, low morbidity, and a large number of harvested lymph nodes. In conclusion, a laparoscopic resection for colorectal cancers can be done safely and effectively and is an acceptable alternative to a conventional open resection.
Adenocarcinoma
;
Blood Transfusion
;
Colorectal Neoplasms*
;
Endoscopy
;
Humans
;
Length of Stay
;
Ligation
;
Lymph Nodes
;
Mortality
;
Operative Time
8.Recurred Angiomyofibroblastoma of the Vulva: Report of a case.
Do Youn PARK ; Ji Yeon KIM ; OK Hyeon KIM ; Hwa Sun LEE ; Mee Young SOL ; Kang Suek SUH ; Sun Kyung LEE
Korean Journal of Pathology 1996;30(10):947-950
Angiomyofibroblastoma is a rare, benign mesenchymal tumor of the vulva. Since it was described in 1992 by Fletcher, 15 cases have been reported in literature. We recently experienced a recurred angiomyofibroblastoma of the vulva. A 45-year-old woman was presented initially in 1991 with a mass of labium major and local excision of tumor mass had been performed. A histologic diagnosis was made of angiomyxoma, but this diagnosis was revised to angiomyofibroblastoma by the authors. The recurred mass was well circumscribed, measuring 2.5x1.6x1.5cm in dimensions. Microscopically the tumor was characterized by high cellularity, numerous blood vessels(which lack prominent hyalinization), and plump stromal cells. Immunohistochemically, the stromal cells were reactive for vimentin and desmin, but not alpha-smooth muscle actin, or S-100 protein. We thought that this case was a recurred angiomyofibrblastoma of the vulva due to incomplete surgical excision.
Female
;
Humans
9.Is Surgical Excision Necessary for a Benign Phyllodes Tumor of the Breast Diagnosed and Excised by Ultrasound-guided Vacuum-assisted Biopsy Device (Mammotome)?.
Hai Lin PARK ; Seok Seon KANG ; Do Youn KIM ; Jung Yeon SHIM
Journal of the Korean Surgical Society 2007;73(3):198-203
PURPOSE: Phyllodes tumors are characterized by a double-layered epithelial component arranged in cleft-like ducts surrounded by a hypercellular spindle-celled stroma. Currently, phyllodes tumors are classified as benign, borderline, or malignant based on microscopic features. The relatively high rate of recurrence is an unsolved management problem. If a malignant phllodes tumor is treated inadequately, it may show a propensity for rapid growth and metastatic spread. However, benign phyllodes tumor are often indistinguishable from fibroadenoma, and can be cured by local surgery. Percutaneous removal of benign breast tumors using the Mammotome system has recently been regarded as a feasible, safe method without serious complications. The Mammotome system has an expanding role in the surgical treatment of benign breast disease, and may further extend its role to the excision of small malignant lesions. The aim of this study was to evaluate the efficacy and the safety of the Mammotome biopsy device in the treatment of benign phyllodes tumor, and to identify whether surgical excision is necessary for benign phyllodes tumors diagnosed and excised by Mammotome. METHODS: From Jan. 2003 to Feb. 2007, a total of 2,751 US- guided mammotome excisions were performed in 2,226 patients at Kangnam Cha hospital. Out of 2,751 lesions, 30 lesions were proved to be benign phyllodes tumors. All lesions were removed using an 8-gauge probe without any residual lesions. Ultrasonographic follow-up was performed at a 3- to 6-month interval to assess recurrence. The mean follow-up period was 33.2 months (max, 51 months; min, 2 months). RESULTS: The mean patient age was 31.4 years. The average size of the lesion was 1.5 cm (SD+0.43 cm). The majority of lesions, 73.3% (22 cases), were palpable, and 26.7% (8 cases) were nonpalpable. Twenty-two lesions (73.8%) were classified as BIRADS category 3, eight lesions (26.7%) were classified as category 4A by ultrasound. During the follow-up period, local recurrence developed in only one patient, making the local recurrence rate 3.3%. No distant metastasis was observed. CONCLUSION: Benign phyllodes tumors found on mammotome excision may not require surgical reexcision if surgeons are sure that the targeted lesions were excised completely and the follow-up ultrasound does not show any residual lesions, especially in small phyllodes tumors, the greatest dimension of which is less than 3 cm.
Biopsy*
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Breast Diseases
;
Breast Neoplasms
;
Breast*
;
Fibroadenoma
;
Follow-Up Studies
;
Humans
;
Neoplasm Metastasis
;
Phyllodes Tumor*
;
Recurrence
;
Ultrasonography
10.A Study of Protein S Deficiency in Antiphospholipid Syndrome.
Yoon Sung NAM ; Nam Keun KIM ; Myung Seo KANG ; Do Yeon OH ; Kwang Yul CHA
Korean Journal of Fertility and Sterility 2001;28(2):105-110
OBJECTIVE: To evaluate the abnormality of protein S in patients with recurrent spontaneous abortion due to antiphospholipid syndrome. MATERIALS AND METHOD: Antigen and activity of protein S were analyzed by enzyme immunoassay and clotting method, respectively. RESULTS: Of 18 patients with antiphospholipid syndrome, 4 patients were found to have no abnormality of protein S. There were 14 cases of protein S abnormality. Among them, there were 8 cases of type 1, 1 case of type 2, and 5 cases of type 3 protein S deficiency. CONCLUSION: So in the workup of patients with recurrent spontaneous abortion due to antiphospholipid syndrome, the evaluation for protein S is required.
Abortion, Spontaneous
;
Antiphospholipid Syndrome*
;
Female
;
Humans
;
Immunoenzyme Techniques
;
Pregnancy
;
Protein S Deficiency*
;
Protein S*